SLC6A14

Functionⁱ

Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na⁺/Cl^--dependent manner.1 Publication

Miscellaneous

Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).

GO - Molecular functionⁱ

amino acid transmembrane transporter activity Source: Reactome
neurotransmitter:sodium symporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amino acid transport Source: Reactome
cellular amino acid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10446133
response to toxic substance
Source: UniProtKB
Inferred from direct assayⁱ
- 17575980

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Symport, Transport

Biological process

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619094 Variant SLC6A14 may confer susceptibility towards obesity

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619094 Variant SLC6A14 may confer susceptibility towards obesity

Protein family/group databases

TCDBⁱ	2.A.22.2.3 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.2.3 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) Alternative name(s): Amino acid transporter ATB0+ Solute carrier family 6 member 14
Gene namesⁱ	Name:SLC6A14
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000268104.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11047 SLC6A14
MIMⁱ	300444 gene
neXtProtⁱ	NX_Q9UN76

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 44	CytoplasmicSequence analysisAdd BLAST	44
Transmembraneⁱ	45 – 65	Helical; Name=1Sequence analysisAdd BLAST	21
Transmembraneⁱ	72 – 92	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	110 – 130	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	131 – 234	ExtracellularSequence analysisAdd BLAST	104
Transmembraneⁱ	235 – 255	Helical; Name=4Sequence analysisAdd BLAST	21
Transmembraneⁱ	261 – 281	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	315 – 335	Helical; Name=6Sequence analysisAdd BLAST	21
Transmembraneⁱ	348 – 368	Helical; Name=7Sequence analysisAdd BLAST	21
Transmembraneⁱ	399 – 419	Helical; Name=8Sequence analysisAdd BLAST	21
Transmembraneⁱ	450 – 477	Helical; Name=9Sequence analysisAdd BLAST	28
Transmembraneⁱ	480 – 500	Helical; Name=10Sequence analysisAdd BLAST	21
Transmembraneⁱ	528 – 548	Helical; Name=11Sequence analysisAdd BLAST	21
Transmembraneⁱ	563 – 583	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	584 – 642	CytoplasmicSequence analysisAdd BLAST	59

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.2 Publications

Keywords - Diseaseⁱ

Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11254
MalaCards human disease database More...MalaCardsⁱ	SLC6A14
Open Targets More...OpenTargetsⁱ	ENSG00000268104
PharmGKBⁱ	PA35910

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03929 D-Serine DB00172 L-Proline DB00577 Valaciclovir DB01610 Valganciclovir
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	937

Polymorphism and mutation databases

DMDMⁱ	41018156

DMDMⁱ

41018156

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214795	1 – 642	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Add BLAST		642

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	155	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	174	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	189	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	202	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	230	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	302	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q9UN76
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UN76
PaxDbⁱ	Q9UN76
PeptideAtlas More...PeptideAtlasⁱ	Q9UN76
PRIDEⁱ	Q9UN76
ProteomicsDBⁱ	85268

PTM databases

GlyConnectⁱ	1751
iPTMnetⁱ	Q9UN76
PhosphoSitePlusⁱ	Q9UN76

Expressionⁱ

Tissue specificityⁱ

Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000268104 Expressed in 96 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_SLC6A14
Genevisibleⁱ	Q9UN76 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003193

HPAⁱ

HPA003193

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000360967

STRINGⁱ

9606.ENSP00000360967

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UN76
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9UN76
KEGG Orthology (KO) More...KOⁱ	K05038
OMAⁱ	SFFKCRG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9UN76
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UN76-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI 
        60         70         80         90        100
GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA 
       110        120        130        140        150
SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE 
       160        170        180        190        200
LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC 
       210        220        230        240        250
INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV 
       260        270        280        290        300
GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 
       310        320        330        340        350
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV 
       360        370        380        390        400
CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA 
       410        420        430        440        450
QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI 
       460        470        480        490        500
TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI 
       510        520        530        540        550
YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR 
       560        570        580        590        600
PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 
       610        620        630        640 
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE

Length:642

Mass (Da):72,153

Last modified:May 1, 2000 - v1

Checksum:ⁱE0FCDD5F173128C0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151978 mRNA Translation: AAD49223.1 Z96810, AL034411 Genomic DNA Translation: CAI42799.1 AL034411, Z96810 Genomic DNA Translation: CAI43081.1 BC093710 mRNA Translation: AAH93710.1 BC093712 mRNA Translation: AAH93712.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14570.1
NCBI Reference Sequences More...RefSeqⁱ	NP_009162.1, NM_007231.4
UniGeneⁱ	Hs.522109

Genome annotation databases

Ensemblⁱ	ENST00000598581; ENSP00000470801; ENSG00000268104
GeneIDⁱ	11254
KEGGⁱ	hsa:11254
UCSC genome browser More...UCSCⁱ	uc033eru.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UN76	Transporter		PIG		676	UniRef90_Q9UN76
Transporter		DESRO		645
Transporter		HUMAN		642
Transporter		PANTR		642
Transporter		CALJA		642
+57

Protein	Similar proteins		Species	Score	Length	Source
Q9UN76	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)		MOUSE		638	UniRef50_Q9UN76
Transporter		PIG		676
Transporter		DESRO		645
Transporter		RHIRO		642
Transporter		NOMLE		642
+323

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151978 mRNA Translation: AAD49223.1 Z96810, AL034411 Genomic DNA Translation: CAI42799.1 AL034411, Z96810 Genomic DNA Translation: CAI43081.1 BC093710 mRNA Translation: AAH93710.1 BC093712 mRNA Translation: AAH93712.1
CCDSⁱ	CCDS14570.1
RefSeqⁱ	NP_009162.1, NM_007231.4
UniGeneⁱ	Hs.522109

3D structure databases

ProteinModelPortalⁱ	Q9UN76
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000360967

STRINGⁱ

9606.ENSP00000360967

Chemistry databases

DrugBankⁱ	DB03929 D-Serine DB00172 L-Proline DB00577 Valaciclovir DB01610 Valganciclovir
GuidetoPHARMACOLOGYⁱ	937

Protein family/group databases

TCDBⁱ	2.A.22.2.3 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.2.3 the neurotransmitter:sodium symporter (nss) family

PTM databases

GlyConnectⁱ	1751
iPTMnetⁱ	Q9UN76
PhosphoSitePlusⁱ	Q9UN76

Polymorphism and mutation databases

DMDMⁱ	41018156

DMDMⁱ

41018156

Proteomic databases

EPDⁱ	Q9UN76
MaxQBⁱ	Q9UN76
PaxDbⁱ	Q9UN76
PeptideAtlasⁱ	Q9UN76
PRIDEⁱ	Q9UN76
ProteomicsDBⁱ	85268

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000598581; ENSP00000470801; ENSG00000268104
GeneIDⁱ	11254
KEGGⁱ	hsa:11254
UCSCⁱ	uc033eru.2 human

Organism-specific databases

CTDⁱ	11254
DisGeNETⁱ	11254
EuPathDBⁱ	HostDB:ENSG00000268104.2
GeneCardsⁱ	SLC6A14
HGNCⁱ	HGNC:11047 SLC6A14
HPAⁱ	HPA003193
MalaCardsⁱ	SLC6A14
MIMⁱ	300444 gene
neXtProtⁱ	NX_Q9UN76
OpenTargetsⁱ	ENSG00000268104
PharmGKBⁱ	PA35910
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	Q9UN76
KOⁱ	K05038
OMAⁱ	SFFKCRG
OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	Q9UN76
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619094 Variant SLC6A14 may confer susceptibility towards obesity

Reactomeⁱ

R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619094 Variant SLC6A14 may confer susceptibility towards obesity

Miscellaneous databases

ChiTaRSⁱ	SLC6A14 human
GeneWikiⁱ	SLC6A14
GenomeRNAiⁱ	11254
Protein Ontology More...PROⁱ	PR:Q9UN76
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000268104 Expressed in 96 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_SLC6A14
Genevisibleⁱ	Q9UN76 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S6A14_HUMAN
Accessionⁱ	Q9UN76Primary (citable) accession number: Q9UN76 Secondary accession number(s): Q5H942
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

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UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - Q9UN76 (S6A14_HUMAN)

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Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ