UniProtKB - Q9UN70 (PCDGK_HUMAN)
Protein
Protocadherin gamma-C3
Gene
PCDHGC3
Organism
Homo sapiens (Human)
Status
Functioni
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- synapse organization Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | Q9UN70 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin gamma-C3Short name: PCDH-gamma-C3 Alternative name(s): Protocadherin-2 Protocadherin-43 Short name: PC-43 |
Gene namesi | Name:PCDHGC3 Synonyms:PCDH2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000240184.6 |
HGNCi | HGNC:8716, PCDHGC3 |
MIMi | 603627, gene 604968, gene |
neXtProti | NX_Q9UN70 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 693 | ExtracellularSequence analysisAdd BLAST | 662 | |
Transmembranei | 694 – 714 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 715 – 934 | CytoplasmicSequence analysisAdd BLAST | 220 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5098 |
OpenTargetsi | ENSG00000240184 |
PharmGKBi | PA33064 |
Miscellaneous databases
Pharosi | Q9UN70, Tdark |
Polymorphism and mutation databases
BioMutai | PCDHGC3 |
DMDMi | 37999813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000003985 | 32 – 934 | Protocadherin gamma-C3Add BLAST | 903 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 245 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 424 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 478 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 550 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 615 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 689 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9UN70 |
jPOSTi | Q9UN70 |
MassIVEi | Q9UN70 |
PaxDbi | Q9UN70 |
PeptideAtlasi | Q9UN70 |
PRIDEi | Q9UN70 |
ProteomicsDBi | 85253 [Q9UN70-1] 85254 [Q9UN70-2] |
PTM databases
GlyGeni | Q9UN70, 6 sites |
iPTMneti | Q9UN70 |
PhosphoSitePlusi | Q9UN70 |
Expressioni
Gene expression databases
Bgeei | ENSG00000240184, Expressed in amygdala and 120 other tissues |
ExpressionAtlasi | Q9UN70, baseline and differential |
Genevisiblei | Q9UN70, HS |
Organism-specific databases
HPAi | ENSG00000240184, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111131, 46 interactors |
IntActi | Q9UN70, 36 interactors |
STRINGi | 9606.ENSP00000312070 |
Miscellaneous databases
RNActi | Q9UN70, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 135 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 136 – 244 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 245 – 352 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 353 – 457 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 458 – 567 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 572 – 685 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 114 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164266 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9UN70 |
OMAi | GSRQNTM |
PhylomeDBi | Q9UN70 |
TreeFami | TF332299 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030728, PCDHGC3 |
PANTHERi | PTHR24028:SF70, PTHR24028:SF70, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UN70-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV
60 70 80 90 100
VANLGLDLGS LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT
110 120 130 140 150
LPSCTVTLEL VVENPLELFS VEVVIQDIND NNPAFPTQEM KLEISEAVAP
160 170 180 190 200
GTRFPLESAH DPDVGSNSLQ TYELSRNEYF ALRVQTREDS TKYAELVLER
210 220 230 240 250
ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN APVFNQSLYR
260 270 280 290 300
ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV
310 320 330 340 350
TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP
360 370 380 390 400
EITVTSVYSP VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT
410 420 430 440 450
SSLKNYFTLK TSADLDRETV PEYNLSITAR DAGTPSLSAL TIVRVQVSDI
460 470 480 490 500
NDNPPQSSQS SYDVYIEENN LPGAPILNLS VWDPDAPQNA RLSFFLLEQG
510 520 530 540 550
AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS DGGTPVLATN
560 570 580 590 600
ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA
610 620 630 640 650
GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD
660 670 680 690 700
NGEPSLSTTA TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL
710 720 730 740 750
VSVGFVVTVF GVIIFKVYKW KQSRDLYRAP VSSLYRTPGP SLHADAVRGG
760 770 780 790 800
LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS PLASRQNTLR SCDPVFYRQV
810 820 830 840 850
LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML
860 870 880 890 900
QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP
910 920 930
GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BR81 | Q9BR81_HUMAN | Protocadherin gamma subfamily C, 3 | PCDHGC3 | 134 | Annotation score: | ||
A0A087WYB5 | A0A087WYB5_HUMAN | Protocadherin gamma-C3 | PCDHGC3 | 185 | Annotation score: | ||
A0A087X1P2 | A0A087X1P2_HUMAN | Protocadherin gamma-C3 | PCDHGC3 | 242 | Annotation score: |
Sequence cautioni
The sequence AAA36421 differs from that shown. Contaminating sequence. The C-terminus matches chromosome 8 region.Curated
The sequence AAA75391 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | R → P in AAA75391 (PubMed:8508762).Curated | 1 | |
Sequence conflicti | 164 | V → L in AAA75391 (PubMed:8508762).Curated | 1 | |
Sequence conflicti | 366 – 367 | PL → S in AAA75391 (PubMed:8508762).Curated | 2 | |
Sequence conflicti | 611 | L → F in AAA75391 (PubMed:8508762).Curated | 1 | |
Sequence conflicti | 768 – 769 | RS → PG in AAC08350 (PubMed:9360932).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008698 | 811 – 863 | QAPPN…SEAAD → VRFSKSCLTLLVLFYSYIIL RKEWSCFFSDEDVFLVMHSH FQLALPRSKLVPL in isoform 2. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_008699 | 864 – 934 | Missing in isoform 2. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11371 mRNA Translation: AAA36420.1 Frameshift. L11372 mRNA Translation: AAA36421.1 Sequence problems. L11373 mRNA Translation: AAA75391.1 Frameshift. AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1 AF152337 mRNA Translation: AAD43731.1 AF152524 mRNA Translation: AAD43784.1 BC019299 mRNA Translation: AAH19299.1 BC026218 mRNA Translation: AAH26218.1 |
CCDSi | CCDS4261.1 [Q9UN70-1] CCDS75348.1 [Q9UN70-2] |
RefSeqi | NP_002579.2, NM_002588.3 [Q9UN70-1] NP_115778.1, NM_032402.1 [Q9UN70-2] |
Genome annotation databases
Ensembli | ENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1] ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2] |
GeneIDi | 5098 |
KEGGi | hsa:5098 |
UCSCi | uc003lku.2, human [Q9UN70-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11371 mRNA Translation: AAA36420.1 Frameshift. L11372 mRNA Translation: AAA36421.1 Sequence problems. L11373 mRNA Translation: AAA75391.1 Frameshift. AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1 AF152337 mRNA Translation: AAD43731.1 AF152524 mRNA Translation: AAD43784.1 BC019299 mRNA Translation: AAH19299.1 BC026218 mRNA Translation: AAH26218.1 |
CCDSi | CCDS4261.1 [Q9UN70-1] CCDS75348.1 [Q9UN70-2] |
RefSeqi | NP_002579.2, NM_002588.3 [Q9UN70-1] NP_115778.1, NM_032402.1 [Q9UN70-2] |
3D structure databases
SMRi | Q9UN70 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111131, 46 interactors |
IntActi | Q9UN70, 36 interactors |
STRINGi | 9606.ENSP00000312070 |
PTM databases
GlyGeni | Q9UN70, 6 sites |
iPTMneti | Q9UN70 |
PhosphoSitePlusi | Q9UN70 |
Polymorphism and mutation databases
BioMutai | PCDHGC3 |
DMDMi | 37999813 |
Proteomic databases
EPDi | Q9UN70 |
jPOSTi | Q9UN70 |
MassIVEi | Q9UN70 |
PaxDbi | Q9UN70 |
PeptideAtlasi | Q9UN70 |
PRIDEi | Q9UN70 |
ProteomicsDBi | 85253 [Q9UN70-1] 85254 [Q9UN70-2] |
Protocols and materials databases
Antibodypediai | 35055, 317 antibodies |
DNASUi | 5098 |
Genome annotation databases
Ensembli | ENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1] ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2] |
GeneIDi | 5098 |
KEGGi | hsa:5098 |
UCSCi | uc003lku.2, human [Q9UN70-1] |
Organism-specific databases
CTDi | 5098 |
DisGeNETi | 5098 |
EuPathDBi | HostDB:ENSG00000240184.6 |
GeneCardsi | PCDHGC3 |
HGNCi | HGNC:8716, PCDHGC3 |
HPAi | ENSG00000240184, Tissue enhanced (brain) |
MIMi | 603627, gene 604968, gene |
neXtProti | NX_Q9UN70 |
OpenTargetsi | ENSG00000240184 |
PharmGKBi | PA33064 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000164266 |
HOGENOMi | CLU_006480_3_0_1 |
InParanoidi | Q9UN70 |
OMAi | GSRQNTM |
PhylomeDBi | Q9UN70 |
TreeFami | TF332299 |
Enzyme and pathway databases
PathwayCommonsi | Q9UN70 |
Miscellaneous databases
BioGRID-ORCSi | 5098, 8 hits in 810 CRISPR screens |
GeneWikii | PCDHGC3 |
GenomeRNAii | 5098 |
Pharosi | Q9UN70, Tdark |
PROi | PR:Q9UN70 |
RNActi | Q9UN70, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240184, Expressed in amygdala and 120 other tissues |
ExpressionAtlasi | Q9UN70, baseline and differential |
Genevisiblei | Q9UN70, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030728, PCDHGC3 |
PANTHERi | PTHR24028:SF70, PTHR24028:SF70, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCDGK_HUMAN | |
Accessioni | Q9UN70Primary (citable) accession number: Q9UN70 Secondary accession number(s): O60622, Q08192, Q9Y5C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot