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Entry version 139 (08 May 2019)
Sequence version 4 (05 May 2009)
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Protein

Protein bassoon

Gene

BSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri170 – 193C4-typeSequence analysisAdd BLAST24
Zinc fingeri198 – 220C4-typeSequence analysisAdd BLAST23
Zinc fingeri465 – 488C4-typeSequence analysisAdd BLAST24
Zinc fingeri493 – 515C4-typeSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein bassoonCurated
Alternative name(s):
Zinc finger protein 231
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BSNImported
Synonyms:KIAA0434, ZNF2311 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1117 BSN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604020 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPA5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8927

Open Targets

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OpenTargetsi
ENSG00000164061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25434

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
BSN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229463040

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000650022 – 3926Protein bassoonAdd BLAST3925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei145PhosphoserineBy similarity1
Modified residuei148Omega-N-methylarginineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Modified residuei867Omega-N-methylarginineBy similarity1
Modified residuei970PhosphoserineBy similarity1
Modified residuei1040PhosphoserineBy similarity1
Modified residuei1041PhosphoserineBy similarity1
Modified residuei1090PhosphoserineBy similarity1
Modified residuei1092PhosphothreonineBy similarity1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1104PhosphoserineBy similarity1
Modified residuei1226PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1343O-linked (GlcNAc) threonineBy similarity1
Glycosylationi1384O-linked (GlcNAc) threonineBy similarity1
Modified residuei1477PhosphoserineBy similarity1
Modified residuei1486PhosphoserineBy similarity1
Modified residuei1488PhosphoserineBy similarity1
Modified residuei1787Omega-N-methylarginineBy similarity1
Modified residuei1791Omega-N-methylarginineBy similarity1
Modified residuei1801Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1801Omega-N-methylarginine; alternateBy similarity1
Modified residuei1813Omega-N-methylarginineBy similarity1
Modified residuei1985PhosphoserineBy similarity1
Modified residuei2041PhosphoserineBy similarity1
Modified residuei2046Omega-N-methylarginineBy similarity1
Modified residuei2076Omega-N-methylarginineBy similarity1
Modified residuei2250Asymmetric dimethylarginineBy similarity1
Modified residuei2260Asymmetric dimethylarginineBy similarity1
Modified residuei2266Asymmetric dimethylarginineBy similarity1
Glycosylationi2314O-linked (GlcNAc) threonineBy similarity1
Modified residuei2570PhosphoserineBy similarity1
Modified residuei2587PhosphothreonineBy similarity1
Modified residuei2614PhosphothreonineBy similarity1
Glycosylationi2691O-linked (GlcNAc) threonineBy similarity1
Modified residuei2802PhosphoserineBy similarity1
Modified residuei2851PhosphoserineBy similarity1
Modified residuei2857PhosphoserineBy similarity1
Glycosylationi2936O-linked (GlcNAc) threonineBy similarity1
Modified residuei3013PhosphoserineBy similarity1
Modified residuei3291PhosphoserineBy similarity1
Modified residuei3373PhosphoserineBy similarity1
Modified residuei3492Omega-N-methylarginineBy similarity1
Modified residuei3808Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UPA5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPA5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UPA5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPA5

PeptideAtlas

More...
PeptideAtlasi
Q9UPA5

PRoteomics IDEntifications database

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PRIDEi
Q9UPA5

ProteomicsDB human proteome resource

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ProteomicsDBi
85364

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UPA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UPA5

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9UPA5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164061 Expressed in 90 organ(s), highest expression level in postcentral gyrus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UPA5 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA034757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCLO, ERC2/CAST1, RIMS1 and UNC13A (By similarity).

Interacts with TPRG1L (By similarity).

Interacts with DYNLL1 and DYNLL2; these interactions potentially link PTVs to dynein and myosin V motor complexes (PubMed:19380881).

Interacts with ATG5; this interaction is important for the regulation of presynaptic autophagy (By similarity).

Interacts (via C-terminus) with TRIO (via N-terminus) (By similarity).

Interacts with CTBP1 (By similarity).

Interacts with SIAH1; this interaction negatively regulates SIAH1 E3 ligase activity (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114441, 7 interactors

Protein interaction database and analysis system

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IntActi
Q9UPA5, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000296452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPA5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati571 – 57717
Repeati578 – 58427
Repeati585 – 59137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 325 X 2 AA tandem repeats of P-G10
Regioni61 – 747 X 2 AA tandem repeats of P-GAdd BLAST14
Regioni571 – 5913 X 7 AA tandem repeats of K-A-S-P-[LQ]-[APS]-[KST]Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1037 – 1092Sequence analysisAdd BLAST56
Coiled coili1181 – 1208Sequence analysisAdd BLAST28
Coiled coili1276 – 1294Sequence analysisAdd BLAST19
Coiled coili2351 – 2476Sequence analysisAdd BLAST126
Coiled coili2939 – 2981Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2600 – 2606Poly-Arg7
Compositional biasi2627 – 2632Poly-Arg6
Compositional biasi3775 – 3783Poly-Gln9

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 193C4-typeSequence analysisAdd BLAST24
Zinc fingeri198 – 220C4-typeSequence analysisAdd BLAST23
Zinc fingeri465 – 488C4-typeSequence analysisAdd BLAST24
Zinc fingeri493 – 515C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGEH Eukaryota
ENOG410XX5R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00620000087961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000095267

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPA5

Identification of Orthologs from Complete Genome Data

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OMAi
EKNEWLC

Database of Orthologous Groups

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OrthoDBi
29707at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPA5

TreeFam database of animal gene trees

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TreeFami
TF326082

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030627 Bsn
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR14113:SF1 PTHR14113:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05715 zf-piccolo, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNEVSLEGG AGDGPLPPGG AGPGPGPGPG PGAGKPPSAP AGGGQLPAAG
60 70 80 90 100
AARSTAVPPV PGPGPGPGPG PGPGSTSRRL DPKEPLGNQR AASPTPKQAS
110 120 130 140 150
ATTPGHESPR ETRAQGPAGQ EADGPRRTLQ VDSRTQRSGR SPSVSPDRGS
160 170 180 190 200
TPTSPYSVPQ IAPLPSSTLC PICKTSDLTS TPSQPNFNTC TQCHNKVCNQ
210 220 230 240 250
CGFNPNPHLT QVKEWLCLNC QMQRALGMDM TTAPRSKSQQ QLHSPALSPA
260 270 280 290 300
HSPAKQPLGK PDQERSRGPG GPQPGSRQAE TARATSVPGP AQAAAPPEVG
310 320 330 340 350
RVSPQPPQPT KPSTAEPRPP AGEAPAKSAT AVPAGLGATE QTQEGLTGKL
360 370 380 390 400
FGLGASLLTQ ASTLMSVQPE ADTQGQPAPS KGTPKIVFND ASKEAGPKPL
410 420 430 440 450
GSGPGPGPAP GAKTEPGARM GPGSGPGALP KTGGTTSPKH GRAEHQAASK
460 470 480 490 500
AAAKPKTMPK ERAICPLCQA ELNVGSKSPA NYNTCTTCRL QVCNLCGFNP
510 520 530 540 550
TPHLVEKTEW LCLNCQTKRL LEGSLGEPTP LPPPTSQQPP VGAPHRASGT
560 570 580 590 600
SPLKQKGPQG LGQPSGPLPA KASPLSTKAS PLPSKASPQA KPLRASEPSK
610 620 630 640 650
TPSSVQEKKT RVPTKAEPMP KPPPETTPTP ATPKVKSGVR RAEPATPVVK
660 670 680 690 700
AVPEAPKGGE AEDLVGKPYS QDASRSPQSL SDTGYSSDGI SSSQSEITGV
710 720 730 740 750
VQQEVEQLDS AGVTGPHPPS PSEIHKVGSS MRPLLQAQGL APSERSKPLS
760 770 780 790 800
SGTGEEQKQR PHSLSITPEA FDSDEELEDI LEEDEDSAEW RRRREQQDTA
810 820 830 840 850
ESSDDFGSQL RHDYVEDSSE GGLSPLPPQP PARAAELTDE DFMRRQILEM
860 870 880 890 900
SAEEDNLEED DTATSGRGLA KHGTQKGGPR PRPEPSQEPA ALPKRRLPHN
910 920 930 940 950
ATTGYEELLP EGGSAEATDG SGTLQGGLRR FKTIELNSTG SYGHELDLGQ
960 970 980 990 1000
GPDPSLDREP ELEMESLTGS PEDRSRGEHS STLPASTPSY TSGTSPTSLS
1010 1020 1030 1040 1050
SLEEDSDSSP SRRQRLEEAK QQRKARHRSH GPLLPTIEDS SEEEELREEE
1060 1070 1080 1090 1100
ELLREQEKMR EVEQQRIRST ARKTRRDKEE LRAQRRRERS KTPPSNLSPI
1110 1120 1130 1140 1150
EDASPTEELR QAAEMEELHR SSCSEYSPSP SLDSEAEALD GGPSRLYKSG
1160 1170 1180 1190 1200
SEYNLPTFMS LYSPTETPSG SSTTPSSGRP LKSAEEAYEE MMRKAELLQR
1210 1220 1230 1240 1250
QQGQAAGARG PHGGPSQPTG PRGLGSFEYQ DTTDREYGQA AQPAAEGTPA
1260 1270 1280 1290 1300
SLGAAVYEEI LQTSQSIVRM RQASSRDLAF AEDKKKEKQF LNAESAYMDP
1310 1320 1330 1340 1350
MKQNGGPLTP GTSPTQLAAP VSFSTPTSSD SSGGRVIPDV RVTQHFAKET
1360 1370 1380 1390 1400
QDPLKLHSSP ASPSSASKEI GMPFSQGPGT PATTAVAPCP AGLPRGYMTP
1410 1420 1430 1440 1450
ASPAGSERSP SPSSTAHSYG HSPTTANYGS QTEDLPQAPS GLAAAGRAAR
1460 1470 1480 1490 1500
EKPLSASDGE GGTPQPSRAY SYFASSSPPL SPSSPSESPT FSPGKMGPRA
1510 1520 1530 1540 1550
TAEFSTQTPS PAPASDMPRS PGAPTPSPMV AQGTQTPHRP STPRLVWQES
1560 1570 1580 1590 1600
SQEAPFMVIT LASDASSQTR MVHASASTSP LCSPTETQPT THGYSQTTPP
1610 1620 1630 1640 1650
SVSQLPPEPP GPPGFPRVPS AGADGPLALY GWGALPAENI SLCRISSVPG
1660 1670 1680 1690 1700
TSRVEPGPRT PGTAVVDLRT AVKPTPIILT DQGMDLTSLA VEARKYGLAL
1710 1720 1730 1740 1750
DPIPGRQSTA VQPLVINLNA QEHTFLATAT TVSITMASSV FMAQQKQPVV
1760 1770 1780 1790 1800
YGDPYQSRLD FGQGGGSPVC LAQVKQVEQA VQTAPYRSGP RGRPREAKFA
1810 1820 1830 1840 1850
RYNLPNQVAP LARRDVLITQ MGTAQSIGLK PGPVPEPGAE PHRATPAELR
1860 1870 1880 1890 1900
SHALPGARKP HTVVVQMGEG TAGTVTTLLP EEPAGALDLT GMRPESQLAC
1910 1920 1930 1940 1950
CDMVYKLPFG SSCTGTFHPA PSVPEKSMAD AAPPGQSSSP FYGPRDPEPP
1960 1970 1980 1990 2000
EPPTYRAQGV VGPGPHEEQR PYPQGLPGRL YSSMSDTNLA EAGLNYHAQR
2010 2020 2030 2040 2050
IGQLFQGPGR DSAMDLSSLK HSYSLGFADG RYLGQGLQYG SVTDLRHPTD
2060 2070 2080 2090 2100
LLAHPLPMRR YSSVSNIYSD HRYGPRGDAV GFQEASLAQY SATTAREISR
2110 2120 2130 2140 2150
MCAALNSMDQ YGGRHGSGGG GPDLVQYQPQ HGPGLSAPQS LVPLRPGLLG
2160 2170 2180 2190 2200
NPTFPEGHPS PGNLAQYGPA AGQGTAVRQL LPSTATVRAA DGMIYSTINT
2210 2220 2230 2240 2250
PIAATLPITT QPASVLRPMV RGGMYRPYAS GGITAVPLTS LTRVPMIAPR
2260 2270 2280 2290 2300
VPLGPTGLYR YPAPSRFPIA SSVPPAEGPV YLGKPAAAKA PGAGGPSRPE
2310 2320 2330 2340 2350
MPVGAAREEP LPTTTPAAIK EAAGAPAPAP LAGQKPPADA APGGGSGALS
2360 2370 2380 2390 2400
RPGFEKEEAS QEERQRKQQE QLLQLERERV ELEKLRQLRL QEELERERVE
2410 2420 2430 2440 2450
LQRHREEEQL LVQRELQELQ TIKHHVLQQQ QEERQAQFAL QREQLAQQRL
2460 2470 2480 2490 2500
QLEQIQQLQQ QLQQQLEEQK QRQKAPFPAA CEAPGRGPPL AAAELAQNGQ
2510 2520 2530 2540 2550
YWPPLTHAAF IAMAGPEGLG QPREPVLHRG LPSSASDMSL QTEEQWEASR
2560 2570 2580 2590 2600
SGIKKRHSMP RLRDACELES GTEPCVVRRI ADSSVQTDDE DGESRYLLSR
2610 2620 2630 2640 2650
RRRARRSADC SVQTDDEDSA EWEQPVRRRR SRLPRHSDSG SDSKHDATAS
2660 2670 2680 2690 2700
SSSAAATVRA MSSVGIQTIS DCSVQTEPDQ LPRVSPAIHI TAATDPKVEI
2710 2720 2730 2740 2750
VRYISAPEKT GRGESLACQT EPDGQAQGVA GPQLVGPTAI SPYLPGIQIV
2760 2770 2780 2790 2800
TPGPLGRFEK KKPDPLEIGY QAHLPPESLS QLVSRQPPKS PQVLYSPVSP
2810 2820 2830 2840 2850
LSPHRLLDTS FASSERLNKA HVSPQKHFTA DSALRQQTLP RPMKTLQRSL
2860 2870 2880 2890 2900
SDPKPLSPTA EESAKERFSL YQHQGGLGSQ VSALPPNSLV RKVKRTLPSP
2910 2920 2930 2940 2950
PPEEAHLPLA GQASPQLYAA SLLQRGLTGP TTVPATKASL LRELDRDLRL
2960 2970 2980 2990 3000
VEHESTKLRK KQAELDEEEK EIDAKLKYLE LGITQRKESL AKDRGGRDYP
3010 3020 3030 3040 3050
PLRGLGEHRD YLSDSELNQL RLQGCTTPAG QFVDFPATAA APATPSGPTA
3060 3070 3080 3090 3100
FQQPRFQPPA PQYSAGSGGP TQNGFPAHQA PTYPGPSTYP APAFPPGASY
3110 3120 3130 3140 3150
PAEPGLPNQQ AFRPTGHYAG QTPMPTTQST LFPVPADSRA PLQKPRQTSL
3160 3170 3180 3190 3200
ADLEQKVPTN YEVIASPVVP MSSAPSETSY SGPAVSSGYE QGKVPEVPRA
3210 3220 3230 3240 3250
GDRGSVSQSP APTYPSDSHY TSLEQNVPRN YVMIDDISEL TKDSTSTAPD
3260 3270 3280 3290 3300
SQRLEPLGPG SSGRPGKEPG EPGVLDGPTL PCCYARGEEE SEEDSYDPRG
3310 3320 3330 3340 3350
KGGHLRSMES NGRPASTHYY GDSDYRHGAR VEKYGPGPMG PKHPSKSLAP
3360 3370 3380 3390 3400
AAISSKRSKH RKQGMEQKIS KFSPIEEAKD VESDLASYPP PAVSSSLVSR
3410 3420 3430 3440 3450
GRKFQDEITY GLKKNVYEQQ KYYGMSSRDA VEDDRIYGGS SRSRAPSAYS
3460 3470 3480 3490 3500
GEKLSSHDFS GWGKGYERER EAVERLQKAG PKPSSLSMAH SRVRPPMRSQ
3510 3520 3530 3540 3550
ASEEESPVSP LGRPRPAGGP LPPGGDTCPQ FCSSHSMPDV QEHVKDGPRA
3560 3570 3580 3590 3600
HAYKREEGYI LDDSHCVVSD SEAYHLGQEE TDWFDKPRDA RSDRFRHHGG
3610 3620 3630 3640 3650
HAVSSSSQKR GPARHSYHDY DEPPEEGLWP HDEGGPGRHA SAKEHRHGDH
3660 3670 3680 3690 3700
GRHSGRHTGE EPGRRAAKPH ARDLGRHEAR PHSQPSSAPA MPKKGQPGYP
3710 3720 3730 3740 3750
SSAEYSQPSR ASSAYHHASD SKKGSRQAHS GPAALQSKAE PQAQPQLQGR
3760 3770 3780 3790 3800
QAAPGPQQSQ SPSSRQIPSG AASRQPQTQQ QQQGLGLQPP QQALTQARLQ
3810 3820 3830 3840 3850
QQSQPTTRGS APAASQPAGK PQPGPSTATG PQPAGPPRAE QTNGSKGTAK
3860 3870 3880 3890 3900
APQQGRAPQA QPAPGPGPAG VKAGARPGGT PGAPAGQPGA DGESVFSKIL
3910 3920
PGGAAEQAGK LTEAVSAFGK KFSSFW
Length:3,926
Mass (Da):416,469
Last modified:May 5, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69B3AA86AD437356
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3925F → L in AAC83555 (PubMed:9806829).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055105741A → T. Corresponds to variant dbSNP:rs34762726Ensembl.1
Natural variantiVAR_0551061213G → D. Corresponds to variant dbSNP:rs35762866Ensembl.1
Natural variantiVAR_0551073863A → T3 PublicationsCorresponds to variant dbSNP:rs2005557Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF052224 mRNA Translation: AAC83555.1
AC099668 Genomic DNA No translation available.
AC104452 Genomic DNA No translation available.
Y18448
, Y18449, Y18450, Y18451 Genomic DNA Translation: CAA77176.1
AB007894 mRNA Translation: BAA23707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2800.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00062

NCBI Reference Sequences

More...
RefSeqi
NP_003449.2, NM_003458.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296452; ENSP00000296452; ENSG00000164061

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8927

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8927

UCSC genome browser

More...
UCSCi
uc003cxe.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052224 mRNA Translation: AAC83555.1
AC099668 Genomic DNA No translation available.
AC104452 Genomic DNA No translation available.
Y18448
, Y18449, Y18450, Y18451 Genomic DNA Translation: CAA77176.1
AB007894 mRNA Translation: BAA23707.1
CCDSiCCDS2800.1
PIRiT00062
RefSeqiNP_003449.2, NM_003458.3

3D structure databases

SMRiQ9UPA5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114441, 7 interactors
IntActiQ9UPA5, 3 interactors
STRINGi9606.ENSP00000296452

PTM databases

iPTMnetiQ9UPA5
PhosphoSitePlusiQ9UPA5
SwissPalmiQ9UPA5

Polymorphism and mutation databases

BioMutaiBSN
DMDMi229463040

Proteomic databases

EPDiQ9UPA5
jPOSTiQ9UPA5
MaxQBiQ9UPA5
PaxDbiQ9UPA5
PeptideAtlasiQ9UPA5
PRIDEiQ9UPA5
ProteomicsDBi85364

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296452; ENSP00000296452; ENSG00000164061
GeneIDi8927
KEGGihsa:8927
UCSCiuc003cxe.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8927
DisGeNETi8927

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BSN
HGNCiHGNC:1117 BSN
HPAiHPA034757
MIMi604020 gene
neXtProtiNX_Q9UPA5
OpenTargetsiENSG00000164061
PharmGKBiPA25434

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGEH Eukaryota
ENOG410XX5R LUCA
GeneTreeiENSGT00620000087961
HOGENOMiHOG000095267
InParanoidiQ9UPA5
OMAiEKNEWLC
OrthoDBi29707at2759
PhylomeDBiQ9UPA5
TreeFamiTF326082

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BSN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8927

Protein Ontology

More...
PROi
PR:Q9UPA5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164061 Expressed in 90 organ(s), highest expression level in postcentral gyrus
GenevisibleiQ9UPA5 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR030627 Bsn
IPR011011 Znf_FYVE_PHD
IPR008899 Znf_piccolo
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR14113:SF1 PTHR14113:SF1, 1 hit
PfamiView protein in Pfam
PF05715 zf-piccolo, 2 hits
SUPFAMiSSF57903 SSF57903, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBSN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPA5
Secondary accession number(s): O43161, Q7LGH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 5, 2009
Last modified: May 8, 2019
This is version 139 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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