UniProtKB - Q9UP95 (S12A4_HUMAN)
Solute carrier family 12 member 4
SLC12A4
Functioni
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia (By similarity).
Isoform 4 has no transport activity.
By similarityActivity regulationi
GO - Molecular functioni
- ammonium transmembrane transporter activity Source: ARUK-UCL
- potassium:chloride symporter activity Source: GO_Central
- protein kinase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- ammonium import across plasma membrane Source: ARUK-UCL
- cell volume homeostasis Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- chloride ion homeostasis Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transport Source: Reactome
- potassium ion homeostasis Source: GO_Central
- potassium ion import across plasma membrane Source: GO_Central
Keywordsi
Biological process | Ion transport, Potassium transport, Symport, Transport |
Ligand | Chloride, Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q9UP95 |
Reactomei | R-HSA-426117, Cation-coupled Chloride cotransporters |
SignaLinki | Q9UP95 |
SIGNORi | Q9UP95 |
Protein family/group databases
TCDBi | 2.A.30.1.17, the cation-chloride cotransporter (ccc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 12 member 4Alternative name(s): Electroneutral potassium-chloride cotransporter 1 Erythroid K-Cl cotransporter 1 Short name: hKCC1 |
Gene namesi | Name:SLC12A4 Synonyms:KCC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10913, SLC12A4 |
MIMi | 604119, gene |
neXtProti | NX_Q9UP95 |
VEuPathDBi | HostDB:ENSG00000124067 |
Subcellular locationi
Other locations
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 118 | CytoplasmicSequence analysisAdd BLAST | 118 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 214 | CytoplasmicSequence analysisAdd BLAST | 45 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 253 – 273 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 274 – 275 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 407 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 408 – 428 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 453 – 473 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 474 – 493 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 494 – 514 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 567 – 587 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 588 – 627 | CytoplasmicSequence analysisAdd BLAST | 40 | |
Transmembranei | 628 – 648 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 845 – 865 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 866 – 1085 | CytoplasmicSequence analysisAdd BLAST | 220 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6560 |
MalaCardsi | SLC12A4 |
OpenTargetsi | ENSG00000124067 |
PharmGKBi | PA35807 |
Miscellaneous databases
Pharosi | Q9UP95, Tbio |
Chemistry databases
DrugBanki | DB00887, Bumetanide DB00761, Potassium chloride |
Genetic variation databases
BioMutai | SLC12A4 |
DMDMi | 27151691 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000178030 | 1 – 1085 | Solute carrier family 12 member 4Add BLAST | 1085 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineBy similarity | 1 | |
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 245 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 312 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 331 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 347 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 967 | PhosphoserineCombined sources | 1 | |
Modified residuei | 983 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9UP95 |
jPOSTi | Q9UP95 |
MassIVEi | Q9UP95 |
MaxQBi | Q9UP95 |
PaxDbi | Q9UP95 |
PeptideAtlasi | Q9UP95 |
PRIDEi | Q9UP95 |
ProteomicsDBi | 25245 25434 26226 85360 [Q9UP95-1] 85361 [Q9UP95-2] 85362 [Q9UP95-3] 85363 [Q9UP95-4] |
PTM databases
GlyGeni | Q9UP95, 5 sites |
iPTMneti | Q9UP95 |
PhosphoSitePlusi | Q9UP95 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000124067, Expressed in heart left ventricle and 205 other tissues |
ExpressionAtlasi | Q9UP95, baseline and differential |
Genevisiblei | Q9UP95, HS |
Organism-specific databases
HPAi | ENSG00000124067, Low tissue specificity |
Interactioni
Subunit structurei
Homomultimer and heteromultimer with other K-Cl cotransporters.
1 PublicationBinary interactionsi
Q9UP95
GO - Molecular functioni
- protein kinase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 112449, 122 interactors |
IntActi | Q9UP95, 38 interactors |
MINTi | Q9UP95 |
STRINGi | 9606.ENSP00000395983 |
Miscellaneous databases
RNActi | Q9UP95, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9UP95 |
SMRi | Q9UP95 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2082, Eukaryota |
GeneTreei | ENSGT00940000157672 |
HOGENOMi | CLU_001883_1_1_1 |
InParanoidi | Q9UP95 |
OMAi | WTRDKHM |
OrthoDBi | 349744at2759 |
PhylomeDBi | Q9UP95 |
TreeFami | TF313657 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR000622, KCC1 IPR000076, KCL_cotranspt IPR018491, SLC12_C IPR004842, SLC12A_fam |
PANTHERi | PTHR11827, PTHR11827, 1 hit PTHR11827:SF46, PTHR11827:SF46, 1 hit |
Pfami | View protein in Pfam PF00324, AA_permease, 2 hits PF03522, SLC12, 2 hits |
PRINTSi | PR01081, KCLTRNSPORT PR01082, KCLTRNSPORT1 |
TIGRFAMsi | TIGR00930, 2a30, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL
60 70 80 90 100
SPLEASRGID YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE
110 120 130 140 150
EAESGEGTRR RAAEAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV
160 170 180 190 200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA
210 220 230 240 250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA HDTSNATLNN
260 270 280 290 300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF
310 320 330 340 350
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT
360 370 380 390 400
DSCDPYFMLN NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD
410 420 430 440 450
APSLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS
460 470 480 490 500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA
510 520 530 540 550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKV
560 570 580 590 600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT
610 620 630 640 650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK
660 670 680 690 700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL
710 720 730 740 750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTIK
760 770 780 790 800
NMMEIEKVKG FCQVVVASKV REGLAHLIQS CGLGGMRHNS VVLGWPYGWR
810 820 830 840 850
QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER YLEGHIDVWW
860 870 880 890 900
IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY
910 920 930 940 950
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA
960 970 980 990 1000
QLVKDRHSAL RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP
1010 1020 1030 1040 1050
DNFRELVHIK PDQSNVRRMH TAVKLNEVIV TRSHDARLVL LNMPGPPRNS
1060 1070 1080
EGDENYMEFL EVLTEGLERV LLVRGGGREV ITIYS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L4N6 | I3L4N6_HUMAN | Solute carrier family 12 member 4 | SLC12A4 | 1,037 | Annotation score: | ||
J3QRE2 | J3QRE2_HUMAN | Solute carrier family 12 member 4 | SLC12A4 | 178 | Annotation score: | ||
J3QSF2 | J3QSF2_HUMAN | Solute carrier family 12 member 4 | SLC12A4 | 90 | Annotation score: | ||
I3L1N8 | I3L1N8_HUMAN | Solute carrier family 12 member 4 | SLC12A4 | 54 | Annotation score: | ||
J3QKM4 | J3QKM4_HUMAN | Solute carrier family 12 member 4 | SLC12A4 | 19 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 42 | N → D in BAG61116 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 211 | F → L in BAG63994 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 288 | I → N in BAG63994 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 370 | G → R in BAG57330 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 697 | L → P in BAG63994 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 1016 | V → A in BAG57330 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 1055 | N → D in BAG57330 (PubMed:14702039).Curated | 1 | ||
Isoform 6 (identifier: Q9UP95-6) | |||||
Sequence conflicti | 4 | E → G in BAH14786 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046369 | 1 – 70 | MPHFT…LALFE → MRAGGACRPGAAGTAAGTAA GGWDGGCGGAEPARCLTSPW CQWTGRGAATMTTSRGSVGW TTGSAPSWMTRT in isoform 7. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_044596 | 1 – 38 | MPHFT…LDDSD → MGDTLSP in isoform 5. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_046146 | 1 – 38 | MPHFT…LDDSD → MAAEGAVCGFVYLEGTAWAV PEDTEPLASCTL in isoform 6. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_006108 | 749 – 955 | Missing in isoform 4. 1 PublicationAdd BLAST | 207 | |
Alternative sequenceiVSP_006109 | 956 – 958 | RHS → PCA in isoform 4. 1 Publication | 3 | |
Alternative sequenceiVSP_006110 | 963 – 987 | ESLYS…TWTRD → PTWPCSCPRTSPSTPATTSA TWRAT in isoform 4. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_006111 | 988 – 1085 | Missing in isoform 4. 1 PublicationAdd BLAST | 98 | |
Alternative sequenceiVSP_006112 | 1012 – 1085 | Missing in isoform 3. 1 PublicationAdd BLAST | 74 | |
Alternative sequenceiVSP_006113 | 1056 – 1068 | YMEFL…TEGLE → CIPLWRGRQLGGG in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_006114 | 1069 – 1085 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U55054 mRNA Translation: AAC50563.1 AF047338 mRNA Translation: AAC32815.1 AF054505 mRNA Translation: AAC39684.1 AF054506 mRNA Translation: AAC39685.1 AK293956 mRNA Translation: BAG57330.1 Different initiation. AK299042 mRNA Translation: BAG61116.1 AK302790 mRNA Translation: BAG63994.1 AK316415 mRNA Translation: BAH14786.1 AC040162 Genomic DNA No translation available. BC021193 mRNA Translation: AAH21193.1 AF053402 mRNA Translation: AAC35282.1 Frameshift. AY026038 mRNA Translation: AAK01946.1 |
CCDSi | CCDS10855.1 [Q9UP95-1] CCDS54030.1 [Q9UP95-6] CCDS54031.1 [Q9UP95-5] CCDS54032.1 [Q9UP95-7] |
RefSeqi | NP_001139433.1, NM_001145961.1 NP_001139434.1, NM_001145962.1 [Q9UP95-7] NP_001139435.1, NM_001145963.1 [Q9UP95-6] NP_001139436.1, NM_001145964.1 [Q9UP95-5] NP_005063.1, NM_005072.4 [Q9UP95-1] |
Genome annotation databases
Ensembli | ENST00000316341.8; ENSP00000318557.3; ENSG00000124067.17 ENST00000422611.6; ENSP00000395983.2; ENSG00000124067.17 [Q9UP95-7] ENST00000537830.6; ENSP00000445962.2; ENSG00000124067.17 [Q9UP95-6] ENST00000541864.6; ENSP00000438334.2; ENSG00000124067.17 [Q9UP95-5] ENST00000576616.5; ENSP00000458902.1; ENSG00000124067.17 [Q9UP95-2] |
GeneIDi | 6560 |
KEGGi | hsa:6560 |
MANE-Selecti | ENST00000316341.8; ENSP00000318557.3; NM_005072.5; NP_005063.1 |
UCSCi | uc002euz.2, human [Q9UP95-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U55054 mRNA Translation: AAC50563.1 AF047338 mRNA Translation: AAC32815.1 AF054505 mRNA Translation: AAC39684.1 AF054506 mRNA Translation: AAC39685.1 AK293956 mRNA Translation: BAG57330.1 Different initiation. AK299042 mRNA Translation: BAG61116.1 AK302790 mRNA Translation: BAG63994.1 AK316415 mRNA Translation: BAH14786.1 AC040162 Genomic DNA No translation available. BC021193 mRNA Translation: AAH21193.1 AF053402 mRNA Translation: AAC35282.1 Frameshift. AY026038 mRNA Translation: AAK01946.1 |
CCDSi | CCDS10855.1 [Q9UP95-1] CCDS54030.1 [Q9UP95-6] CCDS54031.1 [Q9UP95-5] CCDS54032.1 [Q9UP95-7] |
RefSeqi | NP_001139433.1, NM_001145961.1 NP_001139434.1, NM_001145962.1 [Q9UP95-7] NP_001139435.1, NM_001145963.1 [Q9UP95-6] NP_001139436.1, NM_001145964.1 [Q9UP95-5] NP_005063.1, NM_005072.4 [Q9UP95-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6KKR | electron microscopy | 2.90 | A/B | 1-1085 | [»] | |
6KKT | electron microscopy | 2.90 | A/B | 1-1085 | [»] | |
6KKU | electron microscopy | 3.50 | A/B | 1-1085 | [»] | |
7AIP | electron microscopy | 3.12 | A/B | 20-1085 | [»] | |
7AIQ | electron microscopy | 3.72 | A/B | 20-1085 | [»] | |
7AIR | electron microscopy | 3.66 | A/B | 20-1085 | [»] | |
AlphaFoldDBi | Q9UP95 | |||||
SMRi | Q9UP95 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112449, 122 interactors |
IntActi | Q9UP95, 38 interactors |
MINTi | Q9UP95 |
STRINGi | 9606.ENSP00000395983 |
Chemistry databases
DrugBanki | DB00887, Bumetanide DB00761, Potassium chloride |
Protein family/group databases
TCDBi | 2.A.30.1.17, the cation-chloride cotransporter (ccc) family |
PTM databases
GlyGeni | Q9UP95, 5 sites |
iPTMneti | Q9UP95 |
PhosphoSitePlusi | Q9UP95 |
Genetic variation databases
BioMutai | SLC12A4 |
DMDMi | 27151691 |
Proteomic databases
EPDi | Q9UP95 |
jPOSTi | Q9UP95 |
MassIVEi | Q9UP95 |
MaxQBi | Q9UP95 |
PaxDbi | Q9UP95 |
PeptideAtlasi | Q9UP95 |
PRIDEi | Q9UP95 |
ProteomicsDBi | 25245 25434 26226 85360 [Q9UP95-1] 85361 [Q9UP95-2] 85362 [Q9UP95-3] 85363 [Q9UP95-4] |
Protocols and materials databases
Antibodypediai | 29685, 182 antibodies from 31 providers |
DNASUi | 6560 |
Genome annotation databases
Ensembli | ENST00000316341.8; ENSP00000318557.3; ENSG00000124067.17 ENST00000422611.6; ENSP00000395983.2; ENSG00000124067.17 [Q9UP95-7] ENST00000537830.6; ENSP00000445962.2; ENSG00000124067.17 [Q9UP95-6] ENST00000541864.6; ENSP00000438334.2; ENSG00000124067.17 [Q9UP95-5] ENST00000576616.5; ENSP00000458902.1; ENSG00000124067.17 [Q9UP95-2] |
GeneIDi | 6560 |
KEGGi | hsa:6560 |
MANE-Selecti | ENST00000316341.8; ENSP00000318557.3; NM_005072.5; NP_005063.1 |
UCSCi | uc002euz.2, human [Q9UP95-1] |
Organism-specific databases
CTDi | 6560 |
DisGeNETi | 6560 |
GeneCardsi | SLC12A4 |
HGNCi | HGNC:10913, SLC12A4 |
HPAi | ENSG00000124067, Low tissue specificity |
MalaCardsi | SLC12A4 |
MIMi | 604119, gene |
neXtProti | NX_Q9UP95 |
OpenTargetsi | ENSG00000124067 |
PharmGKBi | PA35807 |
VEuPathDBi | HostDB:ENSG00000124067 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2082, Eukaryota |
GeneTreei | ENSGT00940000157672 |
HOGENOMi | CLU_001883_1_1_1 |
InParanoidi | Q9UP95 |
OMAi | WTRDKHM |
OrthoDBi | 349744at2759 |
PhylomeDBi | Q9UP95 |
TreeFami | TF313657 |
Enzyme and pathway databases
PathwayCommonsi | Q9UP95 |
Reactomei | R-HSA-426117, Cation-coupled Chloride cotransporters |
SignaLinki | Q9UP95 |
SIGNORi | Q9UP95 |
Miscellaneous databases
BioGRID-ORCSi | 6560, 25 hits in 1083 CRISPR screens |
ChiTaRSi | SLC12A4, human |
GeneWikii | Chloride_potassium_symporter_4 |
GenomeRNAii | 6560 |
Pharosi | Q9UP95, Tbio |
PROi | PR:Q9UP95 |
RNActi | Q9UP95, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124067, Expressed in heart left ventricle and 205 other tissues |
ExpressionAtlasi | Q9UP95, baseline and differential |
Genevisiblei | Q9UP95, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR000622, KCC1 IPR000076, KCL_cotranspt IPR018491, SLC12_C IPR004842, SLC12A_fam |
PANTHERi | PTHR11827, PTHR11827, 1 hit PTHR11827:SF46, PTHR11827:SF46, 1 hit |
Pfami | View protein in Pfam PF00324, AA_permease, 2 hits PF03522, SLC12, 2 hits |
PRINTSi | PR01081, KCLTRNSPORT PR01082, KCLTRNSPORT1 |
TIGRFAMsi | TIGR00930, 2a30, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S12A4_HUMAN | |
Accessioni | Q9UP95Primary (citable) accession number: Q9UP95 Secondary accession number(s): B4DF69 Q96LD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 13, 2002 |
Last sequence update: | December 13, 2002 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families