UniProtKB - Q9UPM8 (AP4E1_HUMAN)
AP-4 complex subunit epsilon-1
AP4E1
Functioni
GO - Molecular functioni
- cargo adaptor activity Source: GO_Central
GO - Biological processi
- protein localization Source: UniProtKB
- protein targeting Source: UniProtKB
- receptor-mediated endocytosis Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9UPM8 |
Reactomei | R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Protein family/group databases
TCDBi | 9.B.278.1.5, the organellar-targeting adaptor protein complex (o-apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: AP-4 complex subunit epsilon-1CuratedAlternative name(s): AP-4 adaptor complex subunit epsilon Adaptor-related protein complex 4 subunit epsilon-1 Epsilon subunit of AP-4 Epsilon-adaptin |
Gene namesi | Name:AP4E1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000081014.10 |
HGNCi | HGNC:573, AP4E1 |
MIMi | 607244, gene |
neXtProti | NX_Q9UPM8 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane 1 Publication; Peripheral membrane protein Curated
Endosome
- endosome lumen Source: Reactome
Golgi apparatus
- trans-Golgi network membrane Source: Reactome
Other locations
- AP-4 adaptor complex Source: UniProtKB
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Spastic paraplegia 51, autosomal recessive (SPG51)1 Publication
Stuttering, familial persistent 1 (STUT1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076620 | 96 | F → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566579877Ensembl. | 1 | |
Natural variantiVAR_076622 | 205 | H → N in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499164EnsemblClinVar. | 1 | |
Natural variantiVAR_076625 | 311 | N → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536656846EnsemblClinVar. | 1 | |
Natural variantiVAR_076626 | 326 | S → F in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372479885Ensembl. | 1 | |
Natural variantiVAR_076627 | 384 | H → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866266998Ensembl. | 1 | |
Natural variantiVAR_076629 | 475 | A → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200678853EnsemblClinVar. | 1 | |
Natural variantiVAR_076630 | 517 | V → I in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs760021635EnsemblClinVar. | 1 | |
Natural variantiVAR_076631 | 542 | M → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs542940704EnsemblClinVar. | 1 | |
Natural variantiVAR_076633 | 623 | S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766696884Ensembl. | 1 | |
Natural variantiVAR_076635 | 801 | E → K in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs556450190EnsemblClinVar. | 1 | |
Natural variantiVAR_076637 | 905 | S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780520338Ensembl. | 1 | |
Natural variantiVAR_076638 | 978 | P → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141278078EnsemblClinVar. | 1 | |
Natural variantiVAR_076639 | 1080 | I → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767423538Ensembl. | 1 | |
Natural variantiVAR_076640 | 1089 | L → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs550237440Ensembl. | 1 | |
Natural variantiVAR_076641 | 1105 | R → Q in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139640763EnsemblClinVar. | 1 |
Keywords - Diseasei
Hereditary spastic paraplegia, NeurodegenerationOrganism-specific databases
DisGeNETi | 23431 |
MalaCardsi | AP4E1 |
MIMi | 184450, phenotype 613744, phenotype |
OpenTargetsi | ENSG00000081014 |
Orphaneti | 280763, Severe intellectual disability and progressive spastic paraplegia |
PharmGKBi | PA24865 |
Miscellaneous databases
Pharosi | Q9UPM8, Tdark |
Polymorphism and mutation databases
BioMutai | AP4E1 |
DMDMi | 145559441 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193769 | 1 – 1137 | AP-4 complex subunit epsilon-1Add BLAST | 1137 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 700 | PhosphoserineCombined sources | 1 | |
Modified residuei | 857 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UPM8 |
jPOSTi | Q9UPM8 |
MassIVEi | Q9UPM8 |
PaxDbi | Q9UPM8 |
PeptideAtlasi | Q9UPM8 |
PRIDEi | Q9UPM8 |
ProteomicsDBi | 39780 85379 [Q9UPM8-1] |
PTM databases
iPTMneti | Q9UPM8 |
PhosphoSitePlusi | Q9UPM8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000081014, Expressed in female gonad and 216 other tissues |
ExpressionAtlasi | Q9UPM8, baseline and differential |
Genevisiblei | Q9UPM8, HS |
Organism-specific databases
HPAi | ENSG00000081014, Low tissue specificity |
Interactioni
Subunit structurei
Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1) (PubMed:10436028, PubMed:10066790).
Interacts with TEPSIN (PubMed:26542808).
Interacts with GRIA2; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity).
By similarity3 PublicationsProtein-protein interaction databases
BioGRIDi | 116999, 23 interactors |
ComplexPortali | CPX-5151, AP-4 Adaptor complex |
CORUMi | Q9UPM8 |
IntActi | Q9UPM8, 17 interactors |
STRINGi | 9606.ENSP00000261842 |
Miscellaneous databases
RNActi | Q9UPM8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 727 – 1137 | Interaction with TEPSIN1 PublicationAdd BLAST | 411 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1062, Eukaryota |
GeneTreei | ENSGT00950000182838 |
HOGENOMi | CLU_003824_3_1_1 |
InParanoidi | Q9UPM8 |
OMAi | IECLDHS |
PhylomeDBi | Q9UPM8 |
TreeFami | TF332488 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR017109, AP4_complex_esu IPR028269, AP4E1_C IPR011989, ARM-like IPR016024, ARM-type_fold IPR002553, Clathrin/coatomer_adapt-like_N |
Pfami | View protein in Pfam PF01602, Adaptin_N, 1 hit PF14807, AP4E_app_platf, 1 hit |
PIRSFi | PIRSF037097, AP4_complex_epsilon, 1 hit |
SMARTi | View protein in SMART SM01356, AP4E_app_platf, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDIVEKTLT ALPGLFLQNQ PGGGPAAAKA SFSSRLGSLV RGITALTSKH
60 70 80 90 100
EEEKLIQQEL SSLKATVSAP TTTLKMMKEC MVRLIYCEML GYDASFGYIH
110 120 130 140 150
AIKLAQQGNL LEKRVGYLAV SLFLHESHEL LLLLVNTVVK DLQSTNLVEV
160 170 180 190 200
CMALTVVSQI FPCEMIPAVL PLIEDKLQHS KEIVRRKAVL ALYKFHLIAP
210 220 230 240 250
NQVQHIHIKF RKALCDRDVG VMAASLHIYL RMIKENSSGY KDLTGSFVTI
260 270 280 290 300
LKQVVGGKLP VEFNYHSVPA PWLQIQLLRI LGLLGKDDQR TSELMYDVLD
310 320 330 340 350
ESLRRAELNH NVTYAILFEC VHTVYSIYPK SELLEKAAKC IGKFVLSPKI
360 370 380 390 400
NLKYLGLKAL TYVIQQDPTL ALQHQMTIIE CLDHPDPIIK RETLELLYRI
410 420 430 440 450
TNAQNITVIV QKMLEYLHQS KEEYVIVNLV GKIAELAEKY APDNAWFIQT
460 470 480 490 500
MNAVFSVGGD VMHPDIPNNF LRLLAEGFDD ETEDQQLRLY AVQSYLTLLD
510 520 530 540 550
MENVFYPQRF LQVMSWVLGE YSYLLDKETP EEVIAKLYKL LMNDSVSSET
560 570 580 590 600
KAWLIAAVTK LTSQAHSSNT VERLIHEFTI SLDTCMRQHA FELKHLHENV
610 620 630 640 650
ELMKSLLPVD RSCEDLVVDA SLSFLDGFVA EGLSQGAAPY KPPHQRQEEK
660 670 680 690 700
LSQEKVLNFE PYGLSFSSSG FTGRQSPAGI SLGSDVSGNS AETGLKETNS
710 720 730 740 750
LKLEGIKKLW GKEGYLPKKE SKTGDESGAL PVPQESIMEN VDQAITKKDQ
760 770 780 790 800
SQVLTQSKEE KEKQLLASSL FVGLGSESTI NLLGKADTVS HKFRRKSKVK
810 820 830 840 850
EAKSGETTST HNMTCSSFSS LSNVAYEDDY YSNTLHDTGD KELKKFSLTS
860 870 880 890 900
ELLDSESLTE LPLVEKFSYC SLSTPSLFAN NNMEIFHPPQ STAASVAKES
910 920 930 940 950
SLASSFLEET TEYIHSNAME VCNNETISVS SYKIWKDDCL LMVWSVTNKS
960 970 980 990 1000
GLELKSADLE IFPAENFKVT EQPGCCLPVM EAESTKSFQY SVQIEKPFTE
1010 1020 1030 1040 1050
GNLTGFISYH MMDTHSAQLE FSVNLSLLDF IRPLKISSDD FGKLWLSFAN
1060 1070 1080 1090 1100
DVKQNVKMSE SQAALPSALK TLQQKLRLHI IEIIGNEGLL ACQLLPSIPC
1110 1120 1130
LLHCRVHADV LALWFRSSCS TLPDYLLYQC QKVMEGS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YK94 | H0YK94_HUMAN | AP-4 complex subunit epsilon-1 | AP4E1 | 218 | Annotation score: | ||
H0YL95 | H0YL95_HUMAN | AP-4 complex subunit epsilon-1 | AP4E1 | 368 | Annotation score: | ||
H0YK95 | H0YK95_HUMAN | AP-4 complex subunit epsilon-1 | AP4E1 | 321 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | A → G in AAD43326 (PubMed:10436028).Curated | 1 | |
Sequence conflicti | 46 | L → F in AAD43326 (PubMed:10436028).Curated | 1 | |
Sequence conflicti | 214 | L → P in AAD43326 (PubMed:10436028).Curated | 1 | |
Sequence conflicti | 262 – 265 | EFNY → NF in AAD43326 (PubMed:10436028).Curated | 4 | |
Sequence conflicti | 678 | A → V in CAH18399 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 794 | R → G in CAH18399 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 991 | S → G in CAH18399 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076619 | 85 | I → T1 PublicationCorresponds to variant dbSNP:rs147005786EnsemblClinVar. | 1 | |
Natural variantiVAR_076620 | 96 | F → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566579877Ensembl. | 1 | |
Natural variantiVAR_076621 | 145 | T → S1 PublicationCorresponds to variant dbSNP:rs200034177Ensembl. | 1 | |
Natural variantiVAR_031621 | 163 | C → R3 PublicationsCorresponds to variant dbSNP:rs2306331EnsemblClinVar. | 1 | |
Natural variantiVAR_076622 | 205 | H → N in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499164EnsemblClinVar. | 1 | |
Natural variantiVAR_076623 | 211 | R → Q1 PublicationCorresponds to variant dbSNP:rs750328226Ensembl. | 1 | |
Natural variantiVAR_076624 | 264 | N → S1 PublicationCorresponds to variant dbSNP:rs145541719EnsemblClinVar. | 1 | |
Natural variantiVAR_076625 | 311 | N → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536656846EnsemblClinVar. | 1 | |
Natural variantiVAR_076626 | 326 | S → F in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372479885Ensembl. | 1 | |
Natural variantiVAR_076627 | 384 | H → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866266998Ensembl. | 1 | |
Natural variantiVAR_076628 | 426 | I → L1 PublicationCorresponds to variant dbSNP:rs148817957EnsemblClinVar. | 1 | |
Natural variantiVAR_076629 | 475 | A → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200678853EnsemblClinVar. | 1 | |
Natural variantiVAR_076630 | 517 | V → I in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs760021635EnsemblClinVar. | 1 | |
Natural variantiVAR_076631 | 542 | M → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs542940704EnsemblClinVar. | 1 | |
Natural variantiVAR_076632 | 618 | V → I1 PublicationCorresponds to variant dbSNP:rs142215198EnsemblClinVar. | 1 | |
Natural variantiVAR_076633 | 623 | S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766696884Ensembl. | 1 | |
Natural variantiVAR_076634 | 706 | I → K1 PublicationCorresponds to variant dbSNP:rs865868636Ensembl. | 1 | |
Natural variantiVAR_079485 | 719 | K → E Found in deaf patients; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_076635 | 801 | E → K in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs556450190EnsemblClinVar. | 1 | |
Natural variantiVAR_076636 | 813 | M → V1 PublicationCorresponds to variant dbSNP:rs779094838Ensembl. | 1 | |
Natural variantiVAR_076637 | 905 | S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780520338Ensembl. | 1 | |
Natural variantiVAR_076638 | 978 | P → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141278078EnsemblClinVar. | 1 | |
Natural variantiVAR_076639 | 1080 | I → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767423538Ensembl. | 1 | |
Natural variantiVAR_076640 | 1089 | L → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs550237440Ensembl. | 1 | |
Natural variantiVAR_076641 | 1105 | R → Q in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139640763EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046009 | 1 – 75 | Missing in isoform 2. 1 PublicationAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155156 mRNA Translation: AAD43326.2 AB030653 mRNA Translation: BAA82969.1 CR749604 mRNA Translation: CAH18399.1 AC021752 Genomic DNA No translation available. AC022407 Genomic DNA No translation available. AC073964 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77411.1 BC126308 mRNA Translation: AAI26309.1 BC130466 mRNA Translation: AAI30467.1 |
CCDSi | CCDS32240.1 [Q9UPM8-1] CCDS58362.1 [Q9UPM8-2] |
RefSeqi | NP_001239056.1, NM_001252127.1 [Q9UPM8-2] NP_031373.2, NM_007347.4 [Q9UPM8-1] XP_005254321.1, XM_005254264.3 [Q9UPM8-2] XP_006720510.1, XM_006720447.3 [Q9UPM8-2] |
Genome annotation databases
Ensembli | ENST00000261842; ENSP00000261842; ENSG00000081014 [Q9UPM8-1] ENST00000560508; ENSP00000452976; ENSG00000081014 [Q9UPM8-2] |
GeneIDi | 23431 |
KEGGi | hsa:23431 |
UCSCi | uc001zyx.3, human [Q9UPM8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155156 mRNA Translation: AAD43326.2 AB030653 mRNA Translation: BAA82969.1 CR749604 mRNA Translation: CAH18399.1 AC021752 Genomic DNA No translation available. AC022407 Genomic DNA No translation available. AC073964 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77411.1 BC126308 mRNA Translation: AAI26309.1 BC130466 mRNA Translation: AAI30467.1 |
CCDSi | CCDS32240.1 [Q9UPM8-1] CCDS58362.1 [Q9UPM8-2] |
RefSeqi | NP_001239056.1, NM_001252127.1 [Q9UPM8-2] NP_031373.2, NM_007347.4 [Q9UPM8-1] XP_005254321.1, XM_005254264.3 [Q9UPM8-2] XP_006720510.1, XM_006720447.3 [Q9UPM8-2] |
3D structure databases
SMRi | Q9UPM8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116999, 23 interactors |
ComplexPortali | CPX-5151, AP-4 Adaptor complex |
CORUMi | Q9UPM8 |
IntActi | Q9UPM8, 17 interactors |
STRINGi | 9606.ENSP00000261842 |
Protein family/group databases
TCDBi | 9.B.278.1.5, the organellar-targeting adaptor protein complex (o-apc) family |
PTM databases
iPTMneti | Q9UPM8 |
PhosphoSitePlusi | Q9UPM8 |
Polymorphism and mutation databases
BioMutai | AP4E1 |
DMDMi | 145559441 |
Proteomic databases
EPDi | Q9UPM8 |
jPOSTi | Q9UPM8 |
MassIVEi | Q9UPM8 |
PaxDbi | Q9UPM8 |
PeptideAtlasi | Q9UPM8 |
PRIDEi | Q9UPM8 |
ProteomicsDBi | 39780 85379 [Q9UPM8-1] |
Protocols and materials databases
Antibodypediai | 24780, 28 antibodies |
DNASUi | 23431 |
Genome annotation databases
Ensembli | ENST00000261842; ENSP00000261842; ENSG00000081014 [Q9UPM8-1] ENST00000560508; ENSP00000452976; ENSG00000081014 [Q9UPM8-2] |
GeneIDi | 23431 |
KEGGi | hsa:23431 |
UCSCi | uc001zyx.3, human [Q9UPM8-1] |
Organism-specific databases
CTDi | 23431 |
DisGeNETi | 23431 |
EuPathDBi | HostDB:ENSG00000081014.10 |
GeneCardsi | AP4E1 |
HGNCi | HGNC:573, AP4E1 |
HPAi | ENSG00000081014, Low tissue specificity |
MalaCardsi | AP4E1 |
MIMi | 184450, phenotype 607244, gene 613744, phenotype |
neXtProti | NX_Q9UPM8 |
OpenTargetsi | ENSG00000081014 |
Orphaneti | 280763, Severe intellectual disability and progressive spastic paraplegia |
PharmGKBi | PA24865 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1062, Eukaryota |
GeneTreei | ENSGT00950000182838 |
HOGENOMi | CLU_003824_3_1_1 |
InParanoidi | Q9UPM8 |
OMAi | IECLDHS |
PhylomeDBi | Q9UPM8 |
TreeFami | TF332488 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPM8 |
Reactomei | R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 23431, 5 hits in 852 CRISPR screens |
ChiTaRSi | AP4E1, human |
GeneWikii | AP4E1 |
GenomeRNAii | 23431 |
Pharosi | Q9UPM8, Tdark |
PROi | PR:Q9UPM8 |
RNActi | Q9UPM8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000081014, Expressed in female gonad and 216 other tissues |
ExpressionAtlasi | Q9UPM8, baseline and differential |
Genevisiblei | Q9UPM8, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR017109, AP4_complex_esu IPR028269, AP4E1_C IPR011989, ARM-like IPR016024, ARM-type_fold IPR002553, Clathrin/coatomer_adapt-like_N |
Pfami | View protein in Pfam PF01602, Adaptin_N, 1 hit PF14807, AP4E_app_platf, 1 hit |
PIRSFi | PIRSF037097, AP4_complex_epsilon, 1 hit |
SMARTi | View protein in SMART SM01356, AP4E_app_platf, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AP4E1_HUMAN | |
Accessioni | Q9UPM8Primary (citable) accession number: Q9UPM8 Secondary accession number(s): A0AVD6 Q9Y588 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations