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Protein

Rho GTPase-activating protein 26

Gene

ARHGAP26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RHOA and CDC42.

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • phospholipid binding Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 26
Alternative name(s):
GTPase regulator associated with focal adhesion kinase
Oligophrenin-1-like protein
Rho-type GTPase-activating protein 26
Gene namesi
Name:ARHGAP26
Synonyms:GRAF, KIAA0621, OPHN1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145819.15
HGNCiHGNC:17073 ARHGAP26
MIMi605370 gene
neXtProtiNX_Q9UNA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Leukemia, juvenile myelomonocytic (JMML)
The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648).1 Publication
Disease descriptionAn aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
See also OMIM:607785
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013623417N → S in JMML; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918546EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi23092
MalaCardsiARHGAP26
MIMi607785 phenotype
OpenTargetsiENSG00000145819
PharmGKBiPA134946198

Polymorphism and mutation databases

BioMutaiARHGAP26
DMDMi21759332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567181 – 814Rho GTPase-activating protein 26Add BLAST814

Proteomic databases

EPDiQ9UNA1
PaxDbiQ9UNA1
PeptideAtlasiQ9UNA1
PRIDEiQ9UNA1
ProteomicsDBi85274
85275 [Q9UNA1-2]

PTM databases

iPTMnetiQ9UNA1
PhosphoSitePlusiQ9UNA1
SwissPalmiQ9UNA1

Expressioni

Gene expression databases

BgeeiENSG00000145819 Expressed in 208 organ(s), highest expression level in blood
CleanExiHS_ARHGAP26
ExpressionAtlasiQ9UNA1 baseline and differential
GenevisibleiQ9UNA1 HS

Organism-specific databases

HPAiHPA035106
HPA035107

Interactioni

Subunit structurei

Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi116720, 22 interactors
IntActiQ9UNA1, 8 interactors
MINTiQ9UNA1
STRINGi9606.ENSP00000274498

Structurei

Secondary structure

1814
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UNA1
SMRiQ9UNA1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNA1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 369PHPROSITE-ProRule annotationAdd BLAST105
Domaini383 – 568Rho-GAPPROSITE-ProRule annotationAdd BLAST186
Domaini756 – 814SH3PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi584 – 701Ser-richAdd BLAST118

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
HOGENOMiHOG000018767
HOVERGENiHBG067993
InParanoidiQ9UNA1
KOiK20071
OMAiDNQSEGT
OrthoDBiEOG091G01TT
PhylomeDBiQ9UNA1
TreeFamiTF316851

Family and domain databases

CDDicd07636 BAR_GRAF, 1 hit
cd12064 SH3_GRAF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR030061 GRAF
IPR035483 GRAF_BAR
IPR035481 GRAF_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12552:SF4 PTHR12552:SF4, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UNA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL
60 70 80 90 100
KNLSSAKRKF ADSLNEFKFQ CIGDAETDDE MCIARSLQEF ATVLRNLEDE
110 120 130 140 150
RIRMIENASE VLITPLEKFR KEQIGAAKEA KKKYDKETEK YCGILEKHLN
160 170 180 190 200
LSSKKKESQL QEADSQVDLV RQHFYEVSLE YVFKVQEVQE RKMFEFVEPL
210 220 230 240 250
LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE GTRSEVESLM
260 270 280 290 300
KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM
310 320 330 340 350
VPFDQKSGGK GGEDESVILK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ
360 370 380 390 400
ALSEEDRRLW MEAMDGREPV YNSNKDSQSE GTAQLDSIGF SIIRKCIHAV
410 420 430 440 450
ETRGINEQGL YRIVGVNSRV QKLLSVLMDP KTASETETDI CAEWEIKTIT
460 470 480 490 500
SALKTYLRML PGPLMMYQFQ RSFIKAAKLE NQESRVSEIH SLVHRLPEKN
510 520 530 540 550
RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ EETVAAIMDI
560 570 580 590 600
KFQNIVIEIL IENHEKIFNT VPDMPLTNAQ LHLSRKKSSD SKPPSCSERP
610 620 630 640 650
LTLFHTVQST EKQEQRNSII NSSLESVSSN PNSILNSSSS LQPNMNSSDP
660 670 680 690 700
DLAVVKPTRP NSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPVR
710 720 730 740 750
SVAGFVWFSV AAVVLSLARS SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV
760 770 780 790 800
HEDSSTPFRK AKALYACKAE HDSELSFTAG TVFDNVHPSQ EPGWLEGTLN
810
GKTGLIPENY VEFL
Length:814
Mass (Da):92,235
Last modified:May 1, 2000 - v1
Checksum:i5C81DBDECB32B18A
GO
Isoform 2 (identifier: Q9UNA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     700-754: Missing.

Show »
Length:759
Mass (Da):86,165
Checksum:i8FA48FDF1DCAFB7F
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YGB3A0A2R8YGB3_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
686Annotation score:
H0Y835H0Y835_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
294Annotation score:
H0Y4P9H0Y4P9_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
388Annotation score:
A0A2R8Y5C0A0A2R8Y5C0_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
338Annotation score:
H7BZZ0H7BZZ0_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
97Annotation score:
A0A2R8YDK5A0A2R8YDK5_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
161Annotation score:
C9J6V4C9J6V4_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
91Annotation score:
H7C3P8H7C3P8_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
127Annotation score:
H7C1J1H7C1J1_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
127Annotation score:
H7C205H7C205_HUMAN
Rho GTPase-activating protein 26
ARHGAP26
97Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355E → G in CAA71414 (PubMed:10908648).Curated1
Sequence conflicti355E → G in CAC29145 (Ref. 3) Curated1
Sequence conflicti355E → G in CAC29146 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013623417N → S in JMML; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918546EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001659700 – 754Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141884 mRNA Translation: AAD39482.1
Y10388 Genomic DNA Translation: CAA71414.2
CH471062 Genomic DNA Translation: EAW61876.1
BC068555 mRNA Translation: AAH68555.1
AJ309466
, AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309486, AJ309487 Genomic DNA Translation: CAC29145.2
AJ309466
, AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309487 Genomic DNA Translation: CAC29146.2
AB014521 mRNA Translation: BAA31596.1
CCDSiCCDS4277.1 [Q9UNA1-1]
CCDS47297.1 [Q9UNA1-2]
PIRiF59430
RefSeqiNP_001129080.1, NM_001135608.1 [Q9UNA1-2]
NP_055886.1, NM_015071.4 [Q9UNA1-1]
UniGeneiHs.654668

Genome annotation databases

EnsembliENST00000274498; ENSP00000274498; ENSG00000145819 [Q9UNA1-1]
ENST00000378004; ENSP00000367243; ENSG00000145819 [Q9UNA1-1]
ENST00000645722; ENSP00000495131; ENSG00000145819 [Q9UNA1-2]
GeneIDi23092
KEGGihsa:23092
UCSCiuc003lmt.4 human [Q9UNA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Graf1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141884 mRNA Translation: AAD39482.1
Y10388 Genomic DNA Translation: CAA71414.2
CH471062 Genomic DNA Translation: EAW61876.1
BC068555 mRNA Translation: AAH68555.1
AJ309466
, AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309486, AJ309487 Genomic DNA Translation: CAC29145.2
AJ309466
, AJ309467, AJ309468, AJ309469, AJ309470, AJ309471, AJ309472, AJ309473, AJ309474, AJ309475, AJ309476, AJ309477, AJ309478, AJ309479, AJ309480, AJ309481, AJ309482, AJ309483, AJ309484, AJ309485, AJ309487 Genomic DNA Translation: CAC29146.2
AB014521 mRNA Translation: BAA31596.1
CCDSiCCDS4277.1 [Q9UNA1-1]
CCDS47297.1 [Q9UNA1-2]
PIRiF59430
RefSeqiNP_001129080.1, NM_001135608.1 [Q9UNA1-2]
NP_055886.1, NM_015071.4 [Q9UNA1-1]
UniGeneiHs.654668

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UGVNMR-A756-814[»]
ProteinModelPortaliQ9UNA1
SMRiQ9UNA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116720, 22 interactors
IntActiQ9UNA1, 8 interactors
MINTiQ9UNA1
STRINGi9606.ENSP00000274498

PTM databases

iPTMnetiQ9UNA1
PhosphoSitePlusiQ9UNA1
SwissPalmiQ9UNA1

Polymorphism and mutation databases

BioMutaiARHGAP26
DMDMi21759332

Proteomic databases

EPDiQ9UNA1
PaxDbiQ9UNA1
PeptideAtlasiQ9UNA1
PRIDEiQ9UNA1
ProteomicsDBi85274
85275 [Q9UNA1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274498; ENSP00000274498; ENSG00000145819 [Q9UNA1-1]
ENST00000378004; ENSP00000367243; ENSG00000145819 [Q9UNA1-1]
ENST00000645722; ENSP00000495131; ENSG00000145819 [Q9UNA1-2]
GeneIDi23092
KEGGihsa:23092
UCSCiuc003lmt.4 human [Q9UNA1-1]

Organism-specific databases

CTDi23092
DisGeNETi23092
EuPathDBiHostDB:ENSG00000145819.15
GeneCardsiARHGAP26
H-InvDBiHIX0005269
HGNCiHGNC:17073 ARHGAP26
HPAiHPA035106
HPA035107
MalaCardsiARHGAP26
MIMi605370 gene
607785 phenotype
neXtProtiNX_Q9UNA1
OpenTargetsiENSG00000145819
PharmGKBiPA134946198
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1451 Eukaryota
ENOG410YJPS LUCA
GeneTreeiENSGT00930000150818
HOGENOMiHOG000018767
HOVERGENiHBG067993
InParanoidiQ9UNA1
KOiK20071
OMAiDNQSEGT
OrthoDBiEOG091G01TT
PhylomeDBiQ9UNA1
TreeFamiTF316851

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiARHGAP26 human
EvolutionaryTraceiQ9UNA1
GeneWikiiARHGAP26
GenomeRNAii23092
PROiPR:Q9UNA1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145819 Expressed in 208 organ(s), highest expression level in blood
CleanExiHS_ARHGAP26
ExpressionAtlasiQ9UNA1 baseline and differential
GenevisibleiQ9UNA1 HS

Family and domain databases

CDDicd07636 BAR_GRAF, 1 hit
cd12064 SH3_GRAF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR030061 GRAF
IPR035483 GRAF_BAR
IPR035481 GRAF_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12552:SF4 PTHR12552:SF4, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG26_HUMAN
AccessioniPrimary (citable) accession number: Q9UNA1
Secondary accession number(s): O75117
, Q5D035, Q9BYS6, Q9BYS7, Q9UJ00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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