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Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

KCNJ14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296053 Classical Kir channels
R-HSA-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:KCNJ14
Synonyms:IRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182324.6
HGNCiHGNC:6260 KCNJ14
MIMi603953 gene
neXtProtiNX_Q9UNX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicBy similarityAdd BLAST86
Transmembranei87 – 111Helical; Name=M1By similarityAdd BLAST25
Topological domaini112 – 133ExtracellularBy similarityAdd BLAST22
Intramembranei134 – 145Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei146 – 152Pore-formingBy similarity7
Topological domaini153 – 161ExtracellularBy similarity9
Transmembranei162 – 183Helical; Name=M2By similarityAdd BLAST22
Topological domaini184 – 436CytoplasmicBy similarityAdd BLAST253

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3770
OpenTargetsiENSG00000182324
PharmGKBiPA30045

Chemistry databases

DrugBankiDB01392 Yohimbine
GuidetoPHARMACOLOGYi433

Polymorphism and mutation databases

DMDMi54036159

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549681 – 436ATP-sensitive inward rectifier potassium channel 14Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiQ9UNX9
PeptideAtlasiQ9UNX9
PRIDEiQ9UNX9
ProteomicsDBi85341
TopDownProteomicsiQ9UNX9

Expressioni

Tissue specificityi

Expressed preferentially in retina.1 Publication

Gene expression databases

BgeeiENSG00000182324 Expressed in 81 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_KCNJ14
GenevisibleiQ9UNX9 HS

Organism-specific databases

HPAiHPA071765

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341479

Structurei

3D structure databases

ProteinModelPortaliQ9UNX9
SMRiQ9UNX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 152Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiQ9UNX9
KOiK05007
OMAiWLIASAH
OrthoDBiEOG091G08HC
PhylomeDBiQ9UNX9
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UNX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG
60 70 80 90 100
RFVKKDGHCN VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS
110 120 130 140 150
WLLFGLAFWL IASLHGDLAA PPPPAPCFSH VASFLAAFLF ALETQTSIGY
160 170 180 190 200
GVRSVTEECP AAVAAVVLQC IAGCVLDAFV VGAVMAKMAK PKKRNETLVF
210 220 230 240 250
SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR VTPEGEYIPL
260 270 280 290 300
DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV
310 320 330 340 350
VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH
360 370 380 390 400
RTYEVPGTPV CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ
410 420 430
EEDEDDETEE GNGVETEDGA ASPRVLTPTL ALTLPP
Length:436
Mass (Da):47,846
Last modified:May 1, 2000 - v1
Checksum:i9442E664007D1B7C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034019289R → C. Corresponds to variant dbSNP:rs3745725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081466 mRNA Translation: AAD51376.1
AF181988 Genomic DNA Translation: AAF97619.1
BC035918 mRNA Translation: AAH35918.1
CCDSiCCDS12721.1
RefSeqiNP_037480.1, NM_013348.3
UniGeneiHs.144011
Hs.745133

Genome annotation databases

EnsembliENST00000342291; ENSP00000341479; ENSG00000182324
ENST00000391884; ENSP00000375756; ENSG00000182324
GeneIDi3770
KEGGihsa:3770
UCSCiuc002pje.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCJ14_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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