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Entry version 193 (16 Oct 2019)
Sequence version 4 (28 Jun 2011)
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Protein

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7054 – 70651PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7090 – 71012PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processWnt signaling pathway
LigandCalcium, Metal-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UPN3

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UPN3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Alternative name(s):
620 kDa actin-binding protein
Short name:
ABP620
Actin cross-linking family protein 71 Publication
Macrophin-11 Publication
Trabeculin-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1
Synonyms:ABP620, ACF71 Publication, KIAA0465, KIAA1251
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:13664 MACF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608271 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPN3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lissencephaly 9 with complex brainstem malformation (LIS9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS9 is an autosomal dominant form clinically characterized by global developmental delay apparent since infancy, impaired intellectual development with poor or absent speech, and sometimes abnormal or involuntary movements. Brain imaging shows malformation of the brainstem, in addition to pachygyria and lissencephaly.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0819666664G → R in LIS9; unknown pathological significance. 1 Publication1
Natural variantiVAR_0819677135C → F in LIS9. 1 Publication1
Natural variantiVAR_0819687186D → Y in LIS9. 1 Publication1
Natural variantiVAR_0819697188C → F in LIS9. 1 Publication1
Natural variantiVAR_0819707188C → G in LIS9. 1 Publication1

Keywords - Diseasei

Disease mutation, Lissencephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
23499

MalaCards human disease database

More...
MalaCardsi
MACF1
MIMi618325 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000127603

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30518

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPN3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MACF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
338817989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734491 – 7388Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Add BLAST7388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei280PhosphoserineCombined sources1
Modified residuei814PhosphoserineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1376PhosphoserineCombined sources1
Modified residuei2006PhosphoserineCombined sources1
Modified residuei2051PhosphoserineCombined sources1
Modified residuei2077PhosphoserineBy similarity1
Modified residuei3122PhosphoserineBy similarity1
Modified residuei3331PhosphoserineCombined sources1
Modified residuei3927PhosphoserineCombined sources1
Modified residuei4495PhosphoserineCombined sources1
Modified residuei4496PhosphoserineCombined sources1
Modified residuei4521PhosphoserineCombined sources1
Modified residuei4836PhosphoserineCombined sources1
Modified residuei4962PhosphoserineCombined sources1
Modified residuei5435PhosphothreonineBy similarity1
Modified residuei5808PhosphoserineCombined sources1
Modified residuei6032PhosphoserineCombined sources1
Modified residuei6210N6-acetyllysineCombined sources1
Modified residuei6967PhosphoserineCombined sources1
Modified residuei7254PhosphothreonineCombined sources1
Modified residuei7279PhosphoserineCombined sources1
Modified residuei7292PhosphoserineCombined sources1
Modified residuei7330PhosphoserineCombined sources1
Modified residuei7333PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UPN3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPN3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UPN3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UPN3

PeptideAtlas

More...
PeptideAtlasi
Q9UPN3

PRoteomics IDEntifications database

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PRIDEi
Q9UPN3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
85382 [Q9UPN3-1]
85383 [Q9UPN3-2]
85384 [Q9UPN3-3]
85385 [Q9UPN3-4]
85386 [Q9UPN3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UPN3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UPN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127603 Expressed in 240 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPN3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPN3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013713

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2:

Interacts with MAPRE1, CLASP1, CLASP2, AXIN1 and LRP6 (By similarity). Isoform 2:

Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Isoform 2:

Interacts with GOLGA4 (PubMed:15265687). Isoform 2:

Interacts with CAMSAP3 (PubMed:27693509, PubMed:27802168).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI57EBI-522925,EBI-529989

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117048, 81 interactors

Database of interacting proteins

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DIPi
DIP-50616N

Protein interaction database and analysis system

More...
IntActi
Q9UPN3, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9UPN3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354573

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

17388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPN3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 181Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati148 – 171LRR 1Add BLAST24
Domaini194 – 298Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST105
Repeati240 – 264LRR 2Add BLAST25
Repeati377 – 399LRR 3Add BLAST23
Repeati441 – 464LRR 4Add BLAST24
Domaini868 – 925SH3PROSITE-ProRule annotationAdd BLAST58
Repeati1050 – 1073LRR 5Add BLAST24
Repeati1128 – 1154LRR 6Add BLAST27
Repeati1187 – 1210LRR 7Add BLAST24
Repeati1257 – 1282LRR 8Add BLAST26
Repeati1577 – 1621Plectin 1Add BLAST45
Repeati1654 – 1696Plectin 2Add BLAST43
Repeati1769 – 1809Plectin 3Add BLAST41
Repeati1811 – 1848Plectin 4Add BLAST38
Repeati1855 – 1886Plectin 5Add BLAST32
Repeati2290 – 2332Plectin 6Add BLAST43
Repeati2367 – 2410Plectin 7Add BLAST44
Repeati2411 – 2437Plectin 8Add BLAST27
Repeati2501 – 2543Plectin 9Add BLAST43
Repeati2581 – 2612Plectin 10Add BLAST32
Repeati2686 – 2730Plectin 11Add BLAST45
Repeati3239 – 3262LRR 9Add BLAST24
Repeati3264 – 3283LRR 10Add BLAST20
Repeati3646 – 3669LRR 11Add BLAST24
Repeati3696 – 3720LRR 12Add BLAST25
Repeati3883 – 3957Spectrin 1Add BLAST75
Repeati3936 – 3958LRR 13Add BLAST23
Repeati4000 – 4108Spectrin 2Add BLAST109
Repeati4125 – 4150LRR 14Add BLAST26
Repeati4261 – 4287LRR 15Add BLAST27
Repeati4466 – 4574Spectrin 3Add BLAST109
Repeati4511 – 4534LRR 16Add BLAST24
Repeati4601 – 4624LRR 17Add BLAST24
Repeati4769 – 4792LRR 18Add BLAST24
Repeati4800 – 4904Spectrin 4Add BLAST105
Repeati4909 – 5012Spectrin 5Add BLAST104
Repeati5051 – 5076LRR 19Add BLAST26
Repeati5172 – 5194LRR 20Add BLAST23
Repeati5236 – 5341Spectrin 6Add BLAST106
Repeati5281 – 5304LRR 21Add BLAST24
Repeati5348 – 5450Spectrin 7Add BLAST103
Repeati5455 – 5557Spectrin 8Add BLAST103
Repeati5695 – 5719LRR 22Add BLAST25
Repeati5783 – 5885Spectrin 9Add BLAST103
Repeati5804 – 5828LRR 23Add BLAST25
Repeati6005 – 6110Spectrin 10Add BLAST106
Repeati6115 – 6219Spectrin 11Add BLAST105
Repeati6225 – 6328Spectrin 12Add BLAST104
Repeati6333 – 6439Spectrin 13Add BLAST107
Repeati6443 – 6547Spectrin 14Add BLAST105
Repeati6496 – 6519LRR 24Add BLAST24
Repeati6552 – 6658Spectrin 15Add BLAST107
Repeati6665 – 6766Spectrin 16Add BLAST102
Repeati6771 – 6874Spectrin 17Add BLAST104
Domaini7041 – 7076EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini7077 – 7112EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini7117 – 7189GARPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 295Actin-bindingAdd BLAST295
Regioni7117 – 7388C-terminal tailBy similarityAdd BLAST272
Regioni7313 – 73284 X 4 AA tandem repeats of [GS]-S-R-[AR]Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi698 – 703Poly-Glu6
Compositional biasi1122 – 1127Poly-Ser6
Compositional biasi1414 – 1417Poly-Glu4
Compositional biasi1986 – 1989Poly-Leu4
Compositional biasi7222 – 7351Ser-richAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049054

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPN3

KEGG Orthology (KO)

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KOi
K19827

Database of Orthologous Groups

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OrthoDBi
24858at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPN3

TreeFam database of animal gene trees

More...
TreeFami
TF335163

Family and domain databases

Conserved Domains Database

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CDDi
cd00014 CH, 2 hits
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

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PANTHERi
PTHR23169:SF24 PTHR23169:SF24, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 9 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 17 hits
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 20 hits
SM00150 SPEC, 33 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPN3-1) [UniParc]FASTAAdd to basket
Also known as: Macf1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH
60 70 80 90 100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN
110 120 130 140 150
DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ
160 170 180 190 200
VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL
210 220 230 240 250
LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS
260 270 280 290 300
NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV
310 320 330 340 350
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK
360 370 380 390 400
ALYNQYIHFK ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND
410 420 430 440 450
VEEEWGKLII EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA
460 470 480 490 500
KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDENYY
510 520 530 540 550
QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP STLTTTHLKA
560 570 580 590 600
EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ
610 620 630 640 650
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF
660 670 680 690 700
HTSYAETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE
710 720 730 740 750
EEELAYDWSD NNSNISAKRN YFSELTMELE EKQDVFRSLQ DTAELLSLEN
760 770 780 790 800
HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENTAYFQ FFSDARELES
810 820 830 840 850
FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG
860 870 880 890 900
RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR
910 920 930 940 950
TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL
960 970 980 990 1000
HVNTKSLISW NYLRKDLDLV QTWNLEKLRS SAPGECHQIM KNLQAHYEDF
1010 1020 1030 1040 1050
LQDSRDSVLF SVADRLRLEE EVEACKARFQ HLMKSMENED KEETVAKMYI
1060 1070 1080 1090 1100
SELKNIRLRL EEYEQRVVKR IQSLASSRTD RDAWQDNALR IAEQEHTQED
1110 1120 1130 1140 1150
LQQLRSDLDA VSMKCDSFLH QSPSSSSVPT LRSELNLLVE KMDHVYGLST
1160 1170 1180 1190 1200
VYLNKLKTVD VIVRSIQDAE LLVKGYEIKL SQEEVVLADL SALEAHWSTL
1210 1220 1230 1240 1250
RHWLSDVKDK NSVFSVLDEE IAKAKVVAEQ MSRLTPERNL DLERYQEKGS
1260 1270 1280 1290 1300
QLQERWHRVI AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM
1310 1320 1330 1340 1350
MKPGQAEDSR VLSEQLSQQT ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY
1360 1370 1380 1390 1400
ELQLMTYKAF VESQQKSPGK RRRMLSSSDA ITQEFMDLRT RYTALVTLTT
1410 1420 1430 1440 1450
QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST LARNTQGKAT
1460 1470 1480 1490 1500
SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS
1510 1520 1530 1540 1550
EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKECRAVAG
1560 1570 1580 1590 1600
VIDLGTVEIF PIFKAMQKGL LDQDTGLVLL ESQVIMSGLI APETGENLSL
1610 1620 1630 1640 1650
EEGIARNLIN PQMYQQLREL QDALALISRL TESRGPLSVV EAIEKRIISE
1660 1670 1680 1690 1700
TVGLKILEAH LATGGFSLSP SENCINLEEA FHQGLISAWL HSVLESYLRT
1710 1720 1730 1740 1750
SKNLIDPNTA EKIGLLDLMQ RCIVHQESGF KLLPVKQLAG GMVSLKSGRK
1760 1770 1780 1790 1800
VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI
1810 1820 1830 1840 1850
DQDMACAILI RQLQTGGIID TVTGQRLTID EAVSNDLVAA KIALVILESL
1860 1870 1880 1890 1900
WSFMGLLWPE SGEILPITDA LEQGIVSTEL AHKILSNRQH IKALFLPATT
1910 1920 1930 1940 1950
EILSWKKAIE SGILDRDLAN NLKSICIPDV MPHMQLADSA EQNINPGAAV
1960 1970 1980 1990 2000
LPCSKSHPKA TASQSENLLF QLMTHSYINV QNGQRLLLLD KELMETLTSR
2010 2020 2030 2040 2050
DEYQTSPPKV VEIGHQRQKT PEGLQESANV KISGTFSSGW TVRLPEFQFS
2060 2070 2080 2090 2100
SQNKEYPDRE DCTTEKGKKT TVETEDSSVE NPEQDLFVEQ KERNPNIDAL
2110 2120 2130 2140 2150
KVINKVKLEV QRQLIGTQRE DQTAVSVREN ASRGHLLTIP PAEAEGVPLV
2160 2170 2180 2190 2200
VDKDVFSVET PKKEHQPLRN TSFTCQNEQA HTLETEYIHD ETGGSHIKPQ
2210 2220 2230 2240 2250
SKKLQVQVKK TLGIKLELKS ETDGNVHPLD KKEMLKKTFL AKDDHKESQE
2260 2270 2280 2290 2300
AQNIAGGSMM MSEKTDEEDS GREIFLSCSH PLELLEEATL NVLSAQLLDG
2310 2320 2330 2340 2350
GIFHEQTGQK LLLNEAISRG IVPSHTAVKL MEKLNMFQGF FDSQTCESLT
2360 2370 2380 2390 2400
TEEVINEGLM DEKLLHNVLM ADKAISGVLD PRTQTLCSVK DAVTVGLLDK
2410 2420 2430 2440 2450
ETATRILERQ VVTGGIIDLK RGKKVSVTLA STLGLVDVAD QPELINLEKA
2460 2470 2480 2490 2500
SKGRDAEKTV RERLISLQME TTGLIDPDSK APLTVVQSID RGLLEREEAV
2510 2520 2530 2540 2550
RLLTKQVVDG GIIHHISGMR LSVDNAFRHG LIGEDLAEKL KRVENLNIHQ
2560 2570 2580 2590 2600
IFNPETKENI SLPKAIKLDL ITSDLKREIQ EVQAFTGNFV DLISGQRLTL
2610 2620 2630 2640 2650
AEAKKEGLLT NEAVLSPGMM HGIVDPENCR IVPYSELVKK CKIDIESGQR
2660 2670 2680 2690 2700
YLEVIPFSDI KDGVSDKVLT LSQAIQLGKV DFASTLKVLE AQANTGGIID
2710 2720 2730 2740 2750
TATGKRLTLA SALEEKLVDE NMVRIIASHQ VLNGGIVDIF SDQRVTLVEA
2760 2770 2780 2790 2800
IEKRLISPEL ANMIQIDSSE FSDHRAQIEK QEGIEVCALQ NEFLGKDMLI
2810 2820 2830 2840 2850
ACNQTAEMSC NKVEESERLF QVENQSAQEK VKVRVSDGEQ AKKSREISLK
2860 2870 2880 2890 2900
EFGCKDQRKP RMSSDAKEFI SIINPHNLKG KSLGQVSLTH PYSECDFKLK
2910 2920 2930 2940 2950
EVARNNMGND TNEEQEKAVT KIEIISHMKQ STSCLDSEEI RENQGEVILE
2960 2970 2980 2990 3000
VQETYCETSG KLPSEQVLQQ PMNARVKSKR EKREVIVEES IRTCKPAFLS
3010 3020 3030 3040 3050
EEKLYQETAI RDEHDSHIKS QPREMTSSEK GKEADTEMGF SITFKIEESS
3060 3070 3080 3090 3100
SQVVPQGISV KHLDALTLFS SKQANEGKVN NLSLCLTLKP EENLSREIAC
3110 3120 3130 3140 3150
GAQSEPFPCM TPRPEGLHYQ ESDGKAQVTG PSQISKTDKS FQGTTRQETN
3160 3170 3180 3190 3200
YQDSWVTSKT KETKHQISSS NECKEKSYQE VSFDPARGLK LEEITVSRPD
3210 3220 3230 3240 3250
SKEVRYLEFS DRKDLHHQGS KSDDKLCGTL KSEIATQELT GEKFLEMANP
3260 3270 3280 3290 3300
NVAGLEAGSI EDIVTQRGSR VLGSFLPEKL FKGVSQKENT GQQNAIISPT
3310 3320 3330 3340 3350
VLETSEEKTV SLTVCSAVKT EKTPQEKLRE SPGSEQTPFM TAPEGKGNGG
3360 3370 3380 3390 3400
VNPEPFRATQ NVFTRQLCLE HDEKLVSYLS LLRNIEMRTK QIQPLELNLA
3410 3420 3430 3440 3450
ELQDLLCQAK VLERELKDLT TLVSQELECV NQIIISQPQE VPAQLLKALE
3460 3470 3480 3490 3500
KDAKNLQKSL SSVSDTWNSR LLHFQNAVEI EKTKVLNQHT QLEGRLQDLR
3510 3520 3530 3540 3550
AWVGNKNLIL NSKGSNSEID VDSLNLCLQQ YEDLKQPMAE RKAQLDALAF
3560 3570 3580 3590 3600
DIQFFISEHA QDLSPQQNRQ MLRLLNELQR SFQDILEQTA AQVDALQGHL
3610 3620 3630 3640 3650
QQMEQEALVK TLQKQQNTCH QQLEDLCSWV GQAERALAGH QGRTTQQDLS
3660 3670 3680 3690 3700
ALQKNQSDLK DLQDDIQNRA TSFATVVKDI EGFMEENQTK LSPRELTALR
3710 3720 3730 3740 3750
EKLHQAKEQY EALQEETRVA QKELEEAVTS ALQQETEKSK AAKELAENKK
3760 3770 3780 3790 3800
KIDALLDWVT SVGSSGGQLL TNLPGMEQLS GASLEKGALD TTDGYMGVNQ
3810 3820 3830 3840 3850
APEKLDKQCE MMKARHQELL SQQQNFILAT QSAQAFLDQH GHNLTPEEQQ
3860 3870 3880 3890 3900
MLQQKLGELK EQYSTSLAQS EAELKQVQTL QDELQKFLQD HKEFESWLER
3910 3920 3930 3940 3950
SEKELENMHK GGSSPETLPS LLKRQGSFSE DVISHKGDLR FVTISGQKVL
3960 3970 3980 3990 4000
DMENSFKEGK EPSEIGNLVK DKLKDATERY TALHSKCTRL GSHLNMLLGQ
4010 4020 4030 4040 4050
YHQFQNSADS LQAWMQACEA NVEKLLSDTV ASDPGVLQEQ LATTKQLQEE
4060 4070 4080 4090 4100
LAEHQVPVEK LQKVARDIME IEGEPAPDHR HVQETTDSIL SHFQSLSYSL
4110 4120 4130 4140 4150
AERSSLLQKA IAQSQSVQES LESLLQSIGE VEQNLEGKQV SSLSSGVIQE
4160 4170 4180 4190 4200
ALATNMKLKQ DIARQKSSLE ATREMVTRFM ETADSTTAAV LQGKLAEVSQ
4210 4220 4230 4240 4250
RFEQLCLQQQ EKESSLKKLL PQAEMFEHLS GKLQQFMENK SRMLASGNQP
4260 4270 4280 4290 4300
DQDITHFFQQ IQELNLEMED QQENLDTLEH LVTELSSCGF ALDLCQHQDR
4310 4320 4330 4340 4350
VQNLRKDFTE LQKTVKEREK DASSCQEQLD EFRKLVRTFQ KWLKETEGSI
4360 4370 4380 4390 4400
PPTETSMSAK ELEKQIEHLK SLLDDWASKG TLVEEINCKG TSLENLIMEI
4410 4420 4430 4440 4450
TAPDSQGKTG SILPSVGSSV GSVNGYHTCK DLTEIQCDMS DVNLKYEKLG
4460 4470 4480 4490 4500
GVLHERQESL QAILNRMEEV HKEANSVLQW LESKEEVLKS MDAMSSPTKT
4510 4520 4530 4540 4550
ETVKAQAESN KAFLAELEQN SPKIQKVKEA LAGLLVTYPN SQEAENWKKI
4560 4570 4580 4590 4600
QEELNSRWER ATEVTVARQR QLEESASHLA CFQAAESQLR PWLMEKELMM
4610 4620 4630 4640 4650
GVLGPLSIDP NMLNAQKQQV QFMLKEFEAR RQQHEQLNEA AQGILTGPGD
4660 4670 4680 4690 4700
VSLSTSQVQK ELQSINQKWV ELTDKLNSRS SQIDQAIVKS TQYQELLQDL
4710 4720 4730 4740 4750
SEKVRAVGQR LSVQSAISTQ PEAVKQQLEE TSEIRSDLEQ LDHEVKEAQT
4760 4770 4780 4790 4800
LCDELSVLIG EQYLKDELKK RLETVALPLQ GLEDLAADRI NRLQAALAST
4810 4820 4830 4840 4850
QQFQQMFDEL RTWLDDKQSQ QAKNCPISAK LERLQSQLQE NEEFQKSLNQ
4860 4870 4880 4890 4900
HSGSYEVIVA EGESLLLSVP PGEEKRTLQN QLVELKNHWE ELSKKTADRQ
4910 4920 4930 4940 4950
SRLKDCMQKA QKYQWHVEDL VPWIEDCKAK MSELRVTLDP VQLESSLLRS
4960 4970 4980 4990 5000
KAMLNEVEKR RSLLEILNSA ADILINSSEA DEDGIRDEKA GINQNMDAVT
5010 5020 5030 5040 5050
EELQAKTGSL EEMTQRLREF QESFKNIEKK VEGAKHQLEI FDALGSQACS
5060 5070 5080 5090 5100
NKNLEKLRAQ QEVLQALEPQ VDYLRNFTQG LVEDAPDGSD ASQLLHQAEV
5110 5120 5130 5140 5150
AQQEFLEVKQ RVNSGCVMME NKLEGIGQFH CRVREMFSQL ADLDDELDGM
5160 5170 5180 5190 5200
GAIGRDTDSL QSQIEDVRLF LNKIHVLKLD IEASEAECRH MLEEEGTLDL
5210 5220 5230 5240 5250
LGLKRELEAL NKQCGKLTER GKARQEQLEL TLGRVEDFYR KLKGLNDATT
5260 5270 5280 5290 5300
AAEEAEALQW VVGTEVEIIN QQLADFKMFQ KEQVDPLQMK LQQVNGLGQG
5310 5320 5330 5340 5350
LIQSAGKDCD VQGLEHDMEE INARWNTLNK KVAQRIAQLQ EALLHCGKFQ
5360 5370 5380 5390 5400
DALEPLLSWL ADTEELIANQ KPPSAEYKVV KAQIQEQKLL QRLLDDRKAT
5410 5420 5430 5440 5450
VDMLQAEGGR IAQSAELADR EKITGQLESL ESRWTELLSK AAARQKQLED
5460 5470 5480 5490 5500
ILVLAKQFHE TAEPISDFLS VTEKKLANSE PVGTQTAKIQ QQIIRHKALN
5510 5520 5530 5540 5550
EEIVNRKKNV DQAIKNGQAL LKQTTGEEVL LIQEKLDGIK TRYADITVTS
5560 5570 5580 5590 5600
SKALRTLEQA RQLATKFQST YEELTGWLRE VEEELATSGG QSPTGEQIPQ
5610 5620 5630 5640 5650
FQQRQKELKK EVMEHRLVLD TVNEVSRALL ELVPWRAREG LDKLVSDANE
5660 5670 5680 5690 5700
QYKLVSDTIG QRVDEIDAAI QRSQQYEQAA DAELAWVAET KRKLMALGPI
5710 5720 5730 5740 5750
RLEQDQTTAQ LQVQKAFSID IIRHKDSMDE LFSHRSEIFG TCGEEQKTVL
5760 5770 5780 5790 5800
QEKTESLIQQ YEAISLLNSE RYARLERAQV LVNQFWETYE ELSPWIEETR
5810 5820 5830 5840 5850
ALIAQLPSPA IDHEQLRQQQ EEMRQLRESI AEHKPHIDKL LKIGPQLKEL
5860 5870 5880 5890 5900
NPEEGEMVEE KYQKAENMYA QIKEEVRQRA LALDEAVSQS TQITEFHDKI
5910 5920 5930 5940 5950
EPMLETLENL SSRLRMPPLI PAEVDKIREC ISDNKSATVE LEKLQPSFEA
5960 5970 5980 5990 6000
LKRRGEELIG RSQGADKDLA AKEIQDKLDQ MVFFWEDIKA RAEEREIKFL
6010 6020 6030 6040 6050
DVLELAEKFW YDMAALLTTI KDTQDIVHDL ESPGIDPSII KQQVEAAETI
6060 6070 6080 6090 6100
KEETDGLHEE LEFIRILGAD LIFACGETEK PEVRKSIDEM NNAWENLNKT
6110 6120 6130 6140 6150
WKERLEKLED AMQAAVQYQD TLQAMFDWLD NTVIKLCTMP PVGTDLNTVK
6160 6170 6180 6190 6200
DQLNEMKEFK VEVYQQQIEM EKLNHQGELM LKKATDETDR DIIREPLTEL
6210 6220 6230 6240 6250
KHLWENLGEK IAHRQHKLEG ALLALGQFQH ALEELMSWLT HTEELLDAQR
6260 6270 6280 6290 6300
PISGDPKVIE VELAKHHVLK NDVLAHQATV ETVNKAGNEL LESSAGDDAS
6310 6320 6330 6340 6350
SLRSRLEAMN QCWESVLQKT EEREQQLQST LQQAQGFHSE IEDFLLELTR
6360 6370 6380 6390 6400
MESQLSASKP TGGLPETARE QLDTHMELYS QLKAKEETYN QLLDKGRLML
6410 6420 6430 6440 6450
LSRDDSGSGS KTEQSVALLE QKWHVVSSKM EERKSKLEEA LNLATEFQNS
6460 6470 6480 6490 6500
LQEFINWLTL AEQSLNIASP PSLILNTVLS QIEEHKVFAN EVNAHRDQII
6510 6520 6530 6540 6550
ELDQTGNQLK FLSQKQDVVL IKNLLVSVQS RWEKVVQRSI ERGRSLDDAR
6560 6570 6580 6590 6600
KRAKQFHEAW KKLIDWLEDA ESHLDSELEI SNDPDKIKLQ LSKHKEFQKT
6610 6620 6630 6640 6650
LGGKQPVYDT TIRTGRALKE KTLLPEDSQK LDNFLGEVRD KWDTVCGKSV
6660 6670 6680 6690 6700
ERQHKLEEAL LFSGQFMDAL QALVDWLYKV EPQLAEDQPV HGDLDLVMNL
6710 6720 6730 6740 6750
MDAHKVFQKE LGKRTGTVQV LKRSGRELIE NSRDDTTWVK GQLQELSTRW
6760 6770 6780 6790 6800
DTVCKLSVSK QSRLEQALKQ AEVFRDTVHM LLEWLSEAEQ TLRFRGALPD
6810 6820 6830 6840 6850
DTEALQSLID THKEFMKKVE EKRVDVNSAV AMGEVILAVC HPDCITTIKH
6860 6870 6880 6890 6900
WITIIRARFE EVLTWAKQHQ QRLETALSEL VANAELLEEL LAWIQWAETT
6910 6920 6930 6940 6950
LIQRDQEPIP QNIDRVKALI AEHQTFMEEM TRKQPDVDRV TKTYKRKNIE
6960 6970 6980 6990 7000
PTHAPFIEKS RSGGRKSLSQ PTPPPMPILS QSEAKNPRIN QLSARWQQVW
7010 7020 7030 7040 7050
LLALERQRKL NDALDRLEEL KEFANFDFDV WRKKYMRWMN HKKSRVMDFF
7060 7070 7080 7090 7100
RRIDKDQDGK ITRQEFIDGI LASKFPTTKL EMTAVADIFD RDGDGYIDYY
7110 7120 7130 7140 7150
EFVAALHPNK DAYRPTTDAD KIEDEVTRQV AQCKCAKRFQ VEQIGENKYR
7160 7170 7180 7190 7200
FGDSQQLRLV RILRSTVMVR VGGGWMALDE FLVKNDPCRA RGRTNIELRE
7210 7220 7230 7240 7250
KFILPEGASQ GMTPFRSRGR RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS
7260 7270 7280 7290 7300
SPATPASGTK VIPSSGSKLK RPTPTFHSSR TSLAGDTSNS SSPASTGAKT
7310 7320 7330 7340 7350
NRADPKKSAS RPGSRAGSRA GSRASSRRGS DASDFDLLET QSACSDTSES
7360 7370 7380
SAAGGQGNSR RGLNKPSKIP TMSKKTTTAS PRTPGPKR
Length:7,388
Mass (Da):838,308
Last modified:June 28, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB044DC183C048416
GO
Isoform 2 (identifier: Q9UPN3-2) [UniParc]FASTAAdd to basket
Also known as: Macf1a

The sequence of this isoform differs from the canonical sequence as follows:
     1543-3609: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL

Show »
Length:5,430
Mass (Da):620,418
Checksum:i4C0CB72BDFBF9777
GO
Isoform 3 (identifier: Q9UPN3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSSSDEETLS...DPAERAVVRV → MFPVLWAGIP...CTSASRVAVI
     1543-3609: Missing.
     4410-4430: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL

Show »
Length:5,374
Mass (Da):614,153
Checksum:i503537231A91ABDA
GO
Isoform 5 (identifier: Q9UPN3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1543-3609: Missing.
     4410-4430: Missing.

Note: No experimental confirmation available.
Show »
Length:5,300
Mass (Da):606,164
Checksum:iE5364BDE41CBB545
GO
Isoform 4 (identifier: Q9UPN3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1565: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL
     7150-7150: R → RFFLGNQ

Show »
Length:5,938
Mass (Da):670,137
Checksum:i360611C48946A058
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQK9H3BQK9_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,592Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7I1H0Y7I1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNZ4E9PNZ4_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,028Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLY0E9PLY0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,062Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83821 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1295 – 1296TA → LP in AAL39000 (PubMed:16710414).Curated2
Sequence conflicti1487T → A in BAA83821 (PubMed:10529403).Curated1
Sequence conflicti1487T → A in AAL39000 (PubMed:16710414).Curated1
Sequence conflicti3277P → S in AAL38997 (PubMed:11845288).Curated1
Sequence conflicti4030V → A in BAA83821 (PubMed:10529403).Curated1
Sequence conflicti4119E → D in BAA83821 (PubMed:10529403).Curated1
Sequence conflicti4150E → K in AAF06360 (PubMed:10559237).Curated1
Sequence conflicti4388C → Y in BAA83821 (PubMed:10529403).Curated1
Sequence conflicti4411 – 4417SILPSVG → EYRLFKI in BAA86565 (PubMed:10574462).Curated7
Sequence conflicti4590R → Q in BAA83821 (PubMed:10529403).Curated1
Sequence conflicti6791Missing in AAF06360 (PubMed:10559237).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035451302E → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0486254357M → V1 PublicationCorresponds to variant dbSNP:rs2296172Ensembl.1
Natural variantiVAR_0486266201K → R. Corresponds to variant dbSNP:rs682351Ensembl.1
Natural variantiVAR_0486276308A → T. Corresponds to variant dbSNP:rs587404Ensembl.1
Natural variantiVAR_0354526462E → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0486286628S → T2 PublicationsCorresponds to variant dbSNP:rs668556Ensembl.1
Natural variantiVAR_0819666664G → R in LIS9; unknown pathological significance. 1 Publication1
Natural variantiVAR_0486296752T → I. Corresponds to variant dbSNP:rs2296174Ensembl.1
Natural variantiVAR_0486306855I → V. Corresponds to variant dbSNP:rs12068423Ensembl.1
Natural variantiVAR_0652567093G → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0819677135C → F in LIS9. 1 Publication1
Natural variantiVAR_0819687186D → Y in LIS9. 1 Publication1
Natural variantiVAR_0819697188C → F in LIS9. 1 Publication1
Natural variantiVAR_0819707188C → G in LIS9. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436261 – 1565Missing in isoform 4. 1 PublicationAdd BLAST1565
Alternative sequenceiVSP_0413901 – 72MSSSD…AVVRV → MFPVLWAGIPGRDVGSLQPL PPGFKQFCTSASRVAVI in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0413911543 – 3609Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsAdd BLAST2067
Alternative sequenceiVSP_0413924410 – 4430Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0413935497K → KALEEDIENHATDVHQAVKI GQSLSSLTSPAEQGVLSEKI DSLQARYSEIQDRCCRKAAL LDQALSNARLFGEDEVEVLN WLAEVEDKLSSVFVKDFKQD VLHRQHADHL in isoform 2, isoform 3 and isoform 4. 4 Publications1
Alternative sequenceiVSP_0436277150R → RFFLGNQ in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029290 mRNA Translation: BAA83821.1 Frameshift.
AF141968 mRNA Translation: AAF06360.1
AF317696 mRNA Translation: AAL09459.1
AF325341
, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA Translation: AAL38997.1
AF325341
, AF325330, AF325331, AF325332, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA Translation: AAL39000.1
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AB033077 mRNA Translation: BAA86565.1
AB007934 mRNA Translation: BAA32310.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS435.1 [Q9UPN3-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00079

NCBI Reference Sequences

More...
RefSeqi
NP_036222.3, NM_012090.5 [Q9UPN3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000289893; ENSP00000289893; ENSG00000127603 [Q9UPN3-5]
ENST00000361689; ENSP00000354573; ENSG00000127603 [Q9UPN3-2]
ENST00000372915; ENSP00000362006; ENSG00000127603 [Q9UPN3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23499

UCSC genome browser

More...
UCSCi
uc031pmd.2 human [Q9UPN3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029290 mRNA Translation: BAA83821.1 Frameshift.
AF141968 mRNA Translation: AAF06360.1
AF317696 mRNA Translation: AAL09459.1
AF325341
, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA Translation: AAL38997.1
AF325341
, AF325330, AF325331, AF325332, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA Translation: AAL39000.1
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AB033077 mRNA Translation: BAA86565.1
AB007934 mRNA Translation: BAA32310.3
CCDSiCCDS435.1 [Q9UPN3-2]
PIRiT00079
RefSeqiNP_036222.3, NM_012090.5 [Q9UPN3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z6GX-ray2.65A74-421[»]
5VE9X-ray2.79A/B7024-7108[»]
C7118-7191[»]
5X57X-ray1.45A7113-7193[»]
SMRiQ9UPN3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117048, 81 interactors
DIPiDIP-50616N
IntActiQ9UPN3, 50 interactors
MINTiQ9UPN3
STRINGi9606.ENSP00000354573

PTM databases

iPTMnetiQ9UPN3
PhosphoSitePlusiQ9UPN3
SwissPalmiQ9UPN3

Polymorphism and mutation databases

BioMutaiMACF1
DMDMi338817989

Proteomic databases

EPDiQ9UPN3
jPOSTiQ9UPN3
MassIVEiQ9UPN3
PaxDbiQ9UPN3
PeptideAtlasiQ9UPN3
PRIDEiQ9UPN3
ProteomicsDBi85382 [Q9UPN3-1]
85383 [Q9UPN3-2]
85384 [Q9UPN3-3]
85385 [Q9UPN3-4]
85386 [Q9UPN3-5]

Genome annotation databases

EnsembliENST00000289893; ENSP00000289893; ENSG00000127603 [Q9UPN3-5]
ENST00000361689; ENSP00000354573; ENSG00000127603 [Q9UPN3-2]
ENST00000372915; ENSP00000362006; ENSG00000127603 [Q9UPN3-1]
GeneIDi23499
KEGGihsa:23499
UCSCiuc031pmd.2 human [Q9UPN3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23499
DisGeNETi23499

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MACF1
HGNCiHGNC:13664 MACF1
HPAiHPA013713
MalaCardsiMACF1
MIMi608271 gene
618325 phenotype
neXtProtiNX_Q9UPN3
OpenTargetsiENSG00000127603
PharmGKBiPA30518

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000155824
HOGENOMiHOG000049054
InParanoidiQ9UPN3
KOiK19827
OrthoDBi24858at2759
PhylomeDBiQ9UPN3
TreeFamiTF335163

Enzyme and pathway databases

SignaLinkiQ9UPN3
SIGNORiQ9UPN3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MACF1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MACF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23499
PharosiQ9UPN3

Protein Ontology

More...
PROi
PR:Q9UPN3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127603 Expressed in 240 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9UPN3 baseline and differential
GenevisibleiQ9UPN3 HS

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 5 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 9 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 17 hits
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 20 hits
SM00150 SPEC, 33 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMACF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPN3
Secondary accession number(s): B1ALC5
, E9PJT0, O75053, Q5VW20, Q8WXY1, Q8WXY2, Q96PK2, Q9H540, Q9UKP0, Q9ULG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 28, 2011
Last modified: October 16, 2019
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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