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Protein

Probable G-protein coupled receptor 34

Gene

GPR34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 34
Gene namesi
Name:GPR34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000171659.13
HGNCiHGNC:4490 GPR34
MIMi300241 gene
neXtProtiNX_Q9UPC5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 82Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini83 – 88CytoplasmicSequence analysis6
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 128ExtracellularSequence analysisAdd BLAST19
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini150 – 171CytoplasmicSequence analysisAdd BLAST22
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 216ExtracellularSequence analysisAdd BLAST24
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 269CytoplasmicSequence analysisAdd BLAST32
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 310ExtracellularSequence analysisAdd BLAST20
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 381CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2857
OpenTargetsiENSG00000171659
PharmGKBiPA28878

Chemistry databases

ChEMBLiCHEMBL3562165
GuidetoPHARMACOLOGYi101

Polymorphism and mutation databases

BioMutaiGPR34
DMDMi12643337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695591 – 381Probable G-protein coupled receptor 34Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 204PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UPC5
PeptideAtlasiQ9UPC5
PRIDEiQ9UPC5
ProteomicsDBi85365

PTM databases

iPTMnetiQ9UPC5
PhosphoSitePlusiQ9UPC5

Expressioni

Tissue specificityi

Broadly expressed.

Gene expression databases

BgeeiENSG00000171659 Expressed in 169 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_GPR34
ExpressionAtlasiQ9UPC5 baseline and differential
GenevisibleiQ9UPC5 HS

Organism-specific databases

HPAiCAB025490
HPA010668

Interactioni

Protein-protein interaction databases

IntActiQ9UPC5, 1 interactor
STRINGi9606.ENSP00000367378

Chemistry databases

BindingDBiQ9UPC5

Structurei

3D structure databases

ProteinModelPortaliQ9UPC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH53 Eukaryota
ENOG410ZHRR LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000039982
HOVERGENiHBG063715
InParanoidiQ9UPC5
KOiK08383
OMAiNEIMLVF
OrthoDBiEOG091G0DKA
PhylomeDBiQ9UPC5
TreeFamiTF330969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9UPC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE
60 70 80 90 100
KLLSTVLTTS YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD
110 120 130 140 150
LLLIFCLPFR IMYHINQNKW TLGVILCKVV GTLFYMNMYI SIILLGFISL
160 170 180 190 200
DRYIKINRSI QQRKAITTKQ SIYVCCIVWM LALGGFLTMI ILTLKKGGHN
210 220 230 240 250
STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK IGKNLLRISK
260 270 280 290 300
RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
310 320 330 340 350
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP
360 370 380
SRSESTSEFK PGYSLHDTSV AVKIQSSSKS T
Length:381
Mass (Da):43,860
Last modified:January 24, 2001 - v2
Checksum:i491FC016E5624379
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3SAH0Q3SAH0_HUMAN
G-protein-coupled receptor 34 splic...
GPR34
334Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181L → V in AAD50531 (PubMed:10395919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039686 mRNA Translation: AAD50531.1
AF118670 Genomic DNA Translation: AAD17248.1
AK027780 mRNA Translation: BAB55362.1
BC020678 mRNA Translation: AAH20678.1
CCDSiCCDS14258.1
RefSeqiNP_001091048.1, NM_001097579.1
NP_005291.1, NM_005300.3
XP_005272654.1, XM_005272597.3
UniGeneiHs.495989

Genome annotation databases

EnsembliENST00000378138; ENSP00000367378; ENSG00000171659
ENST00000378142; ENSP00000367384; ENSG00000171659
GeneIDi2857
KEGGihsa:2857
UCSCiuc004dfp.4 human

Similar proteinsi

Entry informationi

Entry nameiGPR34_HUMAN
AccessioniPrimary (citable) accession number: Q9UPC5
Secondary accession number(s): O95853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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