We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q9UN76 (S6A14_HUMAN)
Protein
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Gene
SLC6A14
Organism
Homo sapiens (Human)
Status
Functioni
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na+/Cl--dependent manner.
1 PublicationMiscellaneous
Transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid).
GO - Molecular functioni
- alanine transmembrane transporter activity Source: ARUK-UCL
- amino acid transmembrane transporter activity Source: Reactome
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- alanine transport Source: ARUK-UCL
- amino acid import across plasma membrane Source: ARUK-UCL
- amino acid transmembrane transport Source: GO_Central
- amino acid transport Source: Reactome
- response to toxic substance Source: UniProtKB
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9UN76 |
Reactomei | R-HSA-352230, Amino acid transport across the plasma membrane R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619094, Variant SLC6A14 may confer susceptibility towards obesity |
Protein family/group databases
TCDBi | 2.A.22.2.3, the neurotransmitter:sodium symporter (nss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Alternative name(s): Amino acid transporter ATB0+ Solute carrier family 6 member 14 |
Gene namesi | Name:SLC6A14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11047, SLC6A14 |
MIMi | 300444, gene |
neXtProti | NX_Q9UN76 |
VEuPathDBi | HostDB:ENSG00000268104 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: ProtInc
- vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | CytoplasmicSequence analysisAdd BLAST | 44 | |
Transmembranei | 45 – 65 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 92 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 234 | ExtracellularSequence analysisAdd BLAST | 104 | |
Transmembranei | 235 – 255 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 261 – 281 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 315 – 335 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 348 – 368 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Transmembranei | 399 – 419 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Transmembranei | 450 – 477 | Helical; Name=9Sequence analysisAdd BLAST | 28 | |
Transmembranei | 480 – 500 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Transmembranei | 528 – 548 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Transmembranei | 563 – 583 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 584 – 642 | CytoplasmicSequence analysisAdd BLAST | 59 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Genetic variations in SLC6A14 may be associated with obesity in some populations, as shown by significant differences in allele frequencies between obese and non-obese individuals.2 Publications
Keywords - Diseasei
ObesityOrganism-specific databases
DisGeNETi | 11254 |
MalaCardsi | SLC6A14 |
OpenTargetsi | ENSG00000268104 |
Orphaneti | 586, Cystic fibrosis |
PharmGKBi | PA35910 |
Miscellaneous databases
Pharosi | Q9UN76, Tchem |
Chemistry databases
DrugBanki | DB03929, D-Serine DB00130, L-Glutamine DB00172, Proline DB00577, Valaciclovir DB01610, Valganciclovir |
GuidetoPHARMACOLOGYi | 937 |
Genetic variation databases
BioMutai | SLC6A14 |
DMDMi | 41018156 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214795 | 1 – 642 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Add BLAST | 642 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 230 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 302 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9UN76 |
jPOSTi | Q9UN76 |
MassIVEi | Q9UN76 |
MaxQBi | Q9UN76 |
PaxDbi | Q9UN76 |
PeptideAtlasi | Q9UN76 |
PRIDEi | Q9UN76 |
ProteomicsDBi | 85268 |
PTM databases
GlyConnecti | 1751, 3 N-Linked glycans (3 sites) |
GlyGeni | Q9UN76, 8 sites, 3 N-linked glycans (3 sites) |
iPTMneti | Q9UN76 |
PhosphoSitePlusi | Q9UN76 |
Expressioni
Tissue specificityi
Levels are highest in adult and fetal lung, in trachea and salivary gland. Lower levels detected in mammary gland, stomach and pituitary gland, and very low levels in colon, uterus, prostate and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000268104, Expressed in palpebral conjunctiva and 105 other tissues |
Genevisiblei | Q9UN76, HS |
Organism-specific databases
HPAi | ENSG00000268104, Tissue enhanced (lung, salivary gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116415, 2 interactors |
STRINGi | 9606.ENSP00000470801 |
Miscellaneous databases
RNActi | Q9UN76, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 622 – 642 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A14 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000154963 |
HOGENOMi | CLU_006855_4_1_1 |
InParanoidi | Q9UN76 |
OMAi | AQHNGVQ |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q9UN76 |
TreeFami | TF343812 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UN76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI
60 70 80 90 100
GYAVGLGNVW RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA
110 120 130 140 150
SLGPVSVWRI LPLFQGVGIT MVLISIFVTI YYNVIIAYSL YYMFASFQSE
160 170 180 190 200
LPWKNCSSWS DKNCSRSPIV THCNVSTVNK GIQEIIQMNK SWVDINNFTC
210 220 230 240 250
INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA LCLLLAWLIV
260 270 280 290 300
GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ
310 320 330 340 350
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV
360 370 380 390 400
CLTNCLTSVF AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA
410 420 430 440 450
QLPGGPFWSI LFFFMLLTLG LDSQFASIET ITTTIQDLFP KVMKKMRVPI
460 470 480 490 500
TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF CAGWGILIAA ILELVGIIWI
510 520 530 540 550
YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI FIWSLVQFHR
560 570 580 590 600
PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC
610 620 630 640
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151978 mRNA Translation: AAD49223.1 Z96810, AL034411 Genomic DNA Translation: CAI42799.1 AL034411, Z96810 Genomic DNA Translation: CAI43081.1 BC093710 mRNA Translation: AAH93710.1 BC093712 mRNA Translation: AAH93712.1 |
CCDSi | CCDS14570.1 |
RefSeqi | NP_009162.1, NM_007231.4 |
Genome annotation databases
Ensembli | ENST00000598581.3; ENSP00000470801.1; ENSG00000268104.3 |
GeneIDi | 11254 |
KEGGi | hsa:11254 |
MANE-Selecti | ENST00000598581.3; ENSP00000470801.1; NM_007231.5; NP_009162.1 |
UCSCi | uc033eru.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151978 mRNA Translation: AAD49223.1 Z96810, AL034411 Genomic DNA Translation: CAI42799.1 AL034411, Z96810 Genomic DNA Translation: CAI43081.1 BC093710 mRNA Translation: AAH93710.1 BC093712 mRNA Translation: AAH93712.1 |
CCDSi | CCDS14570.1 |
RefSeqi | NP_009162.1, NM_007231.4 |
3D structure databases
AlphaFoldDBi | Q9UN76 |
SMRi | Q9UN76 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116415, 2 interactors |
STRINGi | 9606.ENSP00000470801 |
Chemistry databases
DrugBanki | DB03929, D-Serine DB00130, L-Glutamine DB00172, Proline DB00577, Valaciclovir DB01610, Valganciclovir |
GuidetoPHARMACOLOGYi | 937 |
Protein family/group databases
TCDBi | 2.A.22.2.3, the neurotransmitter:sodium symporter (nss) family |
PTM databases
GlyConnecti | 1751, 3 N-Linked glycans (3 sites) |
GlyGeni | Q9UN76, 8 sites, 3 N-linked glycans (3 sites) |
iPTMneti | Q9UN76 |
PhosphoSitePlusi | Q9UN76 |
Genetic variation databases
BioMutai | SLC6A14 |
DMDMi | 41018156 |
Proteomic databases
EPDi | Q9UN76 |
jPOSTi | Q9UN76 |
MassIVEi | Q9UN76 |
MaxQBi | Q9UN76 |
PaxDbi | Q9UN76 |
PeptideAtlasi | Q9UN76 |
PRIDEi | Q9UN76 |
ProteomicsDBi | 85268 |
Protocols and materials databases
Antibodypediai | 73032, 121 antibodies from 22 providers |
DNASUi | 11254 |
Genome annotation databases
Ensembli | ENST00000598581.3; ENSP00000470801.1; ENSG00000268104.3 |
GeneIDi | 11254 |
KEGGi | hsa:11254 |
MANE-Selecti | ENST00000598581.3; ENSP00000470801.1; NM_007231.5; NP_009162.1 |
UCSCi | uc033eru.2, human |
Organism-specific databases
CTDi | 11254 |
DisGeNETi | 11254 |
GeneCardsi | SLC6A14 |
HGNCi | HGNC:11047, SLC6A14 |
HPAi | ENSG00000268104, Tissue enhanced (lung, salivary gland) |
MalaCardsi | SLC6A14 |
MIMi | 300444, gene |
neXtProti | NX_Q9UN76 |
OpenTargetsi | ENSG00000268104 |
Orphaneti | 586, Cystic fibrosis |
PharmGKBi | PA35910 |
VEuPathDBi | HostDB:ENSG00000268104 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000154963 |
HOGENOMi | CLU_006855_4_1_1 |
InParanoidi | Q9UN76 |
OMAi | AQHNGVQ |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q9UN76 |
TreeFami | TF343812 |
Enzyme and pathway databases
PathwayCommonsi | Q9UN76 |
Reactomei | R-HSA-352230, Amino acid transport across the plasma membrane R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619094, Variant SLC6A14 may confer susceptibility towards obesity |
Miscellaneous databases
BioGRID-ORCSi | 11254, 17 hits in 695 CRISPR screens |
ChiTaRSi | SLC6A14, human |
GeneWikii | SLC6A14 |
GenomeRNAii | 11254 |
Pharosi | Q9UN76, Tchem |
PROi | PR:Q9UN76 |
RNActi | Q9UN76, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000268104, Expressed in palpebral conjunctiva and 105 other tissues |
Genevisiblei | Q9UN76, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S6A14_HUMAN | |
Accessioni | Q9UN76Primary (citable) accession number: Q9UN76 Secondary accession number(s): Q5H942 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families