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Entry version 173 (13 Feb 2019)
Sequence version 2 (02 May 2002)
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Protein

FAS-associated factor 1

Gene

FAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • NF-kappaB binding Source: UniProtKB
  • protein domain specific binding Source: Ensembl
  • protein kinase binding Source: UniProtKB
  • protein kinase regulator activity Source: UniProtKB
  • ubiquitin binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UNN5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UNN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FAS-associated factor 1
Short name:
hFAF1
Alternative name(s):
UBX domain-containing protein 12
UBX domain-containing protein 3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAF1
Synonyms:UBXD12, UBXN3A
ORF Names:CGI-03
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185104.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3578 FAF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604460 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11124

Open Targets

More...
OpenTargetsi
ENSG00000185104

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27976

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3758063

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20454906

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110381 – 650FAS-associated factor 1Add BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei320PhosphoserineCombined sources1
Modified residuei580PhosphothreonineCombined sources1
Modified residuei582PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UNN5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UNN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNN5

PeptideAtlas

More...
PeptideAtlasi
Q9UNN5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85315
85316 [Q9UNN5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185104 Expressed in 220 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UNN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB072814
HPA018253

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDT1 and ATPase VCP/p97 (PubMed:26842564). Interacts (via UBA domain) with FAS (via death domain) (PubMed:10462485). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain) (PubMed:21978668).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
VCPP550724EBI-15930546,EBI-355164

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116298, 139 interactors

Database of interacting proteins

More...
DIPi
DIP-38245N

Protein interaction database and analysis system

More...
IntActi
Q9UNN5, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9UNN5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360843

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1650
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8CNMR-A569-650[»]
2DZMNMR-A99-191[»]
2EC4NMR-A325-495[»]
3E21X-ray1.73A5-47[»]
3QC8X-ray2.20B571-650[»]
3QCAX-ray2.90A/B/C/D571-650[»]
3QQ8X-ray2.00B568-650[»]
3QWZX-ray2.00B571-650[»]
3QX1X-ray1.60A/B571-650[»]
3R3MX-ray3.00A/B/C/D568-650[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UNN5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UNN5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UNN5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57UBA1 PublicationAdd BLAST57
Domaini569 – 646UBXPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043073

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002876

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNN5

KEGG Orthology (KO)

More...
KOi
K20703

Identification of Orthologs from Complete Genome Data

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OMAi
MEIFSAQ

Database of Orthologous Groups

More...
OrthoDBi
845154at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNN5

TreeFam database of animal gene trees

More...
TreeFami
TF314172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01771 Faf1_UBX, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00789 UBX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50033 UBX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q9UNN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG
60 70 80 90 100
ILQSEYGGET IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM
110 120 130 140 150
LDFRVEYRDR NVDVVLEDTC TVGEIKQILE NELQIPVSKM LLKGWKTGDV
160 170 180 190 200
EDSTVLKSLH LPKNNSLYVL TPDLPPPSSS SHAGALQESL NQNFMLIITH
210 220 230 240 250
REVQREYNLN FSGSSTIQEV KRNVYDLTSI PVRHQLWEGW PTSATDDSMC
260 270 280 290 300
LAESGLSYPC HRLTVGRRSS PAQTREQSEE QITDVHMVSD SDGDDFEDAT
310 320 330 340 350
EFGVDDGEVF GMASSALRKS PMMPENAENE GDALLQFTAE FSSRYGDCHP
360 370 380 390 400
VFFIGSLEAA FQEAFYVKAR DRKLLAIYLH HDESVLTNVF CSQMLCAESI
410 420 430 440 450
VSYLSQNFIT WAWDLTKDSN RARFLTMCNR HFGSVVAQTI RTQKTDQFPL
460 470 480 490 500
FLIIMGKRSS NEVLNVIQGN TTVDELMMRL MAAMEIFTAQ QQEDIKDEDE
510 520 530 540 550
REARENVKRE QDEAYRLSLE ADRAKREAHE REMAEQFRLE QIRKEQEEER
560 570 580 590 600
EAIRLSLEQA LPPEPKEENA EPVSKLRIRT PSGEFLERRF LASNKLQIVF
610 620 630 640 650
DFVASKGFPW DEYKLLSTFP RRDVTQLDPN KSLLEVKLFP QETLFLEAKE
Length:650
Mass (Da):73,954
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FB9018B9A230488
GO
Isoform Short (identifier: Q9UNN5-2) [UniParc]FASTAAdd to basket
Also known as: hFAF1(s)

The sequence of this isoform differs from the canonical sequence as follows:
     188-339: Missing.

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):56,934
Checksum:iA9B444F8E8257017
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KT28B3KT28_HUMAN
cDNA FLJ37524 fis, clone BRCAN20071...
FAF1
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ANM7B1ANM7_HUMAN
FAS-associated factor 1
FAF1
490Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD51876 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti448F → K in AAD51886 (PubMed:10462485).Curated1
Sequence conflicti448F → K in AAD51876 (PubMed:10462485).Curated1
Sequence conflicti498E → G in AAD51886 (PubMed:10462485).Curated1
Sequence conflicti498E → G in AAD51876 (PubMed:10462485).Curated1
Sequence conflicti529H → R in AAD51886 (PubMed:10462485).Curated1
Sequence conflicti529H → R in AAD51876 (PubMed:10462485).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006704188 – 339Missing in isoform Short. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF106798 mRNA Translation: AAD51886.1
AF094700 mRNA Translation: AAD51876.1 Different initiation.
AF136173 mRNA Translation: AAP97263.1
AJ271408 mRNA Translation: CAB67705.1
AF132938 mRNA Translation: AAD27713.1
AC091610 Genomic DNA No translation available.
AC118557 Genomic DNA No translation available.
AL049637 Genomic DNA No translation available.
AL359977 Genomic DNA No translation available.
AL603746 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06837.1
BC004970 mRNA Translation: AAH04970.1
BC067100 mRNA Translation: AAH67100.1
AL133631 mRNA Translation: CAB63755.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS554.1 [Q9UNN5-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC7093
T43466

NCBI Reference Sequences

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RefSeqi
NP_008982.1, NM_007051.2 [Q9UNN5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.530402

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396153; ENSP00000379457; ENSG00000185104 [Q9UNN5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11124

UCSC genome browser

More...
UCSCi
uc001cse.2 human [Q9UNN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106798 mRNA Translation: AAD51886.1
AF094700 mRNA Translation: AAD51876.1 Different initiation.
AF136173 mRNA Translation: AAP97263.1
AJ271408 mRNA Translation: CAB67705.1
AF132938 mRNA Translation: AAD27713.1
AC091610 Genomic DNA No translation available.
AC118557 Genomic DNA No translation available.
AL049637 Genomic DNA No translation available.
AL359977 Genomic DNA No translation available.
AL603746 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06837.1
BC004970 mRNA Translation: AAH04970.1
BC067100 mRNA Translation: AAH67100.1
AL133631 mRNA Translation: CAB63755.1
CCDSiCCDS554.1 [Q9UNN5-1]
PIRiJC7093
T43466
RefSeqiNP_008982.1, NM_007051.2 [Q9UNN5-1]
UniGeneiHs.530402

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H8CNMR-A569-650[»]
2DZMNMR-A99-191[»]
2EC4NMR-A325-495[»]
3E21X-ray1.73A5-47[»]
3QC8X-ray2.20B571-650[»]
3QCAX-ray2.90A/B/C/D571-650[»]
3QQ8X-ray2.00B568-650[»]
3QWZX-ray2.00B571-650[»]
3QX1X-ray1.60A/B571-650[»]
3R3MX-ray3.00A/B/C/D568-650[»]
ProteinModelPortaliQ9UNN5
SMRiQ9UNN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116298, 139 interactors
DIPiDIP-38245N
IntActiQ9UNN5, 50 interactors
MINTiQ9UNN5
STRINGi9606.ENSP00000360843

Chemistry databases

ChEMBLiCHEMBL3758063

PTM databases

iPTMnetiQ9UNN5
PhosphoSitePlusiQ9UNN5

Polymorphism and mutation databases

BioMutaiFAF1
DMDMi20454906

Proteomic databases

EPDiQ9UNN5
jPOSTiQ9UNN5
PaxDbiQ9UNN5
PeptideAtlasiQ9UNN5
PRIDEiQ9UNN5
ProteomicsDBi85315
85316 [Q9UNN5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11124
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396153; ENSP00000379457; ENSG00000185104 [Q9UNN5-1]
GeneIDi11124
KEGGihsa:11124
UCSCiuc001cse.2 human [Q9UNN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11124
DisGeNETi11124
EuPathDBiHostDB:ENSG00000185104.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAF1
HGNCiHGNC:3578 FAF1
HPAiCAB072814
HPA018253
MIMi604460 gene
neXtProtiNX_Q9UNN5
OpenTargetsiENSG00000185104
PharmGKBiPA27976

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA
GeneTreeiENSGT00940000154831
HOGENOMiHOG000043073
HOVERGENiHBG002876
InParanoidiQ9UNN5
KOiK20703
OMAiMEIFSAQ
OrthoDBi845154at2759
PhylomeDBiQ9UNN5
TreeFamiTF314172

Enzyme and pathway databases

SignaLinkiQ9UNN5
SIGNORiQ9UNN5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAF1 human
EvolutionaryTraceiQ9UNN5

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11124

Protein Ontology

More...
PROi
PR:Q9UNN5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185104 Expressed in 220 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9UNN5 baseline and differential
GenevisibleiQ9UNN5 HS

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNN5
Secondary accession number(s): Q549F0
, Q9UF34, Q9UNT3, Q9Y2Z3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: February 13, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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