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Protein
Submitted name:

Squalene epoxidase

Gene

ERG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Squalene epoxidaseImported (EC:1.14.99.7Imported)
Submitted name:
cDNA, FLJ93917, highly similar to Homo sapiens squalene epoxidase (SQLE), mRNAImported
Gene namesi
Name:ERG1Imported
Synonyms:SQLEImported
ORF Names:hCG_14874Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000104549.11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei63 – 81HelicalSequence analysisAdd BLAST19
Transmembranei517 – 535HelicalSequence analysisAdd BLAST19
Transmembranei547 – 566HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36108

Expressioni

Gene expression databases

BgeeiENSG00000104549 Expressed in 227 organ(s), highest expression level in adrenal tissue

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 548SEInterPro annotationAdd BLAST272

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1298 Eukaryota
COG0654 LUCA
HOVERGENiHBG005603
KOiK00511
OMAiSSHFVGC
OrthoDBiEOG091G03XY

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UNR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN
60 70 80 90 100
GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK
110 120 130 140 150
GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT
160 170 180 190 200
VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ
210 220 230 240 250
ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV
260 270 280 290 300
LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV
310 320 330 340 350
SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG
360 370 380 390 400
EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK
410 420 430 440 450
RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA
460 470 480 490 500
KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE
510 520 530 540 550
CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS
560 570
GAVLYKACSV IFPLIYSEMK YMVH
Length:574
Mass (Da):63,923
Last modified:May 1, 2000 - v1
Checksum:i6957F5CF1F1624C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098865 mRNA Translation: AAD10823.1
BC017033 mRNA Translation: AAH17033.1
AK313384 mRNA Translation: BAG36182.1
CH471060 Genomic DNA Translation: EAW92079.1
RefSeqiNP_003120.2, NM_003129.3
UniGeneiHs.71465

Genome annotation databases

GeneIDi6713
KEGGihsa:6713
UCSCiuc011liq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098865 mRNA Translation: AAD10823.1
BC017033 mRNA Translation: AAH17033.1
AK313384 mRNA Translation: BAG36182.1
CH471060 Genomic DNA Translation: EAW92079.1
RefSeqiNP_003120.2, NM_003129.3
UniGeneiHs.71465

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi6713
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6713
KEGGihsa:6713
UCSCiuc011liq.3 human

Organism-specific databases

CTDi6713
EuPathDBiHostDB:ENSG00000104549.11
PharmGKBiPA36108

Phylogenomic databases

eggNOGiKOG1298 Eukaryota
COG0654 LUCA
HOVERGENiHBG005603
KOiK00511
OMAiSSHFVGC
OrthoDBiEOG091G03XY

Miscellaneous databases

ChiTaRSiSQLE human
GenomeRNAii6713

Gene expression databases

BgeeiENSG00000104549 Expressed in 227 organ(s), highest expression level in adrenal tissue

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9UNR6_HUMAN
AccessioniPrimary (citable) accession number: Q9UNR6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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