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Protein

Zinc finger protein 232

Gene

ZNF232

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 232
Alternative name(s):
Zinc finger and SCAN domain-containing protein 11
Gene namesi
Name:ZNF232
Synonyms:ZSCAN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167840.13
HGNCiHGNC:13026 ZNF232
MIMi616463 gene
neXtProtiNX_Q9UNY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37604

Polymorphism and mutation databases

DMDMi11136137

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474721 – 417Zinc finger protein 232Add BLAST417

Proteomic databases

PaxDbiQ9UNY5
PeptideAtlasiQ9UNY5
PRIDEiQ9UNY5
ProteomicsDBi85344
85345 [Q9UNY5-2]

PTM databases

iPTMnetiQ9UNY5
PhosphoSitePlusiQ9UNY5

Expressioni

Tissue specificityi

Ubiquitous. Higher expression seen in the liver, testis and ovary.

Gene expression databases

BgeeiENSG00000167840 Expressed in 207 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF232
ExpressionAtlasiQ9UNY5 baseline and differential
GenevisibleiQ9UNY5 HS

Organism-specific databases

HPAiHPA027309
HPA028611

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113557, 48 interactors
IntActiQ9UNY5, 7 interactors
STRINGi9606.ENSP00000250076

Structurei

3D structure databases

ProteinModelPortaliQ9UNY5
SMRiQ9UNY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Met4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9UNY5
KOiK09230
OrthoDBiEOG091G09O3
PhylomeDBiQ9UNY5
TreeFamiTF338304

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q9UNY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSLTAAET LALQGTQGQE KMMMMGPKEE EQSCEYETRL PGNHSTSQEI
60 70 80 90 100
FRQRFRHLRY QETPGPREAL SQLRVLCCEW LRPEKHTKEQ ILEFLVLEQF
110 120 130 140 150
LTILPEELQS WVRGHHPKSG EEAVTVLEDL EKGLEPEPQV PGPAHGPAQE
160 170 180 190 200
EPWEKKESLG AAQEALSIQL QPKETQPFPK SEQVYLHFLS VVTEDGPEPK
210 220 230 240 250
DKGSLPQPPI TEVESQVFSE KLATDTSTFE ATSEGTLELQ QRNPKAERLR
260 270 280 290 300
WSPAQEESFR QMVVIHKEIP TGKKDHECSE CGKTFIYNSH LVVHQRVHSG
310 320 330 340 350
EKPYKCSDCG KTFKQSSNLG QHQRIHTGEK PFECNECGKA FRWGAHLVQH
360 370 380 390 400
QRIHSGEKPY ECNECGKAFS QSSYLSQHRR IHSGEKPFIC KECGKAYGWC
410
SELIRHRRVH ARKEPSH
Length:417
Mass (Da):47,688
Last modified:May 1, 2000 - v1
Checksum:i6FF80EFAB3AF8AE9
GO
Isoform Short (identifier: Q9UNY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-190: Missing.

Show »
Length:408
Mass (Da):46,570
Checksum:iC2AA3346A3A9B375
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4J6I3L4J6_HUMAN
Zinc finger protein 232
ZNF232
435Annotation score:
I3L4H6I3L4H6_HUMAN
Zinc finger protein 232
ZNF232
50Annotation score:

Sequence cautioni

The sequence AAH16039 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035573123A → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006906182 – 190Missing in isoform Short. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080171, AF080170 Genomic DNA Translation: AAD46135.1
Y15067 mRNA Translation: CAB95963.1
AC012146 Genomic DNA No translation available.
BC016039 mRNA Translation: AAH16039.2 Different initiation.
RefSeqiNP_001307882.1, NM_001320953.1 [Q9UNY5-1]
NP_001307883.1, NM_001320954.1 [Q9UNY5-1]
NP_055334.2, NM_014519.3
XP_016880510.1, XM_017025021.1
UniGeneiHs.279914

Genome annotation databases

EnsembliENST00000250076; ENSP00000250076; ENSG00000167840
GeneIDi7775
KEGGihsa:7775
UCSCiuc002gat.4 human [Q9UNY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080171, AF080170 Genomic DNA Translation: AAD46135.1
Y15067 mRNA Translation: CAB95963.1
AC012146 Genomic DNA No translation available.
BC016039 mRNA Translation: AAH16039.2 Different initiation.
RefSeqiNP_001307882.1, NM_001320953.1 [Q9UNY5-1]
NP_001307883.1, NM_001320954.1 [Q9UNY5-1]
NP_055334.2, NM_014519.3
XP_016880510.1, XM_017025021.1
UniGeneiHs.279914

3D structure databases

ProteinModelPortaliQ9UNY5
SMRiQ9UNY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113557, 48 interactors
IntActiQ9UNY5, 7 interactors
STRINGi9606.ENSP00000250076

PTM databases

iPTMnetiQ9UNY5
PhosphoSitePlusiQ9UNY5

Polymorphism and mutation databases

DMDMi11136137

Proteomic databases

PaxDbiQ9UNY5
PeptideAtlasiQ9UNY5
PRIDEiQ9UNY5
ProteomicsDBi85344
85345 [Q9UNY5-2]

Protocols and materials databases

DNASUi7775
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250076; ENSP00000250076; ENSG00000167840
GeneIDi7775
KEGGihsa:7775
UCSCiuc002gat.4 human [Q9UNY5-1]

Organism-specific databases

CTDi7775
EuPathDBiHostDB:ENSG00000167840.13
GeneCardsiZNF232
HGNCiHGNC:13026 ZNF232
HPAiHPA027309
HPA028611
MIMi616463 gene
neXtProtiNX_Q9UNY5
PharmGKBiPA37604
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9UNY5
KOiK09230
OrthoDBiEOG091G09O3
PhylomeDBiQ9UNY5
TreeFamiTF338304

Miscellaneous databases

ChiTaRSiZNF232 human
GenomeRNAii7775
PROiPR:Q9UNY5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167840 Expressed in 207 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF232
ExpressionAtlasiQ9UNY5 baseline and differential
GenevisibleiQ9UNY5 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN232_HUMAN
AccessioniPrimary (citable) accession number: Q9UNY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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