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Protein

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Gene

SLC6A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.1 Publication

Miscellaneous

Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: Reactome
  • cellular amino acid metabolic process Source: ProtInc
  • response to toxic substance Source: UniProtKB

Keywordsi

Biological processAmino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619094 Variant SLC6A14 may confer susceptibility towards obesity

Protein family/group databases

TCDBi2.A.22.2.3 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Alternative name(s):
Amino acid transporter ATB0+
Solute carrier family 6 member 14
Gene namesi
Name:SLC6A14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000268104.2
HGNCiHGNC:11047 SLC6A14
MIMi300444 gene
neXtProtiNX_Q9UN76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 234ExtracellularSequence analysisAdd BLAST104
Transmembranei235 – 255Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei261 – 281Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei315 – 335Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei348 – 368Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei399 – 419Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei450 – 477Helical; Name=9Sequence analysisAdd BLAST28
Transmembranei480 – 500Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei528 – 548Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei563 – 583Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini584 – 642CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.2 Publications

Keywords - Diseasei

Obesity

Organism-specific databases

DisGeNETi11254
MalaCardsiSLC6A14
OpenTargetsiENSG00000268104
PharmGKBiPA35910

Chemistry databases

DrugBankiDB03929 D-Serine
DB00172 L-Proline
DB00577 Valaciclovir
DB01610 Valganciclovir
GuidetoPHARMACOLOGYi937

Polymorphism and mutation databases

DMDMi41018156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147951 – 642Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UN76
PaxDbiQ9UN76
PeptideAtlasiQ9UN76
PRIDEiQ9UN76
ProteomicsDBi85268

PTM databases

iPTMnetiQ9UN76
PhosphoSitePlusiQ9UN76

Expressioni

Tissue specificityi

Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000268104
CleanExiHS_SLC6A14
GenevisibleiQ9UN76 HS

Organism-specific databases

HPAiHPA003193

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360967

Structurei

3D structure databases

ProteinModelPortaliQ9UN76
SMRiQ9UN76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ9UN76
KOiK05038
OMAiSFFKCRG
OrthoDBiEOG091G08PX
PhylomeDBiQ9UN76
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UN76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI
60 70 80 90 100
GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA
110 120 130 140 150
SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE
160 170 180 190 200
LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC
210 220 230 240 250
INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV
260 270 280 290 300
GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ
310 320 330 340 350
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV
360 370 380 390 400
CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA
410 420 430 440 450
QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI
460 470 480 490 500
TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI
510 520 530 540 550
YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR
560 570 580 590 600
PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC
610 620 630 640
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE
Length:642
Mass (Da):72,153
Last modified:May 1, 2000 - v1
Checksum:iE0FCDD5F173128C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151978 mRNA Translation: AAD49223.1
Z96810, AL034411 Genomic DNA Translation: CAI42799.1
AL034411, Z96810 Genomic DNA Translation: CAI43081.1
BC093710 mRNA Translation: AAH93710.1
BC093712 mRNA Translation: AAH93712.1
CCDSiCCDS14570.1
RefSeqiNP_009162.1, NM_007231.4
UniGeneiHs.522109

Genome annotation databases

EnsembliENST00000598581; ENSP00000470801; ENSG00000268104
GeneIDi11254
KEGGihsa:11254
UCSCiuc033eru.2 human

Similar proteinsi

Entry informationi

Entry nameiS6A14_HUMAN
AccessioniPrimary (citable) accession number: Q9UN76
Secondary accession number(s): Q5H942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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