UniProtKB - Q9UNF0 (PACN2_HUMAN)
Protein kinase C and casein kinase substrate in neurons protein 2
PACSIN2
Functioni
Regulates the morphogenesis and endocytosis of caveolae (By similarity).
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
By similarity4 Publications(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700).
Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077).
Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866).
3 PublicationsGO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: Ensembl
- identical protein binding Source: IntAct
- phosphatidic acid binding Source: UniProtKB
- phospholipid binding Source: GO_Central
- transporter activity Source: ProtInc
GO - Biological processi
- actin cytoskeleton organization Source: ProtInc
- caveola assembly Source: UniProtKB
- caveolin-mediated endocytosis Source: UniProtKB
- cell projection morphogenesis Source: UniProtKB
- cytoskeleton organization Source: GO_Central
- modulation of chemical synaptic transmission Source: Ensembl
- negative regulation of endocytosis Source: Ensembl
- plasma membrane tubulation Source: UniProtKB
- protein localization to endosome Source: UniProtKB
- regulation of endocytosis Source: GO_Central
Keywordsi
Biological process | Endocytosis |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UNF0 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q9UNF0 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C and casein kinase substrate in neurons protein 2Alternative name(s): Syndapin-2 Syndapin-II Short name: SdpII |
Gene namesi | Name:PACSIN2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8571, PACSIN2 |
MIMi | 604960, gene |
neXtProti | NX_Q9UNF0 |
VEuPathDBi | HostDB:ENSG00000100266 |
Subcellular locationi
Plasma membrane
Endosome
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
- Cell projection 1 Publication
- caveola 1 Publication
Note: Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB-SubCell
- endosome Source: GO_Central
- recycling endosome membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear speck Source: HPA
Plasma Membrane
- caveola Source: UniProtKB
- plasma membrane Source: HPA
- ruffle membrane Source: UniProtKB-SubCell
Other locations
- cell-cell junction Source: Ensembl
- cytoplasm Source: GO_Central
- extrinsic component of membrane Source: UniProtKB
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 313 | S → A: Increased protein interaction with HCV NS5A. 1 Publication | 1 | |
Mutagenesisi | 313 | S → E: Decreased protein interaction with HCV NS5A. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11252 |
OpenTargetsi | ENSG00000100266 |
PharmGKBi | PA32897 |
Miscellaneous databases
Pharosi | Q9UNF0, Tbio |
Genetic variation databases
BioMutai | PACSIN2 |
DMDMi | 22256968 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161795 | 1 – 486 | Protein kinase C and casein kinase substrate in neurons protein 2Add BLAST | 486 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 273 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 399 | PhosphoserineBy similarity | 1 | |
Modified residuei | 446 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1627 |
EPDi | Q9UNF0 |
jPOSTi | Q9UNF0 |
MassIVEi | Q9UNF0 |
MaxQBi | Q9UNF0 |
PaxDbi | Q9UNF0 |
PeptideAtlasi | Q9UNF0 |
PRIDEi | Q9UNF0 |
ProteomicsDBi | 85284 [Q9UNF0-1] 85285 [Q9UNF0-2] |
PTM databases
GlyGeni | Q9UNF0, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UNF0 |
MetOSitei | Q9UNF0 |
PhosphoSitePlusi | Q9UNF0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100266, Expressed in thoracic mammary gland and 241 other tissues |
ExpressionAtlasi | Q9UNF0, baseline and differential |
Genevisiblei | Q9UNF0, HS |
Organism-specific databases
HPAi | ENSG00000100266, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (By similarity). May form heterooligomers with other PACSINs (By similarity).
Interacts (via NPF motifs) with EHD1 (via EH domain) (PubMed:23596323).
Interacts (via NPF motifs) with EHD2 (via EH domain); this interaction probably stabilizes the caveolae (PubMed:22323287).
Interacts with EHD3 (PubMed:23596323).
Interacts (via the SH3 domain) with MICALL1 (PubMed:23596323).
Interacts with RAC1 (PubMed:21693584).
Interacts (via SH3 domain) with DNM1, SYN1, SYNJ1 and WASL (By similarity).
Interacts (via F-BAR domain) with CAV1 (By similarity).
Interacts with TRPV4 (By similarity).
By similarity3 Publications(Microbial infection) Interacts with ubiquitinated HIV-1 gag (via p6-gag domain); this interaction allows PACSIN2 recruitment to viral assembly sites and its subsequent incorporation into virions.
1 Publication(Microbial infection) Interacts (via F-BAR domain) with Rous sarcoma virus p2B; this interaction allows PACSIN2 recruitment to viral assembly sites.
1 Publication(Microbial infection) Interacts (via N-terminus) with Hepatatis C virus (HCV) non-structural protein 5A (via N-terminus); this interaction attenuates protein kinase C alpha (PRKCA)-mediated phosphorylation of PACSIN2 at Ser-313 by disrupting the interaction between PACSIN2 and PRKCA.
1 PublicationBinary interactionsi
Q9UNF0
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: Ensembl
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 116413, 112 interactors |
IntActi | Q9UNF0, 38 interactors |
MINTi | Q9UNF0 |
STRINGi | 9606.ENSP00000263246 |
Miscellaneous databases
RNActi | Q9UNF0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UNF0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UNF0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 282 | F-BARPROSITE-ProRule annotationAdd BLAST | 272 | |
Domaini | 426 – 486 | SH3PROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 362 | (Microbial infection) Interaction with HCV NS5A1 PublicationAdd BLAST | 362 | |
Regioni | 314 – 426 | DisorderedSequence analysisAdd BLAST | 113 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 25 – 274 | Add BLAST | 250 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 362 – 364 | NPF1 | 3 | |
Motifi | 405 – 407 | NPF2 | 3 | |
Motifi | 417 – 419 | NPF3 | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 324 – 368 | Polar residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 386 – 423 | Polar residuesSequence analysisAdd BLAST | 38 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG2856, Eukaryota |
GeneTreei | ENSGT00950000182973 |
HOGENOMi | CLU_030752_0_0_1 |
InParanoidi | Q9UNF0 |
OMAi | YVEPVGH |
PhylomeDBi | Q9UNF0 |
TreeFami | TF313677 |
Family and domain databases
CDDi | cd07679, F-BAR_PACSIN2, 1 hit cd11998, SH3_PACSIN1-2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR035743, PACSIN1/PACSIN2_SH3 IPR028521, PACSIN2 IPR037453, PACSIN2_F-BAR IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR23065:SF14, PTHR23065:SF14, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR
60 70 80 90 100
IEKAYAQQLT EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV
110 120 130 140 150
KASLMNDDFE KIKNWQKEAF HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK
160 170 180 190 200
EVEAAKKAHH AACKEEKLAI SREANSKADP SLNPEQLKKL QDKIEKCKQD
210 220 230 240 250
VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR LRFFREVLLE
260 270 280 290 300
VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ
310 320 330 340 350
FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN
360 370 380 390 400
PAQSAQSQSS YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD
410 420 430 440 450
DESNNPFSST DANGDSNPFD DDATSGTEVR VRALYDYEGQ EHDELSFKAG
460 470 480
DELTKMEDED EQGWCKGRLD NGQVGLYPAN YVEAIQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RR22 | A0A0U1RR22_HUMAN | Protein kinase C and casein kinase ... | PACSIN2 | 451 | Annotation score: | ||
B0QYG7 | B0QYG7_HUMAN | Protein kinase C and casein kinase ... | PACSIN2 | 152 | Annotation score: | ||
B0QYG8 | B0QYG8_HUMAN | Protein kinase C and casein kinase ... | PACSIN2 | 155 | Annotation score: | ||
H0Y923 | H0Y923_HUMAN | Protein kinase C and casein kinase ... | PACSIN2 | 59 | Annotation score: | ||
B0QYG9 | B0QYG9_HUMAN | Protein kinase C and casein kinase ... | PACSIN2 | 33 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | L → F in AAD41781 (PubMed:10431838).Curated | 1 | |
Sequence conflicti | 256 | D → N in AAD41781 (PubMed:10431838).Curated | 1 | |
Sequence conflicti | 309 | N → I in AAD41781 (PubMed:10431838).Curated | 1 | |
Sequence conflicti | 336 | S → F in AAD41781 (PubMed:10431838).Curated | 1 | |
Sequence conflicti | 378 – 380 | DDT → EDI in AAD41781 (PubMed:10431838).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053555 | 175 | N → S. Corresponds to variant dbSNP:rs35383004Ensembl. | 1 | |
Natural variantiVAR_013711 | 294 | M → I. Corresponds to variant dbSNP:rs2746984Ensembl. | 1 | |
Natural variantiVAR_013712 | 324 | V → F. Corresponds to variant dbSNP:rs1062913Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004517 | 344 – 384 | Missing in isoform 2. 2 PublicationsAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128536 mRNA Translation: AAD41781.1 AL136845 mRNA Translation: CAB66779.1 CR456536 mRNA Translation: CAG30422.1 AL022476 Genomic DNA No translation available. AL049758 Genomic DNA No translation available. BC008037 mRNA Translation: AAH08037.1 AL389984 mRNA Translation: CAB97538.1 |
CCDSi | CCDS43023.1 [Q9UNF0-1] CCDS54536.1 [Q9UNF0-2] |
RefSeqi | NP_001171899.1, NM_001184970.1 [Q9UNF0-1] NP_001171900.1, NM_001184971.1 [Q9UNF0-2] NP_009160.2, NM_007229.3 [Q9UNF0-1] XP_005261376.1, XM_005261319.3 XP_016884053.1, XM_017028564.1 |
Genome annotation databases
Ensembli | ENST00000263246; ENSP00000263246; ENSG00000100266 ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2] ENST00000402229; ENSP00000385040; ENSG00000100266 ENST00000403744; ENSP00000385372; ENSG00000100266 ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2] |
GeneIDi | 11252 |
KEGGi | hsa:11252 |
MANE-Selecti | ENST00000263246.8; ENSP00000263246.3; NM_001184970.3; NP_001171899.1 |
UCSCi | uc003bdf.5, human [Q9UNF0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128536 mRNA Translation: AAD41781.1 AL136845 mRNA Translation: CAB66779.1 CR456536 mRNA Translation: CAG30422.1 AL022476 Genomic DNA No translation available. AL049758 Genomic DNA No translation available. BC008037 mRNA Translation: AAH08037.1 AL389984 mRNA Translation: CAB97538.1 |
CCDSi | CCDS43023.1 [Q9UNF0-1] CCDS54536.1 [Q9UNF0-2] |
RefSeqi | NP_001171899.1, NM_001184970.1 [Q9UNF0-1] NP_001171900.1, NM_001184971.1 [Q9UNF0-2] NP_009160.2, NM_007229.3 [Q9UNF0-1] XP_005261376.1, XM_005261319.3 XP_016884053.1, XM_017028564.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ABH | X-ray | 2.00 | A/B | 1-305 | [»] | |
3ACO | X-ray | 2.70 | A/B | 1-343 | [»] | |
3HAJ | X-ray | 2.78 | A/B | 1-486 | [»] | |
3Q0K | X-ray | 2.60 | A/B/C/D | 16-304 | [»] | |
SMRi | Q9UNF0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116413, 112 interactors |
IntActi | Q9UNF0, 38 interactors |
MINTi | Q9UNF0 |
STRINGi | 9606.ENSP00000263246 |
PTM databases
GlyGeni | Q9UNF0, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UNF0 |
MetOSitei | Q9UNF0 |
PhosphoSitePlusi | Q9UNF0 |
Genetic variation databases
BioMutai | PACSIN2 |
DMDMi | 22256968 |
Proteomic databases
CPTACi | CPTAC-1627 |
EPDi | Q9UNF0 |
jPOSTi | Q9UNF0 |
MassIVEi | Q9UNF0 |
MaxQBi | Q9UNF0 |
PaxDbi | Q9UNF0 |
PeptideAtlasi | Q9UNF0 |
PRIDEi | Q9UNF0 |
ProteomicsDBi | 85284 [Q9UNF0-1] 85285 [Q9UNF0-2] |
Protocols and materials databases
ABCDi | Q9UNF0, 1 sequenced antibody |
Antibodypediai | 34964, 229 antibodies from 31 providers |
DNASUi | 11252 |
Genome annotation databases
Ensembli | ENST00000263246; ENSP00000263246; ENSG00000100266 ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2] ENST00000402229; ENSP00000385040; ENSG00000100266 ENST00000403744; ENSP00000385372; ENSG00000100266 ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2] |
GeneIDi | 11252 |
KEGGi | hsa:11252 |
MANE-Selecti | ENST00000263246.8; ENSP00000263246.3; NM_001184970.3; NP_001171899.1 |
UCSCi | uc003bdf.5, human [Q9UNF0-1] |
Organism-specific databases
CTDi | 11252 |
DisGeNETi | 11252 |
GeneCardsi | PACSIN2 |
HGNCi | HGNC:8571, PACSIN2 |
HPAi | ENSG00000100266, Low tissue specificity |
MIMi | 604960, gene |
neXtProti | NX_Q9UNF0 |
OpenTargetsi | ENSG00000100266 |
PharmGKBi | PA32897 |
VEuPathDBi | HostDB:ENSG00000100266 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2856, Eukaryota |
GeneTreei | ENSGT00950000182973 |
HOGENOMi | CLU_030752_0_0_1 |
InParanoidi | Q9UNF0 |
OMAi | YVEPVGH |
PhylomeDBi | Q9UNF0 |
TreeFami | TF313677 |
Enzyme and pathway databases
PathwayCommonsi | Q9UNF0 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | Q9UNF0 |
Miscellaneous databases
BioGRID-ORCSi | 11252, 5 hits in 1047 CRISPR screens |
ChiTaRSi | PACSIN2, human |
EvolutionaryTracei | Q9UNF0 |
GeneWikii | PACSIN2 |
GenomeRNAii | 11252 |
Pharosi | Q9UNF0, Tbio |
PROi | PR:Q9UNF0 |
RNActi | Q9UNF0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100266, Expressed in thoracic mammary gland and 241 other tissues |
ExpressionAtlasi | Q9UNF0, baseline and differential |
Genevisiblei | Q9UNF0, HS |
Family and domain databases
CDDi | cd07679, F-BAR_PACSIN2, 1 hit cd11998, SH3_PACSIN1-2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR035743, PACSIN1/PACSIN2_SH3 IPR028521, PACSIN2 IPR037453, PACSIN2_F-BAR IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR23065:SF14, PTHR23065:SF14, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PACN2_HUMAN | |
Accessioni | Q9UNF0Primary (citable) accession number: Q9UNF0 Secondary accession number(s): O95921 Q9Y4V2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 2002 |
Last sequence update: | August 13, 2002 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families