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Protein

Cytosolic phospholipase A2 gamma

Gene

PLA2G4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.2 Publications

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.3 Publications

Enzyme regulationi

Inhibited by palmitoyl-CoA (PubMed:14529291). Not regulated by calcium (PubMed:9705332, PubMed:10085124).3 Publications

Kineticsi

    1. Vmax=218 pmol/min/mg enzyme1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei82Nucleophile1 Publication1
    Active sitei385Proton acceptor1 Publication1

    GO - Molecular functioni

    GO - Biological processi

    • arachidonic acid metabolic process Source: UniProtKB
    • glycerophospholipid catabolic process Source: UniProtKB
    • inflammatory response Source: UniProtKB
    • intracellular signal transduction Source: UniProtKB
    • parturition Source: UniProtKB
    • phosphatidylcholine acyl-chain remodeling Source: Reactome
    • phosphatidylethanolamine acyl-chain remodeling Source: Reactome
    • phosphatidylinositol acyl-chain remodeling Source: Reactome
    • phospholipid metabolic process Source: UniProtKB

    Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482922 Acyl chain remodelling of PI
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483152 Hydrolysis of LPE

    Chemistry databases

    SwissLipidsiSLP:000000888
    SLP:000001081 [Q9UP65-1]

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 gamma (EC:3.1.1.43 Publications)
    Short name:
    cPLA2-gamma
    Alternative name(s):
    Phospholipase A2 group IVC
    Gene namesi
    Name:PLA2G4C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 19

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000105499.13
    HGNCiHGNC:9037 PLA2G4C
    MIMi603602 gene
    neXtProtiNX_Q9UP65

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi54R → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi82S → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi385D → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi402R → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi538 – 539CC → SS: Loss of prenylation. 1 Publication2

    Organism-specific databases

    DisGeNETi8605
    OpenTargetsiENSG00000105499
    PharmGKBiPA33365

    Chemistry databases

    ChEMBLiCHEMBL4834

    Polymorphism and mutation databases

    BioMutaiPLA2G4C
    DMDMi322510066

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000229951 – 538Cytosolic phospholipase A2 gammaAdd BLAST538
    PropeptideiPRO_0000022996539 – 541Removed in mature form3

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei337PhosphoserineCombined sources1
    Modified residuei538Cysteine methyl ester1 Publication1 Publication1
    Lipidationi538S-farnesyl cysteine1 Publication1 Publication1

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiQ9UP65
    PeptideAtlasiQ9UP65
    PRIDEiQ9UP65
    ProteomicsDBi85355

    PTM databases

    iPTMnetiQ9UP65
    PhosphoSitePlusiQ9UP65
    SwissPalmiQ9UP65

    Expressioni

    Tissue specificityi

    Highly expressed in heart and skeletal muscle.2 Publications

    Gene expression databases

    BgeeiENSG00000105499
    CleanExiHS_PLA2G4C
    ExpressionAtlasiQ9UP65 baseline and differential
    GenevisibleiQ9UP65 HS

    Organism-specific databases

    HPAiHPA043083

    Interactioni

    Protein-protein interaction databases

    BioGridi114165, 3 interactors
    STRINGi9606.ENSP00000400036

    Chemistry databases

    BindingDBiQ9UP65

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UP65
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini1 – 541PLA2cPROSITE-ProRule annotationAdd BLAST541

    Phylogenomic databases

    eggNOGiKOG1325 Eukaryota
    ENOG410XR72 LUCA
    GeneTreeiENSGT00550000074489
    HOGENOMiHOG000059624
    HOVERGENiHBG058910
    InParanoidiQ9UP65
    KOiK16342
    OMAiAYMVISK
    OrthoDBiEOG091G04R7
    PhylomeDBiQ9UP65
    TreeFamiTF325228

    Family and domain databases

    InterProiView protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR002642 LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF01735 PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00022 PLAc, 1 hit
    SUPFAMiSSF52151 SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS51210 PLA2C, 1 hit

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
    60 70 80 90 100
    GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
    110 120 130 140 150
    LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
    160 170 180 190 200
    PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
    210 220 230 240 250
    GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
    260 270 280 290 300
    EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
    310 320 330 340 350
    EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
    360 370 380 390 400
    CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
    410 420 430 440 450
    TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
    460 470 480 490 500
    ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
    510 520 530 540
    VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
    Length:541
    Mass (Da):60,939
    Last modified:February 8, 2011 - v2
    Checksum:iA114B2A614EA4632
    GO
    Isoform 2 (identifier: Q9UP65-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-541: Missing.

    Show »
    Length:527
    Mass (Da):59,367
    Checksum:i4F4C4884DE7EAD3A
    GO
    Isoform 3 (identifier: Q9UP65-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK

    Show »
    Length:551
    Mass (Da):62,451
    Checksum:iD9A68B760776F943
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti24R → G in BAG58352 (PubMed:14702039).Curated1
    Sequence conflicti465M → I in AAC32823 (PubMed:9705332).Curated1
    Sequence conflicti480E → G in CAG33097 (Ref. 5) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_01876121E → K1 PublicationCorresponds to variant dbSNP:rs11564522Ensembl.1
    Natural variantiVAR_01842038A → P1 PublicationCorresponds to variant dbSNP:rs2307279Ensembl.1
    Natural variantiVAR_018762127A → V1 PublicationCorresponds to variant dbSNP:rs11564532Ensembl.1
    Natural variantiVAR_018763142V → F1 PublicationCorresponds to variant dbSNP:rs11564534Ensembl.1
    Natural variantiVAR_018421143I → V2 PublicationsCorresponds to variant dbSNP:rs2303744Ensembl.1
    Natural variantiVAR_018764148R → G1 PublicationCorresponds to variant dbSNP:rs2307282Ensembl.1
    Natural variantiVAR_018765151P → L1 PublicationCorresponds to variant dbSNP:rs11564538Ensembl.1
    Natural variantiVAR_018422203S → P4 PublicationsCorresponds to variant dbSNP:rs156631Ensembl.1
    Natural variantiVAR_018766226T → S1 PublicationCorresponds to variant dbSNP:rs11564541Ensembl.1
    Natural variantiVAR_018767360T → P1 PublicationCorresponds to variant dbSNP:rs11564620Ensembl.1
    Natural variantiVAR_018768411D → N1 PublicationCorresponds to variant dbSNP:rs11564638Ensembl.1
    Natural variantiVAR_018423430R → C1 PublicationCorresponds to variant dbSNP:rs191276960Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0458491 – 13MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationAdd BLAST13
    Alternative sequenceiVSP_045850528 – 541Missing in isoform 2. CuratedAdd BLAST14

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058921 mRNA Translation: AAC32823.1
    AF065214 mRNA Translation: AAC78835.1
    AY485310 Genomic DNA Translation: AAR25453.1
    AK295400 mRNA Translation: BAG58352.1
    AK314524 mRNA Translation: BAG37118.1
    CR456816 mRNA Translation: CAG33097.1
    AC010458 Genomic DNA No translation available.
    AC011466 Genomic DNA No translation available.
    CH471177 Genomic DNA Translation: EAW52314.1
    BC063416 mRNA Translation: AAH63416.1
    AB105807 Genomic DNA Translation: BAC87745.1
    AL050193 mRNA Translation: CAB43312.3
    CCDSiCCDS12710.1 [Q9UP65-1]
    CCDS54286.1 [Q9UP65-2]
    CCDS59403.1 [Q9UP65-3]
    PIRiT13162
    RefSeqiNP_001152794.1, NM_001159322.1 [Q9UP65-3]
    NP_001152795.1, NM_001159323.1 [Q9UP65-2]
    NP_003697.2, NM_003706.2 [Q9UP65-1]
    UniGeneiHs.631562

    Genome annotation databases

    EnsembliENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2]
    ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3]
    ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1]
    GeneIDi8605
    KEGGihsa:8605
    UCSCiuc002phx.4 human [Q9UP65-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiPA24C_HUMAN
    AccessioniPrimary (citable) accession number: Q9UP65
    Secondary accession number(s): B2RB71
    , B4DI40, O75457, Q6IBI8, Q9UG68
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: February 8, 2011
    Last modified: June 20, 2018
    This is version 140 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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