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Entry version 160 (07 Apr 2021)
Sequence version 2 (08 Feb 2011)
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Protein

Cytosolic phospholipase A2 gamma

Gene

PLA2G4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330).6 Publications
(Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330).2 Publications
(Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not regulated by calcium, coenzyme A or ATP (PubMed:9705332, PubMed:10085124, PubMed:15944408). Lysophospholipase activity is inhibited by palmitoyl-CoA (PubMed:14529291). Lysophospholipase and O-acyltransferase activities are inhibited by methylarachidonoylfluorophosphonate (PubMed:19501189). Lysophospholipase activity is inhibited by phosphatidate or lysophosphatidate (PubMed:19501189). O-acyltransferase activity is up-regulated at low concentration (10-20 µM) of phosphatidate or lysophosphatidate, but inhibited at higher concentrations (PubMed:19501189).4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=40 µM for 1-O-hexadecyl-sn-glycero-3-phosphocholine (O-acyltransferase activity)1 Publication
  1. Vmax=218 pmol/min/mg enzyme1 Publication

pH dependencei

Optimum pH is 6.5 for lysophospholipase activity, and 8-9 for O-acyltransferase activity.1 Publication

Temperature dependencei

Optimum temperature is 40 degrees Celsius for lysophospholipase activity, and 50 degrees Celsius for O-acyltransferase activity. Lysophospholipase activity is present even at 0 degrees Celsius and its rate increases with temperature up to 40 degrees Celsius. O-acyltransferase activity is low below 25 degrees Celsius, but increases sharply between 30 and 40 degrees Celsius and peaked near 50 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei82Nucleophile1 Publication1
Active sitei385Proton acceptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transferase
Biological processHost-virus interaction, Lipid metabolism, Phospholipid metabolism

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UP65

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1483115, Hydrolysis of LPC
R-HSA-1483152, Hydrolysis of LPE

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000888
SLP:000001081 [Q9UP65-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic phospholipase A2 gamma (EC:3.1.1.44 Publications)
Short name:
cPLA2-gamma
Alternative name(s):
Cytosolic lysophospholipase (EC:3.1.1.53 Publications)
Cytosolic lysophospholipid O-acyltransferase (EC:2.3.1.-1 Publication)
Phospholipase A2 group IVC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G4C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9037, PLA2G4C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603602, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UP65

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000105499.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Lipid droplet, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54R → A: Abolishes enzyme activity. Reduces lipid droplet formation; when associated with A-82; A-385 and A-402. 2 Publications1
Mutagenesisi82S → A: Abolishes enzyme activity. Reduces lipid droplet formation; when associated with A-54; A-385 and A-402. 2 Publications1
Mutagenesisi385D → A: Abolishes enzyme activity. Reduces lipid droplet formation; when associated with A-54; A-82 and A-402. 2 Publications1
Mutagenesisi402R → A: Abolishes enzyme activity. Reduces lipid droplet formation; when associated with A-54; A-82 and A-385. 2 Publications1
Mutagenesisi538 – 539CC → SS: Loss of prenylation. 1 Publication2
Mutagenesisi538C → S: Has no effect on membrane localization. Decreases the affinity for 1-O-hexadecyl-sn-glycero-3-phosphocholine acyl acceptor in transacylation reaction. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8605

Open Targets

More...
OpenTargetsi
ENSG00000105499

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33365

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UP65, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4834

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLA2G4C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000229951 – 538Cytosolic phospholipase A2 gammaAdd BLAST538
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000022996539 – 541Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337PhosphoserineCombined sources1
Modified residuei538Cysteine methyl ester1 Publication1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi538S-farnesyl cysteine1 Publication1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UP65

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UP65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UP65

PeptideAtlas

More...
PeptideAtlasi
Q9UP65

PRoteomics IDEntifications database

More...
PRIDEi
Q9UP65

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85355 [Q9UP65-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UP65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UP65

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UP65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and skeletal muscle.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

(Microbial infection) Up-regulated by HCV.1 Publication
(Microbial infection) Transcriptionally up-regulated by HTLV-1 Tax.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105499, Expressed in corpus callosum and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UP65, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UP65, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105499, Tissue enhanced (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with HCV non-structural protein 4B/NS4B; this interaction likely initiates the recruitment of replication complexes to lipid droplets.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114165, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UP65, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000472546

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UP65

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UP65, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 541PLA2cPROSITE-ProRule annotationAdd BLAST541

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 292Required for lipid droplet localization1 PublicationAdd BLAST33

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1325, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011663_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UP65

Identification of Orthologs from Complete Genome Data

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OMAi
LFNIDAC

Database of Orthologous Groups

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OrthoDBi
302848at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UP65

TreeFam database of animal gene trees

More...
TreeFami
TF325228

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR002642, LysoPLipase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01735, PLA2_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00022, PLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52151, SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51210, PLA2C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
60 70 80 90 100
GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
110 120 130 140 150
LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
160 170 180 190 200
PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
210 220 230 240 250
GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
260 270 280 290 300
EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
310 320 330 340 350
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
360 370 380 390 400
CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
410 420 430 440 450
TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
460 470 480 490 500
ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
510 520 530 540
VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
Length:541
Mass (Da):60,939
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA114B2A614EA4632
GO
Isoform 2 (identifier: Q9UP65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-541: Missing.

Show »
Length:527
Mass (Da):59,367
Checksum:i4F4C4884DE7EAD3A
GO
Isoform 3 (identifier: Q9UP65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK

Show »
Length:551
Mass (Da):62,451
Checksum:iD9A68B760776F943
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY18M0QY18_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZB1M0QZB1_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R339M0R339_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1B4M0R1B4_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX83M0QX83_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0F6M0R0F6_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3I9M0R3I9_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0M8M0R0M8_HUMAN
Cytosolic phospholipase A2 gamma
PLA2G4C
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24R → G in BAG58352 (PubMed:14702039).Curated1
Sequence conflicti465M → I in AAC32823 (PubMed:9705332).Curated1
Sequence conflicti480E → G in CAG33097 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01876121E → K1 PublicationCorresponds to variant dbSNP:rs11564522Ensembl.1
Natural variantiVAR_01842038A → P1 PublicationCorresponds to variant dbSNP:rs2307279Ensembl.1
Natural variantiVAR_018762127A → V1 PublicationCorresponds to variant dbSNP:rs11564532Ensembl.1
Natural variantiVAR_018763142V → F1 PublicationCorresponds to variant dbSNP:rs11564534Ensembl.1
Natural variantiVAR_018421143I → V2 PublicationsCorresponds to variant dbSNP:rs2303744Ensembl.1
Natural variantiVAR_018764148R → G1 PublicationCorresponds to variant dbSNP:rs2307282Ensembl.1
Natural variantiVAR_018765151P → L1 PublicationCorresponds to variant dbSNP:rs11564538Ensembl.1
Natural variantiVAR_018422203S → P4 PublicationsCorresponds to variant dbSNP:rs156631Ensembl.1
Natural variantiVAR_018766226T → S1 PublicationCorresponds to variant dbSNP:rs11564541Ensembl.1
Natural variantiVAR_018767360T → P1 PublicationCorresponds to variant dbSNP:rs11564620Ensembl.1
Natural variantiVAR_018768411D → N1 PublicationCorresponds to variant dbSNP:rs11564638EnsemblClinVar.1
Natural variantiVAR_018423430R → C1 PublicationCorresponds to variant dbSNP:rs191276960Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0458491 – 13MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_045850528 – 541Missing in isoform 2. CuratedAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF058921 mRNA Translation: AAC32823.1
AF065214 mRNA Translation: AAC78835.1
AY485310 Genomic DNA Translation: AAR25453.1
AK295400 mRNA Translation: BAG58352.1
AK314524 mRNA Translation: BAG37118.1
CR456816 mRNA Translation: CAG33097.1
AC010458 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52314.1
BC063416 mRNA Translation: AAH63416.1
AB105807 Genomic DNA Translation: BAC87745.1
AL050193 mRNA Translation: CAB43312.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12710.1 [Q9UP65-1]
CCDS54286.1 [Q9UP65-2]
CCDS59403.1 [Q9UP65-3]

Protein sequence database of the Protein Information Resource

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PIRi
T13162

NCBI Reference Sequences

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RefSeqi
NP_001152794.1, NM_001159322.1 [Q9UP65-3]
NP_001152795.1, NM_001159323.1 [Q9UP65-2]
NP_003697.2, NM_003706.2 [Q9UP65-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2]
ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3]
ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8605

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8605

UCSC genome browser

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UCSCi
uc002phx.4, human [Q9UP65-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058921 mRNA Translation: AAC32823.1
AF065214 mRNA Translation: AAC78835.1
AY485310 Genomic DNA Translation: AAR25453.1
AK295400 mRNA Translation: BAG58352.1
AK314524 mRNA Translation: BAG37118.1
CR456816 mRNA Translation: CAG33097.1
AC010458 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52314.1
BC063416 mRNA Translation: AAH63416.1
AB105807 Genomic DNA Translation: BAC87745.1
AL050193 mRNA Translation: CAB43312.3
CCDSiCCDS12710.1 [Q9UP65-1]
CCDS54286.1 [Q9UP65-2]
CCDS59403.1 [Q9UP65-3]
PIRiT13162
RefSeqiNP_001152794.1, NM_001159322.1 [Q9UP65-3]
NP_001152795.1, NM_001159323.1 [Q9UP65-2]
NP_003697.2, NM_003706.2 [Q9UP65-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114165, 11 interactors
IntActiQ9UP65, 1 interactor
STRINGi9606.ENSP00000472546

Chemistry databases

BindingDBiQ9UP65
ChEMBLiCHEMBL4834
SwissLipidsiSLP:000000888
SLP:000001081 [Q9UP65-1]

PTM databases

iPTMnetiQ9UP65
PhosphoSitePlusiQ9UP65
SwissPalmiQ9UP65

Genetic variation databases

BioMutaiPLA2G4C
DMDMi322510066

Proteomic databases

jPOSTiQ9UP65
MassIVEiQ9UP65
PaxDbiQ9UP65
PeptideAtlasiQ9UP65
PRIDEiQ9UP65
ProteomicsDBi85355 [Q9UP65-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31649, 112 antibodies

Genome annotation databases

EnsembliENST00000354276; ENSP00000346228; ENSG00000105499 [Q9UP65-2]
ENST00000599111; ENSP00000472546; ENSG00000105499 [Q9UP65-3]
ENST00000599921; ENSP00000469473; ENSG00000105499 [Q9UP65-1]
GeneIDi8605
KEGGihsa:8605
UCSCiuc002phx.4, human [Q9UP65-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8605
DisGeNETi8605

GeneCards: human genes, protein and diseases

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GeneCardsi
PLA2G4C
HGNCiHGNC:9037, PLA2G4C
HPAiENSG00000105499, Tissue enhanced (brain, skeletal muscle)
MIMi603602, gene
neXtProtiNX_Q9UP65
OpenTargetsiENSG00000105499
PharmGKBiPA33365
VEuPathDBiHostDB:ENSG00000105499.13

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1325, Eukaryota
GeneTreeiENSGT01000000214502
HOGENOMiCLU_011663_2_0_1
InParanoidiQ9UP65
OMAiLFNIDAC
OrthoDBi302848at2759
PhylomeDBiQ9UP65
TreeFamiTF325228

Enzyme and pathway databases

PathwayCommonsiQ9UP65
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1483115, Hydrolysis of LPC
R-HSA-1483152, Hydrolysis of LPE

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8605, 5 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLA2G4C, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PLA2G4C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8605
PharosiQ9UP65, Tchem

Protein Ontology

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PROi
PR:Q9UP65
RNActiQ9UP65, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105499, Expressed in corpus callosum and 226 other tissues
ExpressionAtlasiQ9UP65, baseline and differential
GenevisibleiQ9UP65, HS

Family and domain databases

InterProiView protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR002642, LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735, PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022, PLAc, 1 hit
SUPFAMiSSF52151, SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210, PLA2C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UP65
Secondary accession number(s): B2RB71
, B4DI40, O75457, Q6IBI8, Q9UG68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 8, 2011
Last modified: April 7, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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