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Entry version 155 (07 Oct 2020)
Sequence version 3 (18 May 2010)
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Protein

Conserved oligomeric Golgi complex subunit 5

Gene

COG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function.By similarity

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UP83

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811438, Intra-Golgi traffic
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 5
Short name:
COG complex subunit 5
Alternative name(s):
13S Golgi transport complex 90 kDa subunit
Short name:
GTC-90
Component of oligomeric Golgi complex 5
Golgi transport complex 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG5
Synonyms:GOLTC1, GTC90
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164597.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14857, COG5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606821, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UP83

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 2I (CDG2I)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments.
Related information in OMIM

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10466

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
COG5

MalaCards human disease database

More...
MalaCardsi
COG5
MIMi613612, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164597

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
263487, COG5-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26698

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UP83, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COG5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439390

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135101 – 839Conserved oligomeric Golgi complex subunit 5Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UP83

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UP83

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UP83

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UP83

PeptideAtlas

More...
PeptideAtlasi
Q9UP83

PRoteomics IDEntifications database

More...
PRIDEi
Q9UP83

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85357 [Q9UP83-1]
85358 [Q9UP83-2]
85359 [Q9UP83-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2030, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UP83, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UP83

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9UP83

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UP83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164597, Expressed in secondary oocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UP83, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UP83, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164597, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115729, 47 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UP83

Protein interaction database and analysis system

More...
IntActi
Q9UP83, 40 interactors

Molecular INTeraction database

More...
MINTi
Q9UP83

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297135

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UP83, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UP83

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2211, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009839_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UP83

KEGG Orthology (KO)

More...
KOi
K20292

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSFDECP

Database of Orthologous Groups

More...
OrthoDBi
871605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UP83

TreeFam database of animal gene trees

More...
TreeFami
TF313139

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019465, Cog5

The PANTHER Classification System

More...
PANTHERi
PTHR13228, PTHR13228, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10392, COG5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UP83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG
60 70 80 90 100
AAAATVRELL QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS
110 120 130 140 150
QLDRELHLQV VARHEDLLAQ ATGIESLEGV LQMMQTRIGA LQGAVDRIKA
160 170 180 190 200
KIVEPYNKIV ARTAQLARLQ VACDLLRRII RILNLSKRLQ GQLQGGSREI
210 220 230 240 250
TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE NQAKRLLEQG
260 270 280 290 300
LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL
310 320 330 340 350
TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH
360 370 380 390 400
LQKVLAKKRD PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN
410 420 430 440 450
SSMFLKQAFE GEYPKLLRLY NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL
460 470 480 490 500
QHMEDDAQDI FIPKKPDYDP EKALKDSLQP YEAAYLSKSL SRLFDPINLV
510 520 530 540 550
FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK NVAKTIQLYS
560 570 580 590 600
VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKAIHALME
610 620 630 640 650
NAVQPLLTSV GDAIEAIIIT MHQEDFSGSL SSSGKPDVPC SLYMKELQGF
660 670 680 690 700
IARVMSDYFK HFECLDFVFD NTEAIAQRAV ELFIRHASLI RPLGEGGKMR
710 720 730 740 750
LAADFAQMEL AVGPFCRRVS DLGKSYRMLR SFRPLLFQAS EHVASSPALG
760 770 780 790 800
DVIPFSIIIQ FLFTRAPAEL KSPFQRAEWS HTRFSQWLDD HPSEKDRLLL
810 820 830
IRGALEAYVQ SVRSREGKEF APVYPIMVQL LQKAMSALQ
Length:839
Mass (Da):92,743
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95BD2E254A0C3FF7
GO
Isoform 2 (identifier: Q9UP83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     593-593: K → KVVSSQSSFPLAAEQTIISALK

Show »
Length:860
Mass (Da):94,901
Checksum:iCE98BD7F82CB7D82
GO
Isoform 3 (identifier: Q9UP83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     593-593: K → KVVSSQSSFPLAAEQTIISALK
     803-839: Missing.

Show »
Length:823
Mass (Da):90,810
Checksum:i6E8DA2EC605D40D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQU7U3KQU7_HUMAN
Conserved oligomeric Golgi complex ...
COG5
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112A → V in AAC69276 (PubMed:9792665).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039142330F → L2 PublicationsCorresponds to variant dbSNP:rs2269970Ensembl.1
Natural variantiVAR_039182365I → V. Corresponds to variant dbSNP:rs34087251Ensembl.1
Natural variantiVAR_055664452H → R. Corresponds to variant dbSNP:rs35393416Ensembl.1
Natural variantiVAR_039143558S → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031610593K → KVVSSQSSFPLAAEQTIISA LK in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_031611803 – 839Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF058718 mRNA Translation: AAC69276.1
AC002381 Genomic DNA Translation: AAB63816.2
AC004855 Genomic DNA Translation: AAC83406.1
CH236947 Genomic DNA Translation: EAL24392.1
CH236947 Genomic DNA Translation: EAL24393.1
CH471070 Genomic DNA Translation: EAW83395.1
CH471070 Genomic DNA Translation: EAW83396.1
BC068540 mRNA Translation: AAH68540.1

NCBI Reference Sequences

More...
RefSeqi
NP_001154992.1, NM_001161520.1
NP_006339.3, NM_006348.3
NP_859422.2, NM_181733.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297135; ENSP00000297135; ENSG00000164597 [Q9UP83-2]
ENST00000347053; ENSP00000334703; ENSG00000164597 [Q9UP83-1]
ENST00000393603; ENSP00000377228; ENSG00000164597 [Q9UP83-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10466

UCSC genome browser

More...
UCSCi
uc003vec.3, human [Q9UP83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058718 mRNA Translation: AAC69276.1
AC002381 Genomic DNA Translation: AAB63816.2
AC004855 Genomic DNA Translation: AAC83406.1
CH236947 Genomic DNA Translation: EAL24392.1
CH236947 Genomic DNA Translation: EAL24393.1
CH471070 Genomic DNA Translation: EAW83395.1
CH471070 Genomic DNA Translation: EAW83396.1
BC068540 mRNA Translation: AAH68540.1
RefSeqiNP_001154992.1, NM_001161520.1
NP_006339.3, NM_006348.3
NP_859422.2, NM_181733.2

3D structure databases

SMRiQ9UP83
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115729, 47 interactors
CORUMiQ9UP83
IntActiQ9UP83, 40 interactors
MINTiQ9UP83
STRINGi9606.ENSP00000297135

PTM databases

GlyConnecti2030, 1 N-Linked glycan (1 site)
GlyGeniQ9UP83, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ9UP83
MetOSiteiQ9UP83
PhosphoSitePlusiQ9UP83

Polymorphism and mutation databases

BioMutaiCOG5
DMDMi296439390

Proteomic databases

EPDiQ9UP83
jPOSTiQ9UP83
MassIVEiQ9UP83
PaxDbiQ9UP83
PeptideAtlasiQ9UP83
PRIDEiQ9UP83
ProteomicsDBi85357 [Q9UP83-1]
85358 [Q9UP83-2]
85359 [Q9UP83-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
17176, 44 antibodies

The DNASU plasmid repository

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DNASUi
10466

Genome annotation databases

EnsembliENST00000297135; ENSP00000297135; ENSG00000164597 [Q9UP83-2]
ENST00000347053; ENSP00000334703; ENSG00000164597 [Q9UP83-1]
ENST00000393603; ENSP00000377228; ENSG00000164597 [Q9UP83-3]
GeneIDi10466
KEGGihsa:10466
UCSCiuc003vec.3, human [Q9UP83-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10466
DisGeNETi10466
EuPathDBiHostDB:ENSG00000164597.13

GeneCards: human genes, protein and diseases

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GeneCardsi
COG5
GeneReviewsiCOG5
HGNCiHGNC:14857, COG5
HPAiENSG00000164597, Low tissue specificity
MalaCardsiCOG5
MIMi606821, gene
613612, phenotype
neXtProtiNX_Q9UP83
OpenTargetsiENSG00000164597
Orphaneti263487, COG5-CDG
PharmGKBiPA26698

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2211, Eukaryota
GeneTreeiENSGT00390000004586
HOGENOMiCLU_009839_1_0_1
InParanoidiQ9UP83
KOiK20292
OMAiKSFDECP
OrthoDBi871605at2759
PhylomeDBiQ9UP83
TreeFamiTF313139

Enzyme and pathway databases

PathwayCommonsiQ9UP83
ReactomeiR-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811438, Intra-Golgi traffic
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10466, 50 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COG5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
COG5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10466
PharosiQ9UP83, Tbio

Protein Ontology

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PROi
PR:Q9UP83
RNActiQ9UP83, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164597, Expressed in secondary oocyte and 246 other tissues
ExpressionAtlasiQ9UP83, baseline and differential
GenevisibleiQ9UP83, HS

Family and domain databases

InterProiView protein in InterPro
IPR019465, Cog5
PANTHERiPTHR13228, PTHR13228, 1 hit
PfamiView protein in Pfam
PF10392, COG5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UP83
Secondary accession number(s): A4D0R6
, A4D0R7, O14555, O95008, Q6NUL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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