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UniProtKB - Q9UNE0 (EDAR_HUMAN)
Protein
Tumor necrosis factor receptor superfamily member EDAR
Gene
EDAR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
GO - Molecular functioni
- signaling receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: HGNC-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- epidermis development Source: HGNC-UCL
- hair follicle development Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- pigmentation Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- positive regulation of JNK cascade Source: GO_Central
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- salivary gland cavitation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Apoptosis, Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9UNE0 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | Q9UNE0 |
SIGNORi | Q9UNE0 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member EDARAlternative name(s): Anhidrotic ectodysplasin receptor 1 Downless homolog EDA-A1 receptor Ectodermal dysplasia receptor Ectodysplasin-A receptor |
Gene namesi | Name:EDAR Synonyms:DL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2895, EDAR |
MIMi | 604095, gene |
neXtProti | NX_Q9UNE0 |
VEuPathDBi | HostDB:ENSG00000135960 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- apical part of cell Source: Ensembl
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 187 | ExtracellularSequence analysisAdd BLAST | 161 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 448 | CytoplasmicSequence analysisAdd BLAST | 240 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013450 | 420 | R → Q in ECTD10A and ECTD10B; abolishes NF-kappa-B activation and reduces JNK activation. 6 PublicationsCorresponds to variant dbSNP:rs121908453EnsemblClinVar. | 1 |
Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B)8 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder due to abnormal development of two or more ectodermal structures, and characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054444 | 47 | C → Y in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs778903951Ensembl. | 1 | |
Natural variantiVAR_013448 | 87 | C → R in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs121908451EnsemblClinVar. | 1 | |
Natural variantiVAR_013449 | 89 | R → H in ECTD10B. 4 PublicationsCorresponds to variant dbSNP:rs121908450EnsemblClinVar. | 1 | |
Natural variantiVAR_064830 | 98 | R → Q in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs144473052Ensembl. | 1 | |
Natural variantiVAR_054445 | 110 | D → A in ECTD10B. 2 PublicationsCorresponds to variant dbSNP:rs121908455EnsemblClinVar. | 1 | |
Natural variantiVAR_054446 | 148 | C → R in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_064831 | 358 | R → Q in ECTD10B. 2 PublicationsCorresponds to variant dbSNP:rs886039564EnsemblClinVar. | 1 | |
Natural variantiVAR_054447 | 375 | R → H in ECTD10B; the mutant protein does not interact with EDARADD and is functionally inactive. 1 PublicationCorresponds to variant dbSNP:rs121908454EnsemblClinVar. | 1 | |
Natural variantiVAR_054448 | 377 | L → F in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054449 | 382 | G → S in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs747806672EnsemblClinVar. | 1 | |
Natural variantiVAR_064832 | 396 | Q → QQ in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054450 | 403 | T → M in ECTD10B. 2 Publications | 1 | |
Natural variantiVAR_064833 | 408 | I → F in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054451 | 413 | T → P in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054452 | 418 | I → T in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_013450 | 420 | R → Q in ECTD10A and ECTD10B; abolishes NF-kappa-B activation and reduces JNK activation. 6 PublicationsCorresponds to variant dbSNP:rs121908453EnsemblClinVar. | 1 | |
Natural variantiVAR_054453 | 434 | W → C in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs528478080Ensembl. | 1 | |
Natural variantiVAR_064834 | 434 | W → R in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs773885029Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 379 | E → K: Reduces activation of NF-kappa-B. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Ectodermal dysplasiaOrganism-specific databases
DisGeNETi | 10913 |
GeneReviewsi | EDAR |
MalaCardsi | EDAR |
MIMi | 129490, phenotype 224900, phenotype 612630, phenotype |
OpenTargetsi | ENSG00000135960 |
Orphaneti | 1810, Autosomal dominant hypohidrotic ectodermal dysplasia 248, Autosomal recessive hypohidrotic ectodermal dysplasia |
PharmGKBi | PA27602 |
Miscellaneous databases
Pharosi | Q9UNE0, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1250376 |
Genetic variation databases
BioMutai | EDAR |
DMDMi | 21263572 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000034608 | 27 – 448 | Tumor necrosis factor receptor superfamily member EDARAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 44 | By similarity | ||
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 47 ↔ 60 | By similarity | ||
Disulfide bondi | 50 ↔ 71 | By similarity | ||
Disulfide bondi | 74 ↔ 87 | By similarity | ||
Disulfide bondi | 93 ↔ 113 | By similarity | ||
Disulfide bondi | 135 ↔ 148 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9UNE0 |
MassIVEi | Q9UNE0 |
PaxDbi | Q9UNE0 |
PeptideAtlasi | Q9UNE0 |
PRIDEi | Q9UNE0 |
ProteomicsDBi | 19402 85279 [Q9UNE0-1] |
PTM databases
GlyGeni | Q9UNE0, 1 site |
iPTMneti | Q9UNE0 |
PhosphoSitePlusi | Q9UNE0 |
Expressioni
Tissue specificityi
Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
Developmental stagei
Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation.
Gene expression databases
Bgeei | ENSG00000135960, Expressed in secondary oocyte and 104 other tissues |
Genevisiblei | Q9UNE0, HS |
Organism-specific databases
HPAi | ENSG00000135960, Tissue enhanced (esophagus) |
Interactioni
Subunit structurei
Binds to EDARADD. Associates with TRAF1, TRAF2, TRAF3 and NIK.
Binary interactionsi
Isoform 2 [Q9UNE0-2]
With | #Exp. | IntAct |
---|---|---|
SGTA [O43765] | 3 | EBI-12964110,EBI-347996 |
UPK1B [O75841] | 3 | EBI-12964110,EBI-12237619 |
Protein-protein interaction databases
BioGRIDi | 116118, 73 interactors |
IntActi | Q9UNE0, 8 interactors |
STRINGi | 9606.ENSP00000258443 |
Miscellaneous databases
RNActi | Q9UNE0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9UNE0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 30 – 71 | TNFR-Cys 1Add BLAST | 42 | |
Repeati | 73 – 113 | TNFR-Cys 2Add BLAST | 41 | |
Repeati | 115 – 148 | TNFR-Cys 3Add BLAST | 34 | |
Domaini | 358 – 431 | DeathAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 220 – 297 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 260 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 263 – 280 | Polar residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRV5, Eukaryota |
GeneTreei | ENSGT00940000153259 |
HOGENOMi | CLU_039634_0_0_1 |
InParanoidi | Q9UNE0 |
OMAi | CGENEYH |
OrthoDBi | 672843at2759 |
PhylomeDBi | Q9UNE0 |
TreeFami | TF331385 |
Family and domain databases
CDDi | cd13421, TNFRSF_EDAR, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR034052, EDAR_N |
SUPFAMi | SSF47986, SSF47986, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UNE0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHVGDCTQT PWLPVLVVSL MCSARAEYSN CGENEYYNQT TGLCQECPPC
60 70 80 90 100
GPGEEPYLSC GYGTKDEDYG CVPCPAEKFS KGGYQICRRH KDCEGFFRAT
110 120 130 140 150
VLTPGDMEND AECGPCLPGY YMLENRPRNI YGMVCYSCLL APPNTKECVG
160 170 180 190 200
ATSGASANFP GTSGSSTLSP FQHAHKELSG QGHLATALII AMSTIFIMAI
210 220 230 240 250
AIVLIIMFYI LKTKPSAPAC CTSHPGKSVE AQVSKDEEKK EAPDNVVMFS
260 270 280 290 300
EKDEFEKLTA TPAKPTKSEN DASSENEQLL SRSVDSDEEP APDKQGSPEL
310 320 330 340 350
CLLSLVHLAR EKSATSNKSA GIQSRRKKIL DVYANVCGVV EGLSPTELPF
360 370 380 390 400
DCLEKTSRML SSTYNSEKAV VKTWRHLAES FGLKRDEIGG MTDGMQLFDR
410 420 430 440
ISTAGYSIPE LLTKLVQIER LDAVESLCAD ILEWAGVVPP ASQPHAAS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 156 | S → P in BAG36519 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 262 | P → S in AAD50077 (PubMed:10431241).Curated | 1 | ||
Isoform 2 (identifier: Q9UNE0-2) | |||||
Sequence conflicti | 229 | F → L in BAG59487 (PubMed:14702039).Curated | 1 |
Polymorphismi
Genetic variation in EDAR is associated with variations in head hair thickness and defines the hair morphology locus 1 (HRM1) [MIMi:612630]. Besides skin color and facial features, hair morphology is one of the most distinctive traits among human populations, and classical classification of human population is based on such visible traits.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054444 | 47 | C → Y in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs778903951Ensembl. | 1 | |
Natural variantiVAR_013448 | 87 | C → R in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs121908451EnsemblClinVar. | 1 | |
Natural variantiVAR_013449 | 89 | R → H in ECTD10B. 4 PublicationsCorresponds to variant dbSNP:rs121908450EnsemblClinVar. | 1 | |
Natural variantiVAR_064830 | 98 | R → Q in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs144473052Ensembl. | 1 | |
Natural variantiVAR_054445 | 110 | D → A in ECTD10B. 2 PublicationsCorresponds to variant dbSNP:rs121908455EnsemblClinVar. | 1 | |
Natural variantiVAR_054446 | 148 | C → R in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_064831 | 358 | R → Q in ECTD10B. 2 PublicationsCorresponds to variant dbSNP:rs886039564EnsemblClinVar. | 1 | |
Natural variantiVAR_020011 | 370 | V → A Associated with increase in hair thickness; results in decreased downstream activity of NFKB1 48 hours after transfection into cells. 3 PublicationsCorresponds to variant dbSNP:rs3827760EnsemblClinVar. | 1 | |
Natural variantiVAR_077562 | 370 | V → L1 PublicationCorresponds to variant dbSNP:rs1267372612Ensembl. | 1 | |
Natural variantiVAR_054447 | 375 | R → H in ECTD10B; the mutant protein does not interact with EDARADD and is functionally inactive. 1 PublicationCorresponds to variant dbSNP:rs121908454EnsemblClinVar. | 1 | |
Natural variantiVAR_054448 | 377 | L → F in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054449 | 382 | G → S in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs747806672EnsemblClinVar. | 1 | |
Natural variantiVAR_064832 | 396 | Q → QQ in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054450 | 403 | T → M in ECTD10B. 2 Publications | 1 | |
Natural variantiVAR_064833 | 408 | I → F in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054451 | 413 | T → P in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_054452 | 418 | I → T in ECTD10B. 1 Publication | 1 | |
Natural variantiVAR_013450 | 420 | R → Q in ECTD10A and ECTD10B; abolishes NF-kappa-B activation and reduces JNK activation. 6 PublicationsCorresponds to variant dbSNP:rs121908453EnsemblClinVar. | 1 | |
Natural variantiVAR_054453 | 434 | W → C in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs528478080Ensembl. | 1 | |
Natural variantiVAR_064834 | 434 | W → R in ECTD10B. 1 PublicationCorresponds to variant dbSNP:rs773885029Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054187 | 219 | A → GDGPHAPVPCFLDSPSTPPV GEPGCSLPPLSPA in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130988 mRNA Translation: AAD50076.1 AF130996 , AF130990, AF130991, AF130992, AF130993, AF130994, AF130995 Genomic DNA Translation: AAD50077.1 AK296936 mRNA Translation: BAG59487.1 AK313781 mRNA Translation: BAG36519.1 AC073415 Genomic DNA No translation available. AC092160 Genomic DNA No translation available. AC133784 Genomic DNA No translation available. CH471182 Genomic DNA Translation: EAW53869.1 BC093870 mRNA Translation: AAH93870.1 BC093872 mRNA Translation: AAH93872.1 |
CCDSi | CCDS2081.1 [Q9UNE0-1] |
RefSeqi | NP_071731.1, NM_022336.3 [Q9UNE0-1] XP_006712267.1, XM_006712204.1 [Q9UNE0-2] |
Genome annotation databases
Ensembli | ENST00000258443.7; ENSP00000258443.2; ENSG00000135960.10 ENST00000376651.1; ENSP00000365839.1; ENSG00000135960.10 [Q9UNE0-2] ENST00000409271.5; ENSP00000386371.1; ENSG00000135960.10 [Q9UNE0-2] |
GeneIDi | 10913 |
KEGGi | hsa:10913 |
MANE-Selecti | ENST00000258443.7; ENSP00000258443.2; NM_022336.4; NP_071731.1 |
UCSCi | uc002teq.4, human [Q9UNE0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130988 mRNA Translation: AAD50076.1 AF130996 , AF130990, AF130991, AF130992, AF130993, AF130994, AF130995 Genomic DNA Translation: AAD50077.1 AK296936 mRNA Translation: BAG59487.1 AK313781 mRNA Translation: BAG36519.1 AC073415 Genomic DNA No translation available. AC092160 Genomic DNA No translation available. AC133784 Genomic DNA No translation available. CH471182 Genomic DNA Translation: EAW53869.1 BC093870 mRNA Translation: AAH93870.1 BC093872 mRNA Translation: AAH93872.1 |
CCDSi | CCDS2081.1 [Q9UNE0-1] |
RefSeqi | NP_071731.1, NM_022336.3 [Q9UNE0-1] XP_006712267.1, XM_006712204.1 [Q9UNE0-2] |
3D structure databases
AlphaFoldDBi | Q9UNE0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116118, 73 interactors |
IntActi | Q9UNE0, 8 interactors |
STRINGi | 9606.ENSP00000258443 |
Chemistry databases
ChEMBLi | CHEMBL1250376 |
PTM databases
GlyGeni | Q9UNE0, 1 site |
iPTMneti | Q9UNE0 |
PhosphoSitePlusi | Q9UNE0 |
Genetic variation databases
BioMutai | EDAR |
DMDMi | 21263572 |
Proteomic databases
jPOSTi | Q9UNE0 |
MassIVEi | Q9UNE0 |
PaxDbi | Q9UNE0 |
PeptideAtlasi | Q9UNE0 |
PRIDEi | Q9UNE0 |
ProteomicsDBi | 19402 85279 [Q9UNE0-1] |
Protocols and materials databases
ABCDi | Q9UNE0, 14 sequenced antibodies |
Antibodypediai | 33144, 374 antibodies from 33 providers |
DNASUi | 10913 |
Genome annotation databases
Ensembli | ENST00000258443.7; ENSP00000258443.2; ENSG00000135960.10 ENST00000376651.1; ENSP00000365839.1; ENSG00000135960.10 [Q9UNE0-2] ENST00000409271.5; ENSP00000386371.1; ENSG00000135960.10 [Q9UNE0-2] |
GeneIDi | 10913 |
KEGGi | hsa:10913 |
MANE-Selecti | ENST00000258443.7; ENSP00000258443.2; NM_022336.4; NP_071731.1 |
UCSCi | uc002teq.4, human [Q9UNE0-1] |
Organism-specific databases
CTDi | 10913 |
DisGeNETi | 10913 |
GeneCardsi | EDAR |
GeneReviewsi | EDAR |
HGNCi | HGNC:2895, EDAR |
HPAi | ENSG00000135960, Tissue enhanced (esophagus) |
MalaCardsi | EDAR |
MIMi | 129490, phenotype 224900, phenotype 604095, gene 612630, phenotype |
neXtProti | NX_Q9UNE0 |
OpenTargetsi | ENSG00000135960 |
Orphaneti | 1810, Autosomal dominant hypohidrotic ectodermal dysplasia 248, Autosomal recessive hypohidrotic ectodermal dysplasia |
PharmGKBi | PA27602 |
VEuPathDBi | HostDB:ENSG00000135960 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRV5, Eukaryota |
GeneTreei | ENSGT00940000153259 |
HOGENOMi | CLU_039634_0_0_1 |
InParanoidi | Q9UNE0 |
OMAi | CGENEYH |
OrthoDBi | 672843at2759 |
PhylomeDBi | Q9UNE0 |
TreeFami | TF331385 |
Enzyme and pathway databases
PathwayCommonsi | Q9UNE0 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | Q9UNE0 |
SIGNORi | Q9UNE0 |
Miscellaneous databases
BioGRID-ORCSi | 10913, 97 hits in 1071 CRISPR screens |
GeneWikii | EDAR |
GenomeRNAii | 10913 |
Pharosi | Q9UNE0, Tbio |
PROi | PR:Q9UNE0 |
RNActi | Q9UNE0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135960, Expressed in secondary oocyte and 104 other tissues |
Genevisiblei | Q9UNE0, HS |
Family and domain databases
CDDi | cd13421, TNFRSF_EDAR, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR034052, EDAR_N |
SUPFAMi | SSF47986, SSF47986, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EDAR_HUMAN | |
Accessioni | Q9UNE0Primary (citable) accession number: Q9UNE0 Secondary accession number(s): B2R9H2 Q9UND9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot