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Protein

ATP-binding cassette sub-family G member 2

Gene

ABCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.4 Publications

Miscellaneous

When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 87ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
  • ATP binding Source: ProtInc
  • heme transporter activity Source: Reactome
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic transmembrane transporting ATPase activity Source: ProtInc

GO - Biological processi

  • cellular iron ion homeostasis Source: Reactome
  • cholesterol efflux Source: GO_Central
  • response to drug Source: ProtInc
  • urate metabolic process Source: UniProtKB

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2161517 Abacavir transmembrane transport
R-HSA-917937 Iron uptake and transport
SABIO-RKiQ9UNQ0
SIGNORiQ9UNQ0

Protein family/group databases

TCDBi3.A.1.204.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 2
Alternative name(s):
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD_antigen: CD338
Gene namesi
Name:ABCG2
Synonyms:ABCP, BCRP, BCRP1, MXR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000118777.10
HGNCiHGNC:74 ABCG2
MIMi603756 gene
neXtProtiNX_Q9UNQ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 395CytoplasmicSequence analysisAdd BLAST395
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 428ExtracellularSequence analysisAdd BLAST12
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 477CytoplasmicSequence analysisAdd BLAST28
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularSequence analysis8
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 535CytoplasmicSequence analysis8
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 630ExtracellularSequence analysisAdd BLAST74
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 655CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86K → M: Inactive and altered subcellular location. 1 Publication1
Mutagenesisi418N → Q: No effect. 1 Publication1
Mutagenesisi482R → D: Decreases ATPase activity. 1 Publication1
Mutagenesisi482R → G, N, S or T: Increases ATPase activity. 1 Publication1
Mutagenesisi482R → K, I, M or Y: No change in ATPase activity. 1 Publication1
Mutagenesisi482R → T or Y: Decreases transport activity. 1 Publication1
Mutagenesisi557N → Q: No effect. 1 Publication1
Mutagenesisi583H → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi596N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi603C → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi605Y → A: No effect on hemin binding. 1 Publication1

Organism-specific databases

DisGeNETi9429
MalaCardsiABCG2
MIMi138900 phenotype
614490 phenotype
OpenTargetsiENSG00000118777
PharmGKBiPA390

Chemistry databases

ChEMBLiCHEMBL5393
DrugBankiDB08916 Afatinib
DB11363 Alectinib
DB06605 Apixaban
DB04851 Biricodar dicitrate
DB00921 Buprenorphine
DB06772 Cabazitaxel
DB04690 Camptothecin
DB00958 Carboplatin
DB00439 Cerivastatin
DB04540 Cholesterol
DB00515 Cisplatin
DB00242 Cladribine
DB00631 Clofarabine
DB09065 Cobicistat
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB00970 Dactinomycin
DB02115 Daidzin
DB09183 Dasabuvir
DB01254 Dasatinib
DB00694 Daunorubicin
DB01234 Dexamethasone
DB00255 Diethylstilbestrol
DB01248 Docetaxel
DB00997 Doxorubicin
DB00470 Dronabinol
DB04881 Elacridar
DB11574 Elbasvir
DB00530 Erlotinib
DB00783 Estradiol
DB00655 Estrone
DB00773 Etoposide
DB00973 Ezetimibe
DB03496 Flavopiridol
DB00544 Fluorouracil
DB00158 Folic Acid
DB00317 Gefitinib
DB01645 Genistein
DB01016 Glyburide
DB01094 Hesperetin
DB00741 Hydrocortisone
DB09054 Idelalisib
DB00619 Imatinib
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00448 Lansoprazole
DB01097 Leflunomide
DB09078 Lenvatinib
DB00563 Methotrexate
DB01204 Mitoxantrone
DB00688 Mycophenolate mofetil
DB03467 Naringenin
DB00220 Nelfinavir
DB04868 Nilotinib
DB00698 Nitrofurantoin
DB01051 Novobiocin
DB00338 Omeprazole
DB09330 Osimertinib
DB00526 Oxaliplatin
DB01229 Paclitaxel
DB00213 Pantoprazole
DB06589 Pazopanib
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00457 Prazosin
DB04216 Quercetin
DB01129 Rabeprazole
DB08896 Regorafenib
DB08864 Rilpivirine
DB00740 Riluzole
DB08931 Riociguat
DB00503 Ritonavir
DB09291 Rolapitant
DB01098 Rosuvastatin
DB06654 Safinamide
DB01232 Saquinavir
DB08934 Sofosbuvir
DB00398 Sorafenib
DB00795 Sulfasalazine
DB00669 Sumatriptan
DB01268 Sunitinib
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00966 Telmisartan
DB00444 Teniposide
DB08880 Teriflunomide
DB00624 Testosterone
DB01030 Topotecan
DB05294 Vandetanib
DB08881 Vemurafenib
DB11581 Venetoclax
DB00285 Venlafaxine
DB00661 Verapamil
DB00541 Vincristine
DB08828 Vismodegib
DB00549 Zafirlukast
DB00495 Zidovudine
GuidetoPHARMACOLOGYi792

Polymorphism and mutation databases

BioMutaiABCG2
DMDMi67462103

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933861 – 655ATP-binding cassette sub-family G member 2Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi592 ↔ 6081 Publication
Glycosylationi596N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi603Interchain1 Publication

Post-translational modificationi

Glycosylation-deficient ABCG2 is normally expressed and functional.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei418Not glycosylated1 Publication1
Sitei557Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UNQ0
PaxDbiQ9UNQ0
PeptideAtlasiQ9UNQ0
PRIDEiQ9UNQ0
ProteomicsDBi85323
85324 [Q9UNQ0-2]

PTM databases

iPTMnetiQ9UNQ0
PhosphoSitePlusiQ9UNQ0

Expressioni

Tissue specificityi

Highly expressed in placenta. Low expression in small intestine, liver and colon.2 Publications

Inductioni

Up-regulated in brain tumors.

Gene expression databases

BgeeiENSG00000118777
ExpressionAtlasiQ9UNQ0 baseline and differential
GenevisibleiQ9UNQ0 HS

Organism-specific databases

HPAiCAB037299
HPA054719

Interactioni

Subunit structurei

Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi114821, 18 interactors
DIPiDIP-29162N
IntActiQ9UNQ0, 19 interactors
MINTiQ9UNQ0
STRINGi9606.ENSP00000237612

Chemistry databases

BindingDBiQ9UNQ0

Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 40Combined sources4
Beta strandi69 – 71Combined sources3
Beta strandi73 – 80Combined sources8
Turni82 – 87Combined sources6
Helixi88 – 93Combined sources6
Turni99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Helixi117 – 120Combined sources4
Beta strandi121 – 124Combined sources4
Helixi136 – 147Combined sources12
Helixi154 – 167Combined sources14
Turni172 – 175Combined sources4
Beta strandi181 – 183Combined sources3
Helixi188 – 197Combined sources10
Beta strandi205 – 210Combined sources6
Helixi218 – 232Combined sources15
Turni233 – 235Combined sources3
Beta strandi237 – 240Combined sources4
Helixi247 – 250Combined sources4
Beta strandi254 – 260Combined sources7
Beta strandi263 – 268Combined sources6
Helixi272 – 278Combined sources7
Turni279 – 281Combined sources3
Helixi290 – 299Combined sources10
Helixi329 – 337Combined sources9
Helixi342 – 352Combined sources11
Helixi373 – 390Combined sources18
Helixi392 – 394Combined sources3
Helixi397 – 412Combined sources16
Helixi422 – 439Combined sources18
Helixi440 – 445Combined sources6
Helixi446 – 450Combined sources5
Helixi452 – 460Combined sources9
Helixi466 – 476Combined sources11
Helixi478 – 497Combined sources20
Helixi503 – 528Combined sources26
Helixi535 – 548Combined sources14
Helixi550 – 552Combined sources3
Beta strandi553 – 556Combined sources4
Turni563 – 565Combined sources3
Helixi566 – 571Combined sources6
Helixi573 – 585Combined sources13
Beta strandi586 – 588Combined sources3
Beta strandi602 – 605Combined sources4
Helixi610 – 616Combined sources7
Helixi624 – 649Combined sources26

3D structure databases

ProteinModelPortaliQ9UNQ0
SMRiQ9UNQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 286ABC transporterPROSITE-ProRule annotationAdd BLAST250
Domaini389 – 651ABC transmembrane type-2Add BLAST263

Domaini

The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN8P Eukaryota
COG0842 LUCA
GeneTreeiENSGT00740000114855
HOVERGENiHBG050441
InParanoidiQ9UNQ0
KOiK05681
OMAiSYTTSFC
OrthoDBiEOG091G08QB
PhylomeDBiQ9UNQ0
TreeFamiTF105211

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR030256 ABCG2
IPR027417 P-loop_NTPase
PANTHERiPTHR19241:SF452 PTHR19241:SF452, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS
60 70 80 90 100
GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS
110 120 130 140 150
GLSGDVLING APRPANFKCN SGYVVQDDVV MGTLTVRENL QFSAALRLAT
160 170 180 190 200
TMTNHEKNER INRVIQELGL DKVADSKVGT QFIRGVSGGE RKRTSIGMEL
210 220 230 240 250
ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF SIHQPRYSIF
260 270 280 290 300
KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING
310 320 330 340 350
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH
360 370 380 390 400
QLSGGEKKKK ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII
410 420 430 440 450
VTVVLGLVIG AIYFGLKNDS TGIQNRAGVL FFLTTNQCFS SVSAVELFVV
460 470 480 490 500
EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP MRMLPSIIFT CIVYFMLGLK
510 520 530 540 550
PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL MTICFVFMMI
560 570 580 590 600
FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN
610 620 630 640 650
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF

LKKYS
Length:655
Mass (Da):72,314
Last modified:May 10, 2005 - v3
Checksum:iA8AF66B96034C5A8
GO
Isoform 2 (identifier: Q9UNQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-611: IFSGLLVNLT...PCNYATCTGE → VCWSISQPLH...MQHVLAKNIW
     612-655: Missing.

Note: No experimental confirmation available.
Show »
Length:611
Mass (Da):67,453
Checksum:i9F831226192A2D39
GO

Sequence cautioni

The sequence AF093771 differs from that shown. Reason: Frameshift at positions 486 and 586.Curated
The sequence AF093772 differs from that shown. Reason: Frameshift at positions 386, 502 and 586.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → V in AAD09188 (PubMed:9850061).Curated1
Sequence conflicti24A → V in AAP44087 (PubMed:12958161).Curated1
Sequence conflicti315 – 316Missing in BAA92050 (PubMed:14702039).Curated2
Sequence conflicti390G → V in AAH92408 (PubMed:15489334).Curated1
Sequence conflicti482R → G in AF093771 (PubMed:9892175).Curated1
Sequence conflicti482R → G in AF093772 (PubMed:9892175).Curated1
Sequence conflicti482R → T in AAC97367 (PubMed:9861027).Curated1
Sequence conflicti484 – 485LP → FT in AF093772 (PubMed:9892175).Curated2
Sequence conflicti501P → A in AAG52982 (PubMed:11533706).Curated1

Polymorphismi

Genetic variations in ABCG2 define the blood group Junior system (JR) [MIMi:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait.2 Publications
Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIMi:138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed:18834626, PubMed:19506252, PubMed:20368174).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02077912V → M Found in Jr(a-) blood group phenotype. 6 PublicationsCorresponds to variant dbSNP:rs2231137EnsemblClinVar.1
Natural variantiVAR_06736313S → L1 Publication1
Natural variantiVAR_020780141Q → K Polymorphism associated with high serum levels of uric acid and increased risk of gout; results in lower urate transport rates compared to wild-type. 8 PublicationsCorresponds to variant dbSNP:rs2231142EnsemblClinVar.1
Natural variantiVAR_067364160R → Q1 PublicationCorresponds to variant dbSNP:rs528655917Ensembl.1
Natural variantiVAR_022704166Q → E2 PublicationsCorresponds to variant dbSNP:rs1061017Ensembl.1
Natural variantiVAR_022705206I → L1 PublicationCorresponds to variant dbSNP:rs12721643Ensembl.1
Natural variantiVAR_022706208F → S2 PublicationsCorresponds to variant dbSNP:rs1061018Ensembl.1
Natural variantiVAR_022707248S → P. Corresponds to variant dbSNP:rs3116448Ensembl.1
Natural variantiVAR_030357296D → H1 PublicationCorresponds to variant dbSNP:rs41282401Ensembl.1
Natural variantiVAR_022443316T → P1 Publication1
Natural variantiVAR_067365354G → R1 PublicationCorresponds to variant dbSNP:rs138606116Ensembl.1
Natural variantiVAR_018349431F → L2 Publications1
Natural variantiVAR_067366441S → N1 Publication1
Natural variantiVAR_018350489F → L2 PublicationsCorresponds to variant dbSNP:rs192169063Ensembl.1
Natural variantiVAR_030358528A → T1 PublicationCorresponds to variant dbSNP:rs45605536Ensembl.1
Natural variantiVAR_022708571F → I. Corresponds to variant dbSNP:rs9282571Ensembl.1
Natural variantiVAR_035355590N → Y1 PublicationCorresponds to variant dbSNP:rs34264773Ensembl.1
Natural variantiVAR_022709620D → N1 PublicationCorresponds to variant dbSNP:rs34783571Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014232550 – 611IFSGL…TCTGE → VCWSISQPLHLGCHGFSTSA FHDMDLRLCSIMNFWDKTSA QDSMQQETILVTMQHVLAKN IW in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_014233612 – 655Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103796 mRNA Translation: AAD09188.1
AF098951 mRNA Translation: AAC97367.1
AB056867 mRNA Translation: BAB39212.1
AB051855 mRNA Translation: BAB46933.1
AY017168 mRNA Translation: AAG52982.1
AY289766 mRNA Translation: AAP44087.1
AY288307 mRNA Translation: AAP31310.1
AF463519 mRNA Translation: AAO14617.1
AY333755 mRNA Translation: AAQ92941.1
AY333756 mRNA Translation: AAQ92942.1
AK002040 mRNA Translation: BAA92050.1
AK290000 mRNA Translation: BAF82689.1
DQ996467 Genomic DNA Translation: ABI97388.1
AC084732 Genomic DNA No translation available.
AC097484 Genomic DNA Translation: AAY40902.1
BC021281 mRNA Translation: AAH21281.1
BC092408 mRNA Translation: AAH92408.1
AF093771 mRNA No translation available.
AF093772 mRNA No translation available.
CCDSiCCDS3628.1 [Q9UNQ0-1]
CCDS58910.1 [Q9UNQ0-2]
RefSeqiNP_001244315.1, NM_001257386.1 [Q9UNQ0-2]
NP_004818.2, NM_004827.2 [Q9UNQ0-1]
XP_005263412.1, XM_005263355.3 [Q9UNQ0-1]
XP_011530722.1, XM_011532420.2 [Q9UNQ0-1]
UniGeneiHs.480218

Genome annotation databases

EnsembliENST00000237612; ENSP00000237612; ENSG00000118777 [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777 [Q9UNQ0-2]
GeneIDi9429
KEGGihsa:9429
UCSCiuc003hrg.4 human [Q9UNQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABCG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UNQ0
Secondary accession number(s): A0A1W3
, A8K1T5, O95374, Q4W5I3, Q53ZQ1, Q569L4, Q5YLG4, Q86V64, Q8IX16, Q96LD6, Q96TA8, Q9BY73, Q9NUS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 10, 2005
Last modified: July 18, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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