UniProtKB - Q9UNE7 (CHIP_HUMAN)
E3 ubiquitin-protein ligase CHIP
STUB1
Functioni
Miscellaneous
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- chaperone binding Source: ARUK-UCL
- enzyme binding Source: UniProtKB
- G protein-coupled receptor binding Source: ParkinsonsUK-UCL
- heat shock protein binding Source: ARUK-UCL
- Hsp70 protein binding Source: HGNC-UCL
- Hsp90 protein binding Source: BHF-UCL
- kinase binding Source: BHF-UCL
- misfolded protein binding Source: BHF-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
- protein-macromolecule adaptor activity Source: HGNC-UCL
- SMAD binding Source: HGNC-UCL
- tau protein binding Source: ARUK-UCL
- TPR domain binding Source: HGNC-UCL
- ubiquitin protein ligase activity Source: UniProtKB
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
- ubiquitin-protein transferase activity Source: UniProtKB
- ubiquitin-ubiquitin ligase activity Source: UniProtKB
GO - Biological processi
- cellular response to heat Source: ARUK-UCL
- cellular response to hypoxia Source: ARUK-UCL
- cellular response to misfolded protein Source: BHF-UCL
- chaperone-mediated autophagy Source: Ensembl
- DNA repair Source: UniProtKB-KW
- endoplasmic reticulum unfolded protein response Source: Ensembl
- ERBB2 signaling pathway Source: Reactome
- negative regulation of protein binding Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- positive regulation of chaperone-mediated protein complex assembly Source: BHF-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: HGNC-UCL
- positive regulation of protein ubiquitination Source: HGNC-UCL
- positive regulation of proteolysis Source: GO_Central
- positive regulation of ubiquitin-protein transferase activity Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein autoubiquitination Source: UniProtKB
- protein K63-linked ubiquitination Source: UniProtKB
- protein maturation Source: HGNC-UCL
- protein polyubiquitination Source: HGNC-UCL
- protein quality control for misfolded or incompletely synthesized proteins Source: BHF-UCL
- protein ubiquitination Source: FlyBase
- regulation of glucocorticoid metabolic process Source: HGNC-UCL
- regulation of necroptotic process Source: Reactome
- regulation of protein stability Source: BHF-UCL
- response to ischemia Source: ARUK-UCL
- ubiquitin-dependent ERAD pathway Source: ParkinsonsUK-UCL
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- ubiquitin-dependent SMAD protein catabolic process Source: HGNC-UCL
Keywordsi
Molecular function | Transferase |
Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 2.3.2.B10, 2681 |
PathwayCommonsi | Q9UNE7 |
Reactomei | R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9UNE7 |
SIGNORi | Q9UNE7 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q9UNE7, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase CHIPCurated (EC:2.3.2.272 Publications)Alternative name(s): Antigen NY-CO-71 Publication CLL-associated antigen KW-81 Publication Carboxy terminus of Hsp70-interacting protein1 Publication RING-type E3 ubiquitin transferase CHIPCurated STIP1 homology and U box-containing protein 1Imported |
Gene namesi | ORF Names:PP1131Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11427, STUB1 |
MIMi | 607207, gene |
neXtProti | NX_Q9UNE7 |
VEuPathDBi | HostDB:ENSG00000103266.10 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: ParkinsonsUK-UCL
Nucleus
- nuclear inclusion body Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: ARUK-UCL
Other locations
- chaperone complex Source: ARUK-UCL
- cytoplasm Source: HGNC-UCL
- ubiquitin conjugating enzyme complex Source: HGNC-UCL
- ubiquitin ligase complex Source: UniProtKB
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Spinocerebellar ataxia, autosomal recessive, 16 (SCAR16)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072348 | 28 | E → K in SCAR16; reduces protein level; does not reduce ubiquitin ligase activity and autoubiquitination. 1 Publication | 1 | |
Natural variantiVAR_072349 | 65 | N → S in SCAR16; reduces protein level; reduces ubiquitin ligase activity; does not change autoubiquitination. 1 PublicationCorresponds to variant dbSNP:rs690016544EnsemblClinVar. | 1 | |
Natural variantiVAR_071293 | 79 | A → D in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777347EnsemblClinVar. | 1 | |
Natural variantiVAR_071294 | 79 | A → T in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777346EnsemblClinVar. | 1 | |
Natural variantiVAR_071295 | 123 | L → V in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777344EnsemblClinVar. | 1 | |
Natural variantiVAR_071296 | 130 | N → I in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777341EnsemblClinVar. | 1 | |
Natural variantiVAR_072350 | 145 | K → Q in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs146251364EnsemblClinVar. | 1 | |
Natural variantiVAR_071297 | 147 | W → C in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777342EnsemblClinVar. | 1 | |
Natural variantiVAR_071298 | 165 | L → F in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777340EnsemblClinVar. | 1 | |
Natural variantiVAR_071299 | 236 | S → T in SCAR16. 1 Publication | 1 | |
Natural variantiVAR_071300 | 240 | M → T in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777345EnsemblClinVar. | 1 | |
Natural variantiVAR_071301 | 246 | T → M in SCAR16; inhibits ubiquitin ligase activity and autoubiquitination. 2 PublicationsCorresponds to variant dbSNP:rs587777343EnsemblClinVar. | 1 |
Spinocerebellar ataxia 48 (SCA48)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | K → A: Loss of interaction with FOXP3 and its ability to ubiquitinate FOXP3. Loss of interaction with SMAD3, HSPA8, HSP90AA1 and HSP90AB1. 2 Publications | 1 | |
Mutagenesisi | 260 | H → Q: Loss of ability to ubiquitinate FOXP3. 1 Publication | 1 | |
Mutagenesisi | 269 | P → A: Abolishes E3 ligase activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Neurodegeneration, Spinocerebellar ataxiaOrganism-specific databases
DisGeNETi | 10273 |
MalaCardsi | STUB1 |
MIMi | 615768, phenotype 618093, phenotype |
OpenTargetsi | ENSG00000103266 |
Orphaneti | 412057, Autosomal recessive cerebellar ataxia due to STUB1 deficiency |
PharmGKBi | PA36227 |
Miscellaneous databases
Pharosi | Q9UNE7, Tbio |
Genetic variation databases
BioMutai | STUB1 |
DMDMi | 78099173 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106329 | 1 – 303 | E3 ubiquitin-protein ligase CHIPAdd BLAST | 303 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 2 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 19 | PhosphoserineCombined sources1 Publication | 1 | |
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources | 1 | |
Cross-linki | 221 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 255 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 273 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UNE7 |
jPOSTi | Q9UNE7 |
MassIVEi | Q9UNE7 |
PaxDbi | Q9UNE7 |
PeptideAtlasi | Q9UNE7 |
PRIDEi | Q9UNE7 |
ProteomicsDBi | 85282 [Q9UNE7-1] 85283 [Q9UNE7-2] |
PTM databases
iPTMneti | Q9UNE7 |
PhosphoSitePlusi | Q9UNE7 |
SwissPalmi | Q9UNE7 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000103266, Expressed in lateral nuclear group of thalamus and 241 other tissues |
ExpressionAtlasi | Q9UNE7, baseline and differential |
Genevisiblei | Q9UNE7, HS |
Organism-specific databases
HPAi | ENSG00000103266, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with BAG2 (PubMed:16169850).
Interacts with E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (PubMed:11557750). Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (PubMed:15215316).
Interacts with MKKS (PubMed:18094050).
Interacts with DNAAF4 (PubMed:19423554).
Interacts with POLB (PubMed:19713937).
Interacts (when monoubiquitinated) with ATXN3.
Interacts with UBE2W.
Interacts (via the U-box domain) with the UBE2V2-UBE2N heterodimer; the complex has a specific 'Lys-63'-linked polyubiquitination activity (By similarity).
Interacts with DNAJB6 (PubMed:22366786).
Interacts with FOXP3 (PubMed:23973223).
Interacts with FLCN (PubMed:27353360).
Interacts with HSP90AA1 (PubMed:27353360, PubMed:24613385).
Interacts with HSP90 (PubMed:11146632).
Interacts with UBE2N and UBE2V1 (PubMed:16307917).
Interacts (via TPR repeats) with the C-terminal domain of HSPA1A (PubMed:10330192).
Interacts with the non-acetylated form of HSPA1A and HSPA1B (PubMed:27708256).
Interacts (via TPR repeats) with the C-terminal domain of HSPA8 (PubMed:10330192, PubMed:11557750, PubMed:23990462, PubMed:27708256).
Interacts with SMAD3 and HSP90AB1 (PubMed:24613385).
Interacts with UBE4B (PubMed:17369820).
Interacts with RIPK3 (PubMed:29883609).
Interacts with PRMT5 (PubMed:33376131).
By similarity17 PublicationsBinary interactionsi
Q9UNE7
Isoform 1 [Q9UNE7-1]
With | #Exp. | IntAct |
---|---|---|
AKT1 [P31749] | 5 | EBI-15687717,EBI-296087 |
HSPA8 - isoform 1 [P11142-1] | 4 | EBI-15687717,EBI-351908 |
LRRK2 [Q5S007] | 2 | EBI-15687717,EBI-5323863 |
MAPT [P10636] | 5 | EBI-15687717,EBI-366182 |
GO - Molecular functioni
- chaperone binding Source: ARUK-UCL
- enzyme binding Source: UniProtKB
- G protein-coupled receptor binding Source: ParkinsonsUK-UCL
- heat shock protein binding Source: ARUK-UCL
- Hsp70 protein binding Source: HGNC-UCL
- Hsp90 protein binding Source: BHF-UCL
- kinase binding Source: BHF-UCL
- misfolded protein binding Source: BHF-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
- SMAD binding Source: HGNC-UCL
- tau protein binding Source: ARUK-UCL
- TPR domain binding Source: HGNC-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 115563, 464 interactors |
CORUMi | Q9UNE7 |
DIPi | DIP-29752N |
IntActi | Q9UNE7, 215 interactors |
MINTi | Q9UNE7 |
STRINGi | 9606.ENSP00000219548 |
Miscellaneous databases
RNActi | Q9UNE7, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9UNE7 |
SMRi | Q9UNE7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 59 | TPR 1Add BLAST | 34 | |
Repeati | 60 – 93 | TPR 2Add BLAST | 34 | |
Repeati | 95 – 127 | TPR 3Add BLAST | 33 | |
Domaini | 226 – 300 | U-boxAdd BLAST | 75 |
Domaini
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG4642, Eukaryota |
GeneTreei | ENSGT00930000151045 |
HOGENOMi | CLU_056455_1_0_1 |
InParanoidi | Q9UNE7 |
OMAi | EVPDWAI |
OrthoDBi | 1422450at2759 |
PhylomeDBi | Q9UNE7 |
TreeFami | TF313937 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041312, CHIP_TPR_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR003613, Ubox_domain IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF18391, CHIP_TPR_N, 1 hit PF04564, U-box, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 3 hits SM00504, Ubox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit PS51698, U_BOX, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG
60 70 80 90 100
RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL
110 120 130 140 150
GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI
160 170 180 190 200
EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI
210 220 230 240 250
EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI
260 270 280 290 300
TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV
EDY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BS86 | H3BS86_HUMAN | E3 ubiquitin-protein ligase CHIP | STUB1 | 213 | Annotation score: | ||
H3BUD0 | H3BUD0_HUMAN | E3 ubiquitin-protein ligase CHIP | STUB1 | 185 | Annotation score: | ||
H3BTA3 | H3BTA3_HUMAN | E3 ubiquitin-protein ligase CHIP | STUB1 | 157 | Annotation score: | ||
V9GYH3 | V9GYH3_HUMAN | E3 ubiquitin-protein ligase CHIP | STUB1 | 24 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | A → V in AAD33400 (PubMed:10330192).Curated | 1 | |
Sequence conflicti | 272 | R → G in AAC18038 (PubMed:9610721).Curated | 1 | |
Sequence conflicti | 280 | L → F in AAC18038 (PubMed:9610721).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072348 | 28 | E → K in SCAR16; reduces protein level; does not reduce ubiquitin ligase activity and autoubiquitination. 1 Publication | 1 | |
Natural variantiVAR_072349 | 65 | N → S in SCAR16; reduces protein level; reduces ubiquitin ligase activity; does not change autoubiquitination. 1 PublicationCorresponds to variant dbSNP:rs690016544EnsemblClinVar. | 1 | |
Natural variantiVAR_071293 | 79 | A → D in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777347EnsemblClinVar. | 1 | |
Natural variantiVAR_071294 | 79 | A → T in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777346EnsemblClinVar. | 1 | |
Natural variantiVAR_071295 | 123 | L → V in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777344EnsemblClinVar. | 1 | |
Natural variantiVAR_071296 | 130 | N → I in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777341EnsemblClinVar. | 1 | |
Natural variantiVAR_072350 | 145 | K → Q in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs146251364EnsemblClinVar. | 1 | |
Natural variantiVAR_071297 | 147 | W → C in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777342EnsemblClinVar. | 1 | |
Natural variantiVAR_071298 | 165 | L → F in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777340EnsemblClinVar. | 1 | |
Natural variantiVAR_071299 | 236 | S → T in SCAR16. 1 Publication | 1 | |
Natural variantiVAR_071300 | 240 | M → T in SCAR16. 1 PublicationCorresponds to variant dbSNP:rs587777345EnsemblClinVar. | 1 | |
Natural variantiVAR_071301 | 246 | T → M in SCAR16; inhibits ubiquitin ligase activity and autoubiquitination. 2 PublicationsCorresponds to variant dbSNP:rs587777343EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015947 | 1 – 72 | Missing in isoform 2. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039689 mRNA Translation: AAC18038.1 AF129085 mRNA Translation: AAD33400.1 AF432221 mRNA Translation: AAL99927.1 AF217968 mRNA Translation: AAG17211.1 AE006464 Genomic DNA Translation: AAK61242.1 Z92544 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85758.1 BC007545 mRNA Translation: AAH07545.1 BC017178 mRNA Translation: AAH17178.1 BC022788 mRNA Translation: AAH22788.1 BC063617 mRNA Translation: AAH63617.1 |
CCDSi | CCDS10419.1 [Q9UNE7-1] CCDS76797.1 [Q9UNE7-2] |
RefSeqi | NP_001280126.1, NM_001293197.1 [Q9UNE7-2] NP_005852.2, NM_005861.3 [Q9UNE7-1] |
Genome annotation databases
Ensembli | ENST00000219548; ENSP00000219548; ENSG00000103266 [Q9UNE7-1] ENST00000564370; ENSP00000456875; ENSG00000103266 [Q9UNE7-2] ENST00000565677; ENSP00000457228; ENSG00000103266 [Q9UNE7-2] |
GeneIDi | 10273 |
KEGGi | hsa:10273 |
UCSCi | uc002cit.4, human [Q9UNE7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF039689 mRNA Translation: AAC18038.1 AF129085 mRNA Translation: AAD33400.1 AF432221 mRNA Translation: AAL99927.1 AF217968 mRNA Translation: AAG17211.1 AE006464 Genomic DNA Translation: AAK61242.1 Z92544 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85758.1 BC007545 mRNA Translation: AAH07545.1 BC017178 mRNA Translation: AAH17178.1 BC022788 mRNA Translation: AAH22788.1 BC063617 mRNA Translation: AAH63617.1 |
CCDSi | CCDS10419.1 [Q9UNE7-1] CCDS76797.1 [Q9UNE7-2] |
RefSeqi | NP_001280126.1, NM_001293197.1 [Q9UNE7-2] NP_005852.2, NM_005861.3 [Q9UNE7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4KBQ | X-ray | 2.91 | A/B | 21-154 | [»] | |
6EFK | X-ray | 1.50 | A/B | 23-154 | [»] | |
6NSV | X-ray | 1.30 | A/B | 23-152 | [»] | |
BMRBi | Q9UNE7 | |||||
SMRi | Q9UNE7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115563, 464 interactors |
CORUMi | Q9UNE7 |
DIPi | DIP-29752N |
IntActi | Q9UNE7, 215 interactors |
MINTi | Q9UNE7 |
STRINGi | 9606.ENSP00000219548 |
Protein family/group databases
MoonDBi | Q9UNE7, Predicted |
PTM databases
iPTMneti | Q9UNE7 |
PhosphoSitePlusi | Q9UNE7 |
SwissPalmi | Q9UNE7 |
Genetic variation databases
BioMutai | STUB1 |
DMDMi | 78099173 |
Proteomic databases
EPDi | Q9UNE7 |
jPOSTi | Q9UNE7 |
MassIVEi | Q9UNE7 |
PaxDbi | Q9UNE7 |
PeptideAtlasi | Q9UNE7 |
PRIDEi | Q9UNE7 |
ProteomicsDBi | 85282 [Q9UNE7-1] 85283 [Q9UNE7-2] |
Protocols and materials databases
Antibodypediai | 22808, 471 antibodies |
DNASUi | 10273 |
Genome annotation databases
Ensembli | ENST00000219548; ENSP00000219548; ENSG00000103266 [Q9UNE7-1] ENST00000564370; ENSP00000456875; ENSG00000103266 [Q9UNE7-2] ENST00000565677; ENSP00000457228; ENSG00000103266 [Q9UNE7-2] |
GeneIDi | 10273 |
KEGGi | hsa:10273 |
UCSCi | uc002cit.4, human [Q9UNE7-1] |
Organism-specific databases
CTDi | 10273 |
DisGeNETi | 10273 |
GeneCardsi | STUB1 |
HGNCi | HGNC:11427, STUB1 |
HPAi | ENSG00000103266, Low tissue specificity |
MalaCardsi | STUB1 |
MIMi | 607207, gene 615768, phenotype 618093, phenotype |
neXtProti | NX_Q9UNE7 |
OpenTargetsi | ENSG00000103266 |
Orphaneti | 412057, Autosomal recessive cerebellar ataxia due to STUB1 deficiency |
PharmGKBi | PA36227 |
VEuPathDBi | HostDB:ENSG00000103266.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4642, Eukaryota |
GeneTreei | ENSGT00930000151045 |
HOGENOMi | CLU_056455_1_0_1 |
InParanoidi | Q9UNE7 |
OMAi | EVPDWAI |
OrthoDBi | 1422450at2759 |
PhylomeDBi | Q9UNE7 |
TreeFami | TF313937 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
BRENDAi | 2.3.2.B10, 2681 |
PathwayCommonsi | Q9UNE7 |
Reactomei | R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9UNE7 |
SIGNORi | Q9UNE7 |
Miscellaneous databases
BioGRID-ORCSi | 10273, 85 hits in 998 CRISPR screens |
ChiTaRSi | STUB1, human |
GeneWikii | STUB1 |
GenomeRNAii | 10273 |
Pharosi | Q9UNE7, Tbio |
PROi | PR:Q9UNE7 |
RNActi | Q9UNE7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103266, Expressed in lateral nuclear group of thalamus and 241 other tissues |
ExpressionAtlasi | Q9UNE7, baseline and differential |
Genevisiblei | Q9UNE7, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR041312, CHIP_TPR_N IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat IPR003613, Ubox_domain IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF18391, CHIP_TPR_N, 1 hit PF04564, U-box, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 3 hits SM00504, Ubox, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 3 hits PS50293, TPR_REGION, 1 hit PS51698, U_BOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHIP_HUMAN | |
Accessioni | Q9UNE7Primary (citable) accession number: Q9UNE7 Secondary accession number(s): A2IDB9 Q9HBT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | April 7, 2021 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references