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Protein

Syntaxin-8

Gene

STX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

GO - Molecular functioni

  • chloride channel inhibitor activity Source: UniProtKB
  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Gene namesi
Name:STX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000170310.14
HGNCiHGNC:11443 STX8
MIMi604203 gene
neXtProtiNX_Q9UNK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 215CytoplasmicSequence analysisAdd BLAST215
Transmembranei216 – 232Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST17
Topological domaini233 – 236VesicularSequence analysis4

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9482
OpenTargetsiENSG00000170310
PharmGKBiPA36240

Polymorphism and mutation databases

BioMutaiSTX8
DMDMi9297054

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102171 – 236Syntaxin-8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by HECTD3.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UNK0
MaxQBiQ9UNK0
PaxDbiQ9UNK0
PeptideAtlasiQ9UNK0
PRIDEiQ9UNK0
ProteomicsDBi85299

PTM databases

iPTMnetiQ9UNK0
PhosphoSitePlusiQ9UNK0
SwissPalmiQ9UNK0

Expressioni

Tissue specificityi

Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Gene expression databases

BgeeiENSG00000170310
CleanExiHS_STX8
ExpressionAtlasiQ9UNK0 baseline and differential
GenevisibleiQ9UNK0 HS

Organism-specific databases

HPAiHPA001540

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

BioGridi114867, 74 interactors
DIPiDIP-47274N
IntActiQ9UNK0, 79 interactors
MINTiQ9UNK0
STRINGi9606.ENSP00000305255

Structurei

3D structure databases

ProteinModelPortaliQ9UNK0
SMRiQ9UNK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 207t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 65Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000007779
HOGENOMiHOG000031515
HOVERGENiHBG007572
InParanoidiQ9UNK0
KOiK08501
OMAiAENIHER
OrthoDBiEOG091G0KM1
PhylomeDBiQ9UNK0
TreeFamiTF323262

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UNK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN
60 70 80 90 100
LKEKIALLKD LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GAEPDLIRSS LMSEEAKRGA PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRNE
210 220 230
TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,907
Last modified:December 1, 2000 - v2
Checksum:i1E64A0DA77584CC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78R → Q in AAD20831 (PubMed:9852078).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115323 mRNA Translation: AAD20831.1
AF062077 mRNA Translation: AAC36466.1
AF036715 mRNA Translation: AAC95285.1
BT007319 mRNA Translation: AAP35983.1
CH471108 Genomic DNA Translation: EAW90029.1
BC009713 mRNA Translation: AAH09713.1
CCDSiCCDS32565.1
RefSeqiNP_004844.1, NM_004853.2
UniGeneiHs.431109

Genome annotation databases

EnsembliENST00000306357; ENSP00000305255; ENSG00000170310
GeneIDi9482
KEGGihsa:9482
UCSCiuc002glx.4 human

Similar proteinsi

Entry informationi

Entry nameiSTX8_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK0
Secondary accession number(s): O60712, Q53XT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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