Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (12 Aug 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

SR-related and CTD-associated factor 8

Gene

SCAF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UPN6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SR-related and CTD-associated factor 81 Publication
Alternative name(s):
CDC5L complex-associated protein 71 Publication
RNA-binding motif protein 16Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCAF81 PublicationImported
Synonyms:CCAP71 Publication, KIAA11161 Publication, RBM16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000213079.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20959, SCAF8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616024, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22828

Open Targets

More...
OpenTargetsi
ENSG00000213079

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394587

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPN6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCAF8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30580495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817801 – 1271SR-related and CTD-associated factor 8Add BLAST1271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6Phosphothreonine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Modified residuei273PhosphoserineCombined sources1
Modified residuei615PhosphothreonineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei779PhosphoserineCombined sources1
Modified residuei917Asymmetric dimethylarginineCombined sources1
Modified residuei927Asymmetric dimethylarginineCombined sources1
Modified residuei938Asymmetric dimethylarginineCombined sources1
Modified residuei1073Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPN6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPN6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPN6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPN6

PeptideAtlas

More...
PeptideAtlasi
Q9UPN6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPN6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6932
85390 [Q9UPN6-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UPN6, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213079, Expressed in corpus callosum and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPN6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPN6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213079, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A; via C-terminal heptapeptide repeat domain (CTD) phosphorylated at 'Ser-2' and 'Ser-5' (PubMed:18550522, PubMed:9528809, PubMed:31104839).

Identified in a complex with CDC5L and other spliceosomal proteins (PubMed:11101529).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116503, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UPN6

Protein interaction database and analysis system

More...
IntActi
Q9UPN6, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9UPN6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000413098

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UPN6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UPN6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UPN6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 139CIDPROSITE-ProRule annotationAdd BLAST139
Domaini477 – 551RRMPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi193 – 371Gln-richAdd BLAST179
Compositional biasi397 – 459Arg-richAdd BLAST63
Compositional biasi635 – 1064Pro-richAdd BLAST430
Compositional biasi1120 – 1182Arg-richAdd BLAST63

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0132, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005263_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPN6

KEGG Orthology (KO)

More...
KOi
K13191

Database of Orthologous Groups

More...
OrthoDBi
821342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPN6

TreeFam database of animal gene trees

More...
TreeFami
TF324527

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12462, RRM_SCAF8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.90, 1 hit
3.30.70.330, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID00590

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR006903, RNA_pol_II-bd
IPR000504, RRM_dom
IPR034370, SCAF8_RRM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818, CTD_bind, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVKTFNSE LYSLNDYKPP ISKAKMTQIT KAAIKAIKFY KHVVQSVEKF
60 70 80 90 100
IQKCKPEYKV PGLYVIDSIV RQSRHQFGQE KDVFAPRFSN NIISTFQNLY
110 120 130 140 150
RCPGDDKSKI VRVLNLWQKN NVFKSEIIQP LLDMAAGIPP PVVTPVLAST
160 170 180 190 200
TTAMSNTPGT PVTPVTPANV VQGLPDPWVS QITNTDTLAA VAQILQSPQG
210 220 230 240 250
QQLQQLIQTL QIQQQKPQPS ILQALDAGLV VQLQALTAQL TAAAAAANTL
260 270 280 290 300
TPLEQGVSFN KKLMDRFDFG EDSEHSEEPK KEIPASQLSH VSESVNNSIF
310 320 330 340 350
HQIAEQLQQQ NLEHLRQQLL EQQQPQKATP QDSQEGTFGS EHSASPSQGS
360 370 380 390 400
SQQHFLEPEV NLDDSIDIQQ QDMDIDEGQD GVEEEVFEQE AKKVAVRSRS
410 420 430 440 450
RTHSRSRSRS PRKRRSRSRS GSRKRKHRKR SRSRSRERKR KSSRSYSSER
460 470 480 490 500
RAREREKERQ KKGLPPIRSK TLSVCSTTLW VGQVDKKATQ QDLTNLFEEF
510 520 530 540 550
GQIESINMIP PRGCAYVCMV HRQDAFRALQ KLSSGSYKIG SKVIKIAWAL
560 570 580 590 600
NKGVKTEYKQ FWDVDLGVTY IPWEKVKVDD LEGFAEGGMI DQETVNTEWE
610 620 630 640 650
TVKSSEPVKE TVQTTQSPTP VEKETVVTTQ AEVFPPPVAM LQIPVAPAVP
660 670 680 690 700
TVSLVPPAFP VSMPVPPPGF SPIPPPPFLR ASFNPSQPPP GFMPPPVPPP
710 720 730 740 750
VVPPPTIPPV VPTSLVQPSL SMTPETVKDV GFGSLVIPGG SVASNLATSA
760 770 780 790 800
LPAGNVFNAP TKQAEPEEKV PHLIDHQISS GENTRSVIPN DISSNAAILG
810 820 830 840 850
GQPPNVTSNS GILGVQRPNV SSNSEILGVR PSNVSSSSGI IAAQPPNILN
860 870 880 890 900
NSGILGIQPP SVSNSSGLLG VLPPNIPNNS GLVGVQPPNV PNTPGLLGTQ
910 920 930 940 950
PPAGPQNLPP LSIPNQRMPT MPMLDIRPGL IPQAPGPRFP LIQPGIPPQR
960 970 980 990 1000
GIPPPSVLDS ALHPPPRGPF PPGDIFSQPE RPFLAPGRQS VDNVTNPEKR
1010 1020 1030 1040 1050
IPLGNDNIQQ EGDRDYRFPP IETRESISRP PPVDVRDVVG RPIDPREGPG
1060 1070 1080 1090 1100
RPPLDGRDHF GRPPVDIREN LVRPGIDHLG RRDHFGFNPE KPWGHRGDFD
1110 1120 1130 1140 1150
EREHRVLPVY GGPKGLHEER GRFRSGNYRF DPRSGPWNRG FGQEVHRDFD
1160 1170 1180 1190 1200
DRRRPWERQR DRDDRDFDFC REMNGNRLGR DRIQNTWVPP PHARVFDYFE
1210 1220 1230 1240 1250
GATSQRKGDN VPQVNGENTE RHAQPPPIPV QNDPELYEKL TSSNEINKEK
1260 1270
SDTVADIESE PVVESTETEG T
Length:1,271
Mass (Da):140,519
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9856758DB7622319
GO
Isoform 2 (identifier: Q9UPN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPQPLLPALPPLSSPSGAGSCGPSGGECSGRRLFRRRARGLRSDNM
     10-10: E → EDCASTPACTDCFSSSMDTRSI

Show »
Length:1,337
Mass (Da):147,345
Checksum:i9E5DC6D4A9329466
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT33A0A0A0MT33_HUMAN
SR-related and CTD-associated facto...
SCAF8
1,349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83068 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti297N → I in AAH70071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052220865S → N. Corresponds to variant dbSNP:rs34802160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561491M → MPQPLLPALPPLSSPSGAGS CGPSGGECSGRRLFRRRARG LRSDNM in isoform 2. 1 Publication1
Alternative sequenceiVSP_05615010E → EDCASTPACTDCFSSSMDTR SI in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029039 mRNA Translation: BAA83068.2 Different initiation.
AK303001 mRNA Translation: BAH13874.1
AL121952 Genomic DNA No translation available.
AL136976 Genomic DNA No translation available.
AL591499 Genomic DNA No translation available.
BC070071 mRNA Translation: AAH70071.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5247.1 [Q9UPN6-1]
CCDS69226.1 [Q9UPN6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273117.1, NM_001286188.1
NP_001273118.1, NM_001286189.1 [Q9UPN6-2]
NP_001273123.1, NM_001286194.1
NP_001273128.1, NM_001286199.1 [Q9UPN6-1]
NP_055707.3, NM_014892.4 [Q9UPN6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367178; ENSP00000356146; ENSG00000213079 [Q9UPN6-1]
ENST00000367186; ENSP00000356154; ENSG00000213079 [Q9UPN6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22828

UCSC genome browser

More...
UCSCi
uc003qpz.5, human [Q9UPN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029039 mRNA Translation: BAA83068.2 Different initiation.
AK303001 mRNA Translation: BAH13874.1
AL121952 Genomic DNA No translation available.
AL136976 Genomic DNA No translation available.
AL591499 Genomic DNA No translation available.
BC070071 mRNA Translation: AAH70071.1
CCDSiCCDS5247.1 [Q9UPN6-1]
CCDS69226.1 [Q9UPN6-2]
RefSeqiNP_001273117.1, NM_001286188.1
NP_001273118.1, NM_001286189.1 [Q9UPN6-2]
NP_001273123.1, NM_001286194.1
NP_001273128.1, NM_001286199.1 [Q9UPN6-1]
NP_055707.3, NM_014892.4 [Q9UPN6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIWNMR-A1-137[»]
3D9IX-ray1.91A/B1-136[»]
3D9JX-ray1.60A/B1-136[»]
3D9KX-ray2.20A/B1-136[»]
3D9LX-ray2.20A/B1-136[»]
3D9MX-ray1.75A/B1-136[»]
3D9NX-ray1.60A/B1-136[»]
3D9OX-ray2.00A/B1-136[»]
3D9PX-ray2.10A/B1-136[»]
SMRiQ9UPN6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116503, 27 interactors
CORUMiQ9UPN6
IntActiQ9UPN6, 18 interactors
MINTiQ9UPN6
STRINGi9606.ENSP00000413098

PTM databases

GlyGeniQ9UPN6, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ9UPN6
PhosphoSitePlusiQ9UPN6

Polymorphism and mutation databases

BioMutaiSCAF8
DMDMi30580495

Proteomic databases

EPDiQ9UPN6
jPOSTiQ9UPN6
MassIVEiQ9UPN6
PaxDbiQ9UPN6
PeptideAtlasiQ9UPN6
PRIDEiQ9UPN6
ProteomicsDBi6932
85390 [Q9UPN6-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33407, 85 antibodies

Genome annotation databases

EnsembliENST00000367178; ENSP00000356146; ENSG00000213079 [Q9UPN6-1]
ENST00000367186; ENSP00000356154; ENSG00000213079 [Q9UPN6-2]
GeneIDi22828
KEGGihsa:22828
UCSCiuc003qpz.5, human [Q9UPN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22828
DisGeNETi22828
EuPathDBiHostDB:ENSG00000213079.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SCAF8
HGNCiHGNC:20959, SCAF8
HPAiENSG00000213079, Low tissue specificity
MIMi616024, gene
neXtProtiNX_Q9UPN6
OpenTargetsiENSG00000213079
PharmGKBiPA128394587

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0132, Eukaryota
GeneTreeiENSGT00530000063946
HOGENOMiCLU_005263_1_0_1
InParanoidiQ9UPN6
KOiK13191
OrthoDBi821342at2759
PhylomeDBiQ9UPN6
TreeFamiTF324527

Enzyme and pathway databases

PathwayCommonsiQ9UPN6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22828, 22 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SCAF8, human
EvolutionaryTraceiQ9UPN6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22828
PharosiQ9UPN6, Tdark

Protein Ontology

More...
PROi
PR:Q9UPN6
RNActiQ9UPN6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213079, Expressed in corpus callosum and 245 other tissues
ExpressionAtlasiQ9UPN6, baseline and differential
GenevisibleiQ9UPN6, HS

Family and domain databases

CDDicd12462, RRM_SCAF8, 1 hit
Gene3Di1.25.40.90, 1 hit
3.30.70.330, 1 hit
IDEALiIID00590
InterProiView protein in InterPro
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR006903, RNA_pol_II-bd
IPR000504, RRM_dom
IPR034370, SCAF8_RRM
PfamiView protein in Pfam
PF04818, CTD_bind, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00582, RPR, 1 hit
SM00360, RRM, 1 hit
SUPFAMiSSF48464, SSF48464, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391, CID, 1 hit
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCAF8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPN6
Secondary accession number(s): B7Z888
, Q5TBU6, Q6NSK3, Q9BQN8, Q9BX43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again