PACSIN2

Functionⁱ

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.5 Publications

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
cytoskeletal protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
phosphatidic acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23596323
phospholipid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transporter activity
Source: ProtInc
Traceable author statementⁱ
- 10431838

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: ProtInc
Traceable author statementⁱ
- 10431838
caveola assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21610094
caveolin-mediated endocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21610094
cell projection morphogenesis Source: UniProtKB
cytoskeleton organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
membrane organization Source: Reactome
modulation of chemical synaptic transmission Source: Ensembl
negative regulation of endocytosis Source: Ensembl
plasma membrane tubulation
Source: UniProtKB
Inferred from direct assayⁱ
- 23596323
protein localization to endosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23596323

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein kinase C and casein kinase substrate in neurons protein 2 Alternative name(s): Syndapin-2 Syndapin-II
Gene namesⁱ	Name:PACSIN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100266.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8571 PACSIN2
MIMⁱ	604960 gene
neXtProtⁱ	NX_Q9UNF0

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11252
Open Targets More...OpenTargetsⁱ	ENSG00000100266
PharmGKBⁱ	PA32897

Polymorphism and mutation databases

BioMutaⁱ	PACSIN2
DMDMⁱ	22256968

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000161795	1 – 486	Protein kinase C and casein kinase substrate in neurons protein 2Add BLAST		486

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	N6-acetyllysineBy similarity	1
Modified residueⁱ	273	PhosphoserineCombined sources	1
Modified residueⁱ	399	PhosphoserineBy similarity	1
Modified residueⁱ	446	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UNF0
PaxDbⁱ	Q9UNF0
PeptideAtlas More...PeptideAtlasⁱ	Q9UNF0
PRIDEⁱ	Q9UNF0
ProteomicsDBⁱ	85284 85285 [Q9UNF0-2]

PTM databases

iPTMnetⁱ	Q9UNF0
PhosphoSitePlusⁱ	Q9UNF0

Expressionⁱ

Tissue specificityⁱ

Widely expressed.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000100266 Expressed in 231 organ(s), highest expression level in thoracic mammary gland
ExpressionAtlasⁱ	Q9UNF0 baseline and differential
Genevisibleⁱ	Q9UNF0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049854 HPA056520

HPAⁱ

HPA049854
HPA056520

Interactionⁱ

Subunit structureⁱ

Homodimer. May form heterooligomers with other PACSINs. Interacts (via NPF motifs) with EHD1 (via EH domain). Interacts with EHD3. Interacts (via the SH3 domain) with MICALL1. Interacts with RAC1. Interacts (via SH3 domain) with DNM1, SYN1, SYNJ1 and WASL. Interacts with CAV1. Interacts with TRPV4.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		5	EBI-742503,EBI-742503
DNM2	P50570	4	EBI-742503,EBI-346547
FASLG	P48023	4	EBI-742503,EBI-495538
MEOX2	P50222	3	EBI-742503,EBI-748397
PACSIN1	Q9BY11	7	EBI-742503,EBI-721769
TERF1	P54274	2	EBI-742503,EBI-710997

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116413, 52 interactors
IntActⁱ	Q9UNF0, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q9UNF0
STRINGⁱ	9606.ENSP00000263246

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	21 – 24	Combined sources	4
Helixⁱ	25 – 72	Combined sources	48
Helixⁱ	77 – 106	Combined sources	30
Helixⁱ	108 – 119	Combined sources	12
Beta strandⁱ	126 – 128	Combined sources	3
Helixⁱ	129 – 169	Combined sources	41
Helixⁱ	172 – 177	Combined sources	6
Helixⁱ	185 – 188	Combined sources	4
Helixⁱ	189 – 191	Combined sources	3
Turnⁱ	192 – 195	Combined sources	4
Helixⁱ	197 – 255	Combined sources	59
Helixⁱ	257 – 259	Combined sources	3
Helixⁱ	263 – 275	Combined sources	13
Helixⁱ	279 – 290	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UNF0
SMRⁱ	Q9UNF0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UNF0

EvolutionaryTraceⁱ

Q9UNF0

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 282	F-BARPROSITE-ProRule annotationAdd BLAST		272
Domainⁱ	426 – 486	SH3PROSITE-ProRule annotationAdd BLAST		61

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	25 – 274	Add BLAST		250

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	362 – 364	NPF1	3
Motifⁱ	405 – 407	NPF2	3
Motifⁱ	417 – 419	NPF3	3

Domainⁱ

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain.4 Publications

Sequence similaritiesⁱ

Belongs to the PACSIN family.Curated

Keywords - Domainⁱ

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG2856 Eukaryota ENOG410XRX2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046376
HOGENOMⁱ	HOG000007245
HOVERGENⁱ	HBG053486
InParanoidⁱ	Q9UNF0
KEGG Orthology (KO) More...KOⁱ	K20123
OMAⁱ	SYKNIYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AS9
PhylomeDBⁱ	Q9UNF0
TreeFamⁱ	TF313677

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07679 F-BAR_PACSIN2, 1 hit cd11998 SH3_PACSIN1-2, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR035743 PACSIN1/PACSIN2_SH3 IPR028521 PACSIN2 IPR037453 PACSIN2_F-BAR IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23065:SF14 PTHR23065:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS50002 SH3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UNF0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR 
        60         70         80         90        100
IEKAYAQQLT EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV 
       110        120        130        140        150
KASLMNDDFE KIKNWQKEAF HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK 
       160        170        180        190        200
EVEAAKKAHH AACKEEKLAI SREANSKADP SLNPEQLKKL QDKIEKCKQD 
       210        220        230        240        250
VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR LRFFREVLLE 
       260        270        280        290        300
VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ 
       310        320        330        340        350
FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN 
       360        370        380        390        400
PAQSAQSQSS YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD 
       410        420        430        440        450
DESNNPFSST DANGDSNPFD DDATSGTEVR VRALYDYEGQ EHDELSFKAG 
       460        470        480 
DELTKMEDED EQGWCKGRLD NGQVGLYPAN YVEAIQ

Length:486

Mass (Da):55,739

Last modified:August 13, 2002 - v2

Checksum:ⁱ821DBEF65DAD1AA8

GO

Isoform 2 (identifier: Q9UNF0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
344-384: Missing.

« Hide

        10         20         30         40         50
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR 
        60         70         80         90        100
IEKAYAQQLT EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV 
       110        120        130        140        150
KASLMNDDFE KIKNWQKEAF HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK 
       160        170        180        190        200
EVEAAKKAHH AACKEEKLAI SREANSKADP SLNPEQLKKL QDKIEKCKQD 
       210        220        230        240        250
VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR LRFFREVLLE 
       260        270        280        290        300
VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ 
       310        320        330        340        350
FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSVSSYEKT 
       360        370        380        390        400
QSYPTDWSDD ESNNPFSSTD ANGDSNPFDD DATSGTEVRV RALYDYEGQE 
       410        420        430        440 
HDELSFKAGD ELTKMEDEDE QGWCKGRLDN GQVGLYPANY VEAIQ

Show »

Length:445

Mass (Da):51,353

Checksum:ⁱ1DA87A2D42B5D5F9

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RR22	A0A0U1RR22_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 2	PACSIN2	451	Annotation score:
B0QYG8	B0QYG8_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 2	PACSIN2	155	Annotation score:
B0QYG7	B0QYG7_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 2	PACSIN2	152	Annotation score:
H0Y923	H0Y923_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 2	PACSIN2	59	Annotation score:
B0QYG9	B0QYG9_HUMAN	Protein kinase C and casein kinase ... Protein kinase C and casein kinase substrate in neurons protein 2	PACSIN2	33	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	182	L → F in AAD41781 (PubMed:10431838).Curated	1
Sequence conflictⁱ	256	D → N in AAD41781 (PubMed:10431838).Curated	1
Sequence conflictⁱ	309	N → I in AAD41781 (PubMed:10431838).Curated	1
Sequence conflictⁱ	336	S → F in AAD41781 (PubMed:10431838).Curated	1
Sequence conflictⁱ	378 – 380	DDT → EDI in AAD41781 (PubMed:10431838).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053555	175	N → S. Corresponds to variant dbSNP:rs35383004Ensembl.	1
Natural variantⁱVAR_013711	294	M → I. Corresponds to variant dbSNP:rs2746984Ensembl.	1
Natural variantⁱVAR_013712	324	V → F. Corresponds to variant dbSNP:rs1062913Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004517	344 – 384	Missing in isoform 2. 2 PublicationsAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF128536 mRNA Translation: AAD41781.1 AL136845 mRNA Translation: CAB66779.1 CR456536 mRNA Translation: CAG30422.1 AL022476 Genomic DNA No translation available. AL049758 Genomic DNA No translation available. BC008037 mRNA Translation: AAH08037.1 AL389984 mRNA Translation: CAB97538.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43023.1 [Q9UNF0-1] CCDS54536.1 [Q9UNF0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171899.1, NM_001184970.1 [Q9UNF0-1] NP_001171900.1, NM_001184971.1 [Q9UNF0-2] NP_009160.2, NM_007229.3 [Q9UNF0-1] XP_005261376.1, XM_005261319.3 [Q9UNF0-2] XP_016884053.1, XM_017028564.1 [Q9UNF0-1]
UniGeneⁱ	Hs.162877

Genome annotation databases

Ensemblⁱ	ENST00000263246; ENSP00000263246; ENSG00000100266 [Q9UNF0-1] ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2] ENST00000402229; ENSP00000385040; ENSG00000100266 [Q9UNF0-1] ENST00000403744; ENSP00000385372; ENSG00000100266 [Q9UNF0-1] ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2]
GeneIDⁱ	11252
KEGGⁱ	hsa:11252
UCSC genome browser More...UCSCⁱ	uc003bdf.5 human [Q9UNF0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UNF0-2	PACSIN2 protein		HUMAN		445	UniRef100_Q6FIA3
PACSIN2 isoform 6		PONAB		445

Protein	Similar proteins		Species	Score	Length	Source
Q9UNF0	Protein kinase C and casein kinase substrate in neurons 2 protein		RAT		488	UniRef90_Q9UNF0
Protein kinase C and casein kinase substrate in neurons protein 2	)	MOUSE		486
Uncharacterized protein		AOTNA		551
Uncharacterized protein		CALJA		551
protein kinase C and casein kinase substrate in neurons protein 2 isoform X1		TARSY		488
+184
Q9UNF0-2	Isoform 2 of Protein kinase C and casein kinase substrate in neurons 2 protein		RAT		447	UniRef90_Q9QY17-2
Protein kinase C and casein kinase substrate in neurons protein 2 isoform B		CALJA		447
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		ERIEU		447
Uncharacterized protein DKFZp459J1025		PONAB		447
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		BALAS		447
+126

Protein	Similar proteins		Species	Score	Length	Source
Q9UNF0	Protein kinase C and casein kinase substrate in neurons 2 protein		RAT		488	UniRef50_Q9UNF0
Protein kinase C and casein kinase substrate in neurons protein 2	)	MOUSE		486
Uncharacterized protein		AOTNA		551
Uncharacterized protein		CALJA		551
Protein kinase C and casein kinase substrate in neurons protein 2 isoform A		MACMU		488
+349
Q9UNF0-2	Isoform 2 of Protein kinase C and casein kinase substrate in neurons 2 protein		RAT		447	UniRef50_Q9QY17-2
Protein kinase C and casein kinase substrate in neurons protein 3		HUMAN		424
Protein kinase C and casein kinase II substrate protein 3	)	MOUSE		424
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		ERIEU		447
protein kinase C and casein kinase substrate in neurons protein 2 isoform X3		TARSY		447
+411

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF128536 mRNA Translation: AAD41781.1 AL136845 mRNA Translation: CAB66779.1 CR456536 mRNA Translation: CAG30422.1 AL022476 Genomic DNA No translation available. AL049758 Genomic DNA No translation available. BC008037 mRNA Translation: AAH08037.1 AL389984 mRNA Translation: CAB97538.1
CCDSⁱ	CCDS43023.1 [Q9UNF0-1] CCDS54536.1 [Q9UNF0-2]
RefSeqⁱ	NP_001171899.1, NM_001184970.1 [Q9UNF0-1] NP_001171900.1, NM_001184971.1 [Q9UNF0-2] NP_009160.2, NM_007229.3 [Q9UNF0-1] XP_005261376.1, XM_005261319.3 [Q9UNF0-2] XP_016884053.1, XM_017028564.1 [Q9UNF0-1]
UniGeneⁱ	Hs.162877

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3ABH	X-ray	2.00	A/B	1-305	[»]
	3ACO	X-ray	2.70	A/B	1-343	[»]
	3HAJ	X-ray	2.78	A/B	1-486	[»]
	3Q0K	X-ray	2.60	A/B/C/D	16-304	[»]
ProteinModelPortalⁱ	Q9UNF0
SMRⁱ	Q9UNF0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116413, 52 interactors
IntActⁱ	Q9UNF0, 25 interactors
MINTⁱ	Q9UNF0
STRINGⁱ	9606.ENSP00000263246

PTM databases

iPTMnetⁱ	Q9UNF0
PhosphoSitePlusⁱ	Q9UNF0

Polymorphism and mutation databases

BioMutaⁱ	PACSIN2
DMDMⁱ	22256968

Proteomic databases

EPDⁱ	Q9UNF0
PaxDbⁱ	Q9UNF0
PeptideAtlasⁱ	Q9UNF0
PRIDEⁱ	Q9UNF0
ProteomicsDBⁱ	85284 85285 [Q9UNF0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11252
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263246; ENSP00000263246; ENSG00000100266 [Q9UNF0-1] ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2] ENST00000402229; ENSP00000385040; ENSG00000100266 [Q9UNF0-1] ENST00000403744; ENSP00000385372; ENSG00000100266 [Q9UNF0-1] ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2]
GeneIDⁱ	11252
KEGGⁱ	hsa:11252
UCSCⁱ	uc003bdf.5 human [Q9UNF0-1]

Organism-specific databases

CTDⁱ	11252
DisGeNETⁱ	11252
EuPathDBⁱ	HostDB:ENSG00000100266.18
GeneCardsⁱ	PACSIN2
HGNCⁱ	HGNC:8571 PACSIN2
HPAⁱ	HPA049854 HPA056520
MIMⁱ	604960 gene
neXtProtⁱ	NX_Q9UNF0
OpenTargetsⁱ	ENSG00000100266
PharmGKBⁱ	PA32897
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2856 Eukaryota ENOG410XRX2 LUCA
GeneTreeⁱ	ENSGT00510000046376
HOGENOMⁱ	HOG000007245
HOVERGENⁱ	HBG053486
InParanoidⁱ	Q9UNF0
KOⁱ	K20123
OMAⁱ	SYKNIYR
OrthoDBⁱ	EOG091G0AS9
PhylomeDBⁱ	Q9UNF0
TreeFamⁱ	TF313677

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSⁱ	PACSIN2 human
EvolutionaryTraceⁱ	Q9UNF0
GeneWikiⁱ	PACSIN2
GenomeRNAiⁱ	11252
Protein Ontology More...PROⁱ	PR:Q9UNF0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100266 Expressed in 231 organ(s), highest expression level in thoracic mammary gland
ExpressionAtlasⁱ	Q9UNF0 baseline and differential
Genevisibleⁱ	Q9UNF0 HS

Family and domain databases

CDDⁱ	cd07679 F-BAR_PACSIN2, 1 hit cd11998 SH3_PACSIN1-2, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR035743 PACSIN1/PACSIN2_SH3 IPR028521 PACSIN2 IPR037453 PACSIN2_F-BAR IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23065:SF14 PTHR23065:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PACN2_HUMAN
Accessionⁱ	Q9UNF0Primary (citable) accession number: Q9UNF0 Secondary accession number(s): O95921 , Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
	Last sequence update:	August 13, 2002
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UNF0 (PACN2_HUMAN)

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Protein kinase C and casein kinase substrate in neurons protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ