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Entry version 174 (07 Apr 2021)
Sequence version 2 (11 Feb 2002)
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Protein

Group IID secretory phospholipase A2

Gene

PLA2G2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7-9.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1
Metal bindingi51Calcium; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei67By similarity1
Metal bindingi68CalciumBy similarity1
Active sitei112By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UNK4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483166, Synthesis of PA

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000652

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Group IID secretory phospholipase A2 (EC:3.1.1.42 Publications)
Short name:
GIID sPLA2
Short name:
sPLA2-IID
Alternative name(s):
PLA2IID
Phosphatidylcholine 2-acylhydrolase 2D
Secretory-type PLA, stroma-associated homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2G2D
Synonyms:SPLASH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9033, PLA2G2D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605630, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNK4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000117215.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26279

Open Targets

More...
OpenTargetsi
ENSG00000117215

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33363

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UNK4, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4281

Drug and drug target database

More...
DrugBanki
DB03017, Lauric acid
DB03193, Stearic acid

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1418

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLA2G2D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002275521 – 145Group IID secretory phospholipase A2Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 138By similarity
Disulfide bondi48 ↔ 64By similarity
Disulfide bondi63 ↔ 118By similarity
Disulfide bondi69 ↔ 145By similarity
Disulfide bondi70 ↔ 111By similarity
Disulfide bondi79 ↔ 104By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 109By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UNK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNK4

PeptideAtlas

More...
PeptideAtlasi
Q9UNK4

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNK4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85300

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UNK4, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas and spleen and less abundantly in colon, thymus, placenta, small intestine, and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117215, Expressed in lymph node and 73 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNK4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UNK4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000117215, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117662, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364246

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9UNK4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UNK4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UNK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4087, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090683_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UNK4

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIHCSDK

Database of Orthologous Groups

More...
OrthoDBi
1422829at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNK4

TreeFam database of animal gene trees

More...
TreeFami
TF319283

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00125, PLA2c, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001211, PLipase_A2
IPR033112, PLipase_A2_Asp_AS
IPR016090, PLipase_A2_dom
IPR036444, PLipase_A2_dom_sf
IPR033113, PLipase_A2_His_AS

The PANTHER Classification System

More...
PANTHERi
PTHR11716, PTHR11716, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00068, Phospholip_A2_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00389, PHPHLIPASEA2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00085, PA2c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48619, SSF48619, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00119, PA2_ASP, 1 hit
PS00118, PA2_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UNK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELALLCGLV VMAGVIPIQG GILNLNKMVK QVTGKMPILS YWPYGCHCGL
60 70 80 90 100
GGRGQPKDAT DWCCQTHDCC YDHLKTQGCS IYKDYYRYNF SQGNIHCSDK
110 120 130 140
GSWCEQQLCA CDKEVAFCLK RNLDTYQKRL RFYWRPHCRG QTPGC
Length:145
Mass (Da):16,546
Last modified:February 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF3A49DE516BD1EF
GO
Isoform 2 (identifier: Q9UNK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: W → C
     63-145: Missing.

Show »
Length:62
Mass (Da):6,561
Checksum:i0B2B82C56D1F177E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05538765Q → H1 PublicationCorresponds to variant dbSNP:rs62541890Ensembl.1
Natural variantiVAR_05538873H → R1 PublicationCorresponds to variant dbSNP:rs62541891Ensembl.1
Natural variantiVAR_01274180S → G3 PublicationsCorresponds to variant dbSNP:rs584367Ensembl.1
Natural variantiVAR_05538996H → R1 PublicationCorresponds to variant dbSNP:rs62541892Ensembl.1
Natural variantiVAR_055390121R → C1 PublicationCorresponds to variant dbSNP:rs62541900Ensembl.1
Natural variantiVAR_055391121R → L1 PublicationCorresponds to variant dbSNP:rs62541901Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_06059562W → C in isoform 2. 1
Alternative sequenceiVSP_06059663 – 145Missing in isoform 2. Add BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF112982 mRNA Translation: AAD51390.1
AF188625 mRNA Translation: AAF09020.1
AK290406 mRNA Translation: BAF83095.1
AK310156 mRNA No translation available.
EU447440 Genomic DNA Translation: ACA06110.1
AL158172 Genomic DNA No translation available.
BC025706 mRNA Translation: AAH25706.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS203.1 [Q9UNK4-1]
CCDS72721.1 [Q9UNK4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001258743.1, NM_001271814.1 [Q9UNK4-2]
NP_036532.1, NM_012400.3 [Q9UNK4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375105; ENSP00000364246; ENSG00000117215 [Q9UNK4-1]
ENST00000617227; ENSP00000482871; ENSG00000117215 [Q9UNK4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26279

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26279

UCSC genome browser

More...
UCSCi
uc001bcz.5, human [Q9UNK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112982 mRNA Translation: AAD51390.1
AF188625 mRNA Translation: AAF09020.1
AK290406 mRNA Translation: BAF83095.1
AK310156 mRNA No translation available.
EU447440 Genomic DNA Translation: ACA06110.1
AL158172 Genomic DNA No translation available.
BC025706 mRNA Translation: AAH25706.1
CCDSiCCDS203.1 [Q9UNK4-1]
CCDS72721.1 [Q9UNK4-2]
RefSeqiNP_001258743.1, NM_001271814.1 [Q9UNK4-2]
NP_036532.1, NM_012400.3 [Q9UNK4-1]

3D structure databases

SMRiQ9UNK4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117662, 18 interactors
STRINGi9606.ENSP00000364246

Chemistry databases

BindingDBiQ9UNK4
ChEMBLiCHEMBL4281
DrugBankiDB03017, Lauric acid
DB03193, Stearic acid
GuidetoPHARMACOLOGYi1418
SwissLipidsiSLP:000000652

PTM databases

GlyGeniQ9UNK4, 1 site
iPTMnetiQ9UNK4
PhosphoSitePlusiQ9UNK4

Genetic variation databases

BioMutaiPLA2G2D
DMDMi20139286

Proteomic databases

MassIVEiQ9UNK4
PaxDbiQ9UNK4
PeptideAtlasiQ9UNK4
PRIDEiQ9UNK4
ProteomicsDBi85300

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
47984, 186 antibodies

The DNASU plasmid repository

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DNASUi
26279

Genome annotation databases

EnsembliENST00000375105; ENSP00000364246; ENSG00000117215 [Q9UNK4-1]
ENST00000617227; ENSP00000482871; ENSG00000117215 [Q9UNK4-2]
GeneIDi26279
KEGGihsa:26279
UCSCiuc001bcz.5, human [Q9UNK4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26279
DisGeNETi26279

GeneCards: human genes, protein and diseases

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GeneCardsi
PLA2G2D
HGNCiHGNC:9033, PLA2G2D
HPAiENSG00000117215, Tissue enriched (lymphoid)
MIMi605630, gene
neXtProtiNX_Q9UNK4
OpenTargetsiENSG00000117215
PharmGKBiPA33363
VEuPathDBiHostDB:ENSG00000117215.14

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4087, Eukaryota
GeneTreeiENSGT00940000161938
HOGENOMiCLU_090683_3_0_1
InParanoidiQ9UNK4
OMAiDIHCSDK
OrthoDBi1422829at2759
PhylomeDBiQ9UNK4
TreeFamiTF319283

Enzyme and pathway databases

PathwayCommonsiQ9UNK4
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482801, Acyl chain remodelling of PS
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1482925, Acyl chain remodelling of PG
R-HSA-1483166, Synthesis of PA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26279, 7 hits in 983 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLA2G2D, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PLA2G2D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26279
PharosiQ9UNK4, Tchem

Protein Ontology

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PROi
PR:Q9UNK4
RNActiQ9UNK4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000117215, Expressed in lymph node and 73 other tissues
ExpressionAtlasiQ9UNK4, baseline and differential
GenevisibleiQ9UNK4, HS

Family and domain databases

CDDicd00125, PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211, PLipase_A2
IPR033112, PLipase_A2_Asp_AS
IPR016090, PLipase_A2_dom
IPR036444, PLipase_A2_dom_sf
IPR033113, PLipase_A2_His_AS
PANTHERiPTHR11716, PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068, Phospholip_A2_1, 1 hit
PRINTSiPR00389, PHPHLIPASEA2
SMARTiView protein in SMART
SM00085, PA2c, 1 hit
SUPFAMiSSF48619, SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119, PA2_ASP, 1 hit
PS00118, PA2_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA2GD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNK4
Secondary accession number(s): A0A087WZT4
, A8K2Z1, B1AEL9, Q9UK01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 7, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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