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Entry version 191 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Ras GTPase-activating protein-binding protein 2

Gene

G3BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Immunity, Innate immunity, mRNA transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras GTPase-activating protein-binding protein 2
Short name:
G3BP-2
Alternative name(s):
GAP SH3 domain-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:G3BP2
Synonyms:KIAA0660
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30291 G3BP2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UN86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9908

Open Targets

More...
OpenTargetsi
ENSG00000138757

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UN86

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
G3BP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242482

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001948002 – 482Ras GTPase-activating protein-binding protein 2Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei227PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392N6-succinyllysineBy similarity1
Modified residuei457Omega-N-methylarginineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei468Omega-N-methylarginineCombined sources1
Isoform B (identifier: Q9UN86-2)
Modified residuei227PhosphothreonineCombined sources1
Modified residuei235PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
(Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UN86

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UN86

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UN86

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UN86

PeptideAtlas

More...
PeptideAtlasi
Q9UN86

PRoteomics IDEntifications database

More...
PRIDEi
Q9UN86

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85270 [Q9UN86-1]
85271 [Q9UN86-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UN86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UN86

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UN86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138757 Expressed in 240 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UN86 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UN86 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018304
HPA018425

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers (PubMed:23279204). Forms heterodimers with G3BP1 (PubMed:23279204).

Interacts with NFKBIA (via N-terminus) (PubMed:10969074).

Interacts with USP10 (PubMed:23279204).

Interacts with PABPC1 (PubMed:23279204).

2 Publications

(Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115237, 141 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UN86

Database of interacting proteins

More...
DIPi
DIP-50299N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9UN86

Protein interaction database and analysis system

More...
IntActi
Q9UN86, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9UN86

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UN86

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 133NTF2PROSITE-ProRule annotationAdd BLAST123
Domaini331 – 409RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 223Glu-richAdd BLAST90
Compositional biasi419 – 479Gly-richAdd BLAST61

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0116 Eukaryota
ENOG410YV57 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220838

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UN86

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKDEVGW

Database of Orthologous Groups

More...
OrthoDBi
1526879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UN86

TreeFam database of animal gene trees

More...
TreeFami
TF325464

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00780 NTF2, 1 hit
cd12464 RRM_G3BP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034377 G3BP2
IPR034376 G3BP2_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR039539 Ras_GTPase_bind_prot
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10693 PTHR10693, 1 hit
PTHR10693:SF10 PTHR10693:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9UN86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK
60 70 80 90 100
PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN
110 120 130 140 150
SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE
160 170 180 190 200
DEVEEEQEER QPSPEPVQEN ANSGYYEAHP VTNGIEEPLE ESSHEPEPEP
210 220 230 240 250
ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP PKAFSWASVT
260 270 280 290 300
SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP
310 320 330 340 350
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF
360 370 380 390 400
FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV
410 420 430 440 450
RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD
460 470 480
GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ RR
Length:482
Mass (Da):54,121
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74B8EA43C0560229
GO
Isoform B (identifier: Q9UN86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-275: Missing.

Show »
Length:449
Mass (Da):50,817
Checksum:i1B0F021C138992E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RB17D6RB17_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAC7D6RAC7_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBR0D6RBR0_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGJ4D6RGJ4_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBW8D6RBW8_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE13D6RE13_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REX8D6REX8_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9A4D6R9A4_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9X5D6R9X5_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBM9D6RBM9_HUMAN
Ras GTPase-activating protein-bindi...
G3BP2
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti267P → S in AAD51932 (Ref. 1) Curated1
Sequence conflicti359E → V in AAC15705 (Ref. 3) Curated1
Sequence conflicti460M → I in AAC15705 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036128434P → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003605243 – 275Missing in isoform B. 4 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF145284 mRNA Translation: AAD51932.1
AB014560 mRNA Translation: BAA31635.2 Different initiation.
AF051311 mRNA Translation: AAC15705.1
AF053535 mRNA Translation: AAC95292.1
AK291786 mRNA Translation: BAF84475.1
CH471057 Genomic DNA Translation: EAX05742.1
BC011731 mRNA Translation: AAH11731.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3571.1 [Q9UN86-1]
CCDS3572.1 [Q9UN86-2]

NCBI Reference Sequences

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RefSeqi
NP_036429.2, NM_012297.4 [Q9UN86-1]
NP_987100.1, NM_203504.2 [Q9UN86-2]
NP_987101.1, NM_203505.2 [Q9UN86-1]
XP_005263439.1, XM_005263382.2 [Q9UN86-1]
XP_005263440.1, XM_005263383.3 [Q9UN86-1]
XP_011530743.1, XM_011532441.2 [Q9UN86-1]
XP_016864365.1, XM_017008876.1 [Q9UN86-1]
XP_016864366.1, XM_017008877.1
XP_016864367.1, XM_017008878.1 [Q9UN86-2]
XP_016864368.1, XM_017008879.1 [Q9UN86-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357854; ENSP00000350518; ENSG00000138757 [Q9UN86-2]
ENST00000359707; ENSP00000352738; ENSG00000138757 [Q9UN86-1]
ENST00000395719; ENSP00000379069; ENSG00000138757 [Q9UN86-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9908

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9908

UCSC genome browser

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UCSCi
uc003hir.4 human [Q9UN86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145284 mRNA Translation: AAD51932.1
AB014560 mRNA Translation: BAA31635.2 Different initiation.
AF051311 mRNA Translation: AAC15705.1
AF053535 mRNA Translation: AAC95292.1
AK291786 mRNA Translation: BAF84475.1
CH471057 Genomic DNA Translation: EAX05742.1
BC011731 mRNA Translation: AAH11731.1
CCDSiCCDS3571.1 [Q9UN86-1]
CCDS3572.1 [Q9UN86-2]
RefSeqiNP_036429.2, NM_012297.4 [Q9UN86-1]
NP_987100.1, NM_203504.2 [Q9UN86-2]
NP_987101.1, NM_203505.2 [Q9UN86-1]
XP_005263439.1, XM_005263382.2 [Q9UN86-1]
XP_005263440.1, XM_005263383.3 [Q9UN86-1]
XP_011530743.1, XM_011532441.2 [Q9UN86-1]
XP_016864365.1, XM_017008876.1 [Q9UN86-1]
XP_016864366.1, XM_017008877.1
XP_016864367.1, XM_017008878.1 [Q9UN86-2]
XP_016864368.1, XM_017008879.1 [Q9UN86-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DRVX-ray2.75A1-139[»]
SMRiQ9UN86
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115237, 141 interactors
CORUMiQ9UN86
DIPiDIP-50299N
ELMiQ9UN86
IntActiQ9UN86, 50 interactors
MINTiQ9UN86
STRINGi9606.ENSP00000352738

PTM databases

iPTMnetiQ9UN86
PhosphoSitePlusiQ9UN86
SwissPalmiQ9UN86

Polymorphism and mutation databases

BioMutaiG3BP2
DMDMi116242482

Proteomic databases

EPDiQ9UN86
jPOSTiQ9UN86
MassIVEiQ9UN86
PaxDbiQ9UN86
PeptideAtlasiQ9UN86
PRIDEiQ9UN86
ProteomicsDBi85270 [Q9UN86-1]
85271 [Q9UN86-2]

Genome annotation databases

EnsembliENST00000357854; ENSP00000350518; ENSG00000138757 [Q9UN86-2]
ENST00000359707; ENSP00000352738; ENSG00000138757 [Q9UN86-1]
ENST00000395719; ENSP00000379069; ENSG00000138757 [Q9UN86-1]
GeneIDi9908
KEGGihsa:9908
UCSCiuc003hir.4 human [Q9UN86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9908
DisGeNETi9908

GeneCards: human genes, protein and diseases

More...
GeneCardsi
G3BP2
HGNCiHGNC:30291 G3BP2
HPAiHPA018304
HPA018425
neXtProtiNX_Q9UN86
OpenTargetsiENSG00000138757
PharmGKBiPA162389134

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0116 Eukaryota
ENOG410YV57 LUCA
GeneTreeiENSGT00390000011365
HOGENOMiHOG000220838
InParanoidiQ9UN86
OMAiPKDEVGW
OrthoDBi1526879at2759
PhylomeDBiQ9UN86
TreeFamiTF325464

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
G3BP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
G3BP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9908
PharosiQ9UN86

Protein Ontology

More...
PROi
PR:Q9UN86

Gene expression databases

BgeeiENSG00000138757 Expressed in 240 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9UN86 baseline and differential
GenevisibleiQ9UN86 HS

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd12464 RRM_G3BP2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034377 G3BP2
IPR034376 G3BP2_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR039539 Ras_GTPase_bind_prot
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10693 PTHR10693, 1 hit
PTHR10693:SF10 PTHR10693:SF10, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3BP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UN86
Secondary accession number(s): A8K6X1
, O60606, O75149, Q9UPA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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