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UniProtKB - Q9UNL4 (ING4_HUMAN)

Entry version 179 (22 Apr 2020)
Sequence version 1 (01 May 2000)
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Protein

Inhibitor of growth protein 4

Gene

ING4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).By similarity5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei198Histone H3K4me3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi199Zinc 1By similarity1
Metal bindingi201Zinc 1By similarity1
Binding sitei209Histone H3K4me3By similarity1
Metal bindingi212Zinc 2By similarity1
Binding sitei213Histone H3K4me3By similarity1
Metal bindingi217Zinc 2By similarity1
Binding sitei221Histone H3K4me3By similarity1
Metal bindingi223Zinc 1; via pros nitrogenBy similarity1
Metal bindingi226Zinc 1By similarity1
Metal bindingi239Zinc 2By similarity1
Metal bindingi242Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri196 – 245PHD-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processApoptosis, Cell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847 HATs acetylate histones

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UNL4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of growth protein 4
Alternative name(s):
p29ING4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ING4
ORF Names:My036
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19423 ING4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608524 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UNL4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		51147

Open Targets

More...OpenTargetsi		ENSG00000111653

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134976283

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UNL4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ING4

Domain mapping of disease mutations (DMDM)

More...DMDMi		57012981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126681 – 249Inhibitor of growth protein 4Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112N6-acetyllysineCombined sources1
Modified residuei127N6-acetyllysineCombined sources1
Modified residuei129N6-acetyllysineBy similarity1
Modified residuei133Citrulline1 Publication1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei148N6-acetyllysineCombined sources1
Modified residuei156N6-acetyllysineCombined sources1
Modified residuei166Citrulline1 Publication1
Isoform 4 (identifier: Q9UNL4-4)
Modified residuei114N6-acetyllysineCombined sources1
Modified residuei127N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation.1 Publication

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UNL4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UNL4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UNL4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UNL4

PeptideAtlas

More...PeptideAtlasi		Q9UNL4

PRoteomics IDEntifications database

More...PRIDEi		Q9UNL4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85303 [Q9UNL4-1]
85304 [Q9UNL4-2]
85305 [Q9UNL4-3]
85306 [Q9UNL4-4]
85307 [Q9UNL4-5]
85308 [Q9UNL4-6]
85309 [Q9UNL4-7]
85310 [Q9UNL4-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UNL4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UNL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111653 Expressed in kidney and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UNL4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UNL4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111653 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:19187765, PubMed:22334692).

Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653).

Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments KAT7/HBO1 acetylation activity on H3 tails (PubMed:16728974, PubMed:18381289).

Interacts with EP300, RELA and TP53; these interactions may be indirect (PubMed:12750254, PubMed:15029197).

Interacts with EGLN1 (PubMed:15897452).

Interacts with BCL2A1 (By similarity).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119331, 51 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UNL4

Database of interacting proteins

More...DIPi		DIP-42222N

Protein interaction database and analysis system

More...IntActi		Q9UNL4, 34 interactors

Molecular INTeraction database

More...MINTi		Q9UNL4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380024

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UNL4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UNL4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UNL4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili25 – 1181 PublicationAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi127 – 148Bipartite nuclear localization signalAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.2 Publications
The N-terminal coiled-coil domain mediates homodimerization.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 245PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1973 Eukaryota
COG5034 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031900_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UNL4

KEGG Orthology (KO)

More...KOi		K11346

Identification of Orthologs from Complete Genome Data

More...OMAi		SNFGNVH

Database of Orthologous Groups

More...OrthoDBi		1434088at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UNL4

TreeFam database of animal gene trees

More...TreeFami		TF352014

Family and domain databases

Database of protein disorder

More...DisProti		DP01347

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028647 ING4
IPR028651 ING_fam
IPR024610 ING_N_histone-binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR10333 PTHR10333, 1 hit
PTHR10333:SF40 PTHR10333:SF40, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12998 ING, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNL4-1) [UniParc]FASTAAdd to basket
Also known as: ING4_v1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM 
        60         70         80         90        100
SSARSLSSEE KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL 
       110        120        130        140        150
DTDLARFEAD LKEKQIESSD YDSSSSKGKK KGRTQKEKKA ARARSKGKNS 
       160        170        180        190        200
DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS VHPSDVLDMP VDPNEPTYCL 
       210        220        230        240 
CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP RCSQERKKK
Length:249
Mass (Da):28,530
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE3FD9CC9F0CE949
GO
Isoform 2 (identifier: Q9UNL4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: K → S
     132-132: Missing.

Note: May be due to a competing donor splice site.Curated
Show »
Length:248
Mass (Da):28,432
Checksum:i76907CB2119B07E8
GO
Isoform 3 (identifier: Q9UNL4-3) [UniParc]FASTAAdd to basket
Also known as: deltaEx2

The sequence of this isoform differs from the canonical sequence as follows:
     13-37: SIENLPFELQRNFQLMRDLDQRTED → N

Show »
Length:225
Mass (Da):25,554
Checksum:i56E4C5F4AB305918
GO
Isoform 4 (identifier: Q9UNL4-4) [UniParc]FASTAAdd to basket
Also known as: ING4_v4

The sequence of this isoform differs from the canonical sequence as follows:
     129-132: Missing.

Note: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization.Curated
Show »
Length:245
Mass (Da):28,089
Checksum:iD6D1003F066112AC
GO
Isoform 5 (identifier: Q9UNL4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-131: GKKK → E

Show »
Length:246
Mass (Da):28,218
Checksum:iAE5F98B0081B189B
GO
Isoform 6 (identifier: Q9UNL4-6) [UniParc]FASTAAdd to basket
Also known as: ING4_v2

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: Missing.

Note: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization.Curated
Show »
Length:248
Mass (Da):28,402
Checksum:i86907CA611946A45
GO
Isoform 7 (identifier: Q9UNL4-7) [UniParc]FASTAAdd to basket
Also known as: ING4_v3

The sequence of this isoform differs from the canonical sequence as follows:
     128-130: Missing.

Note: Lacks the nuclear localization signal (NLS), resulting in increased cytoplasmic localization.Curated
Show »
Length:246
Mass (Da):28,217
Checksum:i405F98B0061B1C31
GO
Isoform 8 (identifier: Q9UNL4-8) [UniParc]FASTAAdd to basket
Also known as: deltaEx6A

The sequence of this isoform differs from the canonical sequence as follows:
     168-249: SPEYGMPSVT...PRCSQERKKK → VPLSGSILPVWG

Show »
Length:179
Mass (Da):20,482
Checksum:iCE8BCDAD65CECE67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNG1R4GNG1_HUMAN
Inhibitor of growth protein 4
ING4
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4KYM5A4KYM5_HUMAN
Inhibitor of growth family member 4...
ING4
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ14E9PJ14_HUMAN
Inhibitor of growth protein 4
ING4
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEH7H0YEH7_HUMAN
Inhibitor of growth protein 4
ING4
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNE3E9PNE3_HUMAN
Inhibitor of growth protein 4
ING4
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG43153 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04128813 – 37SIENL…QRTED → N in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_041289128 – 131GKKK → E in isoform 5. 1 Publication4
Alternative sequenceiVSP_041290128 – 130Missing in isoform 7. 1 Publication3
Alternative sequenceiVSP_041291129 – 132Missing in isoform 4. 1 Publication4
Alternative sequenceiVSP_012518131K → S in isoform 2. 3 Publications1
Alternative sequenceiVSP_041292131Missing in isoform 6. 1 Publication1
Alternative sequenceiVSP_012519132Missing in isoform 2. 3 Publications1
Alternative sequenceiVSP_041293168 – 249SPEYG…ERKKK → VPLSGSILPVWG in isoform 8. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF156552 mRNA Translation: AAL79773.1
AB197695 mRNA Translation: BAF30477.1
AB197696 mRNA Translation: BAF30478.1
AB197697 mRNA Translation: BAF30479.1
EF152349 mRNA Translation: ABO61139.1
EF152351 mRNA Translation: ABO61141.1
AF063594 mRNA Translation: AAG43153.1 Frameshift.
AF110645 mRNA Translation: AAD48585.1
CH471116 Genomic DNA Translation: EAW88763.1
CH471116 Genomic DNA Translation: EAW88768.1
CH471116 Genomic DNA Translation: EAW88770.1
CH471116 Genomic DNA Translation: EAW88772.1
BC007781 mRNA Translation: AAH07781.1
BC013038 mRNA Translation: AAH13038.2
BC095434 mRNA Translation: AAH95434.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44812.1 [Q9UNL4-3]
CCDS44813.1 [Q9UNL4-1]
CCDS44814.1 [Q9UNL4-5]
CCDS44815.1 [Q9UNL4-4]
CCDS44816.1 [Q9UNL4-8]
CCDS8555.1 [Q9UNL4-2]

NCBI Reference Sequences

More...RefSeqi		NP_001121054.1, NM_001127582.1 [Q9UNL4-1]
NP_001121055.1, NM_001127583.1 [Q9UNL4-5]
NP_001121056.1, NM_001127584.1 [Q9UNL4-4]
NP_001121057.1, NM_001127585.1 [Q9UNL4-3]
NP_001121058.1, NM_001127586.1 [Q9UNL4-8]
NP_057246.2, NM_016162.3 [Q9UNL4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341550; ENSP00000343396; ENSG00000111653 [Q9UNL4-2]
ENST00000396807; ENSP00000380024; ENSG00000111653 [Q9UNL4-1]
ENST00000412586; ENSP00000412705; ENSG00000111653 [Q9UNL4-5]
ENST00000423703; ENSP00000414008; ENSG00000111653 [Q9UNL4-8]
ENST00000444704; ENSP00000397343; ENSG00000111653 [Q9UNL4-3]
ENST00000446105; ENSP00000415903; ENSG00000111653 [Q9UNL4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51147

UCSC genome browser

More...UCSCi		uc001qpv.5 human [Q9UNL4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156552 mRNA Translation: AAL79773.1
AB197695 mRNA Translation: BAF30477.1
AB197696 mRNA Translation: BAF30478.1
AB197697 mRNA Translation: BAF30479.1
EF152349 mRNA Translation: ABO61139.1
EF152351 mRNA Translation: ABO61141.1
AF063594 mRNA Translation: AAG43153.1 Frameshift.
AF110645 mRNA Translation: AAD48585.1
CH471116 Genomic DNA Translation: EAW88763.1
CH471116 Genomic DNA Translation: EAW88768.1
CH471116 Genomic DNA Translation: EAW88770.1
CH471116 Genomic DNA Translation: EAW88772.1
BC007781 mRNA Translation: AAH07781.1
BC013038 mRNA Translation: AAH13038.2
BC095434 mRNA Translation: AAH95434.1
CCDSiCCDS44812.1 [Q9UNL4-3]
CCDS44813.1 [Q9UNL4-1]
CCDS44814.1 [Q9UNL4-5]
CCDS44815.1 [Q9UNL4-4]
CCDS44816.1 [Q9UNL4-8]
CCDS8555.1 [Q9UNL4-2]
RefSeqiNP_001121054.1, NM_001127582.1 [Q9UNL4-1]
NP_001121055.1, NM_001127583.1 [Q9UNL4-5]
NP_001121056.1, NM_001127584.1 [Q9UNL4-4]
NP_001121057.1, NM_001127585.1 [Q9UNL4-3]
NP_001121058.1, NM_001127586.1 [Q9UNL4-8]
NP_057246.2, NM_016162.3 [Q9UNL4-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1JNMR-A188-249[»]
2M1RNMR-A188-249[»]
2PNXX-ray1.80A/C194-246[»]
2VNFX-ray1.76A/C188-246[»]
4AFLX-ray2.28A/B/C/D/E/F2-105[»]
SMRiQ9UNL4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119331, 51 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CORUMiQ9UNL4
DIPiDIP-42222N
IntActiQ9UNL4, 34 interactors
MINTiQ9UNL4
STRINGi9606.ENSP00000380024

PTM databases

iPTMnetiQ9UNL4
PhosphoSitePlusiQ9UNL4

Polymorphism and mutation databases

BioMutaiING4
DMDMi57012981

Proteomic databases

EPDiQ9UNL4
jPOSTiQ9UNL4
MassIVEiQ9UNL4
PaxDbiQ9UNL4
PeptideAtlasiQ9UNL4
PRIDEiQ9UNL4
ProteomicsDBi85303 [Q9UNL4-1]
85304 [Q9UNL4-2]
85305 [Q9UNL4-3]
85306 [Q9UNL4-4]
85307 [Q9UNL4-5]
85308 [Q9UNL4-6]
85309 [Q9UNL4-7]
85310 [Q9UNL4-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22581 260 antibodies

The DNASU plasmid repository

More...DNASUi		51147

Genome annotation databases

EnsembliENST00000341550; ENSP00000343396; ENSG00000111653 [Q9UNL4-2]
ENST00000396807; ENSP00000380024; ENSG00000111653 [Q9UNL4-1]
ENST00000412586; ENSP00000412705; ENSG00000111653 [Q9UNL4-5]
ENST00000423703; ENSP00000414008; ENSG00000111653 [Q9UNL4-8]
ENST00000444704; ENSP00000397343; ENSG00000111653 [Q9UNL4-3]
ENST00000446105; ENSP00000415903; ENSG00000111653 [Q9UNL4-4]
GeneIDi51147
KEGGihsa:51147
UCSCiuc001qpv.5 human [Q9UNL4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51147
DisGeNETi51147

GeneCards: human genes, protein and diseases

More...GeneCardsi		ING4
HGNCiHGNC:19423 ING4
HPAiENSG00000111653 Low tissue specificity
MIMi608524 gene
neXtProtiNX_Q9UNL4
OpenTargetsiENSG00000111653
PharmGKBiPA134976283

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00940000159033
HOGENOMiCLU_031900_5_1_1
InParanoidiQ9UNL4
KOiK11346
OMAiSNFGNVH
OrthoDBi1434088at2759
PhylomeDBiQ9UNL4
TreeFamiTF352014

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ9UNL4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ING4 human
EvolutionaryTraceiQ9UNL4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ING4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51147
PharosiQ9UNL4 Tbio

Protein Ontology

More...PROi		PR:Q9UNL4
RNActiQ9UNL4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111653 Expressed in kidney and 213 other tissues
ExpressionAtlasiQ9UNL4 baseline and differential
GenevisibleiQ9UNL4 HS

Family and domain databases

DisProtiDP01347
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028647 ING4
IPR028651 ING_fam
IPR024610 ING_N_histone-binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333 PTHR10333, 1 hit
PTHR10333:SF40 PTHR10333:SF40, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiING4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNL4
Secondary accession number(s): A4KYM4
, A4KYM6, D3DUR8, Q0EF62, Q0EF63, Q4VBQ6, Q96E15, Q9H3J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: April 22, 2020
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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