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Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • negative regulation of coagulation Source: BHF-UCL

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:PROCR
Synonyms:EPCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101000.5
HGNCiHGNC:9452 PROCR
MIMi600646 gene
neXtProtiNX_Q9UNN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 210ExtracellularSequence analysisAdd BLAST193
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 238CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10544
OpenTargetsiENSG00000101000
Orphaneti64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA33800

Chemistry databases

DrugBankiDB00055 Drotrecogin alfa
DB04327 Phosphatidylethanolamine

Polymorphism and mutation databases

DMDMi13626550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002119118 – 238Endothelial protein C receptorAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 1861 Publication
Glycosylationi136N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi172N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UNN8
MaxQBiQ9UNN8
PaxDbiQ9UNN8
PeptideAtlasiQ9UNN8
PRIDEiQ9UNN8
ProteomicsDBi85317

PTM databases

iPTMnetiQ9UNN8
PhosphoSitePlusiQ9UNN8
SwissPalmiQ9UNN8

Expressioni

Tissue specificityi

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Gene expression databases

BgeeiENSG00000101000 Expressed in 205 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_PROCR
ExpressionAtlasiQ9UNN8 baseline and differential
GenevisibleiQ9UNN8 HS

Organism-specific databases

HPAiHPA039461

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
F2RP251165EBI-719705,EBI-2803960

Protein-protein interaction databases

BioGridi115797, 24 interactors
DIPiDIP-48671N
IntActiQ9UNN8, 7 interactors
MINTiQ9UNN8
STRINGi9606.ENSP00000216968

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UNN8
SMRiQ9UNN8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNN8

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ9UNN8
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
PhylomeDBiQ9UNN8
TreeFamiTF335868

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UNN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL
60 70 80 90 100
GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV
110 120 130 140 150
HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW
160 170 180 190 200
QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK
210 220 230
GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC
Length:238
Mass (Da):26,671
Last modified:May 1, 2000 - v1
Checksum:iEA7F0658CD19695C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQQ4A0A0U1RQQ4_HUMAN
Endothelial protein C receptor
PROCR
213Annotation score:
A0A0U1RRC4A0A0U1RRC4_HUMAN
Endothelial protein C receptor
PROCR
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6L → P in BAA77249 (PubMed:10570964).Curated1
Sequence conflicti47N → A in BAA77249 (PubMed:10570964).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012282219S → G2 PublicationsCorresponds to variant dbSNP:rs867186Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA Translation: AAA63647.1
X89079 mRNA Translation: CAA61450.1
AF106202 Genomic DNA Translation: AAD43967.1
AB026584 Genomic DNA Translation: BAA77249.2
CR456948 mRNA Translation: CAG33229.1
AF375468 Genomic DNA Translation: AAK53045.1
AK314887 mRNA Translation: BAG37401.1
AL356652 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76224.1
BC014451 mRNA Translation: AAH14451.1
CCDSiCCDS13248.1
PIRiA55365
RefSeqiNP_006395.2, NM_006404.4
UniGeneiHs.647450

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000
GeneIDi10544
KEGGihsa:10544
UCSCiuc002xbt.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA Translation: AAA63647.1
X89079 mRNA Translation: CAA61450.1
AF106202 Genomic DNA Translation: AAD43967.1
AB026584 Genomic DNA Translation: BAA77249.2
CR456948 mRNA Translation: CAG33229.1
AF375468 Genomic DNA Translation: AAK53045.1
AK314887 mRNA Translation: BAG37401.1
AL356652 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76224.1
BC014451 mRNA Translation: AAH14451.1
CCDSiCCDS13248.1
PIRiA55365
RefSeqiNP_006395.2, NM_006404.4
UniGeneiHs.647450

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8
SMRiQ9UNN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115797, 24 interactors
DIPiDIP-48671N
IntActiQ9UNN8, 7 interactors
MINTiQ9UNN8
STRINGi9606.ENSP00000216968

Chemistry databases

DrugBankiDB00055 Drotrecogin alfa
DB04327 Phosphatidylethanolamine

PTM databases

iPTMnetiQ9UNN8
PhosphoSitePlusiQ9UNN8
SwissPalmiQ9UNN8

Polymorphism and mutation databases

DMDMi13626550

Proteomic databases

EPDiQ9UNN8
MaxQBiQ9UNN8
PaxDbiQ9UNN8
PeptideAtlasiQ9UNN8
PRIDEiQ9UNN8
ProteomicsDBi85317

Protocols and materials databases

DNASUi10544
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000
GeneIDi10544
KEGGihsa:10544
UCSCiuc002xbt.5 human

Organism-specific databases

CTDi10544
DisGeNETi10544
EuPathDBiHostDB:ENSG00000101000.5
GeneCardsiPROCR
HGNCiHGNC:9452 PROCR
HPAiHPA039461
MIMi600646 gene
neXtProtiNX_Q9UNN8
OpenTargetsiENSG00000101000
Orphaneti64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA33800
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ9UNN8
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
PhylomeDBiQ9UNN8
TreeFamiTF335868

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiPROCR human
EvolutionaryTraceiQ9UNN8
GeneWikiiEndothelial_protein_C_receptor
GenomeRNAii10544
PROiPR:Q9UNN8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101000 Expressed in 205 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_PROCR
ExpressionAtlasiQ9UNN8 baseline and differential
GenevisibleiQ9UNN8 HS

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPCR_HUMAN
AccessioniPrimary (citable) accession number: Q9UNN8
Secondary accession number(s): B2RC04
, Q14218, Q6IB56, Q96CB3, Q9ULX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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