UniProtKB - Q9UNX4 (WDR3_HUMAN)
Protein
WD repeat-containing protein 3
Gene
WDR3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: Reactome
Enzyme and pathway databases
Reactomei | R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q9UNX4 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 3 |
Gene namesi | Name:WDR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000065183.15 |
HGNCi | HGNC:12755 WDR3 |
MIMi | 604737 gene |
neXtProti | NX_Q9UNX4 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nuclear membrane Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: HPA
- Pwp2p-containing subcomplex of 90S preribosome Source: GO_Central
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10885 |
OpenTargetsi | ENSG00000065183 |
PharmGKBi | PA37359 |
Polymorphism and mutation databases
BioMutai | WDR3 |
DMDMi | 12230773 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051347 | 1 – 943 | WD repeat-containing protein 3Add BLAST | 943 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 240 | PhosphoserineCombined sources | 1 | |
Modified residuei | 241 | PhosphoserineCombined sources | 1 | |
Modified residuei | 257 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 474 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 529 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 726 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UNX4 |
jPOSTi | Q9UNX4 |
MaxQBi | Q9UNX4 |
PaxDbi | Q9UNX4 |
PeptideAtlasi | Q9UNX4 |
PRIDEi | Q9UNX4 |
ProteomicsDBi | 85340 |
2D gel databases
SWISS-2DPAGEi | Q9UNX4 |
PTM databases
iPTMneti | Q9UNX4 |
PhosphoSitePlusi | Q9UNX4 |
SwissPalmi | Q9UNX4 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000065183 Expressed in 219 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q9UNX4 baseline and differential |
Genevisiblei | Q9UNX4 HS |
Organism-specific databases
HPAi | HPA027509 HPA054354 |
Interactioni
Protein-protein interaction databases
BioGridi | 116092, 43 interactors |
IntActi | Q9UNX4, 16 interactors |
MINTi | Q9UNX4 |
STRINGi | 9606.ENSP00000308179 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 21 – 60 | WD 1Add BLAST | 40 | |
Repeati | 63 – 102 | WD 2Add BLAST | 40 | |
Repeati | 105 – 144 | WD 3Add BLAST | 40 | |
Repeati | 147 – 186 | WD 4Add BLAST | 40 | |
Repeati | 189 – 228 | WD 5Add BLAST | 40 | |
Repeati | 277 – 316 | WD 6Add BLAST | 40 | |
Repeati | 413 – 451 | WD 7Add BLAST | 39 | |
Repeati | 453 – 493 | WD 8Add BLAST | 41 | |
Repeati | 494 – 533 | WD 9Add BLAST | 40 | |
Repeati | 547 – 586 | WD 10Add BLAST | 40 | |
Repeati | 589 – 630 | WD 11Add BLAST | 42 | |
Repeati | 631 – 670 | WD 12Add BLAST | 40 | |
Repeati | 673 – 712 | WD 13Add BLAST | 40 |
Sequence similaritiesi
Belongs to the WD repeat WDR3/UTP12 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0306 Eukaryota ENOG410XR1C LUCA |
GeneTreei | ENSGT00940000153859 |
HOGENOMi | HOG000212524 |
HOVERGENi | HBG013192 |
InParanoidi | Q9UNX4 |
KOi | K14556 |
OMAi | TQIKFWN |
OrthoDBi | 459903at2759 |
PhylomeDBi | Q9UNX4 |
TreeFami | TF300427 |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR024977 Apc4_WD40_dom IPR020472 G-protein_beta_WD-40_rep IPR007148 SSU_processome_Utp12 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12894 ANAPC4_WD40, 1 hit PF04003 Utp12, 1 hit PF00400 WD40, 7 hits |
PRINTSi | PR00320 GPROTEINBRPT |
SMARTi | View protein in SMART SM00320 WD40, 11 hits |
SUPFAMi | SSF50978 SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 9 hits PS50294 WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UNX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW
60 70 80 90 100
DLRKGEKILI LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN
110 120 130 140 150
VTFNGHKAAI TTLKYDQLGG RLASGSKDTD IIVWDVINES GLYRLKGHKD
160 170 180 190 200
AITQALFLRE KNLLVTSGKD TMVKWWDLDT QHCFKTMVGH RTEVWGLVLL
210 220 230 240 250
SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS SPGIQDTLEA
260 270 280 290 300
EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD
310 320 330 340 350
SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ
360 370 380 390 400
DEIQRVTNIK TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT
410 420 430 440 450
PQPVRTSRIT IGGHRSDVRT LSFSSDNIAV LSAAADSIKI WNRSTLQCIR
460 470 480 490 500
TMTCEYALCS FFVPGDRQVV IGTKTGKLQL YDLASGNLLE TIDAHDGALW
510 520 530 540 550
SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV KQTRTLQLDE
560 570 580 590 600
DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
610 620 630 640 650
HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT
660 670 680 690 700
AGKDHKIKQW DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR
710 720 730 740 750
LWERTREPLI LEEEREMERE AEYEESVAKE DQPAVPGETQ GDSYFTGKKT
760 770 780 790 800
IETVKAAERI MEAIELYREE TAKMKEHKAI CKAAGKEVPL PSNPILMAYG
810 820 830 840 850
SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN EFIQLGSDVE
860 870 880 890 900
LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA
910 920 930 940
GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6PDA5 | Q6PDA5_HUMAN | WD repeat-containing protein 3 | WDR3 | 40 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033809 | 234 | P → A. Corresponds to variant dbSNP:rs3738420Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083217 mRNA Translation: AAD45865.1 |
CCDSi | CCDS898.1 |
RefSeqi | NP_006775.1, NM_006784.2 |
UniGenei | Hs.310809 |
Genome annotation databases
Ensembli | ENST00000349139; ENSP00000308179; ENSG00000065183 |
GeneIDi | 10885 |
KEGGi | hsa:10885 |
UCSCi | uc010oxe.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083217 mRNA Translation: AAD45865.1 |
CCDSi | CCDS898.1 |
RefSeqi | NP_006775.1, NM_006784.2 |
UniGenei | Hs.310809 |
3D structure databases
ProteinModelPortali | Q9UNX4 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 116092, 43 interactors |
IntActi | Q9UNX4, 16 interactors |
MINTi | Q9UNX4 |
STRINGi | 9606.ENSP00000308179 |
PTM databases
iPTMneti | Q9UNX4 |
PhosphoSitePlusi | Q9UNX4 |
SwissPalmi | Q9UNX4 |
Polymorphism and mutation databases
BioMutai | WDR3 |
DMDMi | 12230773 |
2D gel databases
SWISS-2DPAGEi | Q9UNX4 |
Proteomic databases
EPDi | Q9UNX4 |
jPOSTi | Q9UNX4 |
MaxQBi | Q9UNX4 |
PaxDbi | Q9UNX4 |
PeptideAtlasi | Q9UNX4 |
PRIDEi | Q9UNX4 |
ProteomicsDBi | 85340 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000349139; ENSP00000308179; ENSG00000065183 |
GeneIDi | 10885 |
KEGGi | hsa:10885 |
UCSCi | uc010oxe.2 human |
Organism-specific databases
CTDi | 10885 |
DisGeNETi | 10885 |
EuPathDBi | HostDB:ENSG00000065183.15 |
GeneCardsi | WDR3 |
HGNCi | HGNC:12755 WDR3 |
HPAi | HPA027509 HPA054354 |
MIMi | 604737 gene |
neXtProti | NX_Q9UNX4 |
OpenTargetsi | ENSG00000065183 |
PharmGKBi | PA37359 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0306 Eukaryota ENOG410XR1C LUCA |
GeneTreei | ENSGT00940000153859 |
HOGENOMi | HOG000212524 |
HOVERGENi | HBG013192 |
InParanoidi | Q9UNX4 |
KOi | K14556 |
OMAi | TQIKFWN |
OrthoDBi | 459903at2759 |
PhylomeDBi | Q9UNX4 |
TreeFami | TF300427 |
Enzyme and pathway databases
Reactomei | R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol |
SignaLinki | Q9UNX4 |
Miscellaneous databases
ChiTaRSi | WDR3 human |
GeneWikii | WDR3 |
GenomeRNAii | 10885 |
PROi | PR:Q9UNX4 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065183 Expressed in 219 organ(s), highest expression level in female gonad |
ExpressionAtlasi | Q9UNX4 baseline and differential |
Genevisiblei | Q9UNX4 HS |
Family and domain databases
Gene3Di | 2.130.10.10, 4 hits |
InterProi | View protein in InterPro IPR024977 Apc4_WD40_dom IPR020472 G-protein_beta_WD-40_rep IPR007148 SSU_processome_Utp12 IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12894 ANAPC4_WD40, 1 hit PF04003 Utp12, 1 hit PF00400 WD40, 7 hits |
PRINTSi | PR00320 GPROTEINBRPT |
SMARTi | View protein in SMART SM00320 WD40, 11 hits |
SUPFAMi | SSF50978 SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678 WD_REPEATS_1, 2 hits PS50082 WD_REPEATS_2, 9 hits PS50294 WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | WDR3_HUMAN | |
Accessioni | Q9UNX4Primary (citable) accession number: Q9UNX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 13, 2019 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations