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UniProtKB - Q9UN70 (PCDGK_HUMAN)

Entry version 170 (02 Dec 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Protocadherin gamma-C3

Gene

PCDHGC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UN70

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin gamma-C3
Short name:
PCDH-gamma-C3
Alternative name(s):
Protocadherin-2
Protocadherin-43
Short name:
PC-43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDHGC3
Synonyms:PCDH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000240184.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:8716, PCDHGC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603627, gene
604968, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UN70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 693ExtracellularSequence analysisAdd BLAST662
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Topological domaini715 – 934CytoplasmicSequence analysisAdd BLAST220

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5098

Open Targets

More...OpenTargetsi		ENSG00000240184

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33064

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UN70, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PCDHGC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		37999813

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000398532 – 934Protocadherin gamma-C3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UN70

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UN70

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UN70

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UN70

PeptideAtlas

More...PeptideAtlasi		Q9UN70

PRoteomics IDEntifications database

More...PRIDEi		Q9UN70

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85253 [Q9UN70-1]
85254 [Q9UN70-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UN70, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UN70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UN70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000240184, Expressed in amygdala and 120 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UN70, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UN70, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000240184, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111131, 46 interactors

Protein interaction database and analysis system

More...IntActi		Q9UN70, 36 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312070

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UN70, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UN70

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini136 – 244Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini245 – 352Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini353 – 457Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini458 – 567Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini572 – 685Cadherin 6PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164266

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006480_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UN70

Identification of Orthologs from Complete Genome Data

More...OMAi		GSRQNTM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UN70

TreeFam database of animal gene trees

More...TreeFami		TF332299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR032455, Cadherin_C
IPR031904, Cadherin_CBD
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030728, PCDHGC3

The PANTHER Classification System

More...PANTHERi		PTHR24028:SF70, PTHR24028:SF70, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit
PF16492, Cadherin_C_2, 1 hit
PF15974, Cadherin_tail, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UN70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV 
        60         70         80         90        100
VANLGLDLGS LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT 
       110        120        130        140        150
LPSCTVTLEL VVENPLELFS VEVVIQDIND NNPAFPTQEM KLEISEAVAP 
       160        170        180        190        200
GTRFPLESAH DPDVGSNSLQ TYELSRNEYF ALRVQTREDS TKYAELVLER 
       210        220        230        240        250
ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN APVFNQSLYR 
       260        270        280        290        300
ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV 
       310        320        330        340        350
TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP 
       360        370        380        390        400
EITVTSVYSP VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT 
       410        420        430        440        450
SSLKNYFTLK TSADLDRETV PEYNLSITAR DAGTPSLSAL TIVRVQVSDI 
       460        470        480        490        500
NDNPPQSSQS SYDVYIEENN LPGAPILNLS VWDPDAPQNA RLSFFLLEQG 
       510        520        530        540        550
AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS DGGTPVLATN 
       560        570        580        590        600
ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA 
       610        620        630        640        650
GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD 
       660        670        680        690        700
NGEPSLSTTA TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL 
       710        720        730        740        750
VSVGFVVTVF GVIIFKVYKW KQSRDLYRAP VSSLYRTPGP SLHADAVRGG 
       760        770        780        790        800
LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS PLASRQNTLR SCDPVFYRQV 
       810        820        830        840        850
LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML 
       860        870        880        890        900
QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP 
       910        920        930 
GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
Length:934
Mass (Da):101,077
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C8E1EADD485AB10
GO
Isoform 2 (identifier: Q9UN70-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     811-863: QAPPNTDWRF...ILASASEAAD → VRFSKSCLTL...ALPRSKLVPL
     864-934: Missing.

Show »
Length:863
Mass (Da):94,458
Checksum:i884E5FF5A1F227A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BR81Q9BR81_HUMAN
Protocadherin gamma subfamily C, 3
PCDHGC3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYB5A0A087WYB5_HUMAN
Protocadherin gamma-C3
PCDHGC3
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1P2A0A087X1P2_HUMAN
Protocadherin gamma-C3
PCDHGC3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36420 differs from that shown. Reason: Frameshift.Curated
The sequence AAA36421 differs from that shown. Contaminating sequence. The C-terminus matches chromosome 8 region.Curated
The sequence AAA75391 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67R → P in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti164V → L in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti366 – 367PL → S in AAA75391 (PubMed:8508762).Curated2
Sequence conflicti611L → F in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti768 – 769RS → PG in AAC08350 (PubMed:9360932).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008698811 – 863QAPPN…SEAAD → VRFSKSCLTLLVLFYSYIIL RKEWSCFFSDEDVFLVMHSH FQLALPRSKLVPL in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_008699864 – 934Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L11371 mRNA Translation: AAA36420.1 Frameshift.
L11372 mRNA Translation: AAA36421.1 Sequence problems.
L11373 mRNA Translation: AAA75391.1 Frameshift.
AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1
AF152337 mRNA Translation: AAD43731.1
AF152524 mRNA Translation: AAD43784.1
BC019299 mRNA Translation: AAH19299.1
BC026218 mRNA Translation: AAH26218.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4261.1 [Q9UN70-1]
CCDS75348.1 [Q9UN70-2]

NCBI Reference Sequences

More...RefSeqi		NP_002579.2, NM_002588.3 [Q9UN70-1]
NP_115778.1, NM_032402.1 [Q9UN70-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5098

UCSC genome browser

More...UCSCi		uc003lku.2, human [Q9UN70-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11371 mRNA Translation: AAA36420.1 Frameshift.
L11372 mRNA Translation: AAA36421.1 Sequence problems.
L11373 mRNA Translation: AAA75391.1 Frameshift.
AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1
AF152337 mRNA Translation: AAD43731.1
AF152524 mRNA Translation: AAD43784.1
BC019299 mRNA Translation: AAH19299.1
BC026218 mRNA Translation: AAH26218.1
CCDSiCCDS4261.1 [Q9UN70-1]
CCDS75348.1 [Q9UN70-2]
RefSeqiNP_002579.2, NM_002588.3 [Q9UN70-1]
NP_115778.1, NM_032402.1 [Q9UN70-2]

3D structure databases

SMRiQ9UN70
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111131, 46 interactors
IntActiQ9UN70, 36 interactors
STRINGi9606.ENSP00000312070

PTM databases

GlyGeniQ9UN70, 6 sites
iPTMnetiQ9UN70
PhosphoSitePlusiQ9UN70

Polymorphism and mutation databases

BioMutaiPCDHGC3
DMDMi37999813

Proteomic databases

EPDiQ9UN70
jPOSTiQ9UN70
MassIVEiQ9UN70
PaxDbiQ9UN70
PeptideAtlasiQ9UN70
PRIDEiQ9UN70
ProteomicsDBi85253 [Q9UN70-1]
85254 [Q9UN70-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35055, 317 antibodies

The DNASU plasmid repository

More...DNASUi		5098

Genome annotation databases

EnsembliENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2]
GeneIDi5098
KEGGihsa:5098
UCSCiuc003lku.2, human [Q9UN70-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5098
DisGeNETi5098
EuPathDBiHostDB:ENSG00000240184.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		PCDHGC3
HGNCiHGNC:8716, PCDHGC3
HPAiENSG00000240184, Tissue enhanced (brain)
MIMi603627, gene
604968, gene
neXtProtiNX_Q9UN70
OpenTargetsiENSG00000240184
PharmGKBiPA33064

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT00940000164266
HOGENOMiCLU_006480_3_0_1
InParanoidiQ9UN70
OMAiGSRQNTM
PhylomeDBiQ9UN70
TreeFamiTF332299

Enzyme and pathway databases

PathwayCommonsiQ9UN70

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5098, 8 hits in 810 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PCDHGC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5098
PharosiQ9UN70, Tdark

Protein Ontology

More...PROi		PR:Q9UN70
RNActiQ9UN70, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000240184, Expressed in amygdala and 120 other tissues
ExpressionAtlasiQ9UN70, baseline and differential
GenevisibleiQ9UN70, HS

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR032455, Cadherin_C
IPR031904, Cadherin_CBD
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030728, PCDHGC3
PANTHERiPTHR24028:SF70, PTHR24028:SF70, 1 hit
PfamiView protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit
PF16492, Cadherin_C_2, 1 hit
PF15974, Cadherin_tail, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 6 hits
SUPFAMiSSF49313, SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDGK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UN70
Secondary accession number(s): O60622, Q08192, Q9Y5C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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