UniProtKB - Q9UNA1 (RHG26_HUMAN)
Protein
Rho GTPase-activating protein 26
Gene
ARHGAP26
Organism
Homo sapiens (Human)
Status
Functioni
GTPase-activating protein for RHOA and CDC42.
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- phospholipid binding Source: FlyBase
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- nervous system development Source: UniProtKB
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9UNA1 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9UNA1 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 26Alternative name(s): GTPase regulator associated with focal adhesion kinase Oligophrenin-1-like protein Rho-type GTPase-activating protein 26 |
Gene namesi | Name:ARHGAP26 Synonyms:GRAF, KIAA0621, OPHN1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17073, ARHGAP26 |
MIMi | 605370, gene |
neXtProti | NX_Q9UNA1 |
VEuPathDBi | HostDB:ENSG00000145819.15 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- focal adhesion By similarity
Note: Colocalizes with actin stress fibers and cortical actin structures.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Other locations
- focal adhesion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Leukemia, juvenile myelomonocytic (JMML)
The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648).1 Publication
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013623 | 417 | N → S in JMML; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918546EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 23092 |
MalaCardsi | ARHGAP26 |
MIMi | 607785, phenotype |
OpenTargetsi | ENSG00000145819 |
PharmGKBi | PA134946198 |
Miscellaneous databases
Pharosi | Q9UNA1, Tbio |
Genetic variation databases
BioMutai | ARHGAP26 |
DMDMi | 21759332 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056718 | 1 – 814 | Rho GTPase-activating protein 26Add BLAST | 814 |
Proteomic databases
EPDi | Q9UNA1 |
jPOSTi | Q9UNA1 |
MassIVEi | Q9UNA1 |
PaxDbi | Q9UNA1 |
PeptideAtlasi | Q9UNA1 |
PRIDEi | Q9UNA1 |
ProteomicsDBi | 85274 [Q9UNA1-1] 85275 [Q9UNA1-2] |
PTM databases
iPTMneti | Q9UNA1 |
PhosphoSitePlusi | Q9UNA1 |
SwissPalmi | Q9UNA1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145819, Expressed in colon and 219 other tissues |
ExpressionAtlasi | Q9UNA1, baseline and differential |
Genevisiblei | Q9UNA1, HS |
Organism-specific databases
HPAi | ENSG00000145819, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.
By similarityBinary interactionsi
Hide detailsQ9UNA1
With | #Exp. | IntAct |
---|---|---|
CDC42EP2 [O14613] | 3 | EBI-1390913,EBI-3438291 |
PKN3 [Q6P5Z2] | 4 | EBI-1390913,EBI-1384335 |
Isoform 2 [Q9UNA1-2]
With | #Exp. | IntAct |
---|---|---|
CDC42EP2 [O14613] | 3 | EBI-16430964,EBI-3438291 |
Protein-protein interaction databases
BioGRIDi | 116720, 54 interactors |
IntActi | Q9UNA1, 31 interactors |
MINTi | Q9UNA1 |
STRINGi | 9606.ENSP00000274498 |
Miscellaneous databases
RNActi | Q9UNA1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9UNA1 |
SMRi | Q9UNA1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UNA1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 265 – 369 | PHPROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 383 – 568 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 186 | |
Domaini | 756 – 814 | SH3PROSITE-ProRule annotationAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 584 – 701 | Ser-richAdd BLAST | 118 |
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG1451, Eukaryota |
GeneTreei | ENSGT00940000157254 |
HOGENOMi | CLU_011532_2_0_1 |
InParanoidi | Q9UNA1 |
OMAi | MNKMKDM |
OrthoDBi | 693048at2759 |
PhylomeDBi | Q9UNA1 |
TreeFami | TF316851 |
Family and domain databases
CDDi | cd07636, BAR_GRAF, 1 hit cd12064, SH3_GRAF, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR030061, GRAF IPR035483, GRAF_BAR IPR035481, GRAF_SH3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12552:SF4, PTHR12552:SF4, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UNA1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL
60 70 80 90 100
KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF ATVLRNLEDE
110 120 130 140 150
RIRMIENASE VLITPLEKFR KEQIGAAKEA KKKYDKETEK YCGILEKHLN
160 170 180 190 200
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL
210 220 230 240 250
LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM
260 270 280 290 300
KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM
310 320 330 340 350
VPFDQKSGGK GGEDESVILK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ
360 370 380 390 400
ALSEEDRRLW MEAMDGREPV YNSNKDSQSE GTAQLDSIGF SIIRKCIHAV
410 420 430 440 450
ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KTASETETDI CAEWEIKTIT
460 470 480 490 500
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQESRVSEIH SLVHRLPEKN
510 520 530 540 550
RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI
560 570 580 590 600
KFQNIVIEIL IENHEKIFNT VPDMPLTNAQ LHLSRKKSSD SKPPSCSERP
610 620 630 640 650
LTLFHTVQST EKQEQRNSII NSSLESVSSN PNSILNSSSS LQPNMNSSDP
660 670 680 690 700
DLAVVKPTRP NSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPVR
710 720 730 740 750
SVAGFVWFSV AAVVLSLARS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV
760 770 780 790 800
HEDSSTPFRK AKALYACKAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN
810
GKTGLIPENY VEFL
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YGB3 | A0A2R8YGB3_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 686 | Annotation score: | ||
H0Y4P9 | H0Y4P9_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 388 | Annotation score: | ||
H0Y835 | H0Y835_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 294 | Annotation score: | ||
C9J6V4 | C9J6V4_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 91 | Annotation score: | ||
H7BZE1 | H7BZE1_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 154 | Annotation score: | ||
H7C205 | H7C205_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 97 | Annotation score: | ||
H7C3P8 | H7C3P8_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 127 | Annotation score: | ||
H7C1J1 | H7C1J1_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 127 | Annotation score: | ||
A0A2R8YDK5 | A0A2R8YDK5_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 161 | Annotation score: | ||
A0A2R8Y5C0 | A0A2R8Y5C0_HUMAN | Rho GTPase-activating protein 26 | ARHGAP26 | 338 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 355 | E → G in CAA71414 (PubMed:10908648).Curated | 1 | |
Sequence conflicti | 355 | E → G in CAC29145 (Ref. 3) Curated | 1 | |
Sequence conflicti | 355 | E → G in CAC29146 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013623 | 417 | N → S in JMML; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918546EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001659 | 700 – 754 | Missing in isoform 2. 1 PublicationAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF141884 mRNA Translation: AAD39482.1 Y10388 Genomic DNA Translation: CAA71414.2 CH471062 Genomic DNA Translation: EAW61876.1 BC068555 mRNA Translation: AAH68555.1 AJ309466 , AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309486, AJ309487 Genomic DNA Translation: CAC29145.2 AJ309466 , AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309487 Genomic DNA Translation: CAC29146.2 AB014521 mRNA Translation: BAA31596.1 |
CCDSi | CCDS4277.1 [Q9UNA1-1] CCDS47297.1 [Q9UNA1-2] |
PIRi | F59430 |
RefSeqi | NP_001129080.1, NM_001135608.1 [Q9UNA1-2] NP_055886.1, NM_015071.4 [Q9UNA1-1] |
Genome annotation databases
Ensembli | ENST00000274498; ENSP00000274498; ENSG00000145819 [Q9UNA1-1] ENST00000645722; ENSP00000495131; ENSG00000145819 [Q9UNA1-2] |
GeneIDi | 23092 |
KEGGi | hsa:23092 |
UCSCi | uc003lmt.4, human [Q9UNA1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Graf1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF141884 mRNA Translation: AAD39482.1 Y10388 Genomic DNA Translation: CAA71414.2 CH471062 Genomic DNA Translation: EAW61876.1 BC068555 mRNA Translation: AAH68555.1 AJ309466 , AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309486, AJ309487 Genomic DNA Translation: CAC29145.2 AJ309466 , AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309487 Genomic DNA Translation: CAC29146.2 AB014521 mRNA Translation: BAA31596.1 |
CCDSi | CCDS4277.1 [Q9UNA1-1] CCDS47297.1 [Q9UNA1-2] |
PIRi | F59430 |
RefSeqi | NP_001129080.1, NM_001135608.1 [Q9UNA1-2] NP_055886.1, NM_015071.4 [Q9UNA1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UGV | NMR | - | A | 756-814 | [»] | |
BMRBi | Q9UNA1 | |||||
SMRi | Q9UNA1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116720, 54 interactors |
IntActi | Q9UNA1, 31 interactors |
MINTi | Q9UNA1 |
STRINGi | 9606.ENSP00000274498 |
PTM databases
iPTMneti | Q9UNA1 |
PhosphoSitePlusi | Q9UNA1 |
SwissPalmi | Q9UNA1 |
Genetic variation databases
BioMutai | ARHGAP26 |
DMDMi | 21759332 |
Proteomic databases
EPDi | Q9UNA1 |
jPOSTi | Q9UNA1 |
MassIVEi | Q9UNA1 |
PaxDbi | Q9UNA1 |
PeptideAtlasi | Q9UNA1 |
PRIDEi | Q9UNA1 |
ProteomicsDBi | 85274 [Q9UNA1-1] 85275 [Q9UNA1-2] |
Protocols and materials databases
Antibodypediai | 27437, 250 antibodies |
Genome annotation databases
Ensembli | ENST00000274498; ENSP00000274498; ENSG00000145819 [Q9UNA1-1] ENST00000645722; ENSP00000495131; ENSG00000145819 [Q9UNA1-2] |
GeneIDi | 23092 |
KEGGi | hsa:23092 |
UCSCi | uc003lmt.4, human [Q9UNA1-1] |
Organism-specific databases
CTDi | 23092 |
DisGeNETi | 23092 |
GeneCardsi | ARHGAP26 |
HGNCi | HGNC:17073, ARHGAP26 |
HPAi | ENSG00000145819, Low tissue specificity |
MalaCardsi | ARHGAP26 |
MIMi | 605370, gene 607785, phenotype |
neXtProti | NX_Q9UNA1 |
OpenTargetsi | ENSG00000145819 |
PharmGKBi | PA134946198 |
VEuPathDBi | HostDB:ENSG00000145819.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1451, Eukaryota |
GeneTreei | ENSGT00940000157254 |
HOGENOMi | CLU_011532_2_0_1 |
InParanoidi | Q9UNA1 |
OMAi | MNKMKDM |
OrthoDBi | 693048at2759 |
PhylomeDBi | Q9UNA1 |
TreeFami | TF316851 |
Enzyme and pathway databases
PathwayCommonsi | Q9UNA1 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9UNA1 |
Miscellaneous databases
BioGRID-ORCSi | 23092, 6 hits in 987 CRISPR screens |
ChiTaRSi | ARHGAP26, human |
EvolutionaryTracei | Q9UNA1 |
GeneWikii | ARHGAP26 |
GenomeRNAii | 23092 |
Pharosi | Q9UNA1, Tbio |
PROi | PR:Q9UNA1 |
RNActi | Q9UNA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145819, Expressed in colon and 219 other tissues |
ExpressionAtlasi | Q9UNA1, baseline and differential |
Genevisiblei | Q9UNA1, HS |
Family and domain databases
CDDi | cd07636, BAR_GRAF, 1 hit cd12064, SH3_GRAF, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 1.20.1270.60, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR030061, GRAF IPR035483, GRAF_BAR IPR035481, GRAF_SH3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12552:SF4, PTHR12552:SF4, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF48350, SSF48350, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG26_HUMAN | |
Accessioni | Q9UNA1Primary (citable) accession number: Q9UNA1 Secondary accession number(s): O75117 Q9UJ00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references