UniProtKB - Q9UN30 (SCML1_HUMAN)
Sex comb on midleg-like protein 1
SCML1
Functioni
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity).
By similarityGO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9UN30 |
SignaLinki | Q9UN30 |
Names & Taxonomyi
Protein namesi | Recommended name: Sex comb on midleg-like protein 1 |
Gene namesi | Name:SCML1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10580, SCML1 |
MIMi | 300227, gene |
neXtProti | NX_Q9UN30 |
VEuPathDBi | HostDB:ENSG00000047634 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6322 |
OpenTargetsi | ENSG00000047634 |
PharmGKBi | PA34998 |
Miscellaneous databases
Pharosi | Q9UN30, Tdark |
Genetic variation databases
BioMutai | SCML1 |
DMDMi | 254763330 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097627 | 1 – 329 | Sex comb on midleg-like protein 1Add BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 138 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q9UN30 |
PaxDbi | Q9UN30 |
PeptideAtlasi | Q9UN30 |
PRIDEi | Q9UN30 |
ProteomicsDBi | 85240 [Q9UN30-3] 85241 [Q9UN30-1] 85242 [Q9UN30-2] |
PTM databases
iPTMneti | Q9UN30 |
PhosphoSitePlusi | Q9UN30 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000047634, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | Q9UN30, baseline and differential |
Genevisiblei | Q9UN30, HS |
Organism-specific databases
HPAi | ENSG00000047634, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 2 [Q9UN30-2]
GO - Molecular functioni
- histone binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112227, 52 interactors |
IntActi | Q9UN30, 27 interactors |
MINTi | Q9UN30 |
STRINGi | 9606.ENSP00000369380 |
Miscellaneous databases
RNActi | Q9UN30, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 258 – 325 | SAMPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 157 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 138 – 156 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000164589 |
HOGENOMi | CLU_1320505_0_0_1 |
InParanoidi | Q9UN30 |
OMAi | YETKPEF |
OrthoDBi | 298184at2759 |
PhylomeDBi | Q9UN30 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSNSSSEID VIKTRIPTYD EDDNTILYAY ETKPEFVNKE PNIVSDASCN
60 70 80 90 100
TEEQLKTVDD VLIHCQVIYD ALQNLDKKID VIRRKVSKIQ RFHARSLWTN
110 120 130 140 150
HKRYGYKKHS YRLVKKLKLQ KMKKNEVYET FSYPESYSPT LPVSRRENNS
160 170 180 190 200
PSNLPRPSFC MEEYQRAELE EDPILSRTPS PVHPSDFSEH NCQPYYASDG
210 220 230 240 250
ATYGSSSGLC LGNPRADSIH NTYSTDHASA APPSVTRSPV ENDGYIEEGS
260 270 280 290 300
ITKHPSTWSV EAVVLFLKQT DPLALCPLVD LFRSHEIDGK ALLLLTSDVL
310 320
LKHLGVKLGT AVKLCYYIDR LKQGKCFEN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5H966 | Q5H966_HUMAN | Sex comb on midleg-like protein 1 | SCML1 | 147 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037800 | 1 – 121 | Missing in isoform 1. 3 PublicationsAdd BLAST | 121 | |
Alternative sequenceiVSP_037801 | 12 – 39 | IKTRI…EFVNK → Q in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160728 mRNA Translation: AAD47635.1 EU370780 Genomic DNA Translation: ABY68575.1 AK313993 mRNA Translation: BAG36705.1 Z93242 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98929.1 BC105028 mRNA Translation: AAI05029.1 BC026159 mRNA Translation: AAH26159.2 |
CCDSi | CCDS14182.2 [Q9UN30-2] CCDS35210.1 [Q9UN30-3] CCDS35211.1 [Q9UN30-1] |
RefSeqi | NP_001032624.1, NM_001037535.2 [Q9UN30-1] NP_001032625.1, NM_001037536.2 [Q9UN30-1] NP_001032629.1, NM_001037540.2 [Q9UN30-3] NP_006737.2, NM_006746.5 [Q9UN30-2] XP_006724571.1, XM_006724508.3 [Q9UN30-3] XP_016885212.1, XM_017029723.1 [Q9UN30-2] |
Genome annotation databases
Ensembli | ENST00000380041.8; ENSP00000369380.3; ENSG00000047634.15 ENST00000380043.7; ENSP00000369382.3; ENSG00000047634.15 [Q9UN30-2] ENST00000380045.7; ENSP00000369384.3; ENSG00000047634.15 [Q9UN30-1] ENST00000398080.5; ENSP00000381154.1; ENSG00000047634.15 [Q9UN30-1] |
GeneIDi | 6322 |
KEGGi | hsa:6322 |
MANE-Selecti | ENST00000380041.8; ENSP00000369380.3; NM_001037540.3; NP_001032629.1 |
UCSCi | uc004cyb.5, human [Q9UN30-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF160728 mRNA Translation: AAD47635.1 EU370780 Genomic DNA Translation: ABY68575.1 AK313993 mRNA Translation: BAG36705.1 Z93242 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98929.1 BC105028 mRNA Translation: AAI05029.1 BC026159 mRNA Translation: AAH26159.2 |
CCDSi | CCDS14182.2 [Q9UN30-2] CCDS35210.1 [Q9UN30-3] CCDS35211.1 [Q9UN30-1] |
RefSeqi | NP_001032624.1, NM_001037535.2 [Q9UN30-1] NP_001032625.1, NM_001037536.2 [Q9UN30-1] NP_001032629.1, NM_001037540.2 [Q9UN30-3] NP_006737.2, NM_006746.5 [Q9UN30-2] XP_006724571.1, XM_006724508.3 [Q9UN30-3] XP_016885212.1, XM_017029723.1 [Q9UN30-2] |
3D structure databases
AlphaFoldDBi | Q9UN30 |
SMRi | Q9UN30 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112227, 52 interactors |
IntActi | Q9UN30, 27 interactors |
MINTi | Q9UN30 |
STRINGi | 9606.ENSP00000369380 |
PTM databases
iPTMneti | Q9UN30 |
PhosphoSitePlusi | Q9UN30 |
Genetic variation databases
BioMutai | SCML1 |
DMDMi | 254763330 |
Proteomic databases
MassIVEi | Q9UN30 |
PaxDbi | Q9UN30 |
PeptideAtlasi | Q9UN30 |
PRIDEi | Q9UN30 |
ProteomicsDBi | 85240 [Q9UN30-3] 85241 [Q9UN30-1] 85242 [Q9UN30-2] |
Protocols and materials databases
Antibodypediai | 24087, 171 antibodies from 24 providers |
DNASUi | 6322 |
Genome annotation databases
Ensembli | ENST00000380041.8; ENSP00000369380.3; ENSG00000047634.15 ENST00000380043.7; ENSP00000369382.3; ENSG00000047634.15 [Q9UN30-2] ENST00000380045.7; ENSP00000369384.3; ENSG00000047634.15 [Q9UN30-1] ENST00000398080.5; ENSP00000381154.1; ENSG00000047634.15 [Q9UN30-1] |
GeneIDi | 6322 |
KEGGi | hsa:6322 |
MANE-Selecti | ENST00000380041.8; ENSP00000369380.3; NM_001037540.3; NP_001032629.1 |
UCSCi | uc004cyb.5, human [Q9UN30-3] |
Organism-specific databases
CTDi | 6322 |
DisGeNETi | 6322 |
GeneCardsi | SCML1 |
HGNCi | HGNC:10580, SCML1 |
HPAi | ENSG00000047634, Low tissue specificity |
MIMi | 300227, gene |
neXtProti | NX_Q9UN30 |
OpenTargetsi | ENSG00000047634 |
PharmGKBi | PA34998 |
VEuPathDBi | HostDB:ENSG00000047634 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
GeneTreei | ENSGT00940000164589 |
HOGENOMi | CLU_1320505_0_0_1 |
InParanoidi | Q9UN30 |
OMAi | YETKPEF |
OrthoDBi | 298184at2759 |
PhylomeDBi | Q9UN30 |
Enzyme and pathway databases
PathwayCommonsi | Q9UN30 |
SignaLinki | Q9UN30 |
Miscellaneous databases
BioGRID-ORCSi | 6322, 13 hits in 703 CRISPR screens |
ChiTaRSi | SCML1, human |
GenomeRNAii | 6322 |
Pharosi | Q9UN30, Tdark |
PROi | PR:Q9UN30 |
RNActi | Q9UN30, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000047634, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | Q9UN30, baseline and differential |
Genevisiblei | Q9UN30, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCML1_HUMAN | |
Accessioni | Q9UN30Primary (citable) accession number: Q9UN30 Secondary accession number(s): B0FZN6 Q5H969 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | July 28, 2009 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families