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Entry version 203 (12 Aug 2020)
Sequence version 3 (10 May 2005)
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Protein

Broad substrate specificity ATP-binding cassette transporter ABCG2

Gene

ABCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity).By similarity1 Publication16 Publications

Caution

Was originally proposed to function as a glutathione transporter (PubMed:20332504). However, some evidences suggest it is not the case (PubMed:24312054).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Specifically inhibited by the fungal toxin fumitremorgin C and Ko143.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=16.6 µM for estrone 3-sulfate1 Publication
  2. KM=1.23 mM for ATP1 Publication
  3. KM=12.9 µM for 4-methylumbelliferone sulfate1 Publication
  4. KM=26.9 µM for 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole sulfate1 Publication
  5. KM=8.24 mM for urate1 Publication
  1. Vmax=2.34 nmol/min/mg enzyme for estrone 3-sulfate transport1 Publication
  2. Vmax=6.96 nmol/min/mg enzyme for urate transport1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei211ATPCombined sources1 Publication1
Binding sitei243ATPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi80 – 87ATPPROSITE-ProRule annotationCombined sources1 Publication8
Nucleotide bindingi184 – 190ATPCombined sources1 Publication7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9UNQ0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-189451, Heme biosynthesis
R-HSA-189483, Heme degradation
R-HSA-2161517, Abacavir transmembrane transport
R-HSA-917937, Iron uptake and transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9UNQ0

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UNQ0

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.204.2, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Broad substrate specificity ATP-binding cassette transporter ABCG2Curated (EC:7.6.2.22 Publications)
Alternative name(s):
ATP-binding cassette sub-family G member 2
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD_antigen: CD338
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCG2
Synonyms:ABCP, BCRP, BCRP1, MXR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000118777.10

Human Gene Nomenclature Database

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HGNCi
HGNC:74, ABCG2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603756, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 395CytoplasmicSequence analysisAdd BLAST395
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 428ExtracellularSequence analysisAdd BLAST12
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 477CytoplasmicSequence analysisAdd BLAST28
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularSequence analysis8
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 535CytoplasmicSequence analysis8
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 630ExtracellularSequence analysisAdd BLAST74
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 655CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71M → V: Decreased protein abundance. No effect on substrate transmembrane transport. 1 Publication1
Mutagenesisi86K → M: Decreased protein abundance. Decreased localization to the plasma membrane and retained intracellularly. Loss of ATPase-coupled transmembrane transporter activity. 2 Publications1
Mutagenesisi211E → Q: Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Decreased substrate-induced ATP hydrolysis. Decreased substrate transport. 2 Publications1
Mutagenesisi362T → A: Loss of phosphorylation by PIM1. Decreased localization to the plasma membrane. Decreased homooligomerization. Loss of function in resistance to drug treatment. 1 Publication1
Mutagenesisi362T → D: Loss of phosphorylation by PIM1. Constitutive drug resistance independent of PIM1. 1 Publication1
Mutagenesisi383R → C: Loss of protein expression. 1 Publication1
Mutagenesisi418N → Q: No effect. 1 Publication1
Mutagenesisi435T → A: No effect on stability. Increased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Increased substrate-induced ATP hydrolysis. Increased substrate transport. 1 Publication1
Mutagenesisi435T → F: No effect on stability. Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Decreased substrate-induced ATP hydrolysis. Decreased substrate transport. 1 Publication1
Mutagenesisi436N → A: No effect on stability. Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Decreased substrate-induced ATP hydrolysis. Decreased substrate transport. 1 Publication1
Mutagenesisi439F → A: No effect on stability. Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Decreased substrate-induced ATP hydrolysis. Decreased substrate transport. 1 Publication1
Mutagenesisi482R → D: Decreases ATPase activity. 1 Publication1
Mutagenesisi482R → G, N, S or T: Increases ATPase activity. 1 Publication1
Mutagenesisi482R → K, I, M or Y: No change in ATPase activity. 1 Publication1
Mutagenesisi482R → T or Y: Decreases transport activity. 1 Publication1
Mutagenesisi546V → A: No effect on stability. No effect on estrone-3 sulfate ATPase-coupled transmembrane transporter activity. No effect on substrate-induced ATP hydrolysis. No effect on substrate transport. 1 Publication1
Mutagenesisi546V → F: No effect on stability. Decreased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Increased basal and substrate-induced ATP hydrolysis. Decreased substrate transport. 1 Publication1
Mutagenesisi549M → A: No effect on stability. No effect on estrone-3 sulfate ATPase-coupled transmembrane transporter activity. No effect on substrate-induced ATP hydrolysis. No effect on substrate transport. 1 Publication1
Mutagenesisi554L → A: No effect on stability. Increased estrone-3 sulfate ATPase-coupled transmembrane transporter activity. Increased basal and substrate-induced ATP hydrolysis. Increased substrate transport. 1 Publication1
Mutagenesisi555L → A: Loss of protein expression. 1 Publication1
Mutagenesisi557N → Q: No effect. 1 Publication1
Mutagenesisi583H → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi596N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi603C → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi605Y → A: No effect on hemin binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9429

MalaCards human disease database

More...
MalaCardsi
ABCG2
MIMi138900, phenotype
614490, phenotype

Open Targets

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OpenTargetsi
ENSG00000118777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA390

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UNQ0, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5393

Drug and drug target database

More...
DrugBanki
DB12001, Abemaciclib
DB08916, Afatinib
DB11363, Alectinib
DB00437, Allopurinol
DB12015, Alpelisib
DB03496, Alvocidib
DB11901, Apalutamide
DB06605, Apixaban
DB15233, Avapritinib
DB11995, Avatrombopag
DB11817, Baricitinib
DB00394, Beclomethasone dipropionate
DB04851, Biricodar
DB12267, Brigatinib
DB00921, Buprenorphine
DB06772, Cabazitaxel
DB00201, Caffeine
DB04690, Camptothecin
DB08907, Canagliflozin
DB09061, Cannabidiol
DB00958, Carboplatin
DB00482, Celecoxib
DB00439, Cerivastatin
DB04540, Cholesterol
DB00515, Cisplatin
DB00242, Cladribine
DB00631, Clofarabine
DB09065, Cobicistat
DB05239, Cobimetinib
DB00286, Conjugated estrogens
DB12483, Copanlisib
DB00091, Cyclosporine
DB08912, Dabrafenib
DB09102, Daclatasvir
DB11963, Dacomitinib
DB00970, Dactinomycin
DB02115, Daidzin
DB12941, Darolutamide
DB09183, Dasabuvir
DB01254, Dasatinib
DB00694, Daunorubicin
DB11943, Delafloxacin
DB01234, Dexamethasone
DB00255, Diethylstilbestrol
DB01248, Docetaxel
DB08930, Dolutegravir
DB00843, Donepezil
DB05928, Dovitinib
DB00997, Doxorubicin
DB00470, Dronabinol
DB11952, Duvelisib
DB04881, Elacridar
DB06210, Eltrombopag
DB13874, Enasidenib
DB00530, Erlotinib
DB11827, Ertugliflozin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB00773, Etoposide
DB00973, Ezetimibe
DB12500, Fedratinib
DB09279, Fimasartan
DB00544, Fluorouracil
DB00158, Folic acid
DB12010, Fostamatinib
DB02703, Fusidic acid
DB00317, Gefitinib
DB01645, Genistein
DB12141, Gilteritinib
DB11978, Glasdegib
DB13879, Glecaprevir
DB01016, Glyburide
DB01094, Hesperetin
DB14538, Hydrocortisone aceponate
DB14539, Hydrocortisone acetate
DB14540, Hydrocortisone butyrate
DB14541, Hydrocortisone cypionate
DB14542, Hydrocortisone phosphate
DB14543, Hydrocortisone probutate
DB14544, Hydrocortisone valerate
DB09054, Idelalisib
DB00619, Imatinib
DB00762, Irinotecan
DB11633, Isavuconazole
DB11757, Istradefylline
DB00602, Ivermectin
DB00709, Lamivudine
DB00448, Lansoprazole
DB14723, Larotrectinib
DB11732, Lasmiditan
DB09027, Ledipasvir
DB01097, Leflunomide
DB09078, Lenvatinib
DB12070, Letermovir
DB13125, Lusutrombopag
DB14009, Medical Cannabis
DB00563, Methotrexate
DB01204, Mitoxantrone
DB00688, Mycophenolate mofetil
DB14011, Nabiximols
DB03467, Naringenin
DB00220, Nelfinavir
DB04868, Nilotinib
DB09079, Nintedanib
DB00698, Nitrofurantoin
DB01051, Novobiocin
DB09074, Olaparib
DB09296, Ombitasvir
DB00338, Omeprazole
DB09330, Osimertinib
DB00526, Oxaliplatin
DB12612, Ozanimod
DB09073, Palbociclib
DB00213, Pantoprazole
DB09297, Paritaprevir
DB06589, Pazopanib
DB13878, Pibrentasvir
DB08860, Pitavastatin
DB08901, Ponatinib
DB01708, Prasterone
DB00175, Pravastatin
DB00457, Prazosin
DB00396, Progesterone
DB04216, Quercetin
DB01129, Rabeprazole
DB00481, Raloxifene
DB08896, Regorafenib
DB11855, Revefenacin
DB08864, Rilpivirine
DB00740, Riluzole
DB12457, Rimegepant
DB08931, Riociguat
DB00503, Ritonavir
DB06228, Rivaroxaban
DB09291, Rolapitant
DB01098, Rosuvastatin
DB12332, Rucaparib
DB06654, Safinamide
DB01232, Saquinavir
DB11689, Selumetinib
DB06290, Simeprevir
DB08934, Sofosbuvir
DB00398, Sorafenib
DB00795, Sulfasalazine
DB00669, Sumatriptan
DB01268, Sunitinib
DB11644, Tafamidis
DB11760, Talazoparib
DB00675, Tamoxifen
DB04348, Taurocholic acid
DB12887, Tazemetostat
DB01079, Tegaserod
DB00966, Telmisartan
DB00444, Teniposide
DB09299, Tenofovir alafenamide
DB08880, Teriflunomide
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB11712, Tezacaftor
DB01685, Topiroxostat
DB01030, Topotecan
DB14962, Trastuzumab deruxtecan
DB11652, Tucatinib
DB15328, Ubrogepant
DB15091, Upadacitinib
DB05294, Vandetanib
DB11613, Velpatasvir
DB08881, Vemurafenib
DB11581, Venetoclax
DB00285, Venlafaxine
DB00541, Vincristine
DB08828, Vismodegib
DB12026, Voxilaprevir
DB00549, Zafirlukast
DB00495, Zidovudine

DrugCentral

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DrugCentrali
Q9UNQ0

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
792

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67462103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933861 – 655Broad substrate specificity ATP-binding cassette transporter ABCG2Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei362Phosphothreonine; by PIM11 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi592 ↔ 608Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi596N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi603InterchainCombined sources2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:15807535, PubMed:23189181). Glycosylation-deficient ABCG2 is normally expressed and functional.2 Publications
Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei418Not glycosylated1 Publication1
Sitei557Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UNQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UNQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNQ0

PeptideAtlas

More...
PeptideAtlasi
Q9UNQ0

PRoteomics IDEntifications database

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PRIDEi
Q9UNQ0

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
85323 [Q9UNQ0-1]
85324 [Q9UNQ0-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UNQ0, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta (PubMed:9850061). Low expression in small intestine, liver and colon (PubMed:9861027). Expressed in brain (at protein level) (PubMed:12958161).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000118777, Expressed in jejunal mucosa and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UNQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UNQ0, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000118777, Tissue enhanced (ductus deferens, intestine, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (PubMed:15001581, PubMed:17686774, PubMed:18056989, PubMed:28554189). The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers (PubMed:15001581).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114821, 20 interactors

Database of interacting proteins

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DIPi
DIP-29162N

Protein interaction database and analysis system

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IntActi
Q9UNQ0, 19 interactors

Molecular INTeraction database

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MINTi
Q9UNQ0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000237612

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9UNQ0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9UNQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UNQ0

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 286ABC transporterPROSITE-ProRule annotationAdd BLAST250
Domaini389 – 651ABC transmembrane type-2Add BLAST263

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0061, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000162658

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000604_57_8_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UNQ0

KEGG Orthology (KO)

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KOi
K05681

Identification of Orthologs from Complete Genome Data

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OMAi
GTQFTRG

Database of Orthologous Groups

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OrthoDBi
1022017at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UNQ0

TreeFam database of animal gene trees

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TreeFami
TF105211

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR030256, ABCG2
IPR027417, P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR19241:SF268, PTHR19241:SF268, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01061, ABC2_membrane, 1 hit
PF00005, ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS
60 70 80 90 100
GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS
110 120 130 140 150
GLSGDVLING APRPANFKCN SGYVVQDDVV MGTLTVRENL QFSAALRLAT
160 170 180 190 200
TMTNHEKNER INRVIQELGL DKVADSKVGT QFIRGVSGGE RKRTSIGMEL
210 220 230 240 250
ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF SIHQPRYSIF
260 270 280 290 300
KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING
310 320 330 340 350
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH
360 370 380 390 400
QLSGGEKKKK ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII
410 420 430 440 450
VTVVLGLVIG AIYFGLKNDS TGIQNRAGVL FFLTTNQCFS SVSAVELFVV
460 470 480 490 500
EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP MRMLPSIIFT CIVYFMLGLK
510 520 530 540 550
PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL MTICFVFMMI
560 570 580 590 600
FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN
610 620 630 640 650
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF

LKKYS
Length:655
Mass (Da):72,314
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8AF66B96034C5A8
GO
Isoform 2 (identifier: Q9UNQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-611: IFSGLLVNLT...PCNYATCTGE → VCWSISQPLH...MQHVLAKNIW
     612-655: Missing.

Show »
Length:611
Mass (Da):67,453
Checksum:i9F831226192A2D39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8S0F2F8S0F2_HUMAN
Broad substrate-specificity ATP-bin...
ABCG2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AF093771 differs from that shown. Reason: Frameshift.Curated
The sequence AF093772 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → V in AAD09188 (PubMed:9850061).Curated1
Sequence conflicti24A → V in AAP44087 (PubMed:12958161).Curated1
Sequence conflicti315 – 316Missing in BAA92050 (PubMed:14702039).Curated2
Sequence conflicti390G → V in AAH92408 (PubMed:15489334).Curated1
Sequence conflicti482R → G in AF093771 (PubMed:9892175).Curated1
Sequence conflicti482R → G in AF093772 (PubMed:9892175).Curated1
Sequence conflicti482R → T in AAC97367 (PubMed:9861027).Curated1
Sequence conflicti484 – 485LP → FT in AF093772 (PubMed:9892175).Curated2
Sequence conflicti501P → A in AAG52982 (PubMed:11533706).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in ABCG2 define the blood group Junior system (JR) [MIMi:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait.2 Publications
Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIMi:138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed:18834626, PubMed:19506252, PubMed:20368174).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02077912V → M Found in Jr(a-) blood group phenotype. 6 PublicationsCorresponds to variant dbSNP:rs2231137EnsemblClinVar.1
Natural variantiVAR_06736313S → L1 PublicationCorresponds to variant dbSNP:rs1319203095Ensembl.1
Natural variantiVAR_020780141Q → K Polymorphism associated with high serum levels of uric acid and increased risk of gout; results in lower urate transport rates compared to wild-type; decreased protein abundance. 10 PublicationsCorresponds to variant dbSNP:rs2231142EnsemblClinVar.1
Natural variantiVAR_082302147R → W Loss of protein expression; loss of localization to the plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs372192400Ensembl.1
Natural variantiVAR_082303153T → M Decreased protein abundance; no effect on localization to the plasma membrane; no effect on substrate transmembrane transport; decreased ATPase activity; no effect on ATPase-coupled transmembrane transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs753759474Ensembl.1
Natural variantiVAR_067364160R → Q1 PublicationCorresponds to variant dbSNP:rs528655917Ensembl.1
Natural variantiVAR_022704166Q → E2 PublicationsCorresponds to variant dbSNP:rs1061017Ensembl.1
Natural variantiVAR_022705206I → L1 PublicationCorresponds to variant dbSNP:rs12721643Ensembl.1
Natural variantiVAR_022706208F → S2 PublicationsCorresponds to variant dbSNP:rs1061018Ensembl.1
Natural variantiVAR_022707248S → P. Corresponds to variant dbSNP:rs3116448Ensembl.1
Natural variantiVAR_030357296D → H1 PublicationCorresponds to variant dbSNP:rs41282401Ensembl.1
Natural variantiVAR_022443316T → P1 Publication1
Natural variantiVAR_067365354G → R1 PublicationCorresponds to variant dbSNP:rs138606116Ensembl.1
Natural variantiVAR_082304360Missing No effect on protein abundance; no effect on localization to the plasma membrane; no effect on ATPase activity; no effect on substrate transmembrane transport. 2 Publications1
Natural variantiVAR_082305373F → C Decreased protein abundance; decreased localization to the plasma membrane; no effect on ATPase-coupled transmembrane transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs752626614Ensembl.1
Natural variantiVAR_082306421T → A No effect on protein abundance; no effect on substrate transmembrane transport. 1 PublicationCorresponds to variant dbSNP:rs199854112Ensembl.1
Natural variantiVAR_018349431F → L2 Publications1
Natural variantiVAR_082307434T → M No effect on protein abundance; no effect on localization to the plasma membrane; increased ATPase activity; decreased ATPase-coupled transmembrane transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs769734146Ensembl.1
Natural variantiVAR_067366441S → N1 PublicationCorresponds to variant dbSNP:rs1354553769Ensembl.1
Natural variantiVAR_082308476S → P No effect on protein abundance; no effect on localization to the plasma membrane; no effect on ATPase activity; decreased ATPase-coupled transmembrane transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs1274428653Ensembl.1
Natural variantiVAR_018350489F → L2 PublicationsCorresponds to variant dbSNP:rs192169063Ensembl.1
Natural variantiVAR_030358528A → T1 PublicationCorresponds to variant dbSNP:rs45605536Ensembl.1
Natural variantiVAR_022708571F → I. Corresponds to variant dbSNP:rs9282571Ensembl.1
Natural variantiVAR_082309572S → R Decreased protein abundance; loss of localization to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs200894058Ensembl.1
Natural variantiVAR_035355590N → Y1 PublicationCorresponds to variant dbSNP:rs34264773Ensembl.1
Natural variantiVAR_022709620D → N No effect on protein abundance; no effect on substrate transmembrane transport. 2 PublicationsCorresponds to variant dbSNP:rs34783571Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014232550 – 611IFSGL…TCTGE → VCWSISQPLHLGCHGFSTSA FHDMDLRLCSIMNFWDKTSA QDSMQQETILVTMQHVLAKN IW in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_014233612 – 655Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF103796 mRNA Translation: AAD09188.1
AF098951 mRNA Translation: AAC97367.1
AB056867 mRNA Translation: BAB39212.1
AB051855 mRNA Translation: BAB46933.1
AY017168 mRNA Translation: AAG52982.1
AY289766 mRNA Translation: AAP44087.1
AY288307 mRNA Translation: AAP31310.1
AF463519 mRNA Translation: AAO14617.1
AY333755 mRNA Translation: AAQ92941.1
AY333756 mRNA Translation: AAQ92942.1
AK002040 mRNA Translation: BAA92050.1
AK290000 mRNA Translation: BAF82689.1
DQ996467 Genomic DNA Translation: ABI97388.1
AC084732 Genomic DNA No translation available.
AC097484 Genomic DNA Translation: AAY40902.1
BC021281 mRNA Translation: AAH21281.1
BC092408 mRNA Translation: AAH92408.1
AF093771 mRNA No translation available.
AF093772 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3628.1 [Q9UNQ0-1]
CCDS58910.1 [Q9UNQ0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001244315.1, NM_001257386.1 [Q9UNQ0-2]
NP_004818.2, NM_004827.2 [Q9UNQ0-1]
XP_005263412.1, XM_005263355.3 [Q9UNQ0-1]
XP_011530722.1, XM_011532420.2 [Q9UNQ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000237612; ENSP00000237612; ENSG00000118777 [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777 [Q9UNQ0-2]
ENST00000650821; ENSP00000498246; ENSG00000118777 [Q9UNQ0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9429

UCSC genome browser

More...
UCSCi
uc003hrg.4, human [Q9UNQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
ABCMdb

Database for mutations in ABC proteins

Protein Spotlight

The unwalkable disease - Issue 222 of February 2020

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103796 mRNA Translation: AAD09188.1
AF098951 mRNA Translation: AAC97367.1
AB056867 mRNA Translation: BAB39212.1
AB051855 mRNA Translation: BAB46933.1
AY017168 mRNA Translation: AAG52982.1
AY289766 mRNA Translation: AAP44087.1
AY288307 mRNA Translation: AAP31310.1
AF463519 mRNA Translation: AAO14617.1
AY333755 mRNA Translation: AAQ92941.1
AY333756 mRNA Translation: AAQ92942.1
AK002040 mRNA Translation: BAA92050.1
AK290000 mRNA Translation: BAF82689.1
DQ996467 Genomic DNA Translation: ABI97388.1
AC084732 Genomic DNA No translation available.
AC097484 Genomic DNA Translation: AAY40902.1
BC021281 mRNA Translation: AAH21281.1
BC092408 mRNA Translation: AAH92408.1
AF093771 mRNA No translation available.
AF093772 mRNA No translation available.
CCDSiCCDS3628.1 [Q9UNQ0-1]
CCDS58910.1 [Q9UNQ0-2]
RefSeqiNP_001244315.1, NM_001257386.1 [Q9UNQ0-2]
NP_004818.2, NM_004827.2 [Q9UNQ0-1]
XP_005263412.1, XM_005263355.3 [Q9UNQ0-1]
XP_011530722.1, XM_011532420.2 [Q9UNQ0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJ3electron microscopy3.78A/B2-655[»]
5NJGelectron microscopy3.78A/B2-655[»]
6ETIelectron microscopy3.10A/B1-655[»]
6FEQelectron microscopy3.60A/B1-655[»]
6FFCelectron microscopy3.56A/B2-655[»]
6HBUelectron microscopy3.09A/B1-655[»]
6HCOelectron microscopy3.58A/B2-655[»]
6HIJelectron microscopy3.56A/B1-655[»]
6HZMelectron microscopy3.09A/B1-655[»]
6VXFelectron microscopy3.50A/B1-655[»]
6VXHelectron microscopy4.00A/B1-655[»]
6VXIelectron microscopy3.70A/B1-655[»]
6VXJelectron microscopy4.10A/B1-655[»]
SMRiQ9UNQ0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114821, 20 interactors
DIPiDIP-29162N
IntActiQ9UNQ0, 19 interactors
MINTiQ9UNQ0
STRINGi9606.ENSP00000237612

Chemistry databases

BindingDBiQ9UNQ0
ChEMBLiCHEMBL5393
DrugBankiDB12001, Abemaciclib
DB08916, Afatinib
DB11363, Alectinib
DB00437, Allopurinol
DB12015, Alpelisib
DB03496, Alvocidib
DB11901, Apalutamide
DB06605, Apixaban
DB15233, Avapritinib
DB11995, Avatrombopag
DB11817, Baricitinib
DB00394, Beclomethasone dipropionate
DB04851, Biricodar
DB12267, Brigatinib
DB00921, Buprenorphine
DB06772, Cabazitaxel
DB00201, Caffeine
DB04690, Camptothecin
DB08907, Canagliflozin
DB09061, Cannabidiol
DB00958, Carboplatin
DB00482, Celecoxib
DB00439, Cerivastatin
DB04540, Cholesterol
DB00515, Cisplatin
DB00242, Cladribine
DB00631, Clofarabine
DB09065, Cobicistat
DB05239, Cobimetinib
DB00286, Conjugated estrogens
DB12483, Copanlisib
DB00091, Cyclosporine
DB08912, Dabrafenib
DB09102, Daclatasvir
DB11963, Dacomitinib
DB00970, Dactinomycin
DB02115, Daidzin
DB12941, Darolutamide
DB09183, Dasabuvir
DB01254, Dasatinib
DB00694, Daunorubicin
DB11943, Delafloxacin
DB01234, Dexamethasone
DB00255, Diethylstilbestrol
DB01248, Docetaxel
DB08930, Dolutegravir
DB00843, Donepezil
DB05928, Dovitinib
DB00997, Doxorubicin
DB00470, Dronabinol
DB11952, Duvelisib
DB04881, Elacridar
DB06210, Eltrombopag
DB13874, Enasidenib
DB00530, Erlotinib
DB11827, Ertugliflozin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00655, Estrone
DB00773, Etoposide
DB00973, Ezetimibe
DB12500, Fedratinib
DB09279, Fimasartan
DB00544, Fluorouracil
DB00158, Folic acid
DB12010, Fostamatinib
DB02703, Fusidic acid
DB00317, Gefitinib
DB01645, Genistein
DB12141, Gilteritinib
DB11978, Glasdegib
DB13879, Glecaprevir
DB01016, Glyburide
DB01094, Hesperetin
DB14538, Hydrocortisone aceponate
DB14539, Hydrocortisone acetate
DB14540, Hydrocortisone butyrate
DB14541, Hydrocortisone cypionate
DB14542, Hydrocortisone phosphate
DB14543, Hydrocortisone probutate
DB14544, Hydrocortisone valerate
DB09054, Idelalisib
DB00619, Imatinib
DB00762, Irinotecan
DB11633, Isavuconazole
DB11757, Istradefylline
DB00602, Ivermectin
DB00709, Lamivudine
DB00448, Lansoprazole
DB14723, Larotrectinib
DB11732, Lasmiditan
DB09027, Ledipasvir
DB01097, Leflunomide
DB09078, Lenvatinib
DB12070, Letermovir
DB13125, Lusutrombopag
DB14009, Medical Cannabis
DB00563, Methotrexate
DB01204, Mitoxantrone
DB00688, Mycophenolate mofetil
DB14011, Nabiximols
DB03467, Naringenin
DB00220, Nelfinavir
DB04868, Nilotinib
DB09079, Nintedanib
DB00698, Nitrofurantoin
DB01051, Novobiocin
DB09074, Olaparib
DB09296, Ombitasvir
DB00338, Omeprazole
DB09330, Osimertinib
DB00526, Oxaliplatin
DB12612, Ozanimod
DB09073, Palbociclib
DB00213, Pantoprazole
DB09297, Paritaprevir
DB06589, Pazopanib
DB13878, Pibrentasvir
DB08860, Pitavastatin
DB08901, Ponatinib
DB01708, Prasterone
DB00175, Pravastatin
DB00457, Prazosin
DB00396, Progesterone
DB04216, Quercetin
DB01129, Rabeprazole
DB00481, Raloxifene
DB08896, Regorafenib
DB11855, Revefenacin
DB08864, Rilpivirine
DB00740, Riluzole
DB12457, Rimegepant
DB08931, Riociguat
DB00503, Ritonavir
DB06228, Rivaroxaban
DB09291, Rolapitant
DB01098, Rosuvastatin
DB12332, Rucaparib
DB06654, Safinamide
DB01232, Saquinavir
DB11689, Selumetinib
DB06290, Simeprevir
DB08934, Sofosbuvir
DB00398, Sorafenib
DB00795, Sulfasalazine
DB00669, Sumatriptan
DB01268, Sunitinib
DB11644, Tafamidis
DB11760, Talazoparib
DB00675, Tamoxifen
DB04348, Taurocholic acid
DB12887, Tazemetostat
DB01079, Tegaserod
DB00966, Telmisartan
DB00444, Teniposide
DB09299, Tenofovir alafenamide
DB08880, Teriflunomide
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB11712, Tezacaftor
DB01685, Topiroxostat
DB01030, Topotecan
DB14962, Trastuzumab deruxtecan
DB11652, Tucatinib
DB15328, Ubrogepant
DB15091, Upadacitinib
DB05294, Vandetanib
DB11613, Velpatasvir
DB08881, Vemurafenib
DB11581, Venetoclax
DB00285, Venlafaxine
DB00541, Vincristine
DB08828, Vismodegib
DB12026, Voxilaprevir
DB00549, Zafirlukast
DB00495, Zidovudine
DrugCentraliQ9UNQ0
GuidetoPHARMACOLOGYi792

Protein family/group databases

TCDBi3.A.1.204.2, the atp-binding cassette (abc) superfamily

PTM databases

GlyGeniQ9UNQ0, 1 site
iPTMnetiQ9UNQ0
PhosphoSitePlusiQ9UNQ0

Polymorphism and mutation databases

BioMutaiABCG2
DMDMi67462103

Proteomic databases

jPOSTiQ9UNQ0
MassIVEiQ9UNQ0
PaxDbiQ9UNQ0
PeptideAtlasiQ9UNQ0
PRIDEiQ9UNQ0
ProteomicsDBi85323 [Q9UNQ0-1]
85324 [Q9UNQ0-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9UNQ0, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14577, 328 antibodies

The DNASU plasmid repository

More...
DNASUi
9429

Genome annotation databases

EnsembliENST00000237612; ENSP00000237612; ENSG00000118777 [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777 [Q9UNQ0-2]
ENST00000650821; ENSP00000498246; ENSG00000118777 [Q9UNQ0-1]
GeneIDi9429
KEGGihsa:9429
UCSCiuc003hrg.4, human [Q9UNQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9429
DisGeNETi9429
EuPathDBiHostDB:ENSG00000118777.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCG2
HGNCiHGNC:74, ABCG2
HPAiENSG00000118777, Tissue enhanced (ductus deferens, intestine, seminal vesicle)
MalaCardsiABCG2
MIMi138900, phenotype
603756, gene
614490, phenotype
neXtProtiNX_Q9UNQ0
OpenTargetsiENSG00000118777
PharmGKBiPA390

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0061, Eukaryota
GeneTreeiENSGT00940000162658
HOGENOMiCLU_000604_57_8_1
InParanoidiQ9UNQ0
KOiK05681
OMAiGTQFTRG
OrthoDBi1022017at2759
PhylomeDBiQ9UNQ0
TreeFamiTF105211

Enzyme and pathway databases

PathwayCommonsiQ9UNQ0
ReactomeiR-HSA-189451, Heme biosynthesis
R-HSA-189483, Heme degradation
R-HSA-2161517, Abacavir transmembrane transport
R-HSA-917937, Iron uptake and transport
SABIO-RKiQ9UNQ0
SIGNORiQ9UNQ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9429, 1 hit in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCG2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9429
PharosiQ9UNQ0, Tchem

Protein Ontology

More...
PROi
PR:Q9UNQ0
RNActiQ9UNQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118777, Expressed in jejunal mucosa and 205 other tissues
ExpressionAtlasiQ9UNQ0, baseline and differential
GenevisibleiQ9UNQ0, HS

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR030256, ABCG2
IPR027417, P-loop_NTPase
PANTHERiPTHR19241:SF268, PTHR19241:SF268, 1 hit
PfamiView protein in Pfam
PF01061, ABC2_membrane, 1 hit
PF00005, ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNQ0
Secondary accession number(s): A0A1W3
, A8K1T5, O95374, Q4W5I3, Q53ZQ1, Q569L4, Q5YLG4, Q86V64, Q8IX16, Q96LD6, Q96TA8, Q9BY73, Q9NUS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 10, 2005
Last modified: August 12, 2020
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  8. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  9. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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