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Protein

Leydig cell tumor 10 kDa protein homolog

Gene

C19orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a potential role in hypercalcemia of malignancy.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leydig cell tumor 10 kDa protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:HSPC023
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104979.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24991 C19orf53

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNZ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000104979

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147358407

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C19orf53

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843431 – 99Leydig cell tumor 10 kDa protein homologAdd BLAST99

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UNZ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UNZ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UNZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNZ5

PeptideAtlas

More...
PeptideAtlasi
Q9UNZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNZ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85350

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UNZ5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104979 Expressed in 227 organ(s), highest expression level in left adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_C19orf53

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNZ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UNZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059928
HPA061291

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118798, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-61980N

Protein interaction database and analysis system

More...
IntActi
Q9UNZ5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000465432

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UNZ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0390 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J3AY Eukaryota
ENOG4112C7F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059528

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006239

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQARKPG

Database of Orthologous Groups

More...
OrthoDBi
1629358at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNZ5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019034 UPF0390

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09495 DUF2462, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UNZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK
60 70 80 90
KNLEVGIRKK IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPS
Length:99
Mass (Da):10,577
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5FDF26764BED659
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESE5K7ESE5_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQS3A0A0A0MQS3_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN09K7EN09_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIU1K7EIU1_HUMAN
Leydig cell tumor 10 kDa protein ho...
C19orf53
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05378339K → R. Corresponds to variant dbSNP:rs10104Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF078852 mRNA Translation: AAD44484.1
AK311855 mRNA Translation: BAG34796.1
CH471106 Genomic DNA Translation: EAW84372.1
BC015465 mRNA Translation: AAH15465.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12298.1

NCBI Reference Sequences

More...
RefSeqi
NP_054766.1, NM_014047.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.231616

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000588234; ENSP00000465432; ENSG00000104979

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
28974

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28974

UCSC genome browser

More...
UCSCi
uc002mxg.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA Translation: AAD44484.1
AK311855 mRNA Translation: BAG34796.1
CH471106 Genomic DNA Translation: EAW84372.1
BC015465 mRNA Translation: AAH15465.1
CCDSiCCDS12298.1
RefSeqiNP_054766.1, NM_014047.2
UniGeneiHs.231616

3D structure databases

ProteinModelPortaliQ9UNZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118798, 4 interactors
DIPiDIP-61980N
IntActiQ9UNZ5, 4 interactors
STRINGi9606.ENSP00000465432

PTM databases

iPTMnetiQ9UNZ5
PhosphoSitePlusiQ9UNZ5

Polymorphism and mutation databases

BioMutaiC19orf53
DMDMi17369716

Proteomic databases

EPDiQ9UNZ5
jPOSTiQ9UNZ5
MaxQBiQ9UNZ5
PaxDbiQ9UNZ5
PeptideAtlasiQ9UNZ5
PRIDEiQ9UNZ5
ProteomicsDBi85350
TopDownProteomicsiQ9UNZ5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
28974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979
GeneIDi28974
KEGGihsa:28974
UCSCiuc002mxg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28974
EuPathDBiHostDB:ENSG00000104979.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C19orf53
HGNCiHGNC:24991 C19orf53
HPAiHPA059928
HPA061291
neXtProtiNX_Q9UNZ5
OpenTargetsiENSG00000104979
PharmGKBiPA147358407

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J3AY Eukaryota
ENOG4112C7F LUCA
GeneTreeiENSGT00390000011740
HOGENOMiHOG000059528
HOVERGENiHBG006239
InParanoidiQ9UNZ5
OMAiFQARKPG
OrthoDBi1629358at2759
PhylomeDBiQ9UNZ5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C19orf53 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
28974

Protein Ontology

More...
PROi
PR:Q9UNZ5

Gene expression databases

BgeeiENSG00000104979 Expressed in 227 organ(s), highest expression level in left adrenal gland
CleanExiHS_C19orf53
ExpressionAtlasiQ9UNZ5 baseline and differential
GenevisibleiQ9UNZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR019034 UPF0390
PfamiView protein in Pfam
PF09495 DUF2462, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL10K_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNZ5
Secondary accession number(s): B2R4J9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: January 16, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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