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Protein

AP-4 complex subunit epsilon-1

Gene

AP4E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).2 Publications2 Publications

GO - Biological processi

  • protein localization Source: UniProtKB
  • protein targeting Source: UniProtKB
  • vesicle-mediated transport Source: InterPro

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-4 complex subunit epsilon-1Curated
Alternative name(s):
AP-4 adaptor complex subunit epsilon
Adaptor-related protein complex 4 subunit epsilon-1
Epsilon subunit of AP-4
Epsilon-adaptin
Gene namesi
Name:AP4E1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000081014.10
HGNCiHGNC:573 AP4E1
MIMi607244 gene
neXtProtiNX_Q9UPM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Spastic paraplegia 51, autosomal recessive (SPG51)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG51 is a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication.
See also OMIM:613744
Stuttering, familial persistent 1 (STUT1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of stuttering, a disturbance in the normal fluency and time patterning of speech, characterized by frequent repetitions or prolongations of sounds or syllables, and by interruptions of speech known as blocks. STUT1 inheritance is autosomal dominant.
See also OMIM:184450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07662096F → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566579877Ensembl.1
Natural variantiVAR_076622205H → N in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499164EnsemblClinVar.1
Natural variantiVAR_076625311N → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536656846Ensembl.1
Natural variantiVAR_076626326S → F in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372479885Ensembl.1
Natural variantiVAR_076627384H → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866266998Ensembl.1
Natural variantiVAR_076629475A → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200678853EnsemblClinVar.1
Natural variantiVAR_076630517V → I in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs760021635EnsemblClinVar.1
Natural variantiVAR_076631542M → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs542940704Ensembl.1
Natural variantiVAR_076633623S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766696884Ensembl.1
Natural variantiVAR_076635801E → K in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs556450190EnsemblClinVar.1
Natural variantiVAR_076637905S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780520338Ensembl.1
Natural variantiVAR_076638978P → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141278078EnsemblClinVar.1
Natural variantiVAR_0766391080I → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767423538Ensembl.1
Natural variantiVAR_0766401089L → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs550237440Ensembl.1
Natural variantiVAR_0766411105R → Q in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139640763EnsemblClinVar.1

Keywords - Diseasei

Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNETi23431
MalaCardsiAP4E1
MIMi184450 phenotype
613744 phenotype
OpenTargetsiENSG00000081014
Orphaneti280763 Severe intellectual disability and progressive spastic paraplegia
PharmGKBiPA24865

Polymorphism and mutation databases

BioMutaiAP4E1
DMDMi145559441

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937691 – 1137AP-4 complex subunit epsilon-1Add BLAST1137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei700PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPM8
PaxDbiQ9UPM8
PeptideAtlasiQ9UPM8
PRIDEiQ9UPM8
ProteomicsDBi85379

PTM databases

iPTMnetiQ9UPM8
PhosphoSitePlusiQ9UPM8

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000081014 Expressed in 202 organ(s), highest expression level in female gonad
CleanExiHS_AP4E1
ExpressionAtlasiQ9UPM8 baseline and differential
GenevisibleiQ9UPM8 HS

Organism-specific databases

HPAiHPA041749
HPA041891

Interactioni

Subunit structurei

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1) (PubMed:10436028, PubMed:10066790). Interacts with TEPSIN (PubMed:26542808). Interacts with GRIA2; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi116999, 19 interactors
CORUMiQ9UPM8
IntActiQ9UPM8, 16 interactors
STRINGi9606.ENSP00000261842

Structurei

3D structure databases

ProteinModelPortaliQ9UPM8
SMRiQ9UPM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni727 – 1137Interaction with TEPSIN1 PublicationAdd BLAST411

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000231886
HOVERGENiHBG050522
InParanoidiQ9UPM8
KOiK12400
OMAiSYKIWKD
OrthoDBiEOG091G010Y
PhylomeDBiQ9UPM8
TreeFamiTF332488

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017109 AP4_complex_esu
IPR028269 AP4E1_C
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14807 AP4E_app_platf, 1 hit
PIRSFiPIRSF037097 AP4_complex_epsilon, 1 hit
SMARTiView protein in SMART
SM01356 AP4E_app_platf, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDIVEKTLT ALPGLFLQNQ PGGGPAAAKA SFSSRLGSLV RGITALTSKH
60 70 80 90 100
EEEKLIQQEL SSLKATVSAP TTTLKMMKEC MVRLIYCEML GYDASFGYIH
110 120 130 140 150
AIKLAQQGNL LEKRVGYLAV SLFLHESHEL LLLLVNTVVK DLQSTNLVEV
160 170 180 190 200
CMALTVVSQI FPCEMIPAVL PLIEDKLQHS KEIVRRKAVL ALYKFHLIAP
210 220 230 240 250
NQVQHIHIKF RKALCDRDVG VMAASLHIYL RMIKENSSGY KDLTGSFVTI
260 270 280 290 300
LKQVVGGKLP VEFNYHSVPA PWLQIQLLRI LGLLGKDDQR TSELMYDVLD
310 320 330 340 350
ESLRRAELNH NVTYAILFEC VHTVYSIYPK SELLEKAAKC IGKFVLSPKI
360 370 380 390 400
NLKYLGLKAL TYVIQQDPTL ALQHQMTIIE CLDHPDPIIK RETLELLYRI
410 420 430 440 450
TNAQNITVIV QKMLEYLHQS KEEYVIVNLV GKIAELAEKY APDNAWFIQT
460 470 480 490 500
MNAVFSVGGD VMHPDIPNNF LRLLAEGFDD ETEDQQLRLY AVQSYLTLLD
510 520 530 540 550
MENVFYPQRF LQVMSWVLGE YSYLLDKETP EEVIAKLYKL LMNDSVSSET
560 570 580 590 600
KAWLIAAVTK LTSQAHSSNT VERLIHEFTI SLDTCMRQHA FELKHLHENV
610 620 630 640 650
ELMKSLLPVD RSCEDLVVDA SLSFLDGFVA EGLSQGAAPY KPPHQRQEEK
660 670 680 690 700
LSQEKVLNFE PYGLSFSSSG FTGRQSPAGI SLGSDVSGNS AETGLKETNS
710 720 730 740 750
LKLEGIKKLW GKEGYLPKKE SKTGDESGAL PVPQESIMEN VDQAITKKDQ
760 770 780 790 800
SQVLTQSKEE KEKQLLASSL FVGLGSESTI NLLGKADTVS HKFRRKSKVK
810 820 830 840 850
EAKSGETTST HNMTCSSFSS LSNVAYEDDY YSNTLHDTGD KELKKFSLTS
860 870 880 890 900
ELLDSESLTE LPLVEKFSYC SLSTPSLFAN NNMEIFHPPQ STAASVAKES
910 920 930 940 950
SLASSFLEET TEYIHSNAME VCNNETISVS SYKIWKDDCL LMVWSVTNKS
960 970 980 990 1000
GLELKSADLE IFPAENFKVT EQPGCCLPVM EAESTKSFQY SVQIEKPFTE
1010 1020 1030 1040 1050
GNLTGFISYH MMDTHSAQLE FSVNLSLLDF IRPLKISSDD FGKLWLSFAN
1060 1070 1080 1090 1100
DVKQNVKMSE SQAALPSALK TLQQKLRLHI IEIIGNEGLL ACQLLPSIPC
1110 1120 1130
LLHCRVHADV LALWFRSSCS TLPDYLLYQC QKVMEGS
Length:1,137
Mass (Da):127,287
Last modified:April 17, 2007 - v2
Checksum:i1784E886EC922875
GO
Isoform 2 (identifier: Q9UPM8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:1,062
Mass (Da):119,482
Checksum:i14CBDA9A25B63BFF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK94H0YK94_HUMAN
AP-4 complex subunit epsilon-1
AP4E1
218Annotation score:
H0YL95H0YL95_HUMAN
AP-4 complex subunit epsilon-1
AP4E1
368Annotation score:
H0YK95H0YK95_HUMAN
AP-4 complex subunit epsilon-1
AP4E1
321Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30A → G in AAD43326 (PubMed:10436028).Curated1
Sequence conflicti46L → F in AAD43326 (PubMed:10436028).Curated1
Sequence conflicti214L → P in AAD43326 (PubMed:10436028).Curated1
Sequence conflicti262 – 265EFNY → NF in AAD43326 (PubMed:10436028).Curated4
Sequence conflicti678A → V in CAH18399 (PubMed:17974005).Curated1
Sequence conflicti794R → G in CAH18399 (PubMed:17974005).Curated1
Sequence conflicti991S → G in CAH18399 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07661985I → T1 PublicationCorresponds to variant dbSNP:rs147005786Ensembl.1
Natural variantiVAR_07662096F → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs566579877Ensembl.1
Natural variantiVAR_076621145T → S1 PublicationCorresponds to variant dbSNP:rs200034177Ensembl.1
Natural variantiVAR_031621163C → R3 PublicationsCorresponds to variant dbSNP:rs2306331EnsemblClinVar.1
Natural variantiVAR_076622205H → N in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499164EnsemblClinVar.1
Natural variantiVAR_076623211R → Q1 PublicationCorresponds to variant dbSNP:rs750328226Ensembl.1
Natural variantiVAR_076624264N → S1 PublicationCorresponds to variant dbSNP:rs145541719EnsemblClinVar.1
Natural variantiVAR_076625311N → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs536656846Ensembl.1
Natural variantiVAR_076626326S → F in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs372479885Ensembl.1
Natural variantiVAR_076627384H → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs866266998Ensembl.1
Natural variantiVAR_076628426I → L1 PublicationCorresponds to variant dbSNP:rs148817957EnsemblClinVar.1
Natural variantiVAR_076629475A → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200678853EnsemblClinVar.1
Natural variantiVAR_076630517V → I in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs760021635EnsemblClinVar.1
Natural variantiVAR_076631542M → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs542940704Ensembl.1
Natural variantiVAR_076632618V → I1 PublicationCorresponds to variant dbSNP:rs142215198EnsemblClinVar.1
Natural variantiVAR_076633623S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766696884Ensembl.1
Natural variantiVAR_076634706I → K1 PublicationCorresponds to variant dbSNP:rs865868636Ensembl.1
Natural variantiVAR_079485719K → E Found in deaf patients; unknown pathological significance. 1 Publication1
Natural variantiVAR_076635801E → K in STUT1; slightly decreased assembly of the AP-4 complex. 1 PublicationCorresponds to variant dbSNP:rs556450190EnsemblClinVar.1
Natural variantiVAR_076636813M → V1 PublicationCorresponds to variant dbSNP:rs779094838Ensembl.1
Natural variantiVAR_076637905S → P in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780520338Ensembl.1
Natural variantiVAR_076638978P → S in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141278078EnsemblClinVar.1
Natural variantiVAR_0766391080I → V in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767423538Ensembl.1
Natural variantiVAR_0766401089L → R in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs550237440Ensembl.1
Natural variantiVAR_0766411105R → Q in STUT1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs139640763EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460091 – 75Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155156 mRNA Translation: AAD43326.2
AB030653 mRNA Translation: BAA82969.1
CR749604 mRNA Translation: CAH18399.1
AC021752 Genomic DNA No translation available.
AC022407 Genomic DNA No translation available.
AC073964 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77411.1
BC126308 mRNA Translation: AAI26309.1
BC130466 mRNA Translation: AAI30467.1
CCDSiCCDS32240.1 [Q9UPM8-1]
CCDS58362.1 [Q9UPM8-2]
RefSeqiNP_001239056.1, NM_001252127.1 [Q9UPM8-2]
NP_031373.2, NM_007347.4 [Q9UPM8-1]
XP_005254321.1, XM_005254264.3 [Q9UPM8-2]
XP_006720510.1, XM_006720447.3 [Q9UPM8-2]
UniGeneiHs.413366

Genome annotation databases

EnsembliENST00000261842; ENSP00000261842; ENSG00000081014 [Q9UPM8-1]
ENST00000560508; ENSP00000452976; ENSG00000081014 [Q9UPM8-2]
GeneIDi23431
KEGGihsa:23431
UCSCiuc001zyx.3 human [Q9UPM8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155156 mRNA Translation: AAD43326.2
AB030653 mRNA Translation: BAA82969.1
CR749604 mRNA Translation: CAH18399.1
AC021752 Genomic DNA No translation available.
AC022407 Genomic DNA No translation available.
AC073964 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77411.1
BC126308 mRNA Translation: AAI26309.1
BC130466 mRNA Translation: AAI30467.1
CCDSiCCDS32240.1 [Q9UPM8-1]
CCDS58362.1 [Q9UPM8-2]
RefSeqiNP_001239056.1, NM_001252127.1 [Q9UPM8-2]
NP_031373.2, NM_007347.4 [Q9UPM8-1]
XP_005254321.1, XM_005254264.3 [Q9UPM8-2]
XP_006720510.1, XM_006720447.3 [Q9UPM8-2]
UniGeneiHs.413366

3D structure databases

ProteinModelPortaliQ9UPM8
SMRiQ9UPM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116999, 19 interactors
CORUMiQ9UPM8
IntActiQ9UPM8, 16 interactors
STRINGi9606.ENSP00000261842

PTM databases

iPTMnetiQ9UPM8
PhosphoSitePlusiQ9UPM8

Polymorphism and mutation databases

BioMutaiAP4E1
DMDMi145559441

Proteomic databases

EPDiQ9UPM8
PaxDbiQ9UPM8
PeptideAtlasiQ9UPM8
PRIDEiQ9UPM8
ProteomicsDBi85379

Protocols and materials databases

DNASUi23431
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261842; ENSP00000261842; ENSG00000081014 [Q9UPM8-1]
ENST00000560508; ENSP00000452976; ENSG00000081014 [Q9UPM8-2]
GeneIDi23431
KEGGihsa:23431
UCSCiuc001zyx.3 human [Q9UPM8-1]

Organism-specific databases

CTDi23431
DisGeNETi23431
EuPathDBiHostDB:ENSG00000081014.10
GeneCardsiAP4E1
HGNCiHGNC:573 AP4E1
HPAiHPA041749
HPA041891
MalaCardsiAP4E1
MIMi184450 phenotype
607244 gene
613744 phenotype
neXtProtiNX_Q9UPM8
OpenTargetsiENSG00000081014
Orphaneti280763 Severe intellectual disability and progressive spastic paraplegia
PharmGKBiPA24865
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000231886
HOVERGENiHBG050522
InParanoidiQ9UPM8
KOiK12400
OMAiSYKIWKD
OrthoDBiEOG091G010Y
PhylomeDBiQ9UPM8
TreeFamiTF332488

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRSiAP4E1 human
GeneWikiiAP4E1
GenomeRNAii23431
PROiPR:Q9UPM8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081014 Expressed in 202 organ(s), highest expression level in female gonad
CleanExiHS_AP4E1
ExpressionAtlasiQ9UPM8 baseline and differential
GenevisibleiQ9UPM8 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017109 AP4_complex_esu
IPR028269 AP4E1_C
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14807 AP4E_app_platf, 1 hit
PIRSFiPIRSF037097 AP4_complex_epsilon, 1 hit
SMARTiView protein in SMART
SM01356 AP4E_app_platf, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP4E1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPM8
Secondary accession number(s): A0AVD6
, A1L4A9, A6NNX7, H0YKX4, Q68D31, Q9Y588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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