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Protein

Rab effector Noc2

Gene

RPH3AL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • cytoskeletal protein binding Source: ProtInc
  • LIM domain binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • Rab GTPase binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rab effector Noc2
Alternative name(s):
No C2 domains protein
Rabphilin-3A-like protein
Gene namesi
Name:RPH3AL
Synonyms:NOC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181031.15
HGNCiHGNC:10296 RPH3AL
MIMi604881 gene
neXtProtiNX_Q9UNE2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9501
OpenTargetsiENSG00000181031
PharmGKBiPA34658

Polymorphism and mutation databases

BioMutaiRPH3AL
DMDMi74735140

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782631 – 315Rab effector Noc2Add BLAST315

Proteomic databases

PaxDbiQ9UNE2
PeptideAtlasiQ9UNE2
PRIDEiQ9UNE2
ProteomicsDBi85280
85281 [Q9UNE2-2]

PTM databases

iPTMnetiQ9UNE2
PhosphoSitePlusiQ9UNE2

Expressioni

Tissue specificityi

Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.2 Publications

Gene expression databases

BgeeiENSG00000181031 Expressed in 140 organ(s), highest expression level in pituitary gland
CleanExiHS_RPH3AL
ExpressionAtlasiQ9UNE2 baseline and differential
GenevisibleiQ9UNE2 HS

Organism-specific databases

HPAiHPA024311

Interactioni

Subunit structurei

Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MID2Q9UJV3-23EBI-2855824,EBI-10172526

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114880, 6 interactors
IntActiQ9UNE2, 16 interactors
STRINGi9606.ENSP00000328977

Structurei

3D structure databases

ProteinModelPortaliQ9UNE2
SMRiQ9UNE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 158RabBDPROSITE-ProRule annotationAdd BLAST118

Domaini

The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00440000034248
HOGENOMiHOG000126816
HOVERGENiHBG052990
InParanoidiQ9UNE2
KOiK19939
OMAiQRKSQCL
OrthoDBiEOG091G0FPP
PhylomeDBiQ9UNE2
TreeFamiTF342971

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF244 PTHR10024:SF244, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA
60 70 80 90 100
EVEAILQVIQ RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE
110 120 130 140 150
VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR
160 170 180 190 200
SGAWFYKGLP KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW
210 220 230 240 250
ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR
260 270 280 290 300
MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA
310
PAADAAPAGP SSCLG
Length:315
Mass (Da):34,464
Last modified:May 1, 2000 - v1
Checksum:iFDDB315E0BBC7C23
GO
Isoform 2 (identifier: Q9UNE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-146: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):31,190
Checksum:iE208E7BF9A361BC3
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2N0I3L2N0_HUMAN
Rab effector Noc2
RPH3AL
193Annotation score:
I3L308I3L308_HUMAN
Rab effector Noc2
RPH3AL
201Annotation score:
I3L3M9I3L3M9_HUMAN
Rab effector Noc2
RPH3AL
152Annotation score:
I3L2X0I3L2X0_HUMAN
Rab effector Noc2
RPH3AL
145Annotation score:
I3L2G8I3L2G8_HUMAN
Rab effector Noc2
RPH3AL
157Annotation score:
A0A0J9YX72A0A0J9YX72_HUMAN
Rab effector Noc2
RPH3AL
146Annotation score:
I3L349I3L349_HUMAN
Rab effector Noc2
RPH3AL
110Annotation score:
I3L1Q0I3L1Q0_HUMAN
Rab effector Noc2
RPH3AL
126Annotation score:
I3NI49I3NI49_HUMAN
Rab effector Noc2
RPH3AL
88Annotation score:
I3L2I9I3L2I9_HUMAN
Rab effector Noc2
RPH3AL
148Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85R → Q in AAH05153 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023244118 – 146Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129812 mRNA Translation: AAD45582.1
AK000469 mRNA Translation: BAA91186.1
CH471108 Genomic DNA Translation: EAW90670.1
CH471108 Genomic DNA Translation: EAW90671.1
BC005153 mRNA Translation: AAH05153.1
BC093776 mRNA Translation: AAH93776.1
BC113413 mRNA Translation: AAI13414.1
CCDSiCCDS10994.1 [Q9UNE2-1]
CCDS54059.1 [Q9UNE2-2]
RefSeqiNP_001177340.1, NM_001190411.1 [Q9UNE2-1]
NP_001177341.1, NM_001190412.1 [Q9UNE2-2]
NP_001177342.1, NM_001190413.1 [Q9UNE2-2]
NP_008918.1, NM_006987.3 [Q9UNE2-1]
XP_011533669.1, XM_011535367.2
XP_011533670.1, XM_011535368.2 [Q9UNE2-2]
UniGeneiHs.651925

Genome annotation databases

EnsembliENST00000323434; ENSP00000319210; ENSG00000181031 [Q9UNE2-2]
ENST00000331302; ENSP00000328977; ENSG00000181031 [Q9UNE2-1]
ENST00000536489; ENSP00000438224; ENSG00000181031 [Q9UNE2-2]
ENST00000608278; ENSP00000483035; ENSG00000262334 [Q9UNE2-1]
ENST00000608519; ENSP00000476394; ENSG00000262334 [Q9UNE2-2]
ENST00000618002; ENSP00000479485; ENSG00000181031 [Q9UNE2-1]
ENST00000632000; ENSP00000487689; ENSG00000262334 [Q9UNE2-2]
ENST00000632545; ENSP00000487851; ENSG00000262334 [Q9UNE2-2]
ENST00000632616; ENSP00000487649; ENSG00000262334 [Q9UNE2-1]
GeneIDi9501
KEGGihsa:9501
UCSCiuc002fre.3 human [Q9UNE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129812 mRNA Translation: AAD45582.1
AK000469 mRNA Translation: BAA91186.1
CH471108 Genomic DNA Translation: EAW90670.1
CH471108 Genomic DNA Translation: EAW90671.1
BC005153 mRNA Translation: AAH05153.1
BC093776 mRNA Translation: AAH93776.1
BC113413 mRNA Translation: AAI13414.1
CCDSiCCDS10994.1 [Q9UNE2-1]
CCDS54059.1 [Q9UNE2-2]
RefSeqiNP_001177340.1, NM_001190411.1 [Q9UNE2-1]
NP_001177341.1, NM_001190412.1 [Q9UNE2-2]
NP_001177342.1, NM_001190413.1 [Q9UNE2-2]
NP_008918.1, NM_006987.3 [Q9UNE2-1]
XP_011533669.1, XM_011535367.2
XP_011533670.1, XM_011535368.2 [Q9UNE2-2]
UniGeneiHs.651925

3D structure databases

ProteinModelPortaliQ9UNE2
SMRiQ9UNE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114880, 6 interactors
IntActiQ9UNE2, 16 interactors
STRINGi9606.ENSP00000328977

PTM databases

iPTMnetiQ9UNE2
PhosphoSitePlusiQ9UNE2

Polymorphism and mutation databases

BioMutaiRPH3AL
DMDMi74735140

Proteomic databases

PaxDbiQ9UNE2
PeptideAtlasiQ9UNE2
PRIDEiQ9UNE2
ProteomicsDBi85280
85281 [Q9UNE2-2]

Protocols and materials databases

DNASUi9501
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323434; ENSP00000319210; ENSG00000181031 [Q9UNE2-2]
ENST00000331302; ENSP00000328977; ENSG00000181031 [Q9UNE2-1]
ENST00000536489; ENSP00000438224; ENSG00000181031 [Q9UNE2-2]
ENST00000608278; ENSP00000483035; ENSG00000262334 [Q9UNE2-1]
ENST00000608519; ENSP00000476394; ENSG00000262334 [Q9UNE2-2]
ENST00000618002; ENSP00000479485; ENSG00000181031 [Q9UNE2-1]
ENST00000632000; ENSP00000487689; ENSG00000262334 [Q9UNE2-2]
ENST00000632545; ENSP00000487851; ENSG00000262334 [Q9UNE2-2]
ENST00000632616; ENSP00000487649; ENSG00000262334 [Q9UNE2-1]
GeneIDi9501
KEGGihsa:9501
UCSCiuc002fre.3 human [Q9UNE2-1]

Organism-specific databases

CTDi9501
DisGeNETi9501
EuPathDBiHostDB:ENSG00000181031.15
GeneCardsiRPH3AL
HGNCiHGNC:10296 RPH3AL
HPAiHPA024311
MIMi604881 gene
neXtProtiNX_Q9UNE2
OpenTargetsiENSG00000181031
PharmGKBiPA34658
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
GeneTreeiENSGT00440000034248
HOGENOMiHOG000126816
HOVERGENiHBG052990
InParanoidiQ9UNE2
KOiK19939
OMAiQRKSQCL
OrthoDBiEOG091G0FPP
PhylomeDBiQ9UNE2
TreeFamiTF342971

Miscellaneous databases

ChiTaRSiRPH3AL human
GeneWikiiRPH3AL
GenomeRNAii9501
PROiPR:Q9UNE2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181031 Expressed in 140 organ(s), highest expression level in pituitary gland
CleanExiHS_RPH3AL
ExpressionAtlasiQ9UNE2 baseline and differential
GenevisibleiQ9UNE2 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010911 Rab_BD
IPR030538 Rab_effect_Noc2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF244 PTHR10024:SF244, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPH3L_HUMAN
AccessioniPrimary (citable) accession number: Q9UNE2
Secondary accession number(s): D3DTG7, Q9BSB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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