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Protein

RNA-binding protein Nova-2

Gene

NOVA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-2
Alternative name(s):
Astrocytic NOVA1-like RNA-binding protein
Neuro-oncological ventral antigen 2
Gene namesi
Name:NOVA2
Synonyms:ANOVA, NOVA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104967.6
HGNCiHGNC:7887 NOVA2
MIMi601991 gene
neXtProtiNX_Q9UNW9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4858
OpenTargetsiENSG00000104967
PharmGKBiPA31689

Polymorphism and mutation databases

BioMutaiNOVA2
DMDMi33516944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501191 – 492RNA-binding protein Nova-2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UNW9
MaxQBiQ9UNW9
PaxDbiQ9UNW9
PeptideAtlasiQ9UNW9
PRIDEiQ9UNW9
ProteomicsDBi85338

PTM databases

iPTMnetiQ9UNW9
PhosphoSitePlusiQ9UNW9

Expressioni

Tissue specificityi

Brain. Expression restricted to astrocytes.

Gene expression databases

BgeeiENSG00000104967
CleanExiHS_NOVA2
ExpressionAtlasiQ9UNW9 baseline and differential
GenevisibleiQ9UNW9 HS

Organism-specific databases

HPAiHPA045607

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi110920, 3 interactors
IntActiQ9UNW9, 2 interactors
MINTiQ9UNW9
STRINGi9606.ENSP00000263257

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi407 – 414Combined sources8
Turni415 – 417Combined sources3
Helixi418 – 422Combined sources5
Helixi424 – 426Combined sources3
Helixi427 – 436Combined sources10
Beta strandi439 – 442Combined sources4
Beta strandi454 – 462Combined sources9
Helixi463 – 476Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DTJX-ray2.00A/B/C/D406-480[»]
1EC6X-ray2.40A/B406-491[»]
ProteinModelPortaliQ9UNW9
SMRiQ9UNW9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNW9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99KH 1PROSITE-ProRule annotationAdd BLAST68
Domaini130 – 196KH 2PROSITE-ProRule annotationAdd BLAST67
Domaini406 – 473KH 3PROSITE-ProRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 26Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 405Ala-richAdd BLAST174
Compositional biasi332 – 393Gly-richAdd BLAST62

Domaini

The third KH domain (KH3) recognizes specifically 5'-UCAY-3'.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191 Eukaryota
ENOG410XRZD LUCA
GeneTreeiENSGT00760000119144
HOGENOMiHOG000007833
HOVERGENiHBG082048
InParanoidiQ9UNW9
KOiK14944
OMAiCTKRSNT
OrthoDBiEOG091G185U
PhylomeDBiQ9UNW9
TreeFamiTF316981

Family and domain databases

Gene3Di3.30.1370.10, 3 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR033087 Nova-2
PANTHERiPTHR10288:SF162 PTHR10288:SF162, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 3 hits
SMARTiView protein in SMART
SM00322 KH, 3 hits
SUPFAMiSSF54791 SSF54791, 3 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q9UNW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEAPDSRK RPLETPPEVV CTKRSNTGEE GEYFLKVLIP SYAAGSIIGK
60 70 80 90 100
GGQTIVQLQK ETGATIKLSK SKDFYPGTTE RVCLVQGTAE ALNAVHSFIA
110 120 130 140 150
EKVREIPQAM TKPEVVNILQ PQTTMNPDRA KQAKLIVPNS TAGLIIGKGG
160 170 180 190 200
ATVKAVMEQS GAWVQLSQKP EGINLQERVV TVSGEPEQVH KAVSAIVQKV
210 220 230 240 250
QEDPQSSSCL NISYANVAGP VANSNPTGSP YASPADVLPA AAAASAAAAS
260 270 280 290 300
GLLGPAGLAG VGAFPAALPA FSGTDLLAIS TALNTLASYG YNTNSLGLGL
310 320 330 340 350
NSAAASGVLA AVAAGANPAA AAAANLLASY AGEAGAGPAG GAAPPPPPPP
360 370 380 390 400
GALGSFALAA AANGYLGAGA GGGAGGGGGP LVAAAAAAGA AGGFLTAEKL
410 420 430 440 450
AAESAKELVE IAVPENLVGA ILGKGGKTLV EYQELTGARI QISKKGEFLP
460 470 480 490
GTRNRRVTIT GSPAATQAAQ YLISQRVTYE QGVRASNPQK VG
Length:492
Mass (Da):49,009
Last modified:May 1, 2000 - v1
Checksum:i41B63EAF6899256B
GO

Sequence cautioni

The sequence AAB88661 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247A → R in AAB88661 (PubMed:10735272).Curated1
Sequence conflicti265 – 267PAA → TAT in AAB88661 (PubMed:10735272).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70477 mRNA Translation: AAB88661.1 Different initiation.
AF083898 mRNA Translation: AAC72355.1
AC006540 Genomic DNA Translation: AAD13116.1
CCDSiCCDS12679.1
RefSeqiNP_002507.1, NM_002516.3
UniGeneiHs.375439

Genome annotation databases

EnsembliENST00000263257; ENSP00000263257; ENSG00000104967
GeneIDi4858
KEGGihsa:4858
UCSCiuc002pdv.3 human

Similar proteinsi

Entry informationi

Entry nameiNOVA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UNW9
Secondary accession number(s): O43267, Q9UEA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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