UniProtKB - Q9UP65 (PA24C_HUMAN)
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- BLAST>sp|Q9UP65|PA24C_HUMAN Cytosolic phospholipase A2 gamma OS=Homo sapiens OX=9606 GN=PLA2G4C PE=1 SV=2 MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACL GVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSL QKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQ PSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWG SALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPED EGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTT HNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFET IRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIE AWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCL A
- Align
Cytosolic phospholipase A2 gamma
PLA2G4C
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203.
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203. - Ref.11"Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203. - Ref.11"Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi
- Vmax=218 pmol/min/mg enzyme1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203.
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei | 82 | Nucleophile1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 | |
| <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei | 385 | Proton acceptor1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- calcium-independent phospholipase A2 activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- lysophospholipase activity Source: Reactome
- phosphatidylcholine 1-acylhydrolase activity Source: Reactome
- phospholipase A2 activity Source: Reactome
- phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) Source: UniProtKB-EC
- phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) Source: UniProtKB-EC
- phospholipid binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementi
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- arachidonic acid metabolic process Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementi
- glycerophospholipid catabolic process Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- inflammatory response Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementi
- intracellular signal transduction Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementi
- parturition Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementi
- phosphatidylcholine acyl-chain remodeling Source: Reactome
- phosphatidylethanolamine acyl-chain remodeling Source: Reactome
- phosphatidylinositol acyl-chain remodeling Source: Reactome
- phospholipid metabolic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
Reactome - a knowledgebase of biological pathways and processes More...Reactomei | R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC R-HSA-1483152 Hydrolysis of LPE |
Chemistry databases
SwissLipids knowledge resource for lipid biology More...SwissLipidsi | SLP:000000888 SLP:000001081 [Q9UP65-1] |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Cytosolic phospholipase A2 gamma (EC:3.1.1.43 Publications<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
Short name: cPLA2-gamma Alternative name(s): Phospholipase A2 group IVC |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:PLA2G4C |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Homo sapiens (Human) |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 9606 [NCBI] |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000105499.13 |
Human Gene Nomenclature Database More...HGNCi | HGNC:9037 PLA2G4C |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 603602 gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q9UP65 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Other locations
- Membrane 3 Publications
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203. - Ref.11"Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203. - Ref.11"Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
- Membrane 3 Publications
Cytosol
- cytosol Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Nucleus
- nuclear envelope Source: Ensembl
- nucleoplasm Source: Ensembl
Other locations
- cell cortex Source: Ensembl
- membrane Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Membrane<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 54 | R → A: Abolishes enzyme activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 82 | S → A: Abolishes enzyme activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 385 | D → A: Abolishes enzyme activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 402 | R → A: Abolishes enzyme activity. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 538 – 539 | CC → SS: Loss of prenylation. 1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 2 |
Organism-specific databases
DisGeNET More...DisGeNETi | 8605 |
Open Targets More...OpenTargetsi | ENSG00000105499 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA33365 |
Chemistry databases
ChEMBL database of bioactive drug-like small molecules More...ChEMBLi | CHEMBL4834 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | PLA2G4C |
Domain mapping of disease mutations (DMDM) More...DMDMi | 322510066 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000022995 | 1 – 538 | Cytosolic phospholipase A2 gammaAdd BLAST | 538 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000022996 | 539 – 541 | Removed in mature form | 3 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 337 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 538 | Cysteine methyl ester1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi | 538 | S-farnesyl cysteine1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q9UP65 |
PeptideAtlas More...PeptideAtlasi | Q9UP65 |
PRoteomics IDEntifications database More...PRIDEi | Q9UP65 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 85355 |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q9UP65 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q9UP65 |
SwissPalm database of S-palmitoylation events More...SwissPalmi | Q9UP65 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ISOPRENYLATION AT CYS-538, MUTAGENESIS OF 538-CYS-CYS-539. - Ref.2"Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000105499 |
CleanEx database of gene expression profiles More...CleanExi | HS_PLA2G4C |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q9UP65 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q9UP65 HS |
Organism-specific databases
Human Protein Atlas More...HPAi | HPA043083 |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 114165, 3 interactors |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000400036 |
Chemistry databases
BindingDB database of measured binding affinities More...BindingDBi | Q9UP65 |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q9UP65 |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 1 – 541 | PLA2cPROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 541 |
Phylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG1325 Eukaryota ENOG410XR72 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00550000074489 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | HOG000059624 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG058910 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q9UP65 |
KEGG Orthology (KO) More...KOi | K16342 |
Identification of Orthologs from Complete Genome Data More...OMAi | AYMVISK |
Database of Orthologous Groups More...OrthoDBi | EOG091G04R7 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q9UP65 |
TreeFam database of animal gene trees More...TreeFami | TF325228 |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR002642 LysoPLipase_cat_dom |
Pfam protein domain database More...Pfami | View protein in Pfam PF01735 PLA2_B, 1 hit |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00022 PLAc, 1 hit |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS51210 PLA2C, 1 hit |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
60 70 80 90 100
GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
110 120 130 140 150
LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
160 170 180 190 200
PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
210 220 230 240 250
GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
260 270 280 290 300
EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
310 320 330 340 350
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
360 370 380 390 400
CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
410 420 430 440 450
TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
460 470 480 490 500
ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
510 520 530 540
VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
The sequence of this isoform differs from the canonical sequence as follows:
528-541: Missing.
10 20 30 40 50
MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
60 70 80 90 100
GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
110 120 130 140 150
LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
160 170 180 190 200
PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
210 220 230 240 250
GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
260 270 280 290 300
EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
310 320 330 340 350
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
360 370 380 390 400
CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
410 420 430 440 450
TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
460 470 480 490 500
ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
510 520
VLLLALAKKN VRENKKKILR ELMNVAG
The sequence of this isoform differs from the canonical sequence as follows:
1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK
10 20 30 40 50
MRTRPRPRLR RTENFLTAVH HGKKEEKAAV ERRRLHVLKA LKKLRIEADE
60 70 80 90 100
APVVAVLGSG GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS
110 120 130 140 150
LYTNDGDMEA LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY
160 170 180 190 200
MVISKQTREL PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE
210 220 230 240 250
TWFEFTPHHA GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG
260 270 280 290 300
SALGNTEVIR EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES
310 320 330 340 350
SQGEHPPPED EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN
360 370 380 390 400
LMDFVKKTGI CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI
410 420 430 440 450
NTPFPLVLPP TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE
460 470 480 490 500
AELDLWSKAP ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK
510 520 530 540 550
LADTYTLDVV VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL
A
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 24 | R → G in BAG58352 (PubMed:14702039).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 465 | M → I in AAC32823 (PubMed:9705332).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 480 | E → G in CAG33097 (Ref. 5) Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018761 | 21 | E → K1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018420 | 38 | A → P1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018762 | 127 | A → V1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018763 | 142 | V → F1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018421 | 143 | I → V2 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018764 | 148 | R → G1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018765 | 151 | P → L1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018422 | 203 | S → P4 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018766 | 226 | T → S1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018767 | 360 | T → P1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018768 | 411 | D → N1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 | |
| <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018423 | 430 | R → C1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
| 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045849 | 1 – 13 | MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 Publication <p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
| 13 | |
| <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045850 | 528 – 541 | Missing in isoform 2. CuratedAdd BLAST | 14 |
Sequence databases
| Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AF058921 mRNA Translation: AAC32823.1 AF065214 mRNA Translation: AAC78835.1 AY485310 Genomic DNA Translation: AAR25453.1 AK295400 mRNA Translation: BAG58352.1 AK314524 mRNA Translation: BAG37118.1 CR456816 mRNA Translation: CAG33097.1 AC010458 Genomic DNA No translation available. AC011466 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52314.1 BC063416 mRNA Translation: AAH63416.1 AB105807 Genomic DNA Translation: BAC87745.1 AL050193 mRNA Translation: CAB43312.3 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS12710.1 [Q9UP65-1] CCDS54286.1 [Q9UP65-2] CCDS59403.1 [Q9UP65-3] |
Protein sequence database of the Protein Information Resource More...PIRi | T13162 |
NCBI Reference Sequences More...RefSeqi | NP_001152794.1, NM_001159322.1 [Q9UP65-3] NP_001152795.1, NM_001159323.1 [Q9UP65-2] NP_003697.2, NM_003706.2 [Q9UP65-1] |
UniGene gene-oriented nucleotide sequence clusters More...UniGenei | Hs.631562 |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2] ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3] ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 8605 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:8605 |
UCSC genome browser More...UCSCi | uc002phx.4 human [Q9UP65-1] |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi
Alternative splicing, Polymorphism<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
| Protein | Similar proteins | Species | Score | Length | |
|---|---|---|---|---|---|
| Q9UP65 | Phospholipase A2, group IVC (Cytosolic, calcium-independent), isoform CRA_d | 541 | |||
| PLA2G4C isoform 1 | 552 | ||||
| PLA2G4C isoform 1 | 551 | ||||
| UPI0008F49AA3 | 551 | ||||
| Phospholipase A2 group IVC | 529 | ||||
| +19 | |||||
| Protein | Similar proteins | Species | Score | Length | |
|---|---|---|---|---|---|
| Q9UP65 | Phospholipase A2, group IVC (Cytosolic, calcium-independent), isoform CRA_d | 541 | |||
| PLA2G4C isoform 1 | 552 | ||||
| UPI0008F49AA3 | 551 | ||||
| PLA2G4C isoform 1 | 551 | ||||
| Phospholipase A2 group IVC | 529 | ||||
| +32 | |||||
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi
| NIEHS-SNPs |
Sequence databases
| Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AF058921 mRNA Translation: AAC32823.1 AF065214 mRNA Translation: AAC78835.1 AY485310 Genomic DNA Translation: AAR25453.1 AK295400 mRNA Translation: BAG58352.1 AK314524 mRNA Translation: BAG37118.1 CR456816 mRNA Translation: CAG33097.1 AC010458 Genomic DNA No translation available. AC011466 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52314.1 BC063416 mRNA Translation: AAH63416.1 AB105807 Genomic DNA Translation: BAC87745.1 AL050193 mRNA Translation: CAB43312.3 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS12710.1 [Q9UP65-1] CCDS54286.1 [Q9UP65-2] CCDS59403.1 [Q9UP65-3] |
Protein sequence database of the Protein Information Resource More...PIRi | T13162 |
NCBI Reference Sequences More...RefSeqi | NP_001152794.1, NM_001159322.1 [Q9UP65-3] NP_001152795.1, NM_001159323.1 [Q9UP65-2] NP_003697.2, NM_003706.2 [Q9UP65-1] |
UniGene gene-oriented nucleotide sequence clusters More...UniGenei | Hs.631562 |
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q9UP65 |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 114165, 3 interactors |
STRING: functional protein association networks More...STRINGi | 9606.ENSP00000400036 |
Chemistry databases
BindingDB database of measured binding affinities More...BindingDBi | Q9UP65 |
ChEMBL database of bioactive drug-like small molecules More...ChEMBLi | CHEMBL4834 |
SwissLipids knowledge resource for lipid biology More...SwissLipidsi | SLP:000000888 SLP:000001081 [Q9UP65-1] |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q9UP65 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q9UP65 |
SwissPalm database of S-palmitoylation events More...SwissPalmi | Q9UP65 |
Polymorphism and mutation databases
BioMuta curated single-nucleotide variation and disease association database More...BioMutai | PLA2G4C |
Domain mapping of disease mutations (DMDM) More...DMDMi | 322510066 |
Proteomic databases
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q9UP65 |
PeptideAtlas More...PeptideAtlasi | Q9UP65 |
PRoteomics IDEntifications database More...PRIDEi | Q9UP65 |
ProteomicsDB human proteome resource More...ProteomicsDBi | 85355 |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2] ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3] ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 8605 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | hsa:8605 |
UCSC genome browser More...UCSCi | uc002phx.4 human [Q9UP65-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 8605 |
DisGeNET More...DisGeNETi | 8605 |
Eukaryotic Pathogen Database Resources More...EuPathDBi | HostDB:ENSG00000105499.13 |
GeneCards: human genes, protein and diseases More...GeneCardsi | PLA2G4C |
Human Gene Nomenclature Database More...HGNCi | HGNC:9037 PLA2G4C |
Human Protein Atlas More...HPAi | HPA043083 |
Online Mendelian Inheritance in Man (OMIM) More...MIMi | 603602 gene |
neXtProt; the human protein knowledge platform More...neXtProti | NX_Q9UP65 |
Open Targets More...OpenTargetsi | ENSG00000105499 |
The Pharmacogenetics and Pharmacogenomics Knowledge Base More...PharmGKBi | PA33365 |
GenAtlas: human gene database More...GenAtlasi | Search... |
Phylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG1325 Eukaryota ENOG410XR72 LUCA |
Ensembl GeneTree More...GeneTreei | ENSGT00550000074489 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | HOG000059624 |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG058910 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q9UP65 |
KEGG Orthology (KO) More...KOi | K16342 |
Identification of Orthologs from Complete Genome Data More...OMAi | AYMVISK |
Database of Orthologous Groups More...OrthoDBi | EOG091G04R7 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q9UP65 |
TreeFam database of animal gene trees More...TreeFami | TF325228 |
Enzyme and pathway databases
Reactome - a knowledgebase of biological pathways and processes More...Reactomei | R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC R-HSA-1483152 Hydrolysis of LPE |
Miscellaneous databases
The Gene Wiki collection of pages on human genes and proteins More...GeneWikii | PLA2G4C |
Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens More...GenomeRNAii | 8605 |
Protein Ontology More...PROi | PR:Q9UP65 |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSG00000105499 |
CleanEx database of gene expression profiles More...CleanExi | HS_PLA2G4C |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q9UP65 baseline and differential |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q9UP65 HS |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR016035 Acyl_Trfase/lysoPLipase IPR002642 LysoPLipase_cat_dom |
Pfam protein domain database More...Pfami | View protein in Pfam PF01735 PLA2_B, 1 hit |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00022 PLAc, 1 hit |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF52151 SSF52151, 1 hit |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS51210 PLA2C, 1 hit |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | PA24C_HUMAN | |
| <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q9UP65Primary (citable) accession number: Q9UP65 Secondary accession number(s): B2RB71 , B4DI40, O75457, Q6IBI8, Q9UG68 | |
| <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
| Last sequence update: | February 8, 2011 | |
| Last modified: | June 20, 2018 | |
| This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
| <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
