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Entry version 148 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

Rab effector Noc2

Gene

RPH3AL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab effector Noc2
Alternative name(s):
No C2 domains protein
Rabphilin-3A-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPH3AL
Synonyms:NOC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000181031.15

Human Gene Nomenclature Database

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HGNCi
HGNC:10296 RPH3AL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604881 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UNE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9501

Open Targets

More...
OpenTargetsi
ENSG00000181031

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34658

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UNE2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPH3AL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74735140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782631 – 315Rab effector Noc2Add BLAST315

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UNE2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UNE2

PeptideAtlas

More...
PeptideAtlasi
Q9UNE2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UNE2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85280 [Q9UNE2-1]
85281 [Q9UNE2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UNE2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UNE2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181031 Expressed in pituitary gland and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UNE2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UNE2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000181031 Tissue enhanced (pituitary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells.

Interacts with RAB3A, RAB3B, RAB3C and RAB3D.

Interacts with ZYX (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114880, 7 interactors

Protein interaction database and analysis system

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IntActi
Q9UNE2, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328977

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9UNE2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UNE2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 158RabBDPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1013 Eukaryota
ENOG410XQXA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000034248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076502_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UNE2

KEGG Orthology (KO)

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KOi
K19939

Identification of Orthologs from Complete Genome Data

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OMAi
KRHTWAT

Database of Orthologous Groups

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OrthoDBi
542090at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UNE2

TreeFam database of animal gene trees

More...
TreeFami
TF342971

Family and domain databases

Conserved Domains Database

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CDDi
cd15763 FYVE_RPH3L, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041282 FYVE_2
IPR041857 Noc2_FYVE
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR45729:SF4 PTHR45729:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02318 FYVE_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA
60 70 80 90 100
EVEAILQVIQ RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE
110 120 130 140 150
VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR
160 170 180 190 200
SGAWFYKGLP KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW
210 220 230 240 250
ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR
260 270 280 290 300
MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA
310
PAADAAPAGP SSCLG
Length:315
Mass (Da):34,464
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDDB315E0BBC7C23
GO
Isoform 2 (identifier: Q9UNE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-146: Missing.

Show »
Length:286
Mass (Da):31,190
Checksum:iE208E7BF9A361BC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2N0I3L2N0_HUMAN
Rab effector Noc2
RPH3AL
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L308I3L308_HUMAN
Rab effector Noc2
RPH3AL
201Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2G8I3L2G8_HUMAN
Rab effector Noc2
RPH3AL
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2X0I3L2X0_HUMAN
Rab effector Noc2
RPH3AL
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3M9I3L3M9_HUMAN
Rab effector Noc2
RPH3AL
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX72A0A0J9YX72_HUMAN
Rab effector Noc2
RPH3AL
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L349I3L349_HUMAN
Rab effector Noc2
RPH3AL
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q0I3L1Q0_HUMAN
Rab effector Noc2
RPH3AL
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2I9I3L2I9_HUMAN
Rab effector Noc2
RPH3AL
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI49I3NI49_HUMAN
Rab effector Noc2
RPH3AL
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85R → Q in AAH05153 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023244118 – 146Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF129812 mRNA Translation: AAD45582.1
AK000469 mRNA Translation: BAA91186.1
CH471108 Genomic DNA Translation: EAW90670.1
CH471108 Genomic DNA Translation: EAW90671.1
BC005153 mRNA Translation: AAH05153.1
BC093776 mRNA Translation: AAH93776.1
BC113413 mRNA Translation: AAI13414.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10994.1 [Q9UNE2-1]
CCDS54059.1 [Q9UNE2-2]

NCBI Reference Sequences

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RefSeqi
NP_001177340.1, NM_001190411.1 [Q9UNE2-1]
NP_001177341.1, NM_001190412.1 [Q9UNE2-2]
NP_001177342.1, NM_001190413.1 [Q9UNE2-2]
NP_008918.1, NM_006987.3 [Q9UNE2-1]
XP_011533669.1, XM_011535367.2
XP_011533670.1, XM_011535368.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323434; ENSP00000319210; ENSG00000181031 [Q9UNE2-2]
ENST00000331302; ENSP00000328977; ENSG00000181031 [Q9UNE2-1]
ENST00000536489; ENSP00000438224; ENSG00000181031 [Q9UNE2-2]
ENST00000608278; ENSP00000483035; ENSG00000262334 [Q9UNE2-1]
ENST00000608519; ENSP00000476394; ENSG00000262334 [Q9UNE2-2]
ENST00000618002; ENSP00000479485; ENSG00000181031 [Q9UNE2-1]
ENST00000632000; ENSP00000487689; ENSG00000262334 [Q9UNE2-2]
ENST00000632545; ENSP00000487851; ENSG00000262334 [Q9UNE2-2]
ENST00000632616; ENSP00000487649; ENSG00000262334 [Q9UNE2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9501

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9501

UCSC genome browser

More...
UCSCi
uc002fre.3 human [Q9UNE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129812 mRNA Translation: AAD45582.1
AK000469 mRNA Translation: BAA91186.1
CH471108 Genomic DNA Translation: EAW90670.1
CH471108 Genomic DNA Translation: EAW90671.1
BC005153 mRNA Translation: AAH05153.1
BC093776 mRNA Translation: AAH93776.1
BC113413 mRNA Translation: AAI13414.1
CCDSiCCDS10994.1 [Q9UNE2-1]
CCDS54059.1 [Q9UNE2-2]
RefSeqiNP_001177340.1, NM_001190411.1 [Q9UNE2-1]
NP_001177341.1, NM_001190412.1 [Q9UNE2-2]
NP_001177342.1, NM_001190413.1 [Q9UNE2-2]
NP_008918.1, NM_006987.3 [Q9UNE2-1]
XP_011533669.1, XM_011535367.2
XP_011533670.1, XM_011535368.2

3D structure databases

SMRiQ9UNE2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114880, 7 interactors
IntActiQ9UNE2, 16 interactors
STRINGi9606.ENSP00000328977

PTM databases

iPTMnetiQ9UNE2
PhosphoSitePlusiQ9UNE2

Polymorphism and mutation databases

BioMutaiRPH3AL
DMDMi74735140

Proteomic databases

MassIVEiQ9UNE2
PaxDbiQ9UNE2
PeptideAtlasiQ9UNE2
PRIDEiQ9UNE2
ProteomicsDBi85280 [Q9UNE2-1]
85281 [Q9UNE2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10243 203 antibodies

The DNASU plasmid repository

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DNASUi
9501

Genome annotation databases

EnsembliENST00000323434; ENSP00000319210; ENSG00000181031 [Q9UNE2-2]
ENST00000331302; ENSP00000328977; ENSG00000181031 [Q9UNE2-1]
ENST00000536489; ENSP00000438224; ENSG00000181031 [Q9UNE2-2]
ENST00000608278; ENSP00000483035; ENSG00000262334 [Q9UNE2-1]
ENST00000608519; ENSP00000476394; ENSG00000262334 [Q9UNE2-2]
ENST00000618002; ENSP00000479485; ENSG00000181031 [Q9UNE2-1]
ENST00000632000; ENSP00000487689; ENSG00000262334 [Q9UNE2-2]
ENST00000632545; ENSP00000487851; ENSG00000262334 [Q9UNE2-2]
ENST00000632616; ENSP00000487649; ENSG00000262334 [Q9UNE2-1]
GeneIDi9501
KEGGihsa:9501
UCSCiuc002fre.3 human [Q9UNE2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9501
DisGeNETi9501
EuPathDBiHostDB:ENSG00000181031.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RPH3AL
HGNCiHGNC:10296 RPH3AL
HPAiENSG00000181031 Tissue enhanced (pituitary)
MIMi604881 gene
neXtProtiNX_Q9UNE2
OpenTargetsiENSG00000181031
PharmGKBiPA34658

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00440000034248
HOGENOMiCLU_076502_1_0_1
InParanoidiQ9UNE2
KOiK19939
OMAiKRHTWAT
OrthoDBi542090at2759
PhylomeDBiQ9UNE2
TreeFamiTF342971

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9501 1 hit in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPH3AL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPH3AL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9501
PharosiQ9UNE2 Tbio

Protein Ontology

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PROi
PR:Q9UNE2
RNActiQ9UNE2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181031 Expressed in pituitary gland and 139 other tissues
ExpressionAtlasiQ9UNE2 baseline and differential
GenevisibleiQ9UNE2 HS

Family and domain databases

CDDicd15763 FYVE_RPH3L, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR041282 FYVE_2
IPR041857 Noc2_FYVE
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45729:SF4 PTHR45729:SF4, 1 hit
PfamiView protein in Pfam
PF02318 FYVE_2, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPH3L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UNE2
Secondary accession number(s): D3DTG7, Q9BSB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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