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UniProtKB - Q9UNS1 (TIM_HUMAN)

Entry version 176 (25 May 2022)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Protein timeless homolog

Gene

TIMELESS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098).

Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725).

TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725).

Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214).

In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214).

May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197).

Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588).

Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465).

May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity).

By similarity7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processBiological rhythms, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UNS1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5693607, Processing of DNA double-strand break ends

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UNS1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein timeless homolog
Short name:
hTIM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIMELESSImported
Synonyms:TIM1 Publication, TIM11 Publication, TIMELESS11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11813, TIMELESS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603887, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UNS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1081R → G: Abolishes interaction with PARP1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8914

Open Targets

More...OpenTargetsi		ENSG00000111602

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36520

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UNS1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TIMELESS

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452931

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725381 – 1208Protein timeless homologAdd BLAST1208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei281PhosphoserineCombined sources1
Modified residuei1074PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1089PhosphothreonineCombined sources1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1173PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UNS1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UNS1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UNS1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UNS1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UNS1

PeptideAtlas

More...PeptideAtlasi		Q9UNS1

PRoteomics IDEntifications database

More...PRIDEi		Q9UNS1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85326 [Q9UNS1-1]
85327 [Q9UNS1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UNS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UNS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated by the cell cycle. High levels in S, G2 and M phases, with highest level in S phase. Low expression in G0 and G1 phases.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111602, Expressed in ventricular zone and 181 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UNS1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111602, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homomultimer (By similarity).

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins (PubMed:9856465).

Interacts directly with PER2; the interaction with PER2 is via its second PAS domain (By similarity).

Interacts directly with PER1 and PER3 (By similarity).

Interacts with CRY2, CHEK1, ATR and ATRIP (PubMed:15798197).

Interacts with CRY1 (By similarity).

Interacts with CLSPN (PubMed:17141802).

Interacts with TIPIN (PubMed:17102137, PubMed:17116885, PubMed:17296725).

Interacts with DDX11; this interaction increases recruitment of both proteins onto chromatin in response to replication stress induction by hydroxyurea (PubMed:20124417, PubMed:26503245).

Interacts with PARP1; interaction is direct and independent of poly-ADP-ribose (PubMed:26344098, PubMed:30356214).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114428, 111 interactors

Database of interacting proteins

More...DIPi		DIP-47395N

Protein interaction database and analysis system

More...IntActi		Q9UNS1, 29 interactors

Molecular INTeraction database

More...MINTi		Q9UNS1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000450607

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UNS1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UNS1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UNS1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 309Required for homodimerization and for interaction with CRY1 and CHEK1By similarityAdd BLAST309
Regioni655 – 679DisorderedSequence analysisAdd BLAST25
Regioni971 – 994DisorderedSequence analysisAdd BLAST24
Regioni1000 – 1098Interaction with PARP11 PublicationAdd BLAST99
Regioni1082 – 1208Required for nuclear localizationBy similarityAdd BLAST127
Regioni1091 – 1131DisorderedSequence analysisAdd BLAST41
Regioni1143 – 1208DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi664 – 679Acidic residuesSequence analysisAdd BLAST16
Compositional biasi971 – 991Acidic residuesSequence analysisAdd BLAST21
Compositional biasi1092 – 1106Polar residuesSequence analysisAdd BLAST15
Compositional biasi1117 – 1131Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1145 – 1173Basic and acidic residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the timeless family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1974, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01040000240636

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003493_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UNS1

Identification of Orthologs from Complete Genome Data

More...OMAi		QGPEECG

Database of Orthologous Groups

More...OrthoDBi		839367at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UNS1

TreeFam database of animal gene trees

More...TreeFami		TF312802

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044998, Timeless
IPR007725, TIMELESS_C
IPR006906, Timeless_N

The PANTHER Classification System

More...PANTHERi		PTHR22940, PTHR22940, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04821, TIMELESS, 1 hit
PF05029, TIMELESS_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 12 Publications (identifier: Q9UNS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD 
        60         70         80         90        100
VRQQLGAAQI LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL 
       110        120        130        140        150
PKEPSFRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEERQE 
       160        170        180        190        200
EDNLLIERIL LLVRNILHVP ADLDQEKKID DDASAHDQLL WAIHLSGLDD 
       210        220        230        240        250
LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG RLAQERSADF 
       260        270        280        290        300
AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG 
       310        320        330        340        350
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL 
       360        370        380        390        400
ENCYNRLMGS VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS 
       410        420        430        440        450
ETLSVRTFHF IEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV 
       460        470        480        490        500
NEMDISPDEA VRESSRIIKN NIFYVMEYRE LFLALFRKFD ERCQPRSFLR 
       510        520        530        540        550
DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL DQAIVSGNVP 
       560        570        580        590        600
SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM 
       610        620        630        640        650
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL 
       660        670        680        690        700
SAPLPRQQGP EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC 
       710        720        730        740        750
STVVRAYVLL LRSYQQNSAH TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL 
       760        770        780        790        800
FNRLLSDPAA GAYKELVTFA KYILGKFFAL AAVNQKAFVE LLFWKNTAVV 
       810        820        830        840        850
REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV EGQDVVEAIL 
       860        870        880        890        900
AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL 
       910        920        930        940        950
FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK 
       960        970        980        990       1000
LASSILPNGA ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV 
      1010       1020       1030       1040       1050
LSNENLGQSL HQEGFSIPLL WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE 
      1060       1070       1080       1090       1100
NEEAMENEQF QQLLRKLGVR PPASGQETFW RIPAKLSPTQ LRRAAASLSQ 
      1110       1120       1130       1140       1150
PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA HKKKAGLASP 
      1160       1170       1180       1190       1200
EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY 

QIEDDEDD
Length:1,208
Mass (Da):138,658
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16C6C07DDC6D2701
GO
Isoform 21 Publication (identifier: Q9UNS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: Missing.

Show »
Length:1,207
Mass (Da):138,530
Checksum:iC116D7FF6F29B326
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39842 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047879129A → S1 PublicationCorresponds to variant dbSNP:rs72478986EnsemblClinVar.1
Natural variantiVAR_036435429A → D in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_021483455I → L3 PublicationsCorresponds to variant dbSNP:rs774027Ensembl.1
Natural variantiVAR_047880471N → S1 PublicationCorresponds to variant dbSNP:rs72478993Ensembl.1
Natural variantiVAR_021484831R → Q3 PublicationsCorresponds to variant dbSNP:rs774047Ensembl.1
Natural variantiVAR_047881870M → V1 PublicationCorresponds to variant dbSNP:rs61733875Ensembl.1
Natural variantiVAR_047882922R → H1 PublicationCorresponds to variant dbSNP:rs72478999Ensembl.1
Natural variantiVAR_047883924R → W1 PublicationCorresponds to variant dbSNP:rs72479000Ensembl.1
Natural variantiVAR_0364361008Q → E in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs151188513Ensembl.1
Natural variantiVAR_0478841017I → T1 PublicationCorresponds to variant dbSNP:rs61376834Ensembl.1
Natural variantiVAR_0214851018P → L2 PublicationsCorresponds to variant dbSNP:rs2291739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051693177Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB015597 mRNA Translation: BAA36499.1
AF098162 mRNA Translation: AAC80011.1
EU627094 Genomic DNA Translation: ACD11488.1
AC024884 Genomic DNA No translation available.
BC039842 mRNA Translation: AAH39842.1 Sequence problems.
BC050557 mRNA Translation: AAH50557.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS81699.1 [Q9UNS1-2]
CCDS8918.1 [Q9UNS1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001317224.1, NM_001330295.1 [Q9UNS1-2]
NP_003911.2, NM_003920.4 [Q9UNS1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229201.4; ENSP00000229201.4; ENSG00000111602.12 [Q9UNS1-2]
ENST00000553532.6; ENSP00000450607.1; ENSG00000111602.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8914

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000553532.6; ENSP00000450607.1; NM_003920.5; NP_003911.2

UCSC genome browser

More...UCSCi		uc001slf.3, human [Q9UNS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015597 mRNA Translation: BAA36499.1
AF098162 mRNA Translation: AAC80011.1
EU627094 Genomic DNA Translation: ACD11488.1
AC024884 Genomic DNA No translation available.
BC039842 mRNA Translation: AAH39842.1 Sequence problems.
BC050557 mRNA Translation: AAH50557.1
CCDSiCCDS81699.1 [Q9UNS1-2]
CCDS8918.1 [Q9UNS1-1]
RefSeqiNP_001317224.1, NM_001330295.1 [Q9UNS1-2]
NP_003911.2, NM_003920.4 [Q9UNS1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XHTX-ray1.65A/B/C/D1000-1098[»]
4XHUX-ray2.09B/D1000-1098[»]
4XHWX-ray2.85A/B/C/D1000-1098[»]
5MQIX-ray1.85A1-238[»]
A331-463[»]
6T9QX-ray1.15A883-947[»]
6TAZNMR-B816-954[»]
7PFOelectron microscopy3.20K1-1208[»]
7PLOelectron microscopy2.80K1-1208[»]
AlphaFoldDBiQ9UNS1
SMRiQ9UNS1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114428, 111 interactors
DIPiDIP-47395N
IntActiQ9UNS1, 29 interactors
MINTiQ9UNS1
STRINGi9606.ENSP00000450607

PTM databases

iPTMnetiQ9UNS1
PhosphoSitePlusiQ9UNS1

Genetic variation databases

BioMutaiTIMELESS
DMDMi296452931

Proteomic databases

EPDiQ9UNS1
jPOSTiQ9UNS1
MassIVEiQ9UNS1
MaxQBiQ9UNS1
PaxDbiQ9UNS1
PeptideAtlasiQ9UNS1
PRIDEiQ9UNS1
ProteomicsDBi85326 [Q9UNS1-1]
85327 [Q9UNS1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15850, 204 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		8914

Genome annotation databases

EnsembliENST00000229201.4; ENSP00000229201.4; ENSG00000111602.12 [Q9UNS1-2]
ENST00000553532.6; ENSP00000450607.1; ENSG00000111602.12
GeneIDi8914
KEGGihsa:8914
MANE-SelectiENST00000553532.6; ENSP00000450607.1; NM_003920.5; NP_003911.2
UCSCiuc001slf.3, human [Q9UNS1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8914
DisGeNETi8914

GeneCards: human genes, protein and diseases

More...GeneCardsi		TIMELESS
HGNCiHGNC:11813, TIMELESS
HPAiENSG00000111602, Low tissue specificity
MIMi603887, gene
neXtProtiNX_Q9UNS1
OpenTargetsiENSG00000111602
PharmGKBiPA36520
VEuPathDBiHostDB:ENSG00000111602

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1974, Eukaryota
GeneTreeiENSGT01040000240636
HOGENOMiCLU_003493_0_0_1
InParanoidiQ9UNS1
OMAiQGPEECG
OrthoDBi839367at2759
PhylomeDBiQ9UNS1
TreeFamiTF312802

Enzyme and pathway databases

PathwayCommonsiQ9UNS1
ReactomeiR-HSA-5693607, Processing of DNA double-strand break ends
SignaLinkiQ9UNS1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8914, 723 hits in 1064 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TIMELESS, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8914
PharosiQ9UNS1, Tbio

Protein Ontology

More...PROi		PR:Q9UNS1
RNActiQ9UNS1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111602, Expressed in ventricular zone and 181 other tissues
GenevisibleiQ9UNS1, HS

Family and domain databases

InterProiView protein in InterPro
IPR044998, Timeless
IPR007725, TIMELESS_C
IPR006906, Timeless_N
PANTHERiPTHR22940, PTHR22940, 1 hit
PfamiView protein in Pfam
PF04821, TIMELESS, 1 hit
PF05029, TIMELESS_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNS1
Secondary accession number(s): B2ZAV0
, O94802, Q86VM1, Q8IWH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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