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Entry version 164 (13 Nov 2019)
Sequence version 2 (23 Jan 2002)
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Protein

Protein NDRG2

Gene

NDRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.3 Publications

Caution

Has some similarity to hydrolases, but lacks the conserved Ser-His-Asp catalytic triad. Has no hydrolase activity towards p-nitrophenylbutyrate (in vitro).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Wnt signaling pathway

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UN36

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-NDRG2 Ndr_family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NDRG2
Alternative name(s):
N-myc downstream-regulated gene 2 protein
Protein Syld709613
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDRG2
Synonyms:KIAA1248, SYLD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14460 NDRG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605272 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UN36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi186L → D: Decreased interaction with CTNNB1. Abolishes down-regulation of Wnt signaling. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
57447

Open Targets

More...
OpenTargetsi
ENSG00000165795

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31483

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UN36

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDRG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004411662 – 371Protein NDRG2Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphothreonineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei330PhosphothreonineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei335PhosphoserineBy similarity1
Modified residuei338PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei348PhosphothreonineCombined sources1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei357PhosphothreonineBy similarity1
Modified residuei370PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UN36

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UN36

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UN36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UN36

PeptideAtlas

More...
PeptideAtlasi
Q9UN36

PRoteomics IDEntifications database

More...
PRIDEi
Q9UN36

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3929
85243 [Q9UN36-1]
85244 [Q9UN36-2]
85245 [Q9UN36-3]
85246 [Q9UN36-4]
85247 [Q9UN36-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UN36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UN36

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UN36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).7 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165795 Expressed in 228 organ(s), highest expression level in medial globus pallidus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UN36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UN36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017491
HPA002896
HPA003590

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121520, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UN36, 10 interactors

Molecular INTeraction database

More...
MINTi
Q9UN36

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000451712

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UN36

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UN36

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2931 Eukaryota
ENOG410XSPF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182872

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UN36

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTCFQPL

Database of Orthologous Groups

More...
OrthoDBi
854690at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UN36

TreeFam database of animal gene trees

More...
TreeFami
TF313168

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR004142 NDRG
IPR030690 NDRG2

The PANTHER Classification System

More...
PANTHERi
PTHR11034 PTHR11034, 1 hit
PTHR11034:SF17 PTHR11034:SF17, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03096 Ndr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 43 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UN36-1) [UniParc]FASTAAdd to basket
Also known as: NDRG2ins

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV
60 70 80 90 100
TFTVYGTPKP KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV
110 120 130 140 150
DAPGMEEGAP VFPLGYQYPS LDQLADMIPC VLQYLNFSTI IGVGVGAGAY
160 170 180 190 200
ILARYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPEMILGH
210 220 230 240 250
LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR RDLNFERGGD
260 270 280 290 300
ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP
310 320 330 340 350
GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS
360 370
QSSESGTLSS GPPGHTMEVS C
Length:371
Mass (Da):40,798
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B49B0B12BD3F595
GO
Isoform 2 (identifier: Q9UN36-2) [UniParc]FASTAAdd to basket
Also known as: NDRG2var

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.

Show »
Length:357
Mass (Da):39,289
Checksum:iDD793CDC7173704A
GO
Isoform 3 (identifier: Q9UN36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-272: Missing.

Show »
Length:360
Mass (Da):39,679
Checksum:iCB10621C98F95CED
GO
Isoform 4 (identifier: Q9UN36-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.
     157-185: Missing.

Show »
Length:328
Mass (Da):36,052
Checksum:i3B2E97F79C3E2875
GO
Isoform 5 (identifier: Q9UN36-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-39: Missing.
     272-287: Missing.

Show »
Length:341
Mass (Da):37,497
Checksum:i0A213AAB643816C8
GO
Isoform 6 (identifier: Q9UN36-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MENGGSMQATM
     26-39: Missing.

Note: No experimental confirmation available.
Show »
Length:367
Mass (Da):40,297
Checksum:i26CE96CF6F63D0D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 43 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V280G3V280_HUMAN
Protein NDRG2
NDRG2
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5A6G3V5A6_HUMAN
Protein NDRG2
NDRG2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2I9G3V2I9_HUMAN
Protein NDRG2
NDRG2
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2T2G3V2T2_HUMAN
Protein NDRG2
NDRG2
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V383G3V383_HUMAN
Protein NDRG2
NDRG2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3D5G3V3D5_HUMAN
Protein NDRG2
NDRG2
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3P1G3V3P1_HUMAN
Protein NDRG2
NDRG2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3P6G3V3P6_HUMAN
Protein NDRG2
NDRG2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4T9G3V4T9_HUMAN
Protein NDRG2
NDRG2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V578G3V578_HUMAN
Protein NDRG2
NDRG2
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86562 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAD62350 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54V → A in AAL08624 (PubMed:11936845).Curated1
Sequence conflicti123Q → E in AAH93038 (PubMed:15489334).Curated1
Sequence conflicti172D → G in AAK50340 (PubMed:12845671).Curated1
Sequence conflicti250D → N in AAL08624 (PubMed:11936845).Curated1
Sequence conflicti282Q → R in AAH93038 (PubMed:15489334).Curated1
Sequence conflicti296Q → R in AAK50340 (PubMed:12845671).Curated1
Sequence conflicti306A → V in AAL08624 (PubMed:11936845).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05023645T → S. Corresponds to variant dbSNP:rs36007455Ensembl.1
Natural variantiVAR_02657248G → V1 PublicationCorresponds to variant dbSNP:rs11552412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545831M → MENGGSMQATM in isoform 6. 1 Publication1
Alternative sequenceiVSP_00341726 – 39Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 6 PublicationsAdd BLAST14
Alternative sequenceiVSP_019007157 – 185Missing in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_003418262 – 272Missing in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_019008272 – 287Missing in isoform 5. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF304051 mRNA Translation: AAL08624.1
AF159092 mRNA Translation: AAD43131.2
AY028430 Genomic DNA Translation: AAK50340.1
AB033074 mRNA Translation: BAA86562.1 Different initiation.
AL136574 mRNA Translation: CAB66509.1
BX247987 mRNA Translation: CAD62321.1
BX248031 mRNA Translation: CAD62350.1 Different initiation.
AK096999 mRNA Translation: BAG53405.1
AK293514 mRNA Translation: BAG56997.1
CR749252 mRNA Translation: CAH18108.1
AL161668 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66423.1
CH471078 Genomic DNA Translation: EAW66422.1
CH471078 Genomic DNA Translation: EAW66424.1
CH471078 Genomic DNA Translation: EAW66425.1
CH471078 Genomic DNA Translation: EAW66426.1
CH471078 Genomic DNA Translation: EAW66427.1
CH471078 Genomic DNA Translation: EAW66428.1
CH471078 Genomic DNA Translation: EAW66429.1
CH471078 Genomic DNA Translation: EAW66430.1
BC010458 mRNA Translation: AAH10458.1
BC011240 mRNA Translation: AAH11240.1
BC093038 mRNA Translation: AAH93038.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61384.1 [Q9UN36-3]
CCDS61386.1 [Q9UN36-6]
CCDS73613.1 [Q9UN36-5]
CCDS9564.1 [Q9UN36-2]
CCDS9565.1 [Q9UN36-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269140.1, NM_001282211.1 [Q9UN36-6]
NP_001269141.1, NM_001282212.1 [Q9UN36-5]
NP_001269142.1, NM_001282213.1 [Q9UN36-2]
NP_001269143.1, NM_001282214.1 [Q9UN36-2]
NP_001269144.1, NM_001282215.1 [Q9UN36-3]
NP_001269145.1, NM_001282216.1
NP_001307258.1, NM_001320329.1 [Q9UN36-1]
NP_057334.1, NM_016250.2 [Q9UN36-2]
NP_963293.1, NM_201535.1 [Q9UN36-1]
NP_963294.1, NM_201536.1 [Q9UN36-2]
NP_963831.1, NM_201537.1 [Q9UN36-1]
NP_963832.1, NM_201538.1 [Q9UN36-2]
NP_963833.1, NM_201539.1 [Q9UN36-1]
NP_963834.1, NM_201540.1 [Q9UN36-1]
NP_963835.1, NM_201541.1 [Q9UN36-2]
XP_011535298.1, XM_011536996.2
XP_011535299.1, XM_011536997.1
XP_011535300.1, XM_011536998.1
XP_011535301.1, XM_011536999.1
XP_011535303.1, XM_011537001.1
XP_011535304.1, XM_011537002.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298684; ENSP00000298684; ENSG00000165795 [Q9UN36-4]
ENST00000298687; ENSP00000298687; ENSG00000165795 [Q9UN36-1]
ENST00000350792; ENSP00000344620; ENSG00000165795 [Q9UN36-2]
ENST00000360463; ENSP00000353649; ENSG00000165795 [Q9UN36-2]
ENST00000397844; ENSP00000380943; ENSG00000165795 [Q9UN36-5]
ENST00000397847; ENSP00000380945; ENSG00000165795 [Q9UN36-3]
ENST00000397851; ENSP00000380949; ENSG00000165795 [Q9UN36-1]
ENST00000397853; ENSP00000380951; ENSG00000165795 [Q9UN36-1]
ENST00000397858; ENSP00000380956; ENSG00000165795 [Q9UN36-1]
ENST00000403829; ENSP00000385889; ENSG00000165795 [Q9UN36-6]
ENST00000553503; ENSP00000452306; ENSG00000165795 [Q9UN36-2]
ENST00000554143; ENSP00000452006; ENSG00000165795 [Q9UN36-2]
ENST00000555158; ENSP00000452038; ENSG00000165795 [Q9UN36-2]
ENST00000556147; ENSP00000451712; ENSG00000165795 [Q9UN36-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57447

UCSC genome browser

More...
UCSCi
uc001vyu.4 human [Q9UN36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304051 mRNA Translation: AAL08624.1
AF159092 mRNA Translation: AAD43131.2
AY028430 Genomic DNA Translation: AAK50340.1
AB033074 mRNA Translation: BAA86562.1 Different initiation.
AL136574 mRNA Translation: CAB66509.1
BX247987 mRNA Translation: CAD62321.1
BX248031 mRNA Translation: CAD62350.1 Different initiation.
AK096999 mRNA Translation: BAG53405.1
AK293514 mRNA Translation: BAG56997.1
CR749252 mRNA Translation: CAH18108.1
AL161668 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66423.1
CH471078 Genomic DNA Translation: EAW66422.1
CH471078 Genomic DNA Translation: EAW66424.1
CH471078 Genomic DNA Translation: EAW66425.1
CH471078 Genomic DNA Translation: EAW66426.1
CH471078 Genomic DNA Translation: EAW66427.1
CH471078 Genomic DNA Translation: EAW66428.1
CH471078 Genomic DNA Translation: EAW66429.1
CH471078 Genomic DNA Translation: EAW66430.1
BC010458 mRNA Translation: AAH10458.1
BC011240 mRNA Translation: AAH11240.1
BC093038 mRNA Translation: AAH93038.1
CCDSiCCDS61384.1 [Q9UN36-3]
CCDS61386.1 [Q9UN36-6]
CCDS73613.1 [Q9UN36-5]
CCDS9564.1 [Q9UN36-2]
CCDS9565.1 [Q9UN36-1]
RefSeqiNP_001269140.1, NM_001282211.1 [Q9UN36-6]
NP_001269141.1, NM_001282212.1 [Q9UN36-5]
NP_001269142.1, NM_001282213.1 [Q9UN36-2]
NP_001269143.1, NM_001282214.1 [Q9UN36-2]
NP_001269144.1, NM_001282215.1 [Q9UN36-3]
NP_001269145.1, NM_001282216.1
NP_001307258.1, NM_001320329.1 [Q9UN36-1]
NP_057334.1, NM_016250.2 [Q9UN36-2]
NP_963293.1, NM_201535.1 [Q9UN36-1]
NP_963294.1, NM_201536.1 [Q9UN36-2]
NP_963831.1, NM_201537.1 [Q9UN36-1]
NP_963832.1, NM_201538.1 [Q9UN36-2]
NP_963833.1, NM_201539.1 [Q9UN36-1]
NP_963834.1, NM_201540.1 [Q9UN36-1]
NP_963835.1, NM_201541.1 [Q9UN36-2]
XP_011535298.1, XM_011536996.2
XP_011535299.1, XM_011536997.1
XP_011535300.1, XM_011536998.1
XP_011535301.1, XM_011536999.1
XP_011535303.1, XM_011537001.1
XP_011535304.1, XM_011537002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XMQX-ray2.81A/B/C40-318[»]
2XMRX-ray2.00A/B/C40-318[»]
2XMSX-ray2.15A40-318[»]
SMRiQ9UN36
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121520, 11 interactors
IntActiQ9UN36, 10 interactors
MINTiQ9UN36
STRINGi9606.ENSP00000451712

Protein family/group databases

ESTHERihuman-NDRG2 Ndr_family

PTM databases

iPTMnetiQ9UN36
PhosphoSitePlusiQ9UN36
SwissPalmiQ9UN36

Polymorphism and mutation databases

BioMutaiNDRG2
DMDMi20141615

Proteomic databases

EPDiQ9UN36
jPOSTiQ9UN36
MassIVEiQ9UN36
PaxDbiQ9UN36
PeptideAtlasiQ9UN36
PRIDEiQ9UN36
ProteomicsDBi3929
85243 [Q9UN36-1]
85244 [Q9UN36-2]
85245 [Q9UN36-3]
85246 [Q9UN36-4]
85247 [Q9UN36-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57447

Genome annotation databases

EnsembliENST00000298684; ENSP00000298684; ENSG00000165795 [Q9UN36-4]
ENST00000298687; ENSP00000298687; ENSG00000165795 [Q9UN36-1]
ENST00000350792; ENSP00000344620; ENSG00000165795 [Q9UN36-2]
ENST00000360463; ENSP00000353649; ENSG00000165795 [Q9UN36-2]
ENST00000397844; ENSP00000380943; ENSG00000165795 [Q9UN36-5]
ENST00000397847; ENSP00000380945; ENSG00000165795 [Q9UN36-3]
ENST00000397851; ENSP00000380949; ENSG00000165795 [Q9UN36-1]
ENST00000397853; ENSP00000380951; ENSG00000165795 [Q9UN36-1]
ENST00000397858; ENSP00000380956; ENSG00000165795 [Q9UN36-1]
ENST00000403829; ENSP00000385889; ENSG00000165795 [Q9UN36-6]
ENST00000553503; ENSP00000452306; ENSG00000165795 [Q9UN36-2]
ENST00000554143; ENSP00000452006; ENSG00000165795 [Q9UN36-2]
ENST00000555158; ENSP00000452038; ENSG00000165795 [Q9UN36-2]
ENST00000556147; ENSP00000451712; ENSG00000165795 [Q9UN36-1]
GeneIDi57447
KEGGihsa:57447
UCSCiuc001vyu.4 human [Q9UN36-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57447
DisGeNETi57447

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NDRG2
HGNCiHGNC:14460 NDRG2
HPAiCAB017491
HPA002896
HPA003590
MIMi605272 gene
neXtProtiNX_Q9UN36
OpenTargetsiENSG00000165795
PharmGKBiPA31483

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2931 Eukaryota
ENOG410XSPF LUCA
GeneTreeiENSGT00950000182872
InParanoidiQ9UN36
OMAiKTCFQPL
OrthoDBi854690at2759
PhylomeDBiQ9UN36
TreeFamiTF313168

Enzyme and pathway databases

SIGNORiQ9UN36

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NDRG2 human
EvolutionaryTraceiQ9UN36

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NDRG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57447
PharosiQ9UN36

Protein Ontology

More...
PROi
PR:Q9UN36

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165795 Expressed in 228 organ(s), highest expression level in medial globus pallidus
ExpressionAtlasiQ9UN36 baseline and differential
GenevisibleiQ9UN36 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR004142 NDRG
IPR030690 NDRG2
PANTHERiPTHR11034 PTHR11034, 1 hit
PTHR11034:SF17 PTHR11034:SF17, 1 hit
PfamiView protein in Pfam
PF03096 Ndr, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDRG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UN36
Secondary accession number(s): B3KUE3
, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: November 13, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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