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UniProtKB - Q9UNF0 (PACN2_HUMAN)

Entry version 184 (10 Feb 2021)
Sequence version 2 (13 Aug 2002)
Previous versions | rss
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Protein

Protein kinase C and casein kinase substrate in neurons protein 2

Gene

PACSIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.By similarity4 Publications
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UNF0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase C and casein kinase substrate in neurons protein 2
Alternative name(s):
Syndapin-2
Syndapin-II
Short name:
SdpII
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PACSIN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8571, PACSIN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604960, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UNF0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100266.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi313S → A: Increased protein interaction with HCV NS5A. 1 Publication1
Mutagenesisi313S → E: Decreased protein interaction with HCV NS5A. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		11252

Open Targets

More...OpenTargetsi		ENSG00000100266

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32897

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UNF0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PACSIN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		22256968

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001617951 – 486Protein kinase C and casein kinase substrate in neurons protein 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53N6-acetyllysineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei313Phosphoserine; by PKCBy similarity1
Modified residuei399PhosphoserineBy similarity1
Modified residuei446PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1627

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UNF0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UNF0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UNF0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UNF0

PeptideAtlas

More...PeptideAtlasi		Q9UNF0

PRoteomics IDEntifications database

More...PRIDEi		Q9UNF0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85284 [Q9UNF0-1]
85285 [Q9UNF0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UNF0

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9UNF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UNF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100266, Expressed in thoracic mammary gland and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UNF0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UNF0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100266, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). May form heterooligomers with other PACSINs (By similarity).

Interacts (via NPF motifs) with EHD1 (via EH domain) (PubMed:23596323).

Interacts (via NPF motifs) with EHD2 (via EH domain); this interaction probably stabilizes the caveolae (PubMed:22323287).

Interacts with EHD3 (PubMed:23596323).

Interacts (via the SH3 domain) with MICALL1 (PubMed:23596323).

Interacts with RAC1 (PubMed:21693584).

Interacts (via SH3 domain) with DNM1, SYN1, SYNJ1 and WASL (By similarity).

Interacts (via F-BAR domain) with CAV1 (By similarity).

Interacts with TRPV4 (By similarity).

By similarity3 Publications

(Microbial infection) Interacts with ubiquitinated HIV-1 gag (via p6-gag domain); this interaction allows PACSIN2 recruitment to viral assembly sites and its subsequent incorporation into virions.

1 Publication

(Microbial infection) Interacts (via F-BAR domain) with Rous sarcoma virus p2B; this interaction allows PACSIN2 recruitment to viral assembly sites.

1 Publication

(Microbial infection) Interacts (via N-terminus) with Hepatatis C virus (HCV) non-structural protein 5A (via N-terminus); this interaction attenuates protein kinase C alpha (PRKCA)-mediated phosphorylation of PACSIN2 at Ser-313 by disrupting the interaction between PACSIN2 and PRKCA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116413, 66 interactors

Protein interaction database and analysis system

More...IntActi		Q9UNF0, 36 interactors

Molecular INTeraction database

More...MINTi		Q9UNF0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263246

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UNF0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UNF0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UNF0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 282F-BARPROSITE-ProRule annotationAdd BLAST272
Domaini426 – 486SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 362(Microbial infection) Interaction with HCV NS5A1 PublicationAdd BLAST362

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili25 – 274Add BLAST250

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi362 – 364NPF13
Motifi405 – 407NPF23
Motifi417 – 419NPF33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation (PubMed:19549836). Autoinhibition of these functions is mediated by an interaction between the SH3 and F-BAR domains (PubMed:20188097, PubMed:23236520). The F-Bar domain also mediates the binding to the cell actin cytoskeleton through the interaction with CAV-1 (By similarity).By similarity3 Publications
(Microbial infection) The SH3 domain is required for the cell-to-cell spreading of HIV-1 virions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PACSIN family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2856, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182973

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030752_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UNF0

Identification of Orthologs from Complete Genome Data

More...OMAi		DKCQTFE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UNF0

TreeFam database of animal gene trees

More...TreeFami		TF313677

Family and domain databases

Conserved Domains Database

More...CDDi		cd07679, F-BAR_PACSIN2, 1 hit
cd11998, SH3_PACSIN1-2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR035743, PACSIN1/PACSIN2_SH3
IPR028521, PACSIN2
IPR037453, PACSIN2_F-BAR
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR23065:SF14, PTHR23065:SF14, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00611, FCH, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51741, F_BAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR 
        60         70         80         90        100
IEKAYAQQLT EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV 
       110        120        130        140        150
KASLMNDDFE KIKNWQKEAF HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK 
       160        170        180        190        200
EVEAAKKAHH AACKEEKLAI SREANSKADP SLNPEQLKKL QDKIEKCKQD 
       210        220        230        240        250
VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR LRFFREVLLE 
       260        270        280        290        300
VQKHLDLSNV AGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ 
       310        320        330        340        350
FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPSK PSSTLNVPSN 
       360        370        380        390        400
PAQSAQSQSS YNPFEDEDDT GSTVSEKDDT KAKNVSSYEK TQSYPTDWSD 
       410        420        430        440        450
DESNNPFSST DANGDSNPFD DDATSGTEVR VRALYDYEGQ EHDELSFKAG 
       460        470        480 
DELTKMEDED EQGWCKGRLD NGQVGLYPAN YVEAIQ
Length:486
Mass (Da):55,739
Last modified:August 13, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i821DBEF65DAD1AA8
GO
Isoform 2 (identifier: Q9UNF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-384: Missing.

Show »
Length:445
Mass (Da):51,353
Checksum:i1DA87A2D42B5D5F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RR22A0A0U1RR22_HUMAN
Protein kinase C and casein kinase ...
PACSIN2
451Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYG7B0QYG7_HUMAN
Protein kinase C and casein kinase ...
PACSIN2
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYG8B0QYG8_HUMAN
Protein kinase C and casein kinase ...
PACSIN2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y923H0Y923_HUMAN
Protein kinase C and casein kinase ...
PACSIN2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYG9B0QYG9_HUMAN
Protein kinase C and casein kinase ...
PACSIN2
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182L → F in AAD41781 (PubMed:10431838).Curated1
Sequence conflicti256D → N in AAD41781 (PubMed:10431838).Curated1
Sequence conflicti309N → I in AAD41781 (PubMed:10431838).Curated1
Sequence conflicti336S → F in AAD41781 (PubMed:10431838).Curated1
Sequence conflicti378 – 380DDT → EDI in AAD41781 (PubMed:10431838).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053555175N → S. Corresponds to variant dbSNP:rs35383004Ensembl.1
Natural variantiVAR_013711294M → I. Corresponds to variant dbSNP:rs2746984Ensembl.1
Natural variantiVAR_013712324V → F. Corresponds to variant dbSNP:rs1062913Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004517344 – 384Missing in isoform 2. 2 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF128536 mRNA Translation: AAD41781.1
AL136845 mRNA Translation: CAB66779.1
CR456536 mRNA Translation: CAG30422.1
AL022476 Genomic DNA No translation available.
AL049758 Genomic DNA No translation available.
BC008037 mRNA Translation: AAH08037.1
AL389984 mRNA Translation: CAB97538.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43023.1 [Q9UNF0-1]
CCDS54536.1 [Q9UNF0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001171899.1, NM_001184970.1 [Q9UNF0-1]
NP_001171900.1, NM_001184971.1 [Q9UNF0-2]
NP_009160.2, NM_007229.3 [Q9UNF0-1]
XP_005261376.1, XM_005261319.3
XP_016884053.1, XM_017028564.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263246; ENSP00000263246; ENSG00000100266 [Q9UNF0-1]
ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2]
ENST00000402229; ENSP00000385040; ENSG00000100266 [Q9UNF0-1]
ENST00000403744; ENSP00000385372; ENSG00000100266 [Q9UNF0-1]
ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11252

UCSC genome browser

More...UCSCi		uc003bdf.5, human [Q9UNF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF128536 mRNA Translation: AAD41781.1
AL136845 mRNA Translation: CAB66779.1
CR456536 mRNA Translation: CAG30422.1
AL022476 Genomic DNA No translation available.
AL049758 Genomic DNA No translation available.
BC008037 mRNA Translation: AAH08037.1
AL389984 mRNA Translation: CAB97538.1
CCDSiCCDS43023.1 [Q9UNF0-1]
CCDS54536.1 [Q9UNF0-2]
RefSeqiNP_001171899.1, NM_001184970.1 [Q9UNF0-1]
NP_001171900.1, NM_001184971.1 [Q9UNF0-2]
NP_009160.2, NM_007229.3 [Q9UNF0-1]
XP_005261376.1, XM_005261319.3
XP_016884053.1, XM_017028564.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ABHX-ray2.00A/B1-305[»]
3ACOX-ray2.70A/B1-343[»]
3HAJX-ray2.78A/B1-486[»]
3Q0KX-ray2.60A/B/C/D16-304[»]
SMRiQ9UNF0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116413, 66 interactors
IntActiQ9UNF0, 36 interactors
MINTiQ9UNF0
STRINGi9606.ENSP00000263246

PTM databases

iPTMnetiQ9UNF0
MetOSiteiQ9UNF0
PhosphoSitePlusiQ9UNF0

Genetic variation databases

BioMutaiPACSIN2
DMDMi22256968

Proteomic databases

CPTACiCPTAC-1627
EPDiQ9UNF0
jPOSTiQ9UNF0
MassIVEiQ9UNF0
PaxDbiQ9UNF0
PeptideAtlasiQ9UNF0
PRIDEiQ9UNF0
ProteomicsDBi85284 [Q9UNF0-1]
85285 [Q9UNF0-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9UNF0, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34964, 209 antibodies

The DNASU plasmid repository

More...DNASUi		11252

Genome annotation databases

EnsembliENST00000263246; ENSP00000263246; ENSG00000100266 [Q9UNF0-1]
ENST00000337959; ENSP00000338379; ENSG00000100266 [Q9UNF0-2]
ENST00000402229; ENSP00000385040; ENSG00000100266 [Q9UNF0-1]
ENST00000403744; ENSP00000385372; ENSG00000100266 [Q9UNF0-1]
ENST00000407585; ENSP00000385952; ENSG00000100266 [Q9UNF0-2]
GeneIDi11252
KEGGihsa:11252
UCSCiuc003bdf.5, human [Q9UNF0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11252
DisGeNETi11252

GeneCards: human genes, protein and diseases

More...GeneCardsi		PACSIN2
HGNCiHGNC:8571, PACSIN2
HPAiENSG00000100266, Low tissue specificity
MIMi604960, gene
neXtProtiNX_Q9UNF0
OpenTargetsiENSG00000100266
PharmGKBiPA32897
VEuPathDBiHostDB:ENSG00000100266.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2856, Eukaryota
GeneTreeiENSGT00950000182973
HOGENOMiCLU_030752_0_0_1
InParanoidiQ9UNF0
OMAiDKCQTFE
PhylomeDBiQ9UNF0
TreeFamiTF313677

Enzyme and pathway databases

PathwayCommonsiQ9UNF0
ReactomeiR-HSA-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11252, 5 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PACSIN2, human
EvolutionaryTraceiQ9UNF0

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PACSIN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11252
PharosiQ9UNF0, Tbio

Protein Ontology

More...PROi		PR:Q9UNF0
RNActiQ9UNF0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100266, Expressed in thoracic mammary gland and 240 other tissues
ExpressionAtlasiQ9UNF0, baseline and differential
GenevisibleiQ9UNF0, HS

Family and domain databases

CDDicd07679, F-BAR_PACSIN2, 1 hit
cd11998, SH3_PACSIN1-2, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR035743, PACSIN1/PACSIN2_SH3
IPR028521, PACSIN2
IPR037453, PACSIN2_F-BAR
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR23065:SF14, PTHR23065:SF14, 1 hit
PfamiView protein in Pfam
PF00611, FCH, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741, F_BAR, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPACN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNF0
Secondary accession number(s): O95921
, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: February 10, 2021
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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