SLC12A4

Functionⁱ

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl^- exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.By similarity

Activity regulationⁱ

Inhibited by WNK3.1 Publication

GO - Molecular functionⁱ

potassium:chloride symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 24393035

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell volume homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chloride ion homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chloride transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport Source: Reactome
potassium ion homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
potassium ion import
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Potassium transport, Symport, Transport
Ligand	Chloride, Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-426117 Cation-coupled Chloride cotransporters

Reactomeⁱ

R-HSA-426117 Cation-coupled Chloride cotransporters

Protein family/group databases

TCDBⁱ	2.A.30.1.17 the cation-chloride cotransporter (ccc) family

TCDBⁱ

2.A.30.1.17 the cation-chloride cotransporter (ccc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 12 member 4 Alternative name(s): Electroneutral potassium-chloride cotransporter 1 Erythroid K-Cl cotransporter 1 Short name: hKCC1
Gene namesⁱ	Name:SLC12A4 Synonyms:KCC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124067.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10913 SLC12A4
MIMⁱ	604119 gene
neXtProtⁱ	NX_Q9UP95

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 118	CytoplasmicSequence analysisAdd BLAST	118
Transmembraneⁱ	119 – 139	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	149 – 169	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	170 – 214	CytoplasmicSequence analysisAdd BLAST	45
Transmembraneⁱ	215 – 235	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	253 – 273	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	274 – 275	CytoplasmicSequence analysis	2
Transmembraneⁱ	276 – 296	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	356 – 376	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	377 – 407	CytoplasmicSequence analysisAdd BLAST	31
Transmembraneⁱ	408 – 428	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	453 – 473	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	474 – 493	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	494 – 514	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	567 – 587	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	588 – 627	CytoplasmicSequence analysisAdd BLAST	40
Transmembraneⁱ	628 – 648	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	845 – 865	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	866 – 1085	CytoplasmicSequence analysisAdd BLAST	220

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6560
Open Targets More...OpenTargetsⁱ	ENSG00000124067
PharmGKBⁱ	PA35807

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00887 Bumetanide DB00761 Potassium Chloride

DrugBankⁱ

DB00887 Bumetanide
DB00761 Potassium Chloride

Polymorphism and mutation databases

BioMutaⁱ	SLC12A4
DMDMⁱ	27151691

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000178030	1 – 1085	Solute carrier family 12 member 4Add BLAST		1085

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	24	PhosphoserineCombined sources	1
Modified residueⁱ	47	PhosphoserineBy similarity	1
Modified residueⁱ	51	PhosphoserineCombined sources	1
Modified residueⁱ	81	PhosphoserineBy similarity	1
Modified residueⁱ	88	PhosphoserineCombined sources	1
Glycosylationⁱ	245	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	312	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	331	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	347	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	439	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	967	PhosphoserineCombined sources	1
Modified residueⁱ	983	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UP95
PaxDbⁱ	Q9UP95
PeptideAtlas More...PeptideAtlasⁱ	Q9UP95
PRIDEⁱ	Q9UP95
ProteomicsDBⁱ	85360 85361 [Q9UP95-2] 85362 [Q9UP95-3] 85363 [Q9UP95-4]

PTM databases

iPTMnetⁱ	Q9UP95
PhosphoSitePlusⁱ	Q9UP95

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.

Gene expression databases

Bgeeⁱ	ENSG00000124067 Expressed in 194 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_SLC12A4
ExpressionAtlasⁱ	Q9UP95 baseline and differential
Genevisibleⁱ	Q9UP95 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041138

HPAⁱ

HPA041138

Interactionⁱ

Subunit structureⁱ

Homomultimer and heteromultimer with other K-Cl cotransporters.1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 24393035

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112449, 34 interactors
IntActⁱ	Q9UP95, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q9UP95
STRINGⁱ	9606.ENSP00000395983

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UP95
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	160 – 163	Poly-Cys		4

Sequence similaritiesⁱ

Belongs to the SLC12A transporter family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2082 Eukaryota COG0531 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119053
HOGENOMⁱ	HOG000092644
HOVERGENⁱ	HBG052852
InParanoidⁱ	Q9UP95
KEGG Orthology (KO) More...KOⁱ	K14427
OMAⁱ	PEFPICM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WB4
PhylomeDBⁱ	Q9UP95
TreeFamⁱ	TF313657

Family and domain databases

InterProⁱ	View protein in InterPro IPR004841 AA-permease/SLC12A_dom IPR000622 KCC1 IPR000076 KCL_cotranspt IPR018491 SLC12_C IPR004842 SLC12A_fam
PANTHERⁱ	PTHR11827:SF46 PTHR11827:SF46, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00324 AA_permease, 2 hits PF03522 SLC12, 2 hits
PRINTSⁱ	PR01081 KCLTRNSPORT PR01082 KCLTRNSPORT1
TIGRFAMsⁱ	TIGR00930 2a30, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UP95-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL 
        60         70         80         90        100
SPLEASRGID YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE 
       110        120        130        140        150
EAESGEGTRR RAAEAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV 
       160        170        180        190        200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA 
       210        220        230        240        250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA HDTSNATLNN 
       260        270        280        290        300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
       310        320        330        340        350
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT 
       360        370        380        390        400
DSCDPYFMLN NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD 
       410        420        430        440        450
APSLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS 
       460        470        480        490        500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA 
       510        520        530        540        550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKV 
       560        570        580        590        600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
       610        620        630        640        650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK 
       660        670        680        690        700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL 
       710        720        730        740        750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTIK 
       760        770        780        790        800
NMMEIEKVKG FCQVVVASKV REGLAHLIQS CGLGGMRHNS VVLGWPYGWR 
       810        820        830        840        850
QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER YLEGHIDVWW 
       860        870        880        890        900
IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 
       910        920        930        940        950
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA 
       960        970        980        990       1000
QLVKDRHSAL RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP 
      1010       1020       1030       1040       1050
DNFRELVHIK PDQSNVRRMH TAVKLNEVIV TRSHDARLVL LNMPGPPRNS 
      1060       1070       1080 
EGDENYMEFL EVLTEGLERV LLVRGGGREV ITIYS

Length:1,085

Mass (Da):120,650

Last modified:December 13, 2002 - v2

Checksum:ⁱ42B590EC3D94EA4D

GO

Isoform 2 (identifier: Q9UP95-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1056-1068: YMEFLEVLTEGLE → CIPLWRGRQLGGG
1069-1085: Missing.

« Hide

        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL 
        60         70         80         90        100
SPLEASRGID YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE 
       110        120        130        140        150
EAESGEGTRR RAAEAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV 
       160        170        180        190        200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA 
       210        220        230        240        250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA HDTSNATLNN 
       260        270        280        290        300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
       310        320        330        340        350
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT 
       360        370        380        390        400
DSCDPYFMLN NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD 
       410        420        430        440        450
APSLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS 
       460        470        480        490        500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA 
       510        520        530        540        550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKV 
       560        570        580        590        600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
       610        620        630        640        650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK 
       660        670        680        690        700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL 
       710        720        730        740        750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTIK 
       760        770        780        790        800
NMMEIEKVKG FCQVVVASKV REGLAHLIQS CGLGGMRHNS VVLGWPYGWR 
       810        820        830        840        850
QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER YLEGHIDVWW 
       860        870        880        890        900
IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 
       910        920        930        940        950
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA 
       960        970        980        990       1000
QLVKDRHSAL RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP 
      1010       1020       1030       1040       1050
DNFRELVHIK PDQSNVRRMH TAVKLNEVIV TRSHDARLVL LNMPGPPRNS 
      1060 
EGDENCIPLW RGRQLGGG

Show »

Length:1,068

Mass (Da):118,620

Checksum:ⁱ7A1FB4FD47252C88

GO

Isoform 3 (identifier: Q9UP95-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1012-1085: Missing.

« Hide

        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL 
        60         70         80         90        100
SPLEASRGID YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE 
       110        120        130        140        150
EAESGEGTRR RAAEAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV 
       160        170        180        190        200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA 
       210        220        230        240        250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA HDTSNATLNN 
       260        270        280        290        300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
       310        320        330        340        350
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT 
       360        370        380        390        400
DSCDPYFMLN NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD 
       410        420        430        440        450
APSLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS 
       460        470        480        490        500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA 
       510        520        530        540        550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKV 
       560        570        580        590        600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
       610        620        630        640        650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK 
       660        670        680        690        700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL 
       710        720        730        740        750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTIK 
       760        770        780        790        800
NMMEIEKVKG FCQVVVASKV REGLAHLIQS CGLGGMRHNS VVLGWPYGWR 
       810        820        830        840        850
QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER YLEGHIDVWW 
       860        870        880        890        900
IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 
       910        920        930        940        950
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA 
       960        970        980        990       1000
QLVKDRHSAL RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP 
      1010 
DNFRELVHIK P

Show »

Length:1,011

Mass (Da):112,275

Checksum:ⁱ33860CBEC1BE578B

GO

Isoform 4 (identifier: Q9UP95-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     749-955: Missing.
     956-958: RHS → PCA
     963-987: ESLYSDEEDESAVGADKIQMTWTRD → PTWPCSCPRTSPSTPATTSATWRAT
     988-1085: Missing.

« Hide

        10         20         30         40         50
MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL 
        60         70         80         90        100
SPLEASRGID YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE 
       110        120        130        140        150
EAESGEGTRR RAAEAPSMGT LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV 
       160        170        180        190        200
LQALLIVLIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA 
       210        220        230        240        250
VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA HDTSNATLNN 
       260        270        280        290        300
MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
       310        320        330        340        350
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT 
       360        370        380        390        400
DSCDPYFMLN NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD 
       410        420        430        440        450
APSLKESLPL YVVADIATSF TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS 
       460        470        480        490        500
IPVGTILAII TTSLVYFSSV VLFGACIEGV VLRDKYGDGV SRNLVVGTLA 
       510        520        530        540        550
WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP FLRVFGHGKV 
       560        570        580        590        600
NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
       610        620        630        640        650
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK 
       660        670        680        690        700
YIEYQGAEKE WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL 
       710        720        730        740        750
DEDLHVKYPR LLTFASQLKA GKGLTIVGSV IQGSFLESYG EAQAAEQTPC 
       760        770        780
AALRLPTWPC SCPRTSPSTP ATTSATWRAT

Show »

Length:780

Mass (Da):84,701

Checksum:ⁱ63DD249B6CA8689C

GO

Isoform 5 (identifier: Q9UP95-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSD → MGDTLSP

« Hide

        10         20         30         40         50
MGDTLSPGHG NHRESSPFLS PLEASRGIDY YDRNLALFEE ELDIRPKVSS 
        60         70         80         90        100
LLGKLVSYTN LTQGAKEHEE AESGEGTRRR AAEAPSMGTL MGVYLPCLQN 
       110        120        130        140        150
IFGVILFLRL TWMVGTAGVL QALLIVLICC CCTLLTAISM SAIATNGVVP 
       160        170        180        190        200
AGGSYFMISR SLGPEFGGAV GLCFYLGTTF AAAMYILGAI EILLTYIAPP 
       210        220        230        240        250
AAIFYPSGAH DTSNATLNNM RVYGTIFLTF MTLVVFVGVK YVNKFASLFL 
       260        270        280        290        300
ACVIISILSI YAGGIKSIFD PPVFPVCMLG NRTLSRDQFD ICAKTAVVDN 
       310        320        330        340        350
ETVATQLWSF FCHSPNLTTD SCDPYFMLNN VTEIPGIPGA AAGVLQENLW 
       360        370        380        390        400
SAYLEKGDIV EKHGLPSADA PSLKESLPLY VVADIATSFT VLVGIFFPSV 
       410        420        430        440        450
TGIMAGSNRS GDLRDAQKSI PVGTILAIIT TSLVYFSSVV LFGACIEGVV 
       460        470        480        490        500
LRDKYGDGVS RNLVVGTLAW PSPWVIVIGS FFSTCGAGLQ SLTGAPRLLQ 
       510        520        530        540        550
AIAKDNIIPF LRVFGHGKVN GEPTWALLLT ALIAELGILI ASLDMVAPIL 
       560        570        580        590        600
SMFFLMCYLF VNLACAVQTL LRTPNWRPRF KYYHWALSFL GMSLCLALMF 
       610        620        630        640        650
VSSWYYALVA MLIAGMIYKY IEYQGAEKEW GDGIRGLSLS AARYALLRLE 
       660        670        680        690        700
EGPPHTKNWR PQLLVLLKLD EDLHVKYPRL LTFASQLKAG KGLTIVGSVI 
       710        720        730        740        750
QGSFLESYGE AQAAEQTIKN MMEIEKVKGF CQVVVASKVR EGLAHLIQSC 
       760        770        780        790        800
GLGGMRHNSV VLGWPYGWRQ SEDPRAWKTF IDTVRCTTAA HLALLVPKNI 
       810        820        830        840        850
AFYPSNHERY LEGHIDVWWI VHDGGMLMLL PFLLRQHKVW RKCRMRIFTV 
       860        870        880        890        900
AQMDDNSIQM KKDLAVFLYH LRLEAEVEVV EMHNSDISAY TYERTLMMEQ 
       910        920        930        940        950
RSQMLRQMRL TKTEREREAQ LVKDRHSALR LESLYSDEED ESAVGADKIQ 
       960        970        980        990       1000
MTWTRDKYMT ETWDPSHAPD NFRELVHIKP DQSNVRRMHT AVKLNEVIVT 
      1010       1020       1030       1040       1050
RSHDARLVLL NMPGPPRNSE GDENYMEFLE VLTEGLERVL LVRGGGREVI 

TIYS

Note: No experimental confirmation available.

Show »

Length:1,054

Mass (Da):117,046

Checksum:ⁱ328721D9B50DF738

GO

Isoform 6 (identifier: Q9UP95-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSD → MAAEGAVCGFVYLEGTAWAVPEDTEPLASCTL

« Hide

        10         20         30         40         50
MAAEGAVCGF VYLEGTAWAV PEDTEPLASC TLGHGNHRES SPFLSPLEAS 
        60         70         80         90        100
RGIDYYDRNL ALFEEELDIR PKVSSLLGKL VSYTNLTQGA KEHEEAESGE 
       110        120        130        140        150
GTRRRAAEAP SMGTLMGVYL PCLQNIFGVI LFLRLTWMVG TAGVLQALLI 
       160        170        180        190        200
VLICCCCTLL TAISMSAIAT NGVVPAGGSY FMISRSLGPE FGGAVGLCFY 
       210        220        230        240        250
LGTTFAAAMY ILGAIEILLT YIAPPAAIFY PSGAHDTSNA TLNNMRVYGT 
       260        270        280        290        300
IFLTFMTLVV FVGVKYVNKF ASLFLACVII SILSIYAGGI KSIFDPPVFP 
       310        320        330        340        350
VCMLGNRTLS RDQFDICAKT AVVDNETVAT QLWSFFCHSP NLTTDSCDPY 
       360        370        380        390        400
FMLNNVTEIP GIPGAAAGVL QENLWSAYLE KGDIVEKHGL PSADAPSLKE 
       410        420        430        440        450
SLPLYVVADI ATSFTVLVGI FFPSVTGIMA GSNRSGDLRD AQKSIPVGTI 
       460        470        480        490        500
LAIITTSLVY FSSVVLFGAC IEGVVLRDKY GDGVSRNLVV GTLAWPSPWV 
       510        520        530        540        550
IVIGSFFSTC GAGLQSLTGA PRLLQAIAKD NIIPFLRVFG HGKVNGEPTW 
       560        570        580        590        600
ALLLTALIAE LGILIASLDM VAPILSMFFL MCYLFVNLAC AVQTLLRTPN 
       610        620        630        640        650
WRPRFKYYHW ALSFLGMSLC LALMFVSSWY YALVAMLIAG MIYKYIEYQG 
       660        670        680        690        700
AEKEWGDGIR GLSLSAARYA LLRLEEGPPH TKNWRPQLLV LLKLDEDLHV 
       710        720        730        740        750
KYPRLLTFAS QLKAGKGLTI VGSVIQGSFL ESYGEAQAAE QTIKNMMEIE 
       760        770        780        790        800
KVKGFCQVVV ASKVREGLAH LIQSCGLGGM RHNSVVLGWP YGWRQSEDPR 
       810        820        830        840        850
AWKTFIDTVR CTTAAHLALL VPKNIAFYPS NHERYLEGHI DVWWIVHDGG 
       860        870        880        890        900
MLMLLPFLLR QHKVWRKCRM RIFTVAQMDD NSIQMKKDLA VFLYHLRLEA 
       910        920        930        940        950
EVEVVEMHNS DISAYTYERT LMMEQRSQML RQMRLTKTER EREAQLVKDR 
       960        970        980        990       1000
HSALRLESLY SDEEDESAVG ADKIQMTWTR DKYMTETWDP SHAPDNFREL 
      1010       1020       1030       1040       1050
VHIKPDQSNV RRMHTAVKLN EVIVTRSHDA RLVLLNMPGP PRNSEGDENY 
      1060       1070 
MEFLEVLTEG LERVLLVRGG GREVITIYS

Note: No experimental confirmation available.Curated

Show »

Length:1,079

Mass (Da):119,629

Checksum:ⁱEC9A4E5C31C90A87

GO

Isoform 7 (identifier: Q9UP95-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-70: MPHFTVVPVD...YYDRNLALFE → MRAGGACRPG...GSAPSWMTRT

« Hide

        10         20         30         40         50
MRAGGACRPG AAGTAAGTAA GGWDGGCGGA EPARCLTSPW CQWTGRGAAT 
        60         70         80         90        100
MTTSRGSVGW TTGSAPSWMT RTEELDIRPK VSSLLGKLVS YTNLTQGAKE 
       110        120        130        140        150
HEEAESGEGT RRRAAEAPSM GTLMGVYLPC LQNIFGVILF LRLTWMVGTA 
       160        170        180        190        200
GVLQALLIVL ICCCCTLLTA ISMSAIATNG VVPAGGSYFM ISRSLGPEFG 
       210        220        230        240        250
GAVGLCFYLG TTFAAAMYIL GAIEILLTYI APPAAIFYPS GAHDTSNATL 
       260        270        280        290        300
NNMRVYGTIF LTFMTLVVFV GVKYVNKFAS LFLACVIISI LSIYAGGIKS 
       310        320        330        340        350
IFDPPVFPVC MLGNRTLSRD QFDICAKTAV VDNETVATQL WSFFCHSPNL 
       360        370        380        390        400
TTDSCDPYFM LNNVTEIPGI PGAAAGVLQE NLWSAYLEKG DIVEKHGLPS 
       410        420        430        440        450
ADAPSLKESL PLYVVADIAT SFTVLVGIFF PSVTGIMAGS NRSGDLRDAQ 
       460        470        480        490        500
KSIPVGTILA IITTSLVYFS SVVLFGACIE GVVLRDKYGD GVSRNLVVGT 
       510        520        530        540        550
LAWPSPWVIV IGSFFSTCGA GLQSLTGAPR LLQAIAKDNI IPFLRVFGHG 
       560        570        580        590        600
KVNGEPTWAL LLTALIAELG ILIASLDMVA PILSMFFLMC YLFVNLACAV 
       610        620        630        640        650
QTLLRTPNWR PRFKYYHWAL SFLGMSLCLA LMFVSSWYYA LVAMLIAGMI 
       660        670        680        690        700
YKYIEYQGAE KEWGDGIRGL SLSAARYALL RLEEGPPHTK NWRPQLLVLL 
       710        720        730        740        750
KLDEDLHVKY PRLLTFASQL KAGKGLTIVG SVIQGSFLES YGEAQAAEQT 
       760        770        780        790        800
IKNMMEIEKV KGFCQVVVAS KVREGLAHLI QSCGLGGMRH NSVVLGWPYG 
       810        820        830        840        850
WRQSEDPRAW KTFIDTVRCT TAAHLALLVP KNIAFYPSNH ERYLEGHIDV 
       860        870        880        890        900
WWIVHDGGML MLLPFLLRQH KVWRKCRMRI FTVAQMDDNS IQMKKDLAVF 
       910        920        930        940        950
LYHLRLEAEV EVVEMHNSDI SAYTYERTLM MEQRSQMLRQ MRLTKTERER 
       960        970        980        990       1000
EAQLVKDRHS ALRLESLYSD EEDESAVGAD KIQMTWTRDK YMTETWDPSH 
      1010       1020       1030       1040       1050
APDNFRELVH IKPDQSNVRR MHTAVKLNEV IVTRSHDARL VLLNMPGPPR 
      1060       1070       1080 
NSEGDENYME FLEVLTEGLE RVLLVRGGGR EVITIYS

Note: No experimental confirmation available.

Show »

Length:1,087

Mass (Da):119,745

Checksum:ⁱ701F57E7F5732CBD

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QRE2	J3QRE2_HUMAN	Solute carrier family 12 member 4 Solute carrier family 12 member 4	SLC12A4	178	Annotation score:
I3L4N6	I3L4N6_HUMAN	Solute carrier family 12 member 4 Solute carrier family 12 member 4	SLC12A4	1,037	Annotation score:
J3QSF2	J3QSF2_HUMAN	Solute carrier family 12 member 4 Solute carrier family 12 member 4	SLC12A4	90	Annotation score:
I3L1N8	I3L1N8_HUMAN	Solute carrier family 12 member 4 Solute carrier family 12 member 4	SLC12A4	54	Annotation score:
J3QKM4	J3QKM4_HUMAN	Solute carrier family 12 member 4 Solute carrier family 12 member 4	SLC12A4	19	Annotation score:

Sequence cautionⁱ

The sequence AAC35282 differs from that shown. Reason: Frameshift at position 454.Curated

The sequence BAG57330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	42	N → D in BAG61116 (PubMed:14702039).Curated	1
Sequence conflictⁱ	211	F → L in BAG63994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	288	I → N in BAG63994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	370	G → R in BAG57330 (PubMed:14702039).Curated	1
Sequence conflictⁱ	697	L → P in BAG63994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1016	V → A in BAG57330 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1055	N → D in BAG57330 (PubMed:14702039).Curated	1
Isoform 6 (identifier: Q9UP95-6)
Sequence conflictⁱ	4	E → G in BAH14786 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046369	1 – 70	MPHFT…LALFE → MRAGGACRPGAAGTAAGTAA GGWDGGCGGAEPARCLTSPW CQWTGRGAATMTTSRGSVGW TTGSAPSWMTRT in isoform 7. 1 PublicationAdd BLAST	70
Alternative sequenceⁱVSP_044596	1 – 38	MPHFT…LDDSD → MGDTLSP in isoform 5. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_046146	1 – 38	MPHFT…LDDSD → MAAEGAVCGFVYLEGTAWAV PEDTEPLASCTL in isoform 6. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_006108	749 – 955	Missing in isoform 4. 1 PublicationAdd BLAST	207
Alternative sequenceⁱVSP_006109	956 – 958	RHS → PCA in isoform 4. 1 Publication	3
Alternative sequenceⁱVSP_006110	963 – 987	ESLYS…TWTRD → PTWPCSCPRTSPSTPATTSA TWRAT in isoform 4. 1 PublicationAdd BLAST	25
Alternative sequenceⁱVSP_006111	988 – 1085	Missing in isoform 4. 1 PublicationAdd BLAST	98
Alternative sequenceⁱVSP_006112	1012 – 1085	Missing in isoform 3. 1 PublicationAdd BLAST	74
Alternative sequenceⁱVSP_006113	1056 – 1068	YMEFL…TEGLE → CIPLWRGRQLGGG in isoform 2. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_006114	1069 – 1085	Missing in isoform 2. 1 PublicationAdd BLAST	17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U55054 mRNA Translation: AAC50563.1 AF047338 mRNA Translation: AAC32815.1 AF054505 mRNA Translation: AAC39684.1 AF054506 mRNA Translation: AAC39685.1 AK293956 mRNA Translation: BAG57330.1 Different initiation. AK299042 mRNA Translation: BAG61116.1 AK302790 mRNA Translation: BAG63994.1 AK316415 mRNA Translation: BAH14786.1 AC040162 Genomic DNA No translation available. BC021193 mRNA Translation: AAH21193.1 AF053402 mRNA Translation: AAC35282.1 Frameshift. AY026038 mRNA Translation: AAK01946.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10855.1 [Q9UP95-1] CCDS54030.1 [Q9UP95-6] CCDS54031.1 [Q9UP95-5] CCDS54032.1 [Q9UP95-7]
NCBI Reference Sequences More...RefSeqⁱ	NP_001139433.1, NM_001145961.1 NP_001139434.1, NM_001145962.1 [Q9UP95-7] NP_001139435.1, NM_001145963.1 [Q9UP95-6] NP_001139436.1, NM_001145964.1 [Q9UP95-5] NP_005063.1, NM_005072.4 [Q9UP95-1]
UniGeneⁱ	Hs.10094

Genome annotation databases

Ensemblⁱ	ENST00000316341; ENSP00000318557; ENSG00000124067 [Q9UP95-1] ENST00000422611; ENSP00000395983; ENSG00000124067 [Q9UP95-7] ENST00000537830; ENSP00000445962; ENSG00000124067 [Q9UP95-6] ENST00000541864; ENSP00000438334; ENSG00000124067 [Q9UP95-5] ENST00000576616; ENSP00000458902; ENSG00000124067 [Q9UP95-2]
GeneIDⁱ	6560
KEGGⁱ	hsa:6560
UCSC genome browser More...UCSCⁱ	uc002euz.2 human [Q9UP95-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UP95-7	Solute carrier family 12 member 4		HUMAN		1037	UniRef100_I3L4N6
UPI0008F53772		GORGO		968

Protein	Similar proteins		Species	Score	Length	Source
Q9UP95	Solute carrier family 12 member 4		RAT		1085	UniRef90_Q9UP95
Solute carrier family 12 member 4		MOUSE		1085
Isoform 3 of Solute carrier family 12 member 4		HUMAN		1011
Uncharacterized protein		ICTTR		1174
Solute carrier family 12 member 4		MUSPF		1113
+296
Q9UP95-4	SLC12A4 isoform 12		PANTR		749	UniRef90_Q9UP95-4

Protein	Similar proteins		Species	Score	Length	Source
Q9UP95	Solute carrier family 12 member 6		HUMAN		1150	UniRef50_Q9UHW9
Solute carrier family 12 member 6		MOUSE		1150
Solute carrier family 12 member 4		RAT		1085
Uncharacterized protein		PANPA		1150
Solute carrier family 12 member 6		GORGO		1150
+1452
Q9UP95-4	SLC12A4 isoform 12		PANTR		749	UniRef50_Q9UP95-4
Solute carrier family 12 member 7		FUNHE		811
solute carrier family 12 member 5-like		LEPWE		713
Solute carrier family 12 member 5 (Fragment)		ESCRO		631
Solute carrier family 12 member 5		MYOBR		578
+30

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U55054 mRNA Translation: AAC50563.1 AF047338 mRNA Translation: AAC32815.1 AF054505 mRNA Translation: AAC39684.1 AF054506 mRNA Translation: AAC39685.1 AK293956 mRNA Translation: BAG57330.1 Different initiation. AK299042 mRNA Translation: BAG61116.1 AK302790 mRNA Translation: BAG63994.1 AK316415 mRNA Translation: BAH14786.1 AC040162 Genomic DNA No translation available. BC021193 mRNA Translation: AAH21193.1 AF053402 mRNA Translation: AAC35282.1 Frameshift. AY026038 mRNA Translation: AAK01946.1
CCDSⁱ	CCDS10855.1 [Q9UP95-1] CCDS54030.1 [Q9UP95-6] CCDS54031.1 [Q9UP95-5] CCDS54032.1 [Q9UP95-7]
RefSeqⁱ	NP_001139433.1, NM_001145961.1 NP_001139434.1, NM_001145962.1 [Q9UP95-7] NP_001139435.1, NM_001145963.1 [Q9UP95-6] NP_001139436.1, NM_001145964.1 [Q9UP95-5] NP_005063.1, NM_005072.4 [Q9UP95-1]
UniGeneⁱ	Hs.10094

3D structure databases

ProteinModelPortalⁱ	Q9UP95
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112449, 34 interactors
IntActⁱ	Q9UP95, 17 interactors
MINTⁱ	Q9UP95
STRINGⁱ	9606.ENSP00000395983

Chemistry databases

DrugBankⁱ	DB00887 Bumetanide DB00761 Potassium Chloride

DrugBankⁱ

DB00887 Bumetanide
DB00761 Potassium Chloride

Protein family/group databases

TCDBⁱ	2.A.30.1.17 the cation-chloride cotransporter (ccc) family

TCDBⁱ

2.A.30.1.17 the cation-chloride cotransporter (ccc) family

PTM databases

iPTMnetⁱ	Q9UP95
PhosphoSitePlusⁱ	Q9UP95

Polymorphism and mutation databases

BioMutaⁱ	SLC12A4
DMDMⁱ	27151691

Proteomic databases

EPDⁱ	Q9UP95
PaxDbⁱ	Q9UP95
PeptideAtlasⁱ	Q9UP95
PRIDEⁱ	Q9UP95
ProteomicsDBⁱ	85360 85361 [Q9UP95-2] 85362 [Q9UP95-3] 85363 [Q9UP95-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6560
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316341; ENSP00000318557; ENSG00000124067 [Q9UP95-1] ENST00000422611; ENSP00000395983; ENSG00000124067 [Q9UP95-7] ENST00000537830; ENSP00000445962; ENSG00000124067 [Q9UP95-6] ENST00000541864; ENSP00000438334; ENSG00000124067 [Q9UP95-5] ENST00000576616; ENSP00000458902; ENSG00000124067 [Q9UP95-2]
GeneIDⁱ	6560
KEGGⁱ	hsa:6560
UCSCⁱ	uc002euz.2 human [Q9UP95-1]

Organism-specific databases

CTDⁱ	6560
DisGeNETⁱ	6560
EuPathDBⁱ	HostDB:ENSG00000124067.16
GeneCardsⁱ	SLC12A4
HGNCⁱ	HGNC:10913 SLC12A4
HPAⁱ	HPA041138
MIMⁱ	604119 gene
neXtProtⁱ	NX_Q9UP95
OpenTargetsⁱ	ENSG00000124067
PharmGKBⁱ	PA35807
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2082 Eukaryota COG0531 LUCA
GeneTreeⁱ	ENSGT00760000119053
HOGENOMⁱ	HOG000092644
HOVERGENⁱ	HBG052852
InParanoidⁱ	Q9UP95
KOⁱ	K14427
OMAⁱ	PEFPICM
OrthoDBⁱ	EOG091G0WB4
PhylomeDBⁱ	Q9UP95
TreeFamⁱ	TF313657

Enzyme and pathway databases

Reactomeⁱ	R-HSA-426117 Cation-coupled Chloride cotransporters

Reactomeⁱ

R-HSA-426117 Cation-coupled Chloride cotransporters

Miscellaneous databases

GeneWikiⁱ	Chloride_potassium_symporter_4
GenomeRNAiⁱ	6560
Protein Ontology More...PROⁱ	PR:Q9UP95
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124067 Expressed in 194 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_SLC12A4
ExpressionAtlasⁱ	Q9UP95 baseline and differential
Genevisibleⁱ	Q9UP95 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004841 AA-permease/SLC12A_dom IPR000622 KCC1 IPR000076 KCL_cotranspt IPR018491 SLC12_C IPR004842 SLC12A_fam
PANTHERⁱ	PTHR11827:SF46 PTHR11827:SF46, 1 hit
Pfamⁱ	View protein in Pfam PF00324 AA_permease, 2 hits PF03522 SLC12, 2 hits
PRINTSⁱ	PR01081 KCLTRNSPORT PR01082 KCLTRNSPORT1
TIGRFAMsⁱ	TIGR00930 2a30, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S12A4_HUMAN
Accessionⁱ	Q9UP95Primary (citable) accession number: Q9UP95 Secondary accession number(s): B4DF69 Q96LD5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
	Last sequence update:	December 13, 2002
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9UP95 (S12A4_HUMAN)

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Solute carrier family 12 member 4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Organism-specific databases

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Enzyme and pathway databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ