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Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • negative regulation of coagulation Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROCR
Synonyms:EPCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101000.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9452 PROCR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600646 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 210ExtracellularSequence analysisAdd BLAST193
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 238CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10544

Open Targets

More...
OpenTargetsi
ENSG00000101000

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
64738 NON RARE IN EUROPE: Non rare thrombophilia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33800

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00055 Drotrecogin alfa
DB04327 Phosphatidylethanolamine

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13626550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002119118 – 238Endothelial protein C receptorAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 1861 Publication
Glycosylationi136N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi172N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UNN8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UNN8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNN8

PeptideAtlas

More...
PeptideAtlasi
Q9UNN8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNN8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85317

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNN8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UNN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101000 Expressed in 205 organ(s), highest expression level in layer of synovial tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_PROCR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNN8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UNN8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039461

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
F2RP251165EBI-719705,EBI-2803960

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115797, 24 interactors

Database of interacting proteins

More...
DIPi
DIP-48671N

Protein interaction database and analysis system

More...
IntActi
Q9UNN8, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9UNN8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216968

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UNN8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UNN8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UNN8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWW5 Eukaryota
ENOG41116AV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059633

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNN8

KEGG Orthology (KO)

More...
KOi
K06557

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFLQDTC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0JCK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNN8

TreeFam database of animal gene trees

More...
TreeFami
TF335868

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog

The PANTHER Classification System

More...
PANTHERi
PTHR15349 PTHR15349, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16497 MHC_I_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54452 SSF54452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UNN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL
60 70 80 90 100
GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV
110 120 130 140 150
HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW
160 170 180 190 200
QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK
210 220 230
GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC
Length:238
Mass (Da):26,671
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA7F0658CD19695C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQQ4A0A0U1RQQ4_HUMAN
Endothelial protein C receptor
PROCR
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRC4A0A0U1RRC4_HUMAN
Endothelial protein C receptor
PROCR
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6L → P in BAA77249 (PubMed:10570964).Curated1
Sequence conflicti47N → A in BAA77249 (PubMed:10570964).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012282219S → G2 PublicationsCorresponds to variant dbSNP:rs867186Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L35545 mRNA Translation: AAA63647.1
X89079 mRNA Translation: CAA61450.1
AF106202 Genomic DNA Translation: AAD43967.1
AB026584 Genomic DNA Translation: BAA77249.2
CR456948 mRNA Translation: CAG33229.1
AF375468 Genomic DNA Translation: AAK53045.1
AK314887 mRNA Translation: BAG37401.1
AL356652 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76224.1
BC014451 mRNA Translation: AAH14451.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13248.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55365

NCBI Reference Sequences

More...
RefSeqi
NP_006395.2, NM_006404.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.647450

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216968; ENSP00000216968; ENSG00000101000

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10544

UCSC genome browser

More...
UCSCi
uc002xbt.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA Translation: AAA63647.1
X89079 mRNA Translation: CAA61450.1
AF106202 Genomic DNA Translation: AAD43967.1
AB026584 Genomic DNA Translation: BAA77249.2
CR456948 mRNA Translation: CAG33229.1
AF375468 Genomic DNA Translation: AAK53045.1
AK314887 mRNA Translation: BAG37401.1
AL356652 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76224.1
BC014451 mRNA Translation: AAH14451.1
CCDSiCCDS13248.1
PIRiA55365
RefSeqiNP_006395.2, NM_006404.4
UniGeneiHs.647450

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8
SMRiQ9UNN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115797, 24 interactors
DIPiDIP-48671N
IntActiQ9UNN8, 7 interactors
MINTiQ9UNN8
STRINGi9606.ENSP00000216968

Chemistry databases

DrugBankiDB00055 Drotrecogin alfa
DB04327 Phosphatidylethanolamine

PTM databases

iPTMnetiQ9UNN8
PhosphoSitePlusiQ9UNN8
SwissPalmiQ9UNN8

Polymorphism and mutation databases

DMDMi13626550

Proteomic databases

EPDiQ9UNN8
MaxQBiQ9UNN8
PaxDbiQ9UNN8
PeptideAtlasiQ9UNN8
PRIDEiQ9UNN8
ProteomicsDBi85317

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10544
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000
GeneIDi10544
KEGGihsa:10544
UCSCiuc002xbt.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10544
DisGeNETi10544
EuPathDBiHostDB:ENSG00000101000.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PROCR
HGNCiHGNC:9452 PROCR
HPAiHPA039461
MIMi600646 gene
neXtProtiNX_Q9UNN8
OpenTargetsiENSG00000101000
Orphaneti64738 NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA33800

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ9UNN8
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
PhylomeDBiQ9UNN8
TreeFamiTF335868

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PROCR human
EvolutionaryTraceiQ9UNN8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Endothelial_protein_C_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10544

Protein Ontology

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PROi
PR:Q9UNN8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101000 Expressed in 205 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_PROCR
ExpressionAtlasiQ9UNN8 baseline and differential
GenevisibleiQ9UNN8 HS

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPCR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNN8
Secondary accession number(s): B2RC04
, Q14218, Q6IB56, Q96CB3, Q9ULX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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