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Protein

Protein angel homolog 1

Gene

ANGEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein angel homolog 1
Gene namesi
Name:ANGEL1
Synonyms:KIAA0759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000013523.9
HGNCiHGNC:19961 ANGEL1
neXtProtiNX_Q9UNK9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000013523
PharmGKBiPA134982299

Polymorphism and mutation databases

BioMutaiANGEL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185811 – 670Protein angel homolog 1Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNK9
MaxQBiQ9UNK9
PaxDbiQ9UNK9
PeptideAtlasiQ9UNK9
PRIDEiQ9UNK9
ProteomicsDBi85301

PTM databases

iPTMnetiQ9UNK9
PhosphoSitePlusiQ9UNK9

Expressioni

Gene expression databases

BgeeiENSG00000013523
CleanExiHS_ANGEL1
ExpressionAtlasiQ9UNK9 baseline and differential
GenevisibleiQ9UNK9 HS

Organism-specific databases

HPAiHPA000948

Interactioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase

Protein-protein interaction databases

BioGridi116938, 16 interactors
IntActiQ9UNK9, 4 interactors
STRINGi9606.ENSP00000251089

Structurei

3D structure databases

ProteinModelPortaliQ9UNK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiKOG2338 Eukaryota
COG5239 LUCA
GeneTreeiENSGT00550000074364
HOGENOMiHOG000033940
HOVERGENiHBG057379
InParanoidiQ9UNK9
KOiK18729
OMAiTHFLPQH
OrthoDBiEOG091G0BJF
PhylomeDBiQ9UNK9
TreeFamiTF316126

Family and domain databases

InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits

Sequencei

Sequence statusi: Complete.

Q9UNK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR
60 70 80 90 100
GPEQEECEGL LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE
110 120 130 140 150
ENAASEDRWS SRQLSDLRAA ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI
160 170 180 190 200
PMQSEPQYAD CAALPVGALA TEQWEEDPAV LAWSIAPEPV PQEEASIWPF
210 220 230 240 250
EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG PQFQFTLMSY
260 270 280 290 300
NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ
310 320 330 340 350
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE
360 370 380 390 400
YFRPGLELLN RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG
410 420 430 440 450
DVKLAQMAIL LAEVDKVARL SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE
460 470 480 490 500
LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL WPSSLGITDC CQYVTSCHPK
510 520 530 540 550
RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE RPAGWAESVL
560 570 580 590 600
EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT
610 620 630 640 650
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP
660 670
FCSSDHLCLL ASFGMEVTAP
Length:670
Mass (Da):75,276
Last modified:May 1, 2000 - v1
Checksum:i3D40E26813E27D83
GO

Sequence cautioni

The sequence BAA34479 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG63079 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti415D → G in AAH28714 (PubMed:15489334).Curated1
Sequence conflicti441P → T in BAG63079 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056239141G → W. Corresponds to variant dbSNP:rs34270005Ensembl.1
Natural variantiVAR_061374383V → L. Corresponds to variant dbSNP:rs45499197Ensembl.1
Natural variantiVAR_056240515F → C. Corresponds to variant dbSNP:rs2075773Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018302 mRNA Translation: BAA34479.1 Different initiation.
AL137268 mRNA Translation: CAB70667.2
AF111169 Genomic DNA Translation: AAD44362.1
BC028714 mRNA Translation: AAH28714.1
AK301589 mRNA Translation: BAG63079.1 Different initiation.
CCDSiCCDS9852.1
RefSeqiNP_056120.2, NM_015305.3
UniGeneiHs.497448

Genome annotation databases

EnsembliENST00000251089; ENSP00000251089; ENSG00000013523
GeneIDi23357
KEGGihsa:23357
UCSCiuc001xsv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK9
Secondary accession number(s): B4DWL7, O94859, Q8NCS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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