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Entry version 191 (13 Feb 2019)
Sequence version 3 (10 May 2005)
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Protein

ATP-binding cassette sub-family G member 2

Gene

ABCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.4 Publications

Miscellaneous

When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi80 – 87ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: ProtInc
  • heme transporter activity Source: Reactome
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic transmembrane transporting ATPase activity Source: ProtInc

GO - Biological processi

  • cellular iron ion homeostasis Source: Reactome
  • response to drug Source: ProtInc
  • transmembrane transport Source: GO_Central
  • urate metabolic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2161517 Abacavir transmembrane transport
R-HSA-917937 Iron uptake and transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9UNQ0

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UNQ0

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.204.2 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 2
Alternative name(s):
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD_antigen: CD338
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCG2
Synonyms:ABCP, BCRP, BCRP1, MXR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118777.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:74 ABCG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603756 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 395CytoplasmicSequence analysisAdd BLAST395
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 428ExtracellularSequence analysisAdd BLAST12
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 477CytoplasmicSequence analysisAdd BLAST28
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularSequence analysis8
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 535CytoplasmicSequence analysis8
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 630ExtracellularSequence analysisAdd BLAST74
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 655CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86K → M: Inactive and altered subcellular location. 1 Publication1
Mutagenesisi418N → Q: No effect. 1 Publication1
Mutagenesisi482R → D: Decreases ATPase activity. 1 Publication1
Mutagenesisi482R → G, N, S or T: Increases ATPase activity. 1 Publication1
Mutagenesisi482R → K, I, M or Y: No change in ATPase activity. 1 Publication1
Mutagenesisi482R → T or Y: Decreases transport activity. 1 Publication1
Mutagenesisi557N → Q: No effect. 1 Publication1
Mutagenesisi583H → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi596N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi603C → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi605Y → A: No effect on hemin binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9429

MalaCards human disease database

More...
MalaCardsi
ABCG2
MIMi138900 phenotype
614490 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000118777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA390

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5393

Drug and drug target database

More...
DrugBanki
DB08916 Afatinib
DB11363 Alectinib
DB06605 Apixaban
DB04851 Biricodar dicitrate
DB00921 Buprenorphine
DB06772 Cabazitaxel
DB04690 Camptothecin
DB00958 Carboplatin
DB00439 Cerivastatin
DB04540 Cholesterol
DB00515 Cisplatin
DB00242 Cladribine
DB00631 Clofarabine
DB09065 Cobicistat
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB00970 Dactinomycin
DB02115 Daidzin
DB09183 Dasabuvir
DB01254 Dasatinib
DB00694 Daunorubicin
DB01234 Dexamethasone
DB00255 Diethylstilbestrol
DB01248 Docetaxel
DB00997 Doxorubicin
DB00470 Dronabinol
DB04881 Elacridar
DB11574 Elbasvir
DB00530 Erlotinib
DB00783 Estradiol
DB00655 Estrone
DB00773 Etoposide
DB00973 Ezetimibe
DB03496 Flavopiridol
DB00544 Fluorouracil
DB00158 Folic Acid
DB00317 Gefitinib
DB01645 Genistein
DB01016 Glyburide
DB01094 Hesperetin
DB00741 Hydrocortisone
DB09054 Idelalisib
DB00619 Imatinib
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00448 Lansoprazole
DB01097 Leflunomide
DB09078 Lenvatinib
DB00563 Methotrexate
DB01204 Mitoxantrone
DB00688 Mycophenolate mofetil
DB03467 Naringenin
DB00220 Nelfinavir
DB04868 Nilotinib
DB00698 Nitrofurantoin
DB01051 Novobiocin
DB00338 Omeprazole
DB09330 Osimertinib
DB00526 Oxaliplatin
DB01229 Paclitaxel
DB00213 Pantoprazole
DB06589 Pazopanib
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00457 Prazosin
DB04216 Quercetin
DB01129 Rabeprazole
DB08896 Regorafenib
DB08864 Rilpivirine
DB00740 Riluzole
DB08931 Riociguat
DB00503 Ritonavir
DB09291 Rolapitant
DB01098 Rosuvastatin
DB06654 Safinamide
DB01232 Saquinavir
DB08934 Sofosbuvir
DB00398 Sorafenib
DB00795 Sulfasalazine
DB00669 Sumatriptan
DB01268 Sunitinib
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00966 Telmisartan
DB00444 Teniposide
DB08880 Teriflunomide
DB00624 Testosterone
DB01030 Topotecan
DB05294 Vandetanib
DB08881 Vemurafenib
DB11581 Venetoclax
DB00285 Venlafaxine
DB00661 Verapamil
DB00541 Vincristine
DB08828 Vismodegib
DB00549 Zafirlukast
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
792

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67462103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933861 – 655ATP-binding cassette sub-family G member 2Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi592 ↔ 6081 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi596N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi603Interchain1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation-deficient ABCG2 is normally expressed and functional.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei418Not glycosylated1 Publication1
Sitei557Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UNQ0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UNQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNQ0

PeptideAtlas

More...
PeptideAtlasi
Q9UNQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNQ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85323
85324 [Q9UNQ0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta. Low expression in small intestine, liver and colon.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in brain tumors.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118777 Expressed in 188 organ(s), highest expression level in jejunal mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UNQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037299
HPA054719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114821, 19 interactors

Database of interacting proteins

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DIPi
DIP-29162N

Protein interaction database and analysis system

More...
IntActi
Q9UNQ0, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9UNQ0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000237612

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UNQ0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJ3electron microscopy3.78A/B2-655[»]
5NJGelectron microscopy3.78A/B2-655[»]
6ETIelectron microscopy3.10A/B1-655[»]
6FEQelectron microscopy3.60A/B1-655[»]
6FFCelectron microscopy3.56A/B2-655[»]
6HBUelectron microscopy3.09A/B1-655[»]
6HCOelectron microscopy3.58A/B2-655[»]
6HIJelectron microscopy3.56A/B1-655[»]
6HZMelectron microscopy3.09A/B1-655[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UNQ0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UNQ0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 286ABC transporterPROSITE-ProRule annotationAdd BLAST250
Domaini389 – 651ABC transmembrane type-2Add BLAST263

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IN8P Eukaryota
COG0842 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162658

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050441

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNQ0

KEGG Orthology (KO)

More...
KOi
K05681

Identification of Orthologs from Complete Genome Data

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OMAi
AICTGEE

Database of Orthologous Groups

More...
OrthoDBi
51918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNQ0

TreeFam database of animal gene trees

More...
TreeFami
TF105211

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR030256 ABCG2
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR19241:SF452 PTHR19241:SF452, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS
60 70 80 90 100
GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS
110 120 130 140 150
GLSGDVLING APRPANFKCN SGYVVQDDVV MGTLTVRENL QFSAALRLAT
160 170 180 190 200
TMTNHEKNER INRVIQELGL DKVADSKVGT QFIRGVSGGE RKRTSIGMEL
210 220 230 240 250
ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF SIHQPRYSIF
260 270 280 290 300
KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING
310 320 330 340 350
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH
360 370 380 390 400
QLSGGEKKKK ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII
410 420 430 440 450
VTVVLGLVIG AIYFGLKNDS TGIQNRAGVL FFLTTNQCFS SVSAVELFVV
460 470 480 490 500
EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP MRMLPSIIFT CIVYFMLGLK
510 520 530 540 550
PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL MTICFVFMMI
560 570 580 590 600
FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN
610 620 630 640 650
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF

LKKYS
Length:655
Mass (Da):72,314
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8AF66B96034C5A8
GO
Isoform 2 (identifier: Q9UNQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-611: IFSGLLVNLT...PCNYATCTGE → VCWSISQPLH...MQHVLAKNIW
     612-655: Missing.

Note: No experimental confirmation available.
Show »
Length:611
Mass (Da):67,453
Checksum:i9F831226192A2D39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8S0F2F8S0F2_HUMAN
ATP-binding cassette sub-family G m...
ABCG2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AF093771 differs from that shown. Reason: Frameshift at positions 486 and 586.Curated
The sequence AF093772 differs from that shown. Reason: Frameshift at positions 386, 502 and 586.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → V in AAD09188 (PubMed:9850061).Curated1
Sequence conflicti24A → V in AAP44087 (PubMed:12958161).Curated1
Sequence conflicti315 – 316Missing in BAA92050 (PubMed:14702039).Curated2
Sequence conflicti390G → V in AAH92408 (PubMed:15489334).Curated1
Sequence conflicti482R → G in AF093771 (PubMed:9892175).Curated1
Sequence conflicti482R → G in AF093772 (PubMed:9892175).Curated1
Sequence conflicti482R → T in AAC97367 (PubMed:9861027).Curated1
Sequence conflicti484 – 485LP → FT in AF093772 (PubMed:9892175).Curated2
Sequence conflicti501P → A in AAG52982 (PubMed:11533706).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in ABCG2 define the blood group Junior system (JR) [MIMi:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait.2 Publications
Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIMi:138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed:18834626, PubMed:19506252, PubMed:20368174).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02077912V → M Found in Jr(a-) blood group phenotype. 6 PublicationsCorresponds to variant dbSNP:rs2231137EnsemblClinVar.1
Natural variantiVAR_06736313S → L1 PublicationCorresponds to variant dbSNP:rs1319203095Ensembl.1
Natural variantiVAR_020780141Q → K Polymorphism associated with high serum levels of uric acid and increased risk of gout; results in lower urate transport rates compared to wild-type. 8 PublicationsCorresponds to variant dbSNP:rs2231142EnsemblClinVar.1
Natural variantiVAR_067364160R → Q1 PublicationCorresponds to variant dbSNP:rs528655917Ensembl.1
Natural variantiVAR_022704166Q → E2 PublicationsCorresponds to variant dbSNP:rs1061017Ensembl.1
Natural variantiVAR_022705206I → L1 PublicationCorresponds to variant dbSNP:rs12721643Ensembl.1
Natural variantiVAR_022706208F → S2 PublicationsCorresponds to variant dbSNP:rs1061018Ensembl.1
Natural variantiVAR_022707248S → P. Corresponds to variant dbSNP:rs3116448Ensembl.1
Natural variantiVAR_030357296D → H1 PublicationCorresponds to variant dbSNP:rs41282401Ensembl.1
Natural variantiVAR_022443316T → P1 Publication1
Natural variantiVAR_067365354G → R1 PublicationCorresponds to variant dbSNP:rs138606116Ensembl.1
Natural variantiVAR_018349431F → L2 Publications1
Natural variantiVAR_067366441S → N1 PublicationCorresponds to variant dbSNP:rs1354553769Ensembl.1
Natural variantiVAR_018350489F → L2 PublicationsCorresponds to variant dbSNP:rs192169063Ensembl.1
Natural variantiVAR_030358528A → T1 PublicationCorresponds to variant dbSNP:rs45605536Ensembl.1
Natural variantiVAR_022708571F → I. Corresponds to variant dbSNP:rs9282571Ensembl.1
Natural variantiVAR_035355590N → Y1 PublicationCorresponds to variant dbSNP:rs34264773Ensembl.1
Natural variantiVAR_022709620D → N1 PublicationCorresponds to variant dbSNP:rs34783571Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014232550 – 611IFSGL…TCTGE → VCWSISQPLHLGCHGFSTSA FHDMDLRLCSIMNFWDKTSA QDSMQQETILVTMQHVLAKN IW in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_014233612 – 655Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF103796 mRNA Translation: AAD09188.1
AF098951 mRNA Translation: AAC97367.1
AB056867 mRNA Translation: BAB39212.1
AB051855 mRNA Translation: BAB46933.1
AY017168 mRNA Translation: AAG52982.1
AY289766 mRNA Translation: AAP44087.1
AY288307 mRNA Translation: AAP31310.1
AF463519 mRNA Translation: AAO14617.1
AY333755 mRNA Translation: AAQ92941.1
AY333756 mRNA Translation: AAQ92942.1
AK002040 mRNA Translation: BAA92050.1
AK290000 mRNA Translation: BAF82689.1
DQ996467 Genomic DNA Translation: ABI97388.1
AC084732 Genomic DNA No translation available.
AC097484 Genomic DNA Translation: AAY40902.1
BC021281 mRNA Translation: AAH21281.1
BC092408 mRNA Translation: AAH92408.1
AF093771 mRNA No translation available.
AF093772 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3628.1 [Q9UNQ0-1]
CCDS58910.1 [Q9UNQ0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001244315.1, NM_001257386.1 [Q9UNQ0-2]
NP_004818.2, NM_004827.2 [Q9UNQ0-1]
XP_005263412.1, XM_005263355.3 [Q9UNQ0-1]
XP_011530722.1, XM_011532420.2 [Q9UNQ0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.480218

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000237612; ENSP00000237612; ENSG00000118777 [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777 [Q9UNQ0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9429

UCSC genome browser

More...
UCSCi
uc003hrg.4 human [Q9UNQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103796 mRNA Translation: AAD09188.1
AF098951 mRNA Translation: AAC97367.1
AB056867 mRNA Translation: BAB39212.1
AB051855 mRNA Translation: BAB46933.1
AY017168 mRNA Translation: AAG52982.1
AY289766 mRNA Translation: AAP44087.1
AY288307 mRNA Translation: AAP31310.1
AF463519 mRNA Translation: AAO14617.1
AY333755 mRNA Translation: AAQ92941.1
AY333756 mRNA Translation: AAQ92942.1
AK002040 mRNA Translation: BAA92050.1
AK290000 mRNA Translation: BAF82689.1
DQ996467 Genomic DNA Translation: ABI97388.1
AC084732 Genomic DNA No translation available.
AC097484 Genomic DNA Translation: AAY40902.1
BC021281 mRNA Translation: AAH21281.1
BC092408 mRNA Translation: AAH92408.1
AF093771 mRNA No translation available.
AF093772 mRNA No translation available.
CCDSiCCDS3628.1 [Q9UNQ0-1]
CCDS58910.1 [Q9UNQ0-2]
RefSeqiNP_001244315.1, NM_001257386.1 [Q9UNQ0-2]
NP_004818.2, NM_004827.2 [Q9UNQ0-1]
XP_005263412.1, XM_005263355.3 [Q9UNQ0-1]
XP_011530722.1, XM_011532420.2 [Q9UNQ0-1]
UniGeneiHs.480218

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJ3electron microscopy3.78A/B2-655[»]
5NJGelectron microscopy3.78A/B2-655[»]
6ETIelectron microscopy3.10A/B1-655[»]
6FEQelectron microscopy3.60A/B1-655[»]
6FFCelectron microscopy3.56A/B2-655[»]
6HBUelectron microscopy3.09A/B1-655[»]
6HCOelectron microscopy3.58A/B2-655[»]
6HIJelectron microscopy3.56A/B1-655[»]
6HZMelectron microscopy3.09A/B1-655[»]
ProteinModelPortaliQ9UNQ0
SMRiQ9UNQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114821, 19 interactors
DIPiDIP-29162N
IntActiQ9UNQ0, 19 interactors
MINTiQ9UNQ0
STRINGi9606.ENSP00000237612

Chemistry databases

BindingDBiQ9UNQ0
ChEMBLiCHEMBL5393
DrugBankiDB08916 Afatinib
DB11363 Alectinib
DB06605 Apixaban
DB04851 Biricodar dicitrate
DB00921 Buprenorphine
DB06772 Cabazitaxel
DB04690 Camptothecin
DB00958 Carboplatin
DB00439 Cerivastatin
DB04540 Cholesterol
DB00515 Cisplatin
DB00242 Cladribine
DB00631 Clofarabine
DB09065 Cobicistat
DB05239 Cobimetinib
DB00286 Conjugated Equine Estrogens
DB00091 Cyclosporine
DB08912 Dabrafenib
DB09102 Daclatasvir
DB00970 Dactinomycin
DB02115 Daidzin
DB09183 Dasabuvir
DB01254 Dasatinib
DB00694 Daunorubicin
DB01234 Dexamethasone
DB00255 Diethylstilbestrol
DB01248 Docetaxel
DB00997 Doxorubicin
DB00470 Dronabinol
DB04881 Elacridar
DB11574 Elbasvir
DB00530 Erlotinib
DB00783 Estradiol
DB00655 Estrone
DB00773 Etoposide
DB00973 Ezetimibe
DB03496 Flavopiridol
DB00544 Fluorouracil
DB00158 Folic Acid
DB00317 Gefitinib
DB01645 Genistein
DB01016 Glyburide
DB01094 Hesperetin
DB00741 Hydrocortisone
DB09054 Idelalisib
DB00619 Imatinib
DB00762 Irinotecan
DB00602 Ivermectin
DB00709 Lamivudine
DB00448 Lansoprazole
DB01097 Leflunomide
DB09078 Lenvatinib
DB00563 Methotrexate
DB01204 Mitoxantrone
DB00688 Mycophenolate mofetil
DB03467 Naringenin
DB00220 Nelfinavir
DB04868 Nilotinib
DB00698 Nitrofurantoin
DB01051 Novobiocin
DB00338 Omeprazole
DB09330 Osimertinib
DB00526 Oxaliplatin
DB01229 Paclitaxel
DB00213 Pantoprazole
DB06589 Pazopanib
DB08860 Pitavastatin
DB08901 Ponatinib
DB00175 Pravastatin
DB00457 Prazosin
DB04216 Quercetin
DB01129 Rabeprazole
DB08896 Regorafenib
DB08864 Rilpivirine
DB00740 Riluzole
DB08931 Riociguat
DB00503 Ritonavir
DB09291 Rolapitant
DB01098 Rosuvastatin
DB06654 Safinamide
DB01232 Saquinavir
DB08934 Sofosbuvir
DB00398 Sorafenib
DB00795 Sulfasalazine
DB00669 Sumatriptan
DB01268 Sunitinib
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB00966 Telmisartan
DB00444 Teniposide
DB08880 Teriflunomide
DB00624 Testosterone
DB01030 Topotecan
DB05294 Vandetanib
DB08881 Vemurafenib
DB11581 Venetoclax
DB00285 Venlafaxine
DB00661 Verapamil
DB00541 Vincristine
DB08828 Vismodegib
DB00549 Zafirlukast
DB00495 Zidovudine
GuidetoPHARMACOLOGYi792

Protein family/group databases

TCDBi3.A.1.204.2 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ9UNQ0
PhosphoSitePlusiQ9UNQ0

Polymorphism and mutation databases

BioMutaiABCG2
DMDMi67462103

Proteomic databases

EPDiQ9UNQ0
jPOSTiQ9UNQ0
PaxDbiQ9UNQ0
PeptideAtlasiQ9UNQ0
PRIDEiQ9UNQ0
ProteomicsDBi85323
85324 [Q9UNQ0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9429
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237612; ENSP00000237612; ENSG00000118777 [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777 [Q9UNQ0-2]
GeneIDi9429
KEGGihsa:9429
UCSCiuc003hrg.4 human [Q9UNQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9429
DisGeNETi9429
EuPathDBiHostDB:ENSG00000118777.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCG2
HGNCiHGNC:74 ABCG2
HPAiCAB037299
HPA054719
MalaCardsiABCG2
MIMi138900 phenotype
603756 gene
614490 phenotype
neXtProtiNX_Q9UNQ0
OpenTargetsiENSG00000118777
PharmGKBiPA390

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IN8P Eukaryota
COG0842 LUCA
GeneTreeiENSGT00940000162658
HOVERGENiHBG050441
InParanoidiQ9UNQ0
KOiK05681
OMAiAICTGEE
OrthoDBi51918at2759
PhylomeDBiQ9UNQ0
TreeFamiTF105211

Enzyme and pathway databases

ReactomeiR-HSA-2161517 Abacavir transmembrane transport
R-HSA-917937 Iron uptake and transport
SABIO-RKiQ9UNQ0
SIGNORiQ9UNQ0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCG2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9429

Protein Ontology

More...
PROi
PR:Q9UNQ0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118777 Expressed in 188 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiQ9UNQ0 baseline and differential
GenevisibleiQ9UNQ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR030256 ABCG2
IPR027417 P-loop_NTPase
PANTHERiPTHR19241:SF452 PTHR19241:SF452, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNQ0
Secondary accession number(s): A0A1W3
, A8K1T5, O95374, Q4W5I3, Q53ZQ1, Q569L4, Q5YLG4, Q86V64, Q8IX16, Q96LD6, Q96TA8, Q9BY73, Q9NUS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 10, 2005
Last modified: February 13, 2019
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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