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Protein

Protocadherin gamma-C3

Gene

PCDHGC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse organization Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin gamma-C3
Short name:
PCDH-gamma-C3
Alternative name(s):
Protocadherin-2
Protocadherin-43
Short name:
PC-43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDHGC3
Synonyms:PCDH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000240184.6

Human Gene Nomenclature Database

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HGNCi
HGNC:8716 PCDHGC3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603627 gene
604968 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UN70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 693ExtracellularSequence analysisAdd BLAST662
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Topological domaini715 – 934CytoplasmicSequence analysisAdd BLAST220

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5098

Open Targets

More...
OpenTargetsi
ENSG00000240184

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33064

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PCDHGC3

Domain mapping of disease mutations (DMDM)

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DMDMi
37999813

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000398532 – 934Protocadherin gamma-C3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UN70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UN70

PeptideAtlas

More...
PeptideAtlasi
Q9UN70

PRoteomics IDEntifications database

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PRIDEi
Q9UN70

ProteomicsDB human proteome resource

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ProteomicsDBi
85253
85254 [Q9UN70-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UN70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UN70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000240184 Expressed in 103 organ(s), highest expression level in amygdala

CleanEx database of gene expression profiles

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CleanExi
HS_PCDHGC3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UN70 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UN70 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA008755
HPA010580
HPA077289

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111131, 45 interactors

Protein interaction database and analysis system

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IntActi
Q9UN70, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UN70

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UN70

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini136 – 244Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini245 – 352Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini353 – 457Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini458 – 567Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini572 – 685Cadherin 6PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164266

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220892

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054878

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UN70

KEGG Orthology (KO)

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KOi
K16497

Identification of Orthologs from Complete Genome Data

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OMAi
AHVQIHI

Database of Orthologous Groups

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OrthoDBi
EOG091G00SP

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UN70

TreeFam database of animal gene trees

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TreeFami
TF332299

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030728 PCDHGC3

The PANTHER Classification System

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PANTHERi
PTHR24028:SF70 PTHR24028:SF70, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00112 CA, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UN70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV
60 70 80 90 100
VANLGLDLGS LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT
110 120 130 140 150
LPSCTVTLEL VVENPLELFS VEVVIQDIND NNPAFPTQEM KLEISEAVAP
160 170 180 190 200
GTRFPLESAH DPDVGSNSLQ TYELSRNEYF ALRVQTREDS TKYAELVLER
210 220 230 240 250
ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN APVFNQSLYR
260 270 280 290 300
ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV
310 320 330 340 350
TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP
360 370 380 390 400
EITVTSVYSP VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT
410 420 430 440 450
SSLKNYFTLK TSADLDRETV PEYNLSITAR DAGTPSLSAL TIVRVQVSDI
460 470 480 490 500
NDNPPQSSQS SYDVYIEENN LPGAPILNLS VWDPDAPQNA RLSFFLLEQG
510 520 530 540 550
AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS DGGTPVLATN
560 570 580 590 600
ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA
610 620 630 640 650
GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD
660 670 680 690 700
NGEPSLSTTA TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL
710 720 730 740 750
VSVGFVVTVF GVIIFKVYKW KQSRDLYRAP VSSLYRTPGP SLHADAVRGG
760 770 780 790 800
LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS PLASRQNTLR SCDPVFYRQV
810 820 830 840 850
LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML
860 870 880 890 900
QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP
910 920 930
GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK
Length:934
Mass (Da):101,077
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C8E1EADD485AB10
GO
Isoform 2 (identifier: Q9UN70-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     811-863: QAPPNTDWRF...ILASASEAAD → VRFSKSCLTL...ALPRSKLVPL
     864-934: Missing.

Show »
Length:863
Mass (Da):94,458
Checksum:i884E5FF5A1F227A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1P2A0A087X1P2_HUMAN
Protocadherin gamma-C3
PCDHGC3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BR81Q9BR81_HUMAN
Protocadherin gamma subfamily C, 3
PCDHGC3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYB5A0A087WYB5_HUMAN
Protocadherin gamma-C3
PCDHGC3
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Isoform 2 : The sequence AAA36420 differs from that shown. Reason: Frameshift at position 832.Curated
The sequence AAA36421 differs from that shown. Contaminating sequence. The C-terminus matches chromosome 8 region.Curated
The sequence AAA75391 differs from that shown. Reason: Frameshift at positions 254, 259, 905, 914, 918 and 930.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67R → P in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti164V → L in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti366 – 367PL → S in AAA75391 (PubMed:8508762).Curated2
Sequence conflicti611L → F in AAA75391 (PubMed:8508762).Curated1
Sequence conflicti768 – 769RS → PG in AAC08350 (PubMed:9360932).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008698811 – 863QAPPN…SEAAD → VRFSKSCLTLLVLFYSYIIL RKEWSCFFSDEDVFLVMHSH FQLALPRSKLVPL in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_008699864 – 934Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L11371 mRNA Translation: AAA36420.1 Frameshift.
L11372 mRNA Translation: AAA36421.1 Sequence problems.
L11373 mRNA Translation: AAA75391.1 Frameshift.
AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1
AF152337 mRNA Translation: AAD43731.1
AF152524 mRNA Translation: AAD43784.1
BC019299 mRNA Translation: AAH19299.1
BC026218 mRNA Translation: AAH26218.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4261.1 [Q9UN70-1]
CCDS75348.1 [Q9UN70-2]

NCBI Reference Sequences

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RefSeqi
NP_002579.2, NM_002588.3 [Q9UN70-1]
NP_115778.1, NM_032402.1 [Q9UN70-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368160

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5098

UCSC genome browser

More...
UCSCi
uc003lku.2 human [Q9UN70-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11371 mRNA Translation: AAA36420.1 Frameshift.
L11372 mRNA Translation: AAA36421.1 Sequence problems.
L11373 mRNA Translation: AAA75391.1 Frameshift.
AF052685, AF052683, AF052684 Genomic DNA Translation: AAC08350.1
AF152337 mRNA Translation: AAD43731.1
AF152524 mRNA Translation: AAD43784.1
BC019299 mRNA Translation: AAH19299.1
BC026218 mRNA Translation: AAH26218.1
CCDSiCCDS4261.1 [Q9UN70-1]
CCDS75348.1 [Q9UN70-2]
RefSeqiNP_002579.2, NM_002588.3 [Q9UN70-1]
NP_115778.1, NM_032402.1 [Q9UN70-2]
UniGeneiHs.368160

3D structure databases

ProteinModelPortaliQ9UN70
SMRiQ9UN70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111131, 45 interactors
IntActiQ9UN70, 3 interactors

PTM databases

iPTMnetiQ9UN70
PhosphoSitePlusiQ9UN70

Polymorphism and mutation databases

BioMutaiPCDHGC3
DMDMi37999813

Proteomic databases

EPDiQ9UN70
PaxDbiQ9UN70
PeptideAtlasiQ9UN70
PRIDEiQ9UN70
ProteomicsDBi85253
85254 [Q9UN70-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5098
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308177; ENSP00000312070; ENSG00000240184 [Q9UN70-1]
ENST00000611950; ENSP00000481219; ENSG00000240184 [Q9UN70-2]
GeneIDi5098
KEGGihsa:5098
UCSCiuc003lku.2 human [Q9UN70-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5098
DisGeNETi5098
EuPathDBiHostDB:ENSG00000240184.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PCDHGC3
HGNCiHGNC:8716 PCDHGC3
HPAiHPA008755
HPA010580
HPA077289
MIMi603627 gene
604968 gene
neXtProtiNX_Q9UN70
OpenTargetsiENSG00000240184
PharmGKBiPA33064

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000164266
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ9UN70
KOiK16497
OMAiAHVQIHI
OrthoDBiEOG091G00SP
PhylomeDBiQ9UN70
TreeFamiTF332299

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PCDHGC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5098

Protein Ontology

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PROi
PR:Q9UN70

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000240184 Expressed in 103 organ(s), highest expression level in amygdala
CleanExiHS_PCDHGC3
ExpressionAtlasiQ9UN70 baseline and differential
GenevisibleiQ9UN70 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030728 PCDHGC3
PANTHERiPTHR24028:SF70 PTHR24028:SF70, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDGK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UN70
Secondary accession number(s): O60622, Q08192, Q9Y5C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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