UniProtKB - Q9UP65 (PA24C_HUMAN)
Protein
Cytosolic phospholipase A2 gamma
Gene
PLA2G4C
Organism
Homo sapiens (Human)
Status
Functioni
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.2 Publications
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+3 PublicationsEC:3.1.1.43 Publications
Activity regulationi
Inhibited by palmitoyl-CoA (PubMed:14529291). Not regulated by calcium (PubMed:9705332, PubMed:10085124).3 Publications
Kineticsi
- Vmax=218 pmol/min/mg enzyme1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 82 | Nucleophile1 Publication | 1 | |
Active sitei | 385 | Proton acceptor1 Publication | 1 |
GO - Molecular functioni
- calcium-dependent phospholipase A2 activity Source: GO_Central
- calcium-dependent phospholipid binding Source: GO_Central
- calcium-independent phospholipase A2 activity Source: UniProtKB
- calcium ion binding Source: GO_Central
- lysophospholipase activity Source: Reactome
- phospholipase A1 activity Source: Reactome
- phospholipase A2 activity Source: GO_Central
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
- phospholipid binding Source: UniProtKB
GO - Biological processi
- arachidonic acid metabolic process Source: UniProtKB
- glycerophospholipid catabolic process Source: UniProtKB
- inflammatory response Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- parturition Source: UniProtKB
- phosphatidylcholine acyl-chain remodeling Source: Reactome
- phosphatidylethanolamine acyl-chain remodeling Source: Reactome
- phosphatidylinositol acyl-chain remodeling Source: Reactome
- phospholipid metabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC R-HSA-1483152 Hydrolysis of LPE |
Chemistry databases
SwissLipidsi | SLP:000000888 SLP:000001081 [Q9UP65-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Cytosolic phospholipase A2 gamma (EC:3.1.1.43 Publications)Short name: cPLA2-gamma Alternative name(s): Phospholipase A2 group IVC |
Gene namesi | Name:PLA2G4C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9037 PLA2G4C |
MIMi | 603602 gene |
neXtProti | NX_Q9UP65 |
Subcellular locationi
Other locations
- Membrane 3 Publications; Lipid-anchor 3 Publications
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Nucleus
- nuclear envelope Source: GO_Central
- nucleoplasm Source: GO_Central
Other locations
- cell cortex Source: Ensembl
- cytoplasm Source: GO_Central
- membrane Source: UniProtKB
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | R → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 82 | S → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 385 | D → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 402 | R → A: Abolishes enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 538 – 539 | CC → SS: Loss of prenylation. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 8605 |
OpenTargetsi | ENSG00000105499 |
PharmGKBi | PA33365 |
Miscellaneous databases
Pharosi | Q9UP65 |
Chemistry databases
ChEMBLi | CHEMBL4834 |
Polymorphism and mutation databases
BioMutai | PLA2G4C |
DMDMi | 322510066 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000022995 | 1 – 538 | Cytosolic phospholipase A2 gammaAdd BLAST | 538 | |
PropeptideiPRO_0000022996 | 539 – 541 | Removed in mature form | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 538 | Cysteine methyl ester1 Publication1 Publication | 1 | |
Lipidationi | 538 | S-farnesyl cysteine1 Publication1 Publication | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
jPOSTi | Q9UP65 |
MassIVEi | Q9UP65 |
PaxDbi | Q9UP65 |
PeptideAtlasi | Q9UP65 |
PRIDEi | Q9UP65 |
ProteomicsDBi | 85355 [Q9UP65-1] |
PTM databases
iPTMneti | Q9UP65 |
PhosphoSitePlusi | Q9UP65 |
SwissPalmi | Q9UP65 |
Expressioni
Tissue specificityi
Highly expressed in heart and skeletal muscle.2 Publications
Gene expression databases
Bgeei | ENSG00000105499 Expressed in 212 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q9UP65 baseline and differential |
Genevisiblei | Q9UP65 HS |
Organism-specific databases
HPAi | HPA043083 |
Interactioni
Protein-protein interaction databases
BioGridi | 114165, 11 interactors |
STRINGi | 9606.ENSP00000472546 |
Chemistry databases
BindingDBi | Q9UP65 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 541 | PLA2cPROSITE-ProRule annotationAdd BLAST | 541 |
Phylogenomic databases
eggNOGi | KOG1325 Eukaryota ENOG410XR72 LUCA |
GeneTreei | ENSGT00950000182875 |
HOGENOMi | HOG000059624 |
InParanoidi | Q9UP65 |
KOi | K16342 |
OMAi | LFNIDAC |
OrthoDBi | 302848at2759 |
PhylomeDBi | Q9UP65 |
TreeFami | TF325228 |
Family and domain databases
InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR002642 LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF01735 PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00022 PLAc, 1 hit |
SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS51210 PLA2C, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
60 70 80 90 100
GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
110 120 130 140 150
LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
160 170 180 190 200
PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
210 220 230 240 250
GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
260 270 280 290 300
EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
310 320 330 340 350
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
360 370 380 390 400
CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
410 420 430 440 450
TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
460 470 480 490 500
ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
510 520 530 540
VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY18 | M0QY18_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 130 | Annotation score: | ||
M0QZB1 | M0QZB1_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 213 | Annotation score: | ||
M0R339 | M0R339_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 193 | Annotation score: | ||
M0R1B4 | M0R1B4_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 47 | Annotation score: | ||
M0R3I9 | M0R3I9_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 34 | Annotation score: | ||
M0R0F6 | M0R0F6_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 39 | Annotation score: | ||
M0QX83 | M0QX83_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 43 | Annotation score: | ||
M0R0M8 | M0R0M8_HUMAN | Cytosolic phospholipase A2 gamma | PLA2G4C | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | R → G in BAG58352 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 465 | M → I in AAC32823 (PubMed:9705332).Curated | 1 | |
Sequence conflicti | 480 | E → G in CAG33097 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018761 | 21 | E → K1 PublicationCorresponds to variant dbSNP:rs11564522Ensembl. | 1 | |
Natural variantiVAR_018420 | 38 | A → P1 PublicationCorresponds to variant dbSNP:rs2307279Ensembl. | 1 | |
Natural variantiVAR_018762 | 127 | A → V1 PublicationCorresponds to variant dbSNP:rs11564532Ensembl. | 1 | |
Natural variantiVAR_018763 | 142 | V → F1 PublicationCorresponds to variant dbSNP:rs11564534Ensembl. | 1 | |
Natural variantiVAR_018421 | 143 | I → V2 PublicationsCorresponds to variant dbSNP:rs2303744Ensembl. | 1 | |
Natural variantiVAR_018764 | 148 | R → G1 PublicationCorresponds to variant dbSNP:rs2307282Ensembl. | 1 | |
Natural variantiVAR_018765 | 151 | P → L1 PublicationCorresponds to variant dbSNP:rs11564538Ensembl. | 1 | |
Natural variantiVAR_018422 | 203 | S → P4 PublicationsCorresponds to variant dbSNP:rs156631Ensembl. | 1 | |
Natural variantiVAR_018766 | 226 | T → S1 PublicationCorresponds to variant dbSNP:rs11564541Ensembl. | 1 | |
Natural variantiVAR_018767 | 360 | T → P1 PublicationCorresponds to variant dbSNP:rs11564620Ensembl. | 1 | |
Natural variantiVAR_018768 | 411 | D → N1 PublicationCorresponds to variant dbSNP:rs11564638Ensembl. | 1 | |
Natural variantiVAR_018423 | 430 | R → C1 PublicationCorresponds to variant dbSNP:rs191276960Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045849 | 1 – 13 | MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_045850 | 528 – 541 | Missing in isoform 2. CuratedAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058921 mRNA Translation: AAC32823.1 AF065214 mRNA Translation: AAC78835.1 AY485310 Genomic DNA Translation: AAR25453.1 AK295400 mRNA Translation: BAG58352.1 AK314524 mRNA Translation: BAG37118.1 CR456816 mRNA Translation: CAG33097.1 AC010458 Genomic DNA No translation available. AC011466 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52314.1 BC063416 mRNA Translation: AAH63416.1 AB105807 Genomic DNA Translation: BAC87745.1 AL050193 mRNA Translation: CAB43312.3 |
CCDSi | CCDS12710.1 [Q9UP65-1] CCDS54286.1 [Q9UP65-2] CCDS59403.1 [Q9UP65-3] |
PIRi | T13162 |
RefSeqi | NP_001152794.1, NM_001159322.1 [Q9UP65-3] NP_001152795.1, NM_001159323.1 [Q9UP65-2] NP_003697.2, NM_003706.2 [Q9UP65-1] |
Genome annotation databases
Ensembli | ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2] ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3] ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1] |
GeneIDi | 8605 |
KEGGi | hsa:8605 |
UCSCi | uc002phx.4 human [Q9UP65-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058921 mRNA Translation: AAC32823.1 AF065214 mRNA Translation: AAC78835.1 AY485310 Genomic DNA Translation: AAR25453.1 AK295400 mRNA Translation: BAG58352.1 AK314524 mRNA Translation: BAG37118.1 CR456816 mRNA Translation: CAG33097.1 AC010458 Genomic DNA No translation available. AC011466 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52314.1 BC063416 mRNA Translation: AAH63416.1 AB105807 Genomic DNA Translation: BAC87745.1 AL050193 mRNA Translation: CAB43312.3 |
CCDSi | CCDS12710.1 [Q9UP65-1] CCDS54286.1 [Q9UP65-2] CCDS59403.1 [Q9UP65-3] |
PIRi | T13162 |
RefSeqi | NP_001152794.1, NM_001159322.1 [Q9UP65-3] NP_001152795.1, NM_001159323.1 [Q9UP65-2] NP_003697.2, NM_003706.2 [Q9UP65-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 114165, 11 interactors |
STRINGi | 9606.ENSP00000472546 |
Chemistry databases
BindingDBi | Q9UP65 |
ChEMBLi | CHEMBL4834 |
SwissLipidsi | SLP:000000888 SLP:000001081 [Q9UP65-1] |
PTM databases
iPTMneti | Q9UP65 |
PhosphoSitePlusi | Q9UP65 |
SwissPalmi | Q9UP65 |
Polymorphism and mutation databases
BioMutai | PLA2G4C |
DMDMi | 322510066 |
Proteomic databases
jPOSTi | Q9UP65 |
MassIVEi | Q9UP65 |
PaxDbi | Q9UP65 |
PeptideAtlasi | Q9UP65 |
PRIDEi | Q9UP65 |
ProteomicsDBi | 85355 [Q9UP65-1] |
Genome annotation databases
Ensembli | ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2] ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3] ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1] |
GeneIDi | 8605 |
KEGGi | hsa:8605 |
UCSCi | uc002phx.4 human [Q9UP65-1] |
Organism-specific databases
CTDi | 8605 |
DisGeNETi | 8605 |
GeneCardsi | PLA2G4C |
HGNCi | HGNC:9037 PLA2G4C |
HPAi | HPA043083 |
MIMi | 603602 gene |
neXtProti | NX_Q9UP65 |
OpenTargetsi | ENSG00000105499 |
PharmGKBi | PA33365 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1325 Eukaryota ENOG410XR72 LUCA |
GeneTreei | ENSGT00950000182875 |
HOGENOMi | HOG000059624 |
InParanoidi | Q9UP65 |
KOi | K16342 |
OMAi | LFNIDAC |
OrthoDBi | 302848at2759 |
PhylomeDBi | Q9UP65 |
TreeFami | TF325228 |
Enzyme and pathway databases
Reactomei | R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC R-HSA-1483152 Hydrolysis of LPE |
Miscellaneous databases
ChiTaRSi | PLA2G4C human |
GeneWikii | PLA2G4C |
GenomeRNAii | 8605 |
Pharosi | Q9UP65 |
PROi | PR:Q9UP65 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105499 Expressed in 212 organ(s), highest expression level in corpus callosum |
ExpressionAtlasi | Q9UP65 baseline and differential |
Genevisiblei | Q9UP65 HS |
Family and domain databases
InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR002642 LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF01735 PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00022 PLAc, 1 hit |
SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS51210 PLA2C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PA24C_HUMAN | |
Accessioni | Q9UP65Primary (citable) accession number: Q9UP65 Secondary accession number(s): B2RB71 Q9UG68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | February 8, 2011 | |
Last modified: | October 16, 2019 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot