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Protein

Chymotrypsin-like elastase family member 1

Gene

CELA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Caution

In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133).1 Publication

Catalytic activityi

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay systemBy similarity1
Metal bindingi77CalciumBy similarity1
Metal bindingi82Calcium; via carbonyl oxygenBy similarity1
Metal bindingi87CalciumBy similarity1
Active sitei111Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.36 2681

Protein family/group databases

MEROPSiS01.153

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)
Alternative name(s):
Elastase-1
Pancreatic elastase 1
Gene namesi
Name:CELA1
Synonyms:ELA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139610.1
HGNCiHGNC:3308 CELA1
MIMi130120 gene
neXtProtiNX_Q9UNI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1990
OpenTargetsiENSG00000139610
PharmGKBiPA27734

Chemistry databases

ChEMBLiCHEMBL3000
DrugBankiDB07955 (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE
DB08007 (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID
DB06951 (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid
DB03757 (Tert-Butyloxycarbonyl)-Alanyl-Alanyl-Amine
DB07433 (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE
DB07956 [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER
DB01844 Dimethylformamide
DB07957 METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE
DB03890 N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide
DB03925 ONO-6818
DB02114 Para-Isopropylaniline
GuidetoPHARMACOLOGYi2338

Polymorphism and mutation databases

BioMutaiCELA1
DMDMi62298049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 8By similarity8
PropeptideiPRO_00000276779 – 18Activation peptide10
ChainiPRO_000002767819 – 258Chymotrypsin-like elastase family member 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 212PROSITE-ProRule annotation
Disulfide bondi176 ↔ 192PROSITE-ProRule annotation
Disulfide bondi202 ↔ 232PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UNI1
PeptideAtlasiQ9UNI1
PRIDEiQ9UNI1
ProteomicsDBi85297

Miscellaneous databases

PMAP-CutDBiQ9UNI1

Expressioni

Tissue specificityi

Basal layers of epidermis (at protein level). Not expressed in the pancreas.1 Publication

Gene expression databases

BgeeiENSG00000139610 Expressed in 20 organ(s), highest expression level in leukocyte
CleanExiHS_ELA1
GenevisibleiQ9UNI1 HS

Interactioni

Protein-protein interaction databases

BioGridi108305, 18 interactors
STRINGi9606.ENSP00000293636

Chemistry databases

BindingDBiQ9UNI1

Structurei

3D structure databases

ProteinModelPortaliQ9UNI1
SMRiQ9UNI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 256Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiQ9UNI1
KOiK01326
OMAiNSWPSQI
OrthoDBiEOG091G0DF7
PhylomeDBiQ9UNI1
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UNI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLYGHSTQ DLPETNARVV GGTEAGRNSW PSQISLQYRS GGSRYHTCGG
60 70 80 90 100
TLIRQNWVMT AAHCVDYQKT FRVVAGDHNL SQNDGTEQYV SVQKIVVHPY
110 120 130 140 150
WNSDNVAAGY DIALLRLAQS VTLNSYVQLG VLPQEGAILA NNSPCYITGW
160 170 180 190 200
GKTKTNGQLA QTLQQAYLPS VDYAICSSSS YWGSTVKNTM VCAGGDGVRS
210 220 230 240 250
GCQGDSGGPL HCLVNGKYSV HGVTSFVSSR GCNVSRKPTV FTQVSAYISW

INNVIASN
Length:258
Mass (Da):27,798
Last modified:March 29, 2005 - v2
Checksum:i684EDE8F1F011F8D
GO

Sequence cautioni

The sequence AAV88109 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220V → L in AAD28441 (PubMed:10620133).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03364510Q → H. Corresponds to variant dbSNP:rs17860287Ensembl.1
Natural variantiVAR_03364644R → W. Corresponds to variant dbSNP:rs17860299Ensembl.1
Natural variantiVAR_03364759M → V. Corresponds to variant dbSNP:rs17860300Ensembl.1
Natural variantiVAR_03629576G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033648243Q → R. Corresponds to variant dbSNP:rs17860364Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120493 mRNA Translation: AAD28441.1
AC046135 Genomic DNA No translation available.
BC069454 mRNA Translation: AAH69454.1
BC075091 mRNA Translation: AAH75091.2
AY740424 Genomic DNA Translation: AAV88109.1 Sequence problems.
CCDSiCCDS8812.1
RefSeqiNP_001962.3, NM_001971.5
UniGeneiHs.348395

Genome annotation databases

EnsembliENST00000293636; ENSP00000293636; ENSG00000139610
GeneIDi1990
KEGGihsa:1990
UCSCiuc001ryi.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Elastase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120493 mRNA Translation: AAD28441.1
AC046135 Genomic DNA No translation available.
BC069454 mRNA Translation: AAH69454.1
BC075091 mRNA Translation: AAH75091.2
AY740424 Genomic DNA Translation: AAV88109.1 Sequence problems.
CCDSiCCDS8812.1
RefSeqiNP_001962.3, NM_001971.5
UniGeneiHs.348395

3D structure databases

ProteinModelPortaliQ9UNI1
SMRiQ9UNI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108305, 18 interactors
STRINGi9606.ENSP00000293636

Chemistry databases

BindingDBiQ9UNI1
ChEMBLiCHEMBL3000
DrugBankiDB07955 (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE
DB08007 (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID
DB06951 (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid
DB03757 (Tert-Butyloxycarbonyl)-Alanyl-Alanyl-Amine
DB07433 (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE
DB07956 [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER
DB01844 Dimethylformamide
DB07957 METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE
DB03890 N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide
DB03925 ONO-6818
DB02114 Para-Isopropylaniline
GuidetoPHARMACOLOGYi2338

Protein family/group databases

MEROPSiS01.153

Polymorphism and mutation databases

BioMutaiCELA1
DMDMi62298049

Proteomic databases

PaxDbiQ9UNI1
PeptideAtlasiQ9UNI1
PRIDEiQ9UNI1
ProteomicsDBi85297

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293636; ENSP00000293636; ENSG00000139610
GeneIDi1990
KEGGihsa:1990
UCSCiuc001ryi.1 human

Organism-specific databases

CTDi1990
DisGeNETi1990
EuPathDBiHostDB:ENSG00000139610.1
GeneCardsiCELA1
HGNCiHGNC:3308 CELA1
MIMi130120 gene
neXtProtiNX_Q9UNI1
OpenTargetsiENSG00000139610
PharmGKBiPA27734
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiQ9UNI1
KOiK01326
OMAiNSWPSQI
OrthoDBiEOG091G0DF7
PhylomeDBiQ9UNI1
TreeFamiTF330455

Enzyme and pathway databases

BRENDAi3.4.21.36 2681

Miscellaneous databases

GeneWikiiCELA1
GenomeRNAii1990
PMAP-CutDBiQ9UNI1
PROiPR:Q9UNI1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139610 Expressed in 20 organ(s), highest expression level in leukocyte
CleanExiHS_ELA1
GenevisibleiQ9UNI1 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCELA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UNI1
Secondary accession number(s): Q5MLF0, Q6DJT0, Q6ISM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 29, 2005
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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