UniProtKB - Q9UNL4 (ING4_HUMAN)
Inhibitor of growth protein 4
ING4
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 198 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 199 | Zinc 1By similarity | 1 | |
Metal bindingi | 201 | Zinc 1By similarity | 1 | |
Binding sitei | 209 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 212 | Zinc 2By similarity | 1 | |
Binding sitei | 213 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 217 | Zinc 2By similarity | 1 | |
Binding sitei | 221 | Histone H3K4me3By similarity | 1 | |
Metal bindingi | 223 | Zinc 1; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 226 | Zinc 1By similarity | 1 | |
Metal bindingi | 239 | Zinc 2By similarity | 1 | |
Metal bindingi | 242 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 245 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
- DNA replication Source: UniProtKB
- histone H3 acetylation Source: UniProtKB
- histone H4-K12 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of growth Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- protein acetylation Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Apoptosis, Cell cycle |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UNL4 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SIGNORi | Q9UNL4 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of growth protein 4Alternative name(s): p29ING4 |
Gene namesi | Name:ING4 ORF Names:My036 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111653.19 |
HGNCi | HGNC:19423, ING4 |
MIMi | 608524, gene |
neXtProti | NX_Q9UNL4 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- intermediate filament cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- histone acetyltransferase complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 51147 |
OpenTargetsi | ENSG00000111653 |
PharmGKBi | PA134976283 |
Miscellaneous databases
Pharosi | Q9UNL4, Tbio |
Polymorphism and mutation databases
BioMutai | ING4 |
DMDMi | 57012981 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212668 | 1 – 249 | Inhibitor of growth protein 4Add BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 112 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 127 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 129 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 133 | Citrulline1 Publication | 1 | ||
Modified residuei | 146 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 148 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 156 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 166 | Citrulline1 Publication | 1 | ||
Isoform 4 (identifier: Q9UNL4-4) | |||||
Modified residuei | 114 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 127 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, CitrullinationProteomic databases
EPDi | Q9UNL4 |
jPOSTi | Q9UNL4 |
MassIVEi | Q9UNL4 |
PaxDbi | Q9UNL4 |
PeptideAtlasi | Q9UNL4 |
PRIDEi | Q9UNL4 |
ProteomicsDBi | 85303 [Q9UNL4-1] 85304 [Q9UNL4-2] 85305 [Q9UNL4-3] 85306 [Q9UNL4-4] 85307 [Q9UNL4-5] 85308 [Q9UNL4-6] 85309 [Q9UNL4-7] 85310 [Q9UNL4-8] |
PTM databases
iPTMneti | Q9UNL4 |
PhosphoSitePlusi | Q9UNL4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111653, Expressed in cortical plate and 226 other tissues |
ExpressionAtlasi | Q9UNL4, baseline and differential |
Genevisiblei | Q9UNL4, HS |
Organism-specific databases
HPAi | ENSG00000111653, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:19187765, PubMed:22334692).
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653).
Interacts with H3K4me3 and to a lesser extent with H3K4me2, the interaction augments KAT7/HBO1 acetylation activity on H3 tails (PubMed:16728974, PubMed:18381289).
Interacts with EP300, RELA and TP53; these interactions may be indirect (PubMed:12750254, PubMed:15029197).
Interacts with EGLN1 (PubMed:15897452).
Interacts with BCL2A1 (By similarity).
By similarity8 PublicationsBinary interactionsi
Hide detailsQ9UNL4
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119331, 54 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-719, HBO1-4.2 histone acetyltransferase complex CPX-720, HBO1-4.3 histone acetyltransferase complex |
CORUMi | Q9UNL4 |
DIPi | DIP-42222N |
IntActi | Q9UNL4, 34 interactors |
MINTi | Q9UNL4 |
STRINGi | 9606.ENSP00000380024 |
Miscellaneous databases
RNActi | Q9UNL4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9UNL4 |
SMRi | Q9UNL4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UNL4 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 25 – 118 | 1 PublicationAdd BLAST | 94 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 127 – 148 | Bipartite nuclear localization signalAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 196 – 245 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000159033 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q9UNL4 |
OMAi | NTECSIE |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q9UNL4 |
TreeFami | TF352014 |
Family and domain databases
DisProti | DP01347 |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028647, ING4 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF40, PTHR10333:SF40, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM
60 70 80 90 100
SSARSLSSEE KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL
110 120 130 140 150
DTDLARFEAD LKEKQIESSD YDSSSSKGKK KGRTQKEKKA ARARSKGKNS
160 170 180 190 200
DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS VHPSDVLDMP VDPNEPTYCL
210 220 230 240
CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP RCSQERKKK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GNG1 | R4GNG1_HUMAN | Inhibitor of growth protein 4 | ING4 | 51 | Annotation score: | ||
A4KYM5 | A4KYM5_HUMAN | Inhibitor of growth family member 4... | ING4 | 51 | Annotation score: | ||
E9PJ14 | E9PJ14_HUMAN | Inhibitor of growth protein 4 | ING4 | 47 | Annotation score: | ||
H0YEH7 | H0YEH7_HUMAN | Inhibitor of growth protein 4 | ING4 | 36 | Annotation score: | ||
E9PNE3 | E9PNE3_HUMAN | Inhibitor of growth protein 4 | ING4 | 21 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041288 | 13 – 37 | SIENL…QRTED → N in isoform 3. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_041289 | 128 – 131 | GKKK → E in isoform 5. 1 Publication | 4 | |
Alternative sequenceiVSP_041290 | 128 – 130 | Missing in isoform 7. 1 Publication | 3 | |
Alternative sequenceiVSP_041291 | 129 – 132 | Missing in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_012518 | 131 | K → S in isoform 2. 3 Publications | 1 | |
Alternative sequenceiVSP_041292 | 131 | Missing in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_012519 | 132 | Missing in isoform 2. 3 Publications | 1 | |
Alternative sequenceiVSP_041293 | 168 – 249 | SPEYG…ERKKK → VPLSGSILPVWG in isoform 8. 1 PublicationAdd BLAST | 82 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000341550; ENSP00000343396; ENSG00000111653 [Q9UNL4-2] ENST00000396807; ENSP00000380024; ENSG00000111653 [Q9UNL4-1] ENST00000412586; ENSP00000412705; ENSG00000111653 [Q9UNL4-5] ENST00000423703; ENSP00000414008; ENSG00000111653 [Q9UNL4-8] ENST00000444704; ENSP00000397343; ENSG00000111653 [Q9UNL4-3] ENST00000446105; ENSP00000415903; ENSG00000111653 [Q9UNL4-4] |
GeneIDi | 51147 |
KEGGi | hsa:51147 |
UCSCi | uc001qpv.5, human [Q9UNL4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K1J | NMR | - | A | 188-249 | [»] | |
2M1R | NMR | - | A | 188-249 | [»] | |
2PNX | X-ray | 1.80 | A/C | 194-246 | [»] | |
2VNF | X-ray | 1.76 | A/C | 188-246 | [»] | |
4AFL | X-ray | 2.28 | A/B/C/D/E/F | 2-105 | [»] | |
BMRBi | Q9UNL4 | |||||
SMRi | Q9UNL4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119331, 54 interactors |
ComplexPortali | CPX-718, HBO1-4.1 histone acetyltransferase complex CPX-719, HBO1-4.2 histone acetyltransferase complex CPX-720, HBO1-4.3 histone acetyltransferase complex |
CORUMi | Q9UNL4 |
DIPi | DIP-42222N |
IntActi | Q9UNL4, 34 interactors |
MINTi | Q9UNL4 |
STRINGi | 9606.ENSP00000380024 |
PTM databases
iPTMneti | Q9UNL4 |
PhosphoSitePlusi | Q9UNL4 |
Polymorphism and mutation databases
BioMutai | ING4 |
DMDMi | 57012981 |
Proteomic databases
EPDi | Q9UNL4 |
jPOSTi | Q9UNL4 |
MassIVEi | Q9UNL4 |
PaxDbi | Q9UNL4 |
PeptideAtlasi | Q9UNL4 |
PRIDEi | Q9UNL4 |
ProteomicsDBi | 85303 [Q9UNL4-1] 85304 [Q9UNL4-2] 85305 [Q9UNL4-3] 85306 [Q9UNL4-4] 85307 [Q9UNL4-5] 85308 [Q9UNL4-6] 85309 [Q9UNL4-7] 85310 [Q9UNL4-8] |
Protocols and materials databases
Antibodypediai | 22581, 264 antibodies |
DNASUi | 51147 |
Genome annotation databases
Ensembli | ENST00000341550; ENSP00000343396; ENSG00000111653 [Q9UNL4-2] ENST00000396807; ENSP00000380024; ENSG00000111653 [Q9UNL4-1] ENST00000412586; ENSP00000412705; ENSG00000111653 [Q9UNL4-5] ENST00000423703; ENSP00000414008; ENSG00000111653 [Q9UNL4-8] ENST00000444704; ENSP00000397343; ENSG00000111653 [Q9UNL4-3] ENST00000446105; ENSP00000415903; ENSG00000111653 [Q9UNL4-4] |
GeneIDi | 51147 |
KEGGi | hsa:51147 |
UCSCi | uc001qpv.5, human [Q9UNL4-1] |
Organism-specific databases
CTDi | 51147 |
DisGeNETi | 51147 |
EuPathDBi | HostDB:ENSG00000111653.19 |
GeneCardsi | ING4 |
HGNCi | HGNC:19423, ING4 |
HPAi | ENSG00000111653, Low tissue specificity |
MIMi | 608524, gene |
neXtProti | NX_Q9UNL4 |
OpenTargetsi | ENSG00000111653 |
PharmGKBi | PA134976283 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000159033 |
HOGENOMi | CLU_031900_5_1_1 |
InParanoidi | Q9UNL4 |
OMAi | NTECSIE |
OrthoDBi | 1434088at2759 |
PhylomeDBi | Q9UNL4 |
TreeFami | TF352014 |
Enzyme and pathway databases
PathwayCommonsi | Q9UNL4 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SIGNORi | Q9UNL4 |
Miscellaneous databases
BioGRID-ORCSi | 51147, 3 hits in 844 CRISPR screens |
ChiTaRSi | ING4, human |
EvolutionaryTracei | Q9UNL4 |
GeneWikii | ING4 |
GenomeRNAii | 51147 |
Pharosi | Q9UNL4, Tbio |
PROi | PR:Q9UNL4 |
RNActi | Q9UNL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111653, Expressed in cortical plate and 226 other tissues |
ExpressionAtlasi | Q9UNL4, baseline and differential |
Genevisiblei | Q9UNL4, HS |
Family and domain databases
DisProti | DP01347 |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028647, ING4 IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF40, PTHR10333:SF40, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ING4_HUMAN | |
Accessioni | Q9UNL4Primary (citable) accession number: Q9UNL4 Secondary accession number(s): A4KYM4 Q9H3J0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM