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Entry version 148 (05 Jun 2019)
Sequence version 2 (08 Feb 2011)
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Protein

Cytosolic phospholipase A2 gamma

Gene

PLA2G4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by palmitoyl-CoA (PubMed:14529291). Not regulated by calcium (PubMed:9705332, PubMed:10085124).3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=218 pmol/min/mg enzyme1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei82Nucleophile1 Publication1
    Active sitei385Proton acceptor1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482922 Acyl chain remodelling of PI
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483152 Hydrolysis of LPE

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000888
    SLP:000001081 [Q9UP65-1]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 gamma (EC:3.1.1.43 Publications)
    Short name:
    cPLA2-gamma
    Alternative name(s):
    Phospholipase A2 group IVC
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLA2G4C
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9037 PLA2G4C

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603602 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UP65

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54R → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi82S → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi385D → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi402R → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi538 – 539CC → SS: Loss of prenylation. 1 Publication2

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8605

    Open Targets

    More...
    OpenTargetsi
    ENSG00000105499

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33365

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4834

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PLA2G4C

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    322510066

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000229951 – 538Cytosolic phospholipase A2 gammaAdd BLAST538
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000022996539 – 541Removed in mature form3

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337PhosphoserineCombined sources1
    Modified residuei538Cysteine methyl ester1 Publication1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi538S-farnesyl cysteine1 Publication1 Publication1

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UP65

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UP65

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UP65

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UP65

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    85355

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UP65

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UP65

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9UP65

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in heart and skeletal muscle.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000105499 Expressed in 212 organ(s), highest expression level in corpus callosum

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UP65 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UP65 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA043083

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114165, 11 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000472546

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9UP65

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 541PLA2cPROSITE-ProRule annotationAdd BLAST541

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1325 Eukaryota
    ENOG410XR72 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182875

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000059624

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UP65

    KEGG Orthology (KO)

    More...
    KOi
    K16342

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PASCYIL

    Database of Orthologous Groups

    More...
    OrthoDBi
    302848at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UP65

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325228

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR002642 LysoPLipase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01735 PLA2_B, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00022 PLAc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52151 SSF52151, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51210 PLA2C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
    60 70 80 90 100
    GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
    110 120 130 140 150
    LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
    160 170 180 190 200
    PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
    210 220 230 240 250
    GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
    260 270 280 290 300
    EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
    310 320 330 340 350
    EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
    360 370 380 390 400
    CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
    410 420 430 440 450
    TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
    460 470 480 490 500
    ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
    510 520 530 540
    VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
    Length:541
    Mass (Da):60,939
    Last modified:February 8, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA114B2A614EA4632
    GO
    Isoform 2 (identifier: Q9UP65-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-541: Missing.

    Show »
    Length:527
    Mass (Da):59,367
    Checksum:i4F4C4884DE7EAD3A
    GO
    Isoform 3 (identifier: Q9UP65-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK

    Show »
    Length:551
    Mass (Da):62,451
    Checksum:iD9A68B760776F943
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    M0QY18M0QY18_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    130Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QZB1M0QZB1_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    213Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R339M0R339_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    193Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R1B4M0R1B4_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    47Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R3I9M0R3I9_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    34Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R0F6M0R0F6_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    39Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0QX83M0QX83_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    43Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    M0R0M8M0R0M8_HUMAN
    Cytosolic phospholipase A2 gamma
    PLA2G4C
    36Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24R → G in BAG58352 (PubMed:14702039).Curated1
    Sequence conflicti465M → I in AAC32823 (PubMed:9705332).Curated1
    Sequence conflicti480E → G in CAG33097 (Ref. 5) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01876121E → K1 PublicationCorresponds to variant dbSNP:rs11564522Ensembl.1
    Natural variantiVAR_01842038A → P1 PublicationCorresponds to variant dbSNP:rs2307279Ensembl.1
    Natural variantiVAR_018762127A → V1 PublicationCorresponds to variant dbSNP:rs11564532Ensembl.1
    Natural variantiVAR_018763142V → F1 PublicationCorresponds to variant dbSNP:rs11564534Ensembl.1
    Natural variantiVAR_018421143I → V2 PublicationsCorresponds to variant dbSNP:rs2303744Ensembl.1
    Natural variantiVAR_018764148R → G1 PublicationCorresponds to variant dbSNP:rs2307282Ensembl.1
    Natural variantiVAR_018765151P → L1 PublicationCorresponds to variant dbSNP:rs11564538Ensembl.1
    Natural variantiVAR_018422203S → P4 PublicationsCorresponds to variant dbSNP:rs156631Ensembl.1
    Natural variantiVAR_018766226T → S1 PublicationCorresponds to variant dbSNP:rs11564541Ensembl.1
    Natural variantiVAR_018767360T → P1 PublicationCorresponds to variant dbSNP:rs11564620Ensembl.1
    Natural variantiVAR_018768411D → N1 PublicationCorresponds to variant dbSNP:rs11564638Ensembl.1
    Natural variantiVAR_018423430R → C1 PublicationCorresponds to variant dbSNP:rs191276960Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0458491 – 13MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationAdd BLAST13
    Alternative sequenceiVSP_045850528 – 541Missing in isoform 2. CuratedAdd BLAST14

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF058921 mRNA Translation: AAC32823.1
    AF065214 mRNA Translation: AAC78835.1
    AY485310 Genomic DNA Translation: AAR25453.1
    AK295400 mRNA Translation: BAG58352.1
    AK314524 mRNA Translation: BAG37118.1
    CR456816 mRNA Translation: CAG33097.1
    AC010458 Genomic DNA No translation available.
    AC011466 Genomic DNA No translation available.
    CH471177 Genomic DNA Translation: EAW52314.1
    BC063416 mRNA Translation: AAH63416.1
    AB105807 Genomic DNA Translation: BAC87745.1
    AL050193 mRNA Translation: CAB43312.3

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12710.1 [Q9UP65-1]
    CCDS54286.1 [Q9UP65-2]
    CCDS59403.1 [Q9UP65-3]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T13162

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001152794.1, NM_001159322.1 [Q9UP65-3]
    NP_001152795.1, NM_001159323.1 [Q9UP65-2]
    NP_003697.2, NM_003706.2 [Q9UP65-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2]
    ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3]
    ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8605

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8605

    UCSC genome browser

    More...
    UCSCi
    uc002phx.4 human [Q9UP65-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058921 mRNA Translation: AAC32823.1
    AF065214 mRNA Translation: AAC78835.1
    AY485310 Genomic DNA Translation: AAR25453.1
    AK295400 mRNA Translation: BAG58352.1
    AK314524 mRNA Translation: BAG37118.1
    CR456816 mRNA Translation: CAG33097.1
    AC010458 Genomic DNA No translation available.
    AC011466 Genomic DNA No translation available.
    CH471177 Genomic DNA Translation: EAW52314.1
    BC063416 mRNA Translation: AAH63416.1
    AB105807 Genomic DNA Translation: BAC87745.1
    AL050193 mRNA Translation: CAB43312.3
    CCDSiCCDS12710.1 [Q9UP65-1]
    CCDS54286.1 [Q9UP65-2]
    CCDS59403.1 [Q9UP65-3]
    PIRiT13162
    RefSeqiNP_001152794.1, NM_001159322.1 [Q9UP65-3]
    NP_001152795.1, NM_001159323.1 [Q9UP65-2]
    NP_003697.2, NM_003706.2 [Q9UP65-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi114165, 11 interactors
    STRINGi9606.ENSP00000472546

    Chemistry databases

    BindingDBiQ9UP65
    ChEMBLiCHEMBL4834
    SwissLipidsiSLP:000000888
    SLP:000001081 [Q9UP65-1]

    PTM databases

    iPTMnetiQ9UP65
    PhosphoSitePlusiQ9UP65
    SwissPalmiQ9UP65

    Polymorphism and mutation databases

    BioMutaiPLA2G4C
    DMDMi322510066

    Proteomic databases

    jPOSTiQ9UP65
    PaxDbiQ9UP65
    PeptideAtlasiQ9UP65
    PRIDEiQ9UP65
    ProteomicsDBi85355

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2]
    ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3]
    ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1]
    GeneIDi8605
    KEGGihsa:8605
    UCSCiuc002phx.4 human [Q9UP65-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8605
    DisGeNETi8605

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PLA2G4C
    HGNCiHGNC:9037 PLA2G4C
    HPAiHPA043083
    MIMi603602 gene
    neXtProtiNX_Q9UP65
    OpenTargetsiENSG00000105499
    PharmGKBiPA33365

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1325 Eukaryota
    ENOG410XR72 LUCA
    GeneTreeiENSGT00950000182875
    HOGENOMiHOG000059624
    InParanoidiQ9UP65
    KOiK16342
    OMAiPASCYIL
    OrthoDBi302848at2759
    PhylomeDBiQ9UP65
    TreeFamiTF325228

    Enzyme and pathway databases

    ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482922 Acyl chain remodelling of PI
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483152 Hydrolysis of LPE

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PLA2G4C

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8605

    Protein Ontology

    More...
    PROi
    PR:Q9UP65

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000105499 Expressed in 212 organ(s), highest expression level in corpus callosum
    ExpressionAtlasiQ9UP65 baseline and differential
    GenevisibleiQ9UP65 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR002642 LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF01735 PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00022 PLAc, 1 hit
    SUPFAMiSSF52151 SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS51210 PLA2C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24C_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UP65
    Secondary accession number(s): B2RB71
    , B4DI40, O75457, Q6IBI8, Q9UG68
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: February 8, 2011
    Last modified: June 5, 2019
    This is version 148 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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