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Protein

COP9 signalosome complex subunit 3

Gene

COPS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

Miscellaneous

Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation
SignaLinkiQ9UNS2
SIGNORiQ9UNS2

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 3
Short name:
SGN3
Short name:
Signalosome subunit 3
Alternative name(s):
JAB1-containing signalosome subunit 3
Gene namesi
Name:COPS3
Synonyms:CSN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141030.12
HGNCiHGNC:2239 COPS3
MIMi604665 gene
neXtProtiNX_Q9UNS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8533
OpenTargetsiENSG00000141030
PharmGKBiPA26755

Polymorphism and mutation databases

BioMutaiCOPS3
DMDMi55976621

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001209782 – 423COP9 signalosome complex subunit 3Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei407PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UNS2
PaxDbiQ9UNS2
PeptideAtlasiQ9UNS2
PRIDEiQ9UNS2
ProteomicsDBi85328

PTM databases

iPTMnetiQ9UNS2
PhosphoSitePlusiQ9UNS2
SwissPalmiQ9UNS2

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000141030 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_COPS3
HS_CSN3
ExpressionAtlasiQ9UNS2 baseline and differential
GenevisibleiQ9UNS2 HS

Organism-specific databases

HPAiHPA021997
HPA050557

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). Interacts with CK2 and PKD (PubMed:12628923). Interacts with the translation initiation factor EIF3S6 and IKBKG (PubMed:11418127, PubMed:12220626).5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114103, 98 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CPX-1871 COP9 signalosome variant 2
CORUMiQ9UNS2
DIPiDIP-32478N
IntActiQ9UNS2, 38 interactors
MINTiQ9UNS2
STRINGi9606.ENSP00000268717

Structurei

3D structure databases

ProteinModelPortaliQ9UNS2
SMRiQ9UNS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 365PCIPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the CSN3 family.Curated

Phylogenomic databases

eggNOGiKOG2582 Eukaryota
ENOG410XRKY LUCA
GeneTreeiENSGT00490000043408
HOGENOMiHOG000030451
HOVERGENiHBG051135
InParanoidiQ9UNS2
KOiK12177
OMAiNHYHDLV
OrthoDBiEOG091G07DK
PhylomeDBiQ9UNS2
TreeFamiTF101146

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037753 CSN3
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10758:SF1 PTHR10758:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD
60 70 80 90 100
VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF
110 120 130 140 150
AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS IHADLCQLCL
160 170 180 190 200
LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER
210 220 230 240 250
ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG
260 270 280 290 300
RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS
310 320 330 340 350
SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS
360 370 380 390 400
INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN
410 420
PQFVQKSMGS QEDDSGNKPS SYS
Length:423
Mass (Da):47,873
Last modified:January 23, 2007 - v3
Checksum:i1D371050C7D7BF8D
GO
Isoform 2 (identifier: Q9UNS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:403
Mass (Da):45,727
Checksum:iC835D56B8A9DFA4A
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3P9H7C3P9_HUMAN
COP9 signalosome complex subunit 3
COPS3
345Annotation score:
C9JLV5C9JLV5_HUMAN
COP9 signalosome complex subunit 3
COPS3
318Annotation score:
J3QKR0J3QKR0_HUMAN
COP9 signalosome complex subunit 3
COPS3
116Annotation score:
J3KTQ1J3KTQ1_HUMAN
COP9 signalosome complex subunit 3
COPS3
107Annotation score:
K7ES36K7ES36_HUMAN
COP9 signalosome complex subunit 3
COPS3
122Annotation score:
K7ELN6K7ELN6_HUMAN
COP9 signalosome complex subunit 3
COPS3
51Annotation score:
J3QS85J3QS85_HUMAN
COP9 signalosome complex subunit 3
COPS3
31Annotation score:
J3QL22J3QL22_HUMAN
COP9 signalosome complex subunit 3
COPS3
20Annotation score:
K7EJF9K7EJF9_HUMAN
COP9 signalosome complex subunit 3
COPS3
17Annotation score:

Sequence cautioni

The sequence AAC14197 differs from that shown. Reason: Frameshift at position 5.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442711 – 20Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031647 mRNA Translation: AAC14197.1 Frameshift.
AF098109 mRNA Translation: AAD41247.1
AK312476 mRNA Translation: BAG35380.1
AK302304 mRNA Translation: BAG63643.1
AK316400 mRNA Translation: BAH14771.1
AC055811 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55712.1
BC001891 mRNA Translation: AAH01891.1
CCDSiCCDS11183.1 [Q9UNS2-1]
CCDS56022.1 [Q9UNS2-2]
RefSeqiNP_001186054.1, NM_001199125.1 [Q9UNS2-2]
NP_001303283.1, NM_001316354.1
NP_001303284.1, NM_001316355.1
NP_001303285.1, NM_001316356.1
NP_001303286.1, NM_001316357.1
NP_001303287.1, NM_001316358.1
NP_003644.2, NM_003653.3 [Q9UNS2-1]
XP_005256894.1, XM_005256837.4 [Q9UNS2-2]
UniGeneiHs.6076

Genome annotation databases

EnsembliENST00000268717; ENSP00000268717; ENSG00000141030 [Q9UNS2-1]
ENST00000539941; ENSP00000437606; ENSG00000141030 [Q9UNS2-2]
GeneIDi8533
KEGGihsa:8533
UCSCiuc002grd.4 human [Q9UNS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031647 mRNA Translation: AAC14197.1 Frameshift.
AF098109 mRNA Translation: AAD41247.1
AK312476 mRNA Translation: BAG35380.1
AK302304 mRNA Translation: BAG63643.1
AK316400 mRNA Translation: BAH14771.1
AC055811 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55712.1
BC001891 mRNA Translation: AAH01891.1
CCDSiCCDS11183.1 [Q9UNS2-1]
CCDS56022.1 [Q9UNS2-2]
RefSeqiNP_001186054.1, NM_001199125.1 [Q9UNS2-2]
NP_001303283.1, NM_001316354.1
NP_001303284.1, NM_001316355.1
NP_001303285.1, NM_001316356.1
NP_001303286.1, NM_001316357.1
NP_001303287.1, NM_001316358.1
NP_003644.2, NM_003653.3 [Q9UNS2-1]
XP_005256894.1, XM_005256837.4 [Q9UNS2-2]
UniGeneiHs.6076

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80C/K1-423[»]
4D18X-ray4.08C/K1-423[»]
4WSNX-ray5.50C/K/S/a/i/q1-423[»]
ProteinModelPortaliQ9UNS2
SMRiQ9UNS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114103, 98 interactors
ComplexPortaliCPX-1870 COP9 signalosome variant 1
CPX-1871 COP9 signalosome variant 2
CORUMiQ9UNS2
DIPiDIP-32478N
IntActiQ9UNS2, 38 interactors
MINTiQ9UNS2
STRINGi9606.ENSP00000268717

PTM databases

iPTMnetiQ9UNS2
PhosphoSitePlusiQ9UNS2
SwissPalmiQ9UNS2

Polymorphism and mutation databases

BioMutaiCOPS3
DMDMi55976621

Proteomic databases

EPDiQ9UNS2
PaxDbiQ9UNS2
PeptideAtlasiQ9UNS2
PRIDEiQ9UNS2
ProteomicsDBi85328

Protocols and materials databases

DNASUi8533
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268717; ENSP00000268717; ENSG00000141030 [Q9UNS2-1]
ENST00000539941; ENSP00000437606; ENSG00000141030 [Q9UNS2-2]
GeneIDi8533
KEGGihsa:8533
UCSCiuc002grd.4 human [Q9UNS2-1]

Organism-specific databases

CTDi8533
DisGeNETi8533
EuPathDBiHostDB:ENSG00000141030.12
GeneCardsiCOPS3
HGNCiHGNC:2239 COPS3
HPAiHPA021997
HPA050557
MIMi604665 gene
neXtProtiNX_Q9UNS2
OpenTargetsiENSG00000141030
PharmGKBiPA26755
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2582 Eukaryota
ENOG410XRKY LUCA
GeneTreeiENSGT00490000043408
HOGENOMiHOG000030451
HOVERGENiHBG051135
InParanoidiQ9UNS2
KOiK12177
OMAiNHYHDLV
OrthoDBiEOG091G07DK
PhylomeDBiQ9UNS2
TreeFamiTF101146

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation
SignaLinkiQ9UNS2
SIGNORiQ9UNS2

Miscellaneous databases

ChiTaRSiCOPS3 human
GeneWikiiCOP9_signalosome_complex_subunit_3
GenomeRNAii8533
PROiPR:Q9UNS2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141030 Expressed in 234 organ(s), highest expression level in testis
CleanExiHS_COPS3
HS_CSN3
ExpressionAtlasiQ9UNS2 baseline and differential
GenevisibleiQ9UNS2 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037753 CSN3
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10758:SF1 PTHR10758:SF1, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN3_HUMAN
AccessioniPrimary (citable) accession number: Q9UNS2
Secondary accession number(s): B2R683
, B4DY81, O43191, Q7LDR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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