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Entry version 161 (31 Jul 2019)
Sequence version 4 (20 May 2008)
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Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS03904-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.99.9 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-4085001 Sialic acid metabolism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UNP4

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT29 Glycosyltransferase Family 29

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000751 [Q9UNP4-3]
SLP:000000776
SLP:000000868
SLP:000000877 [Q9UNP4-3]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name:
ST3GalV
Sialyltransferase 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ST3GAL5
Synonyms:SIAT9
ORF Names:UNQ2510/PRO5998
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10872 ST3GAL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604402 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNP4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini83 – 418LumenalSequence analysisAdd BLAST336

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Salt and pepper developmental regression syndrome (SPDRS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive disorder characterized by infantile onset of severe, recurrent and refractory seizures, failure to thrive, psychomotor delay, developmental stagnation, and cortical blindness. Deafness is observed in some patients. Affected individuals have patches of skin hypo- or hyperpigmentation on the trunk, face, and extremities.
Related information in OMIM

Keywords - Diseasei

Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8869

MalaCards human disease database

More...
MalaCardsi
ST3GAL5
MIMi609056 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115525

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
171714 Amish infantile epilepsy syndrome
370938 Salt-and-pepper syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35773

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05867 99mTc-14 F7 Mab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ST3GAL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189047140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001493021 – 418Lactosylceramide alpha-2,3-sialyltransferaseAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi195 ↔ 353By similarity
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UNP4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNP4

PeptideAtlas

More...
PeptideAtlasi
Q9UNP4

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNP4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85318 [Q9UNP4-1]
85319 [Q9UNP4-2]
85320 [Q9UNP4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNP4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNP4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UNP4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115525 Expressed in 217 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNP4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UNP4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034708
HPA040425
HPA068928

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114389, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9UNP4, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UNP4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2692 Eukaryota
ENOG410XT8P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNP4

KEGG Orthology (KO)

More...
KOi
K03370

Identification of Orthologs from Complete Genome Data

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OMAi
YKYDPPF

Database of Orthologous Groups

More...
OrthoDBi
891104at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNP4

TreeFam database of animal gene trees

More...
TreeFami
TF352819

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1480.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00777 Glyco_transf_29, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005557 Sialyl_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 35 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTKAAGCAE RRPLQPRTEA AAAPAGRAMP SEYTYVKLRS DCSRPSLQWY
60 70 80 90 100
TRAQSKMRRP SLLLKDILKC TLLVFGVWIL YILKLNYTTE ECDMKKMHYV
110 120 130 140 150
DPDHVKRAQK YAQQVLQKEC RPKFAKTSMA LLFEHRYSVD LLPFVQKAPK
160 170 180 190 200
DSEAESKYDP PFGFRKFSSK VQTLLELLPE HDLPEHLKAK TCRRCVVIGS
210 220 230 240 250
GGILHGLELG HTLNQFDVVI RLNSAPVEGY SEHVGNKTTI RMTYPEGAPL
260 270 280 290 300
SDLEYYSNDL FVAVLFKSVD FNWLQAMVKK ETLPFWVRLF FWKQVAEKIP
310 320 330 340 350
LQPKHFRILN PVIIKETAFD ILQYSEPQSR FWGRDKNVPT IGVIAVVLAT
360 370 380 390 400
HLCDEVSLAG FGYDLNQPRT PLHYFDSQCM AAMNFQTMHN VTTETKFLLK
410
LVKEGVVKDL SGGIDREF
Length:418
Mass (Da):47,990
Last modified:May 20, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB423540B31C27A8A
GO
Isoform 2 (identifier: Q9UNP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:390
Mass (Da):45,099
Checksum:i30EC0B46B4C29DBF
GO
Isoform 3 (identifier: Q9UNP4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     24-28: PAGRA → MASVP

Show »
Length:395
Mass (Da):45,585
Checksum:i961126EE86517F66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 35 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PR45A0A1W2PR45_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1X7SBT2A0A1X7SBT2_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
378Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRC6A0A1W2PRC6_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
407Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S2Z4Q7A0A0S2Z4Q7_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
337Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQR0A0A1W2PQR0_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRY1A0A1W2PRY1_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRD9A0A1W2PRD9_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQQ6A0A1W2PQQ6_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPT1A0A1W2PPT1_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5 hCG_34610
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQH5A0A1W2PQH5_HUMAN
Lactosylceramide alpha-2,3-sialyltr...
ST3GAL5
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD14634 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF66146 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89463 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAY24147 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA33950 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025510104H → R3 PublicationsCorresponds to variant dbSNP:rs1138484EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0336861 – 28Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0336871 – 23Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_03368824 – 28PAGRA → MASVP in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB018356 mRNA Translation: BAA33950.1 Different initiation.
AF119415 mRNA Translation: AAF66146.1 Different initiation.
AY152815 mRNA Translation: AAO16866.2
AF105026 mRNA Translation: AAD14634.1 Different initiation.
AK001340 mRNA Translation: BAG50894.1
AC105053 Genomic DNA Translation: AAY24147.1 Sequence problems.
CH471053 Genomic DNA Translation: EAW99475.1
CH471053 Genomic DNA Translation: EAW99479.1
BC065936 mRNA Translation: AAH65936.2
AY359105 mRNA Translation: AAQ89463.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1986.2 [Q9UNP4-1]
CCDS42705.1 [Q9UNP4-3]
CCDS86856.1 [Q9UNP4-2]

NCBI Reference Sequences

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RefSeqi
NP_001035902.1, NM_001042437.1 [Q9UNP4-3]
NP_003887.3, NM_003896.3 [Q9UNP4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000393805; ENSP00000377394; ENSG00000115525 [Q9UNP4-2]
ENST00000393808; ENSP00000377397; ENSG00000115525 [Q9UNP4-3]
ENST00000638572; ENSP00000491316; ENSG00000115525 [Q9UNP4-1]
ENST00000638986; ENSP00000491853; ENSG00000115525 [Q9UNP4-2]
ENST00000639432; ENSP00000491828; ENSG00000115525 [Q9UNP4-2]
ENST00000640322; ENSP00000491564; ENSG00000115525 [Q9UNP4-2]
ENST00000640982; ENSP00000492299; ENSG00000115525 [Q9UNP4-2]
ENST00000640992; ENSP00000492753; ENSG00000115525 [Q9UNP4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8869

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8869

UCSC genome browser

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UCSCi
uc002sqp.2 human [Q9UNP4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal V

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018356 mRNA Translation: BAA33950.1 Different initiation.
AF119415 mRNA Translation: AAF66146.1 Different initiation.
AY152815 mRNA Translation: AAO16866.2
AF105026 mRNA Translation: AAD14634.1 Different initiation.
AK001340 mRNA Translation: BAG50894.1
AC105053 Genomic DNA Translation: AAY24147.1 Sequence problems.
CH471053 Genomic DNA Translation: EAW99475.1
CH471053 Genomic DNA Translation: EAW99479.1
BC065936 mRNA Translation: AAH65936.2
AY359105 mRNA Translation: AAQ89463.1 Different initiation.
CCDSiCCDS1986.2 [Q9UNP4-1]
CCDS42705.1 [Q9UNP4-3]
CCDS86856.1 [Q9UNP4-2]
RefSeqiNP_001035902.1, NM_001042437.1 [Q9UNP4-3]
NP_003887.3, NM_003896.3 [Q9UNP4-1]

3D structure databases

SMRiQ9UNP4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114389, 3 interactors
IntActiQ9UNP4, 1 interactor
STRINGi9606.ENSP00000366549

Chemistry databases

DrugBankiDB05867 99mTc-14 F7 Mab
SwissLipidsiSLP:000000751 [Q9UNP4-3]
SLP:000000776
SLP:000000868
SLP:000000877 [Q9UNP4-3]

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

PTM databases

iPTMnetiQ9UNP4
PhosphoSitePlusiQ9UNP4
SwissPalmiQ9UNP4

Polymorphism and mutation databases

BioMutaiST3GAL5
DMDMi189047140

Proteomic databases

jPOSTiQ9UNP4
PaxDbiQ9UNP4
PeptideAtlasiQ9UNP4
PRIDEiQ9UNP4
ProteomicsDBi85318 [Q9UNP4-1]
85319 [Q9UNP4-2]
85320 [Q9UNP4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393805; ENSP00000377394; ENSG00000115525 [Q9UNP4-2]
ENST00000393808; ENSP00000377397; ENSG00000115525 [Q9UNP4-3]
ENST00000638572; ENSP00000491316; ENSG00000115525 [Q9UNP4-1]
ENST00000638986; ENSP00000491853; ENSG00000115525 [Q9UNP4-2]
ENST00000639432; ENSP00000491828; ENSG00000115525 [Q9UNP4-2]
ENST00000640322; ENSP00000491564; ENSG00000115525 [Q9UNP4-2]
ENST00000640982; ENSP00000492299; ENSG00000115525 [Q9UNP4-2]
ENST00000640992; ENSP00000492753; ENSG00000115525 [Q9UNP4-2]
GeneIDi8869
KEGGihsa:8869
UCSCiuc002sqp.2 human [Q9UNP4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8869
DisGeNETi8869

GeneCards: human genes, protein and diseases

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GeneCardsi
ST3GAL5
HGNCiHGNC:10872 ST3GAL5
HPAiHPA034708
HPA040425
HPA068928
MalaCardsiST3GAL5
MIMi604402 gene
609056 phenotype
neXtProtiNX_Q9UNP4
OpenTargetsiENSG00000115525
Orphaneti171714 Amish infantile epilepsy syndrome
370938 Salt-and-pepper syndrome
PharmGKBiPA35773

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00940000157929
InParanoidiQ9UNP4
KOiK03370
OMAiYKYDPPF
OrthoDBi891104at2759
PhylomeDBiQ9UNP4
TreeFamiTF352819

Enzyme and pathway databases

BioCyciMetaCyc:HS03904-MONOMER
BRENDAi2.4.99.9 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism
SIGNORiQ9UNP4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ST3GAL5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ST3GAL5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8869

Protein Ontology

More...
PROi
PR:Q9UNP4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115525 Expressed in 217 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiQ9UNP4 baseline and differential
GenevisibleiQ9UNP4 HS

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIAT9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNP4
Secondary accession number(s): B3KM82
, D6W5L9, O94902, Q53QU1, Q6NZX4, Q6YFL1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 20, 2008
Last modified: July 31, 2019
This is version 161 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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