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Protein

Leydig cell tumor 10 kDa protein homolog

Gene

C19orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a potential role in hypercalcemia of malignancy.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leydig cell tumor 10 kDa protein homolog
Gene namesi
ORF Names:HSPC023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104979.8
HGNCiHGNC:24991 C19orf53
neXtProtiNX_Q9UNZ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104979
PharmGKBiPA147358407

Polymorphism and mutation databases

BioMutaiC19orf53
DMDMi17369716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843431 – 99Leydig cell tumor 10 kDa protein homologAdd BLAST99

Proteomic databases

EPDiQ9UNZ5
MaxQBiQ9UNZ5
PaxDbiQ9UNZ5
PeptideAtlasiQ9UNZ5
PRIDEiQ9UNZ5
ProteomicsDBi85350
TopDownProteomicsiQ9UNZ5

PTM databases

iPTMnetiQ9UNZ5
PhosphoSitePlusiQ9UNZ5

Expressioni

Gene expression databases

BgeeiENSG00000104979 Expressed in 227 organ(s), highest expression level in left adrenal gland
CleanExiHS_C19orf53
ExpressionAtlasiQ9UNZ5 baseline and differential
GenevisibleiQ9UNZ5 HS

Organism-specific databases

HPAiHPA059928
HPA061291

Interactioni

Protein-protein interaction databases

BioGridi118798, 4 interactors
DIPiDIP-61980N
IntActiQ9UNZ5, 4 interactors
STRINGi9606.ENSP00000465432

Structurei

3D structure databases

ProteinModelPortaliQ9UNZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0390 family.Curated

Phylogenomic databases

eggNOGiENOG410J3AY Eukaryota
ENOG4112C7F LUCA
GeneTreeiENSGT00390000011740
HOGENOMiHOG000059528
HOVERGENiHBG006239
InParanoidiQ9UNZ5
OMAiFQARKPG
OrthoDBiEOG091G18TZ
PhylomeDBiQ9UNZ5

Family and domain databases

InterProiView protein in InterPro
IPR019034 UPF0390
PfamiView protein in Pfam
PF09495 DUF2462, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UNZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK
60 70 80 90
KNLEVGIRKK IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPS
Length:99
Mass (Da):10,577
Last modified:May 1, 2000 - v1
Checksum:iA5FDF26764BED659
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESE5K7ESE5_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
56Annotation score:
A0A0A0MQS3A0A0A0MQS3_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
80Annotation score:
K7EN09K7EN09_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
49Annotation score:
K7EIU1K7EIU1_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
31Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05378339K → R. Corresponds to variant dbSNP:rs10104Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA Translation: AAD44484.1
AK311855 mRNA Translation: BAG34796.1
CH471106 Genomic DNA Translation: EAW84372.1
BC015465 mRNA Translation: AAH15465.1
CCDSiCCDS12298.1
RefSeqiNP_054766.1, NM_014047.2
UniGeneiHs.231616

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979
GeneIDi28974
KEGGihsa:28974
UCSCiuc002mxg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA Translation: AAD44484.1
AK311855 mRNA Translation: BAG34796.1
CH471106 Genomic DNA Translation: EAW84372.1
BC015465 mRNA Translation: AAH15465.1
CCDSiCCDS12298.1
RefSeqiNP_054766.1, NM_014047.2
UniGeneiHs.231616

3D structure databases

ProteinModelPortaliQ9UNZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118798, 4 interactors
DIPiDIP-61980N
IntActiQ9UNZ5, 4 interactors
STRINGi9606.ENSP00000465432

PTM databases

iPTMnetiQ9UNZ5
PhosphoSitePlusiQ9UNZ5

Polymorphism and mutation databases

BioMutaiC19orf53
DMDMi17369716

Proteomic databases

EPDiQ9UNZ5
MaxQBiQ9UNZ5
PaxDbiQ9UNZ5
PeptideAtlasiQ9UNZ5
PRIDEiQ9UNZ5
ProteomicsDBi85350
TopDownProteomicsiQ9UNZ5

Protocols and materials databases

DNASUi28974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979
GeneIDi28974
KEGGihsa:28974
UCSCiuc002mxg.4 human

Organism-specific databases

CTDi28974
EuPathDBiHostDB:ENSG00000104979.8
GeneCardsiC19orf53
HGNCiHGNC:24991 C19orf53
HPAiHPA059928
HPA061291
neXtProtiNX_Q9UNZ5
OpenTargetsiENSG00000104979
PharmGKBiPA147358407
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3AY Eukaryota
ENOG4112C7F LUCA
GeneTreeiENSGT00390000011740
HOGENOMiHOG000059528
HOVERGENiHBG006239
InParanoidiQ9UNZ5
OMAiFQARKPG
OrthoDBiEOG091G18TZ
PhylomeDBiQ9UNZ5

Miscellaneous databases

ChiTaRSiC19orf53 human
GenomeRNAii28974
PROiPR:Q9UNZ5

Gene expression databases

BgeeiENSG00000104979 Expressed in 227 organ(s), highest expression level in left adrenal gland
CleanExiHS_C19orf53
ExpressionAtlasiQ9UNZ5 baseline and differential
GenevisibleiQ9UNZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR019034 UPF0390
PfamiView protein in Pfam
PF09495 DUF2462, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL10K_HUMAN
AccessioniPrimary (citable) accession number: Q9UNZ5
Secondary accession number(s): B2R4J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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