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Entry version 168 (02 Jun 2021)
Sequence version 2 (03 Apr 2007)
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Protein

Synergin gamma

Gene

SYNRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025).

May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025).

Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).

1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • intracellular protein transport Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UMZ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synergin gamma
Alternative name(s):
AP1 subunit gamma-binding protein 1
Gamma-synergin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNRG1 PublicationImported
Synonyms:AP1GBP1, SYNG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:557, SYNRG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607291, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UMZ2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000275066.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11276

Open Targets

More...
OpenTargetsi
ENSG00000275066

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24847

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UMZ2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYNRG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723871 – 1314Synergin gammaAdd BLAST1314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei473PhosphoserineCombined sources1
Modified residuei513N6-acetyllysineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei744N6-acetyllysineCombined sources1
Modified residuei752PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1073PhosphoserineBy similarity1
Modified residuei1075PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1100PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UMZ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UMZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UMZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UMZ2

PeptideAtlas

More...
PeptideAtlasi
Q9UMZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UMZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2266
85232 [Q9UMZ2-1]
85233 [Q9UMZ2-3]
85234 [Q9UMZ2-4]
85235 [Q9UMZ2-5]
85236 [Q9UMZ2-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UMZ2

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9UMZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UMZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000275066, Expressed in pituitary gland and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UMZ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UMZ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000275066, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates (PubMed:15758025).

Interacts with GGA1 (via GAE domain) (PubMed:10814529, PubMed:14665628, PubMed:15758025).

Interacts with GGA2 and GGA3 (PubMed:10814529).

Interacts with AP1G1 (via GAE domain), a subunit of adapter protein complex AP-1 (PubMed:10477754, PubMed:10814529, PubMed:12538641, PubMed:14665628).

Interacts with AP1G2 (via GAE domain) a subunit of adapter protein complex AP-1 (PubMed:10814529, PubMed:14665628).

Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated trafficking of transferrin from early to recycling endosomes (PubMed:15758025). Within the complex interacts with AFTPH/aftiphilin and HEATR5B/p200a; the interactions are direct (PubMed:15758025).

Interacts (via EH domain) with SCAMP1 (By similarity).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116432, 26 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9UMZ2

Protein interaction database and analysis system

More...
IntActi
Q9UMZ2, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9UMZ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UMZ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UMZ2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 388EHPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni178 – 199DisorderedSequence analysisAdd BLAST22
Regioni460 – 498DisorderedSequence analysisAdd BLAST39
Regioni518 – 786Interaction with AP1G11 PublicationAdd BLAST269
Regioni666 – 678Interaction with AP1G1, AP1G2 and GGA11 PublicationAdd BLAST13
Regioni972 – 1026DisorderedSequence analysisAdd BLAST55
Regioni1073 – 1102DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili115 – 155Sequence analysisAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi457 – 461DFXDF motif 15
Motifi690 – 694DFXDF motif 25
Motifi775 – 779DFXDF motif 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi463 – 496Polar residuesSequence analysisAdd BLAST34
Compositional biasi974 – 994Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi995 – 1023Polar residuesSequence analysisAdd BLAST29
Compositional biasi1079 – 1096Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0998, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_263817_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UMZ2

Identification of Orthologs from Complete Genome Data

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OMAi
GPIAMQX

Database of Orthologous Groups

More...
OrthoDBi
226328at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UMZ2

TreeFam database of animal gene trees

More...
TreeFami
TF316700

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052, EH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR000261, EH_dom
IPR039656, SYNRG

The PANTHER Classification System

More...
PANTHERi
PTHR15463, PTHR15463, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00027, EH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50031, EH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UMZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRPGAGSG GGGAAGAGAG SAGGGGFMFP VAGGIRPPQA GLMPMQQQGF
60 70 80 90 100
PMVSVMQPNM QGIMGMNYSS QMSQGPIAMQ AGIPMGPMPA AGMPYLGQAP
110 120 130 140 150
FLGMRPPGPQ YTPDMQKQFA EEQQKRFEQQ QKLLEEERKR RQFEEQKQKL
160 170 180 190 200
RLLSSVKPKT GEKSRDDALE AIKGNLDGFS RDAKMHPTPA SHPKKPGPSL
210 220 230 240 250
EEKFLVSCDI STSGQEQIKL NTSEVGHKAL GPGSSKKYPS LMASNGVAVD
260 270 280 290 300
GCVSGTTTAE AENTSDQNLS IEESGVGVFP SQDPAQPRMP PWIYNESLVP
310 320 330 340 350
DAYKKILETT MTPTGIDTAK LYPILMSSGL PRETLGQIWA LANRTTPGKL
360 370 380 390 400
TKEELYTVLA MIAVTQRGVP AMSPDALNQF PAAPIPTLSG FSMTLPTPVS
410 420 430 440 450
QPTVIPSGPA GSMPLSLGQP VMGINLVGPV GGAAAQASSG FIPTYPANQV
460 470 480 490 500
VKPEEDDFQD FQDASKSGSL DDSFSDFQEL PASSKTSNSQ HGNSAPSLLM
510 520 530 540 550
PLPGTKALPS MDKYAVFKGI AADKSSENTV PPGDPGDKYS AFRELEQTAE
560 570 580 590 600
NKPLGESFAE FRSAGTDDGF TDFKTADSVS PLEPPTKDKT FPPSFPSGTI
610 620 630 640 650
QQKQQTQVKN PLNLADLDMF SSVNCSSEKP LSFSAVFSTS KSVSTPQSTG
660 670 680 690 700
SAATMTALAA TKTSSLADDF GEFSLFGEYS GLAPVGEQDD FADFMAFSNS
710 720 730 740 750
SISSEQKPDD KYDALKEEAS PVPLTSNVGS TVKGGQNSTA ASTKYDVFRQ
760 770 780 790 800
LSLEGSGLGV EDLKDNTPSG KSDDDFADFH SSKFSSINSD KSLGEKAVAF
810 820 830 840 850
RHTKEDSASV KSLDLPSIGG SSVGKEDSED ALSVQFDMKL ADVGGDLKHV
860 870 880 890 900
MSDSSLDLPT VSGQHPPAAD IEDLKYAAFG SYSSNFAVST LTSYDWSDRD
910 920 930 940 950
DATQGRKLSP FVLSAGSGSP SATSILQKKE TSFGSSENIT MTSLSKVTTF
960 970 980 990 1000
VSEDALPETT FPALASFKDT IPQTSEQKEY ENRDYKDFTK QDLPTAERSQ
1010 1020 1030 1040 1050
EATCPSPASS GASQETPNEC SDDFGEFQSE KPKISKFDFL VATSQSKMKS
1060 1070 1080 1090 1100
SEEMIKSELA TFDLSVQGSH KRSLSLGDKE ISRSSPSPAL EQPFRDRSNT
1110 1120 1130 1140 1150
LNEKPALPVI RDKYKDLTGE VEENERYAYE WQRCLGSALN VIKKANDTLN
1160 1170 1180 1190 1200
GISSSSVCTE VIQSAQGMEY LLGVVEVYRV TKRVELGIKA TAVCSEKLQQ
1210 1220 1230 1240 1250
LLKDIDKVWN NLIGFMSLAT LTPDENSLDF SSCMLRPGIK NAQELACGVC
1260 1270 1280 1290 1300
LLNVDSRSRK EEKPAEEHPK KAFNSETDSF KLAYGGHQYH ASCANFWINC
1310
VEPKPPGLVL PDLL
Length:1,314
Mass (Da):140,654
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70C105203EF0BBBF
GO
Isoform 2 (identifier: Q9UMZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.

Show »
Length:1,236
Mass (Da):132,654
Checksum:iD22A62B08D8E0B01
GO
Isoform 3 (identifier: Q9UMZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     1260-1271: Missing.

Show »
Length:1,224
Mass (Da):131,222
Checksum:i3D54B7286CED8226
GO
Isoform 4 (identifier: Q9UMZ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1260-1271: Missing.

Show »
Length:1,302
Mass (Da):139,223
Checksum:i35E8013E37F73B80
GO
Isoform 5 (identifier: Q9UMZ2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     366-448: Missing.
     870-914: Missing.

Show »
Length:1,108
Mass (Da):119,509
Checksum:iF31FEC0F4F4515FC
GO
Isoform 6 (identifier: Q9UMZ2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     1222-1222: T → TCCWEKMTVITKHLSPYHELLEEK

Show »
Length:1,259
Mass (Da):135,454
Checksum:i00E53A7CC4AC2FC5
GO
Isoform 7 (identifier: Q9UMZ2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.
     198-275: Missing.

Show »
Length:1,235
Mass (Da):132,582
Checksum:iC243DC3D72946E67
GO
Isoform 8 (identifier: Q9UMZ2-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-275: Missing.
     870-914: Missing.
     1260-1271: Missing.

Show »
Length:1,179
Mass (Da):126,214
Checksum:iBAEC72332586ED58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZS7A0A087WZS7_HUMAN
Synergin gamma
SYNRG
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZF6A0A087WZF6_HUMAN
Synergin gamma
SYNRG
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW94A0A087WW94_HUMAN
Synergin gamma
SYNRG
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK126988 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213S → P in AK126988 (PubMed:14702039).Curated1
Sequence conflicti349K → R in AK126988 (PubMed:14702039).Curated1
Sequence conflicti1123E → K in AAD49732 (PubMed:10477754).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05139540A → G. Corresponds to variant dbSNP:rs12944821Ensembl.1
Natural variantiVAR_051396222T → A. Corresponds to variant dbSNP:rs12602536Ensembl.1
Natural variantiVAR_0807681183R → H Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs370465279Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05473240Missing in isoform 7. 1 Publication1
Alternative sequenceiVSP_023015198 – 275Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_043281366 – 448Missing in isoform 5. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_043282870 – 914Missing in isoform 5 and isoform 8. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0547331222T → TCCWEKMTVITKHLSPYHEL LEEK in isoform 6. Curated1
Alternative sequenceiVSP_0230161260 – 1271Missing in isoform 3, isoform 4 and isoform 8. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF169548 mRNA Translation: AAD49732.1
AC004099 Genomic DNA No translation available.
AC091199 Genomic DNA No translation available.
BC090930 mRNA Translation: AAH90930.1
BC117313 mRNA Translation: AAI17314.1
BC143476 mRNA Translation: AAI43477.1
BC143478 mRNA Translation: AAI43479.1
AK126988 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11321.1 [Q9UMZ2-1]
CCDS11322.2 [Q9UMZ2-4]
CCDS54113.1 [Q9UMZ2-6]
CCDS54114.1 [Q9UMZ2-7]
CCDS59284.1 [Q9UMZ2-8]
CCDS59285.1 [Q9UMZ2-9]

NCBI Reference Sequences

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RefSeqi
NP_001157016.1, NM_001163544.2 [Q9UMZ2-3]
NP_001157017.1, NM_001163545.2 [Q9UMZ2-8]
NP_001157018.1, NM_001163546.2 [Q9UMZ2-9]
NP_001157019.1, NM_001163547.2 [Q9UMZ2-6]
NP_009178.3, NM_007247.5 [Q9UMZ2-1]
NP_542117.3, NM_080550.4 [Q9UMZ2-4]
NP_942583.1, NM_198882.2 [Q9UMZ2-7]
XP_016879582.1, XM_017024093.1 [Q9UMZ2-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000610513; ENSP00000478707; ENSG00000274047 [Q9UMZ2-6]
ENST00000612223; ENSP00000483453; ENSG00000275066 [Q9UMZ2-1]
ENST00000613407; ENSP00000483152; ENSG00000274047 [Q9UMZ2-7]
ENST00000614941; ENSP00000481151; ENSG00000275066 [Q9UMZ2-6]
ENST00000616179; ENSP00000482962; ENSG00000275066 [Q9UMZ2-9]
ENST00000618176; ENSP00000482597; ENSG00000274047 [Q9UMZ2-4]
ENST00000618402; ENSP00000480288; ENSG00000274047 [Q9UMZ2-1]
ENST00000619541; ENSP00000477885; ENSG00000275066 [Q9UMZ2-8]
ENST00000621136; ENSP00000484529; ENSG00000275066 [Q9UMZ2-4]
ENST00000622045; ENSP00000483063; ENSG00000275066 [Q9UMZ2-7]
ENST00000632841; ENSP00000487672; ENSG00000274047 [Q9UMZ2-9]
ENST00000633429; ENSP00000488473; ENSG00000274047 [Q9UMZ2-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11276

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11276

UCSC genome browser

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UCSCi
uc002hoa.4, human [Q9UMZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169548 mRNA Translation: AAD49732.1
AC004099 Genomic DNA No translation available.
AC091199 Genomic DNA No translation available.
BC090930 mRNA Translation: AAH90930.1
BC117313 mRNA Translation: AAI17314.1
BC143476 mRNA Translation: AAI43477.1
BC143478 mRNA Translation: AAI43479.1
AK126988 mRNA No translation available.
CCDSiCCDS11321.1 [Q9UMZ2-1]
CCDS11322.2 [Q9UMZ2-4]
CCDS54113.1 [Q9UMZ2-6]
CCDS54114.1 [Q9UMZ2-7]
CCDS59284.1 [Q9UMZ2-8]
CCDS59285.1 [Q9UMZ2-9]
RefSeqiNP_001157016.1, NM_001163544.2 [Q9UMZ2-3]
NP_001157017.1, NM_001163545.2 [Q9UMZ2-8]
NP_001157018.1, NM_001163546.2 [Q9UMZ2-9]
NP_001157019.1, NM_001163547.2 [Q9UMZ2-6]
NP_009178.3, NM_007247.5 [Q9UMZ2-1]
NP_542117.3, NM_080550.4 [Q9UMZ2-4]
NP_942583.1, NM_198882.2 [Q9UMZ2-7]
XP_016879582.1, XM_017024093.1 [Q9UMZ2-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MX7NMR-A279-388[»]
SMRiQ9UMZ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116432, 26 interactors
ELMiQ9UMZ2
IntActiQ9UMZ2, 14 interactors
MINTiQ9UMZ2
STRINGi9606.ENSP00000483453

PTM databases

iPTMnetiQ9UMZ2
MetOSiteiQ9UMZ2
PhosphoSitePlusiQ9UMZ2

Genetic variation databases

BioMutaiSYNRG
DMDMi143811464

Proteomic databases

EPDiQ9UMZ2
jPOSTiQ9UMZ2
MassIVEiQ9UMZ2
PaxDbiQ9UMZ2
PeptideAtlasiQ9UMZ2
PRIDEiQ9UMZ2
ProteomicsDBi2266
85232 [Q9UMZ2-1]
85233 [Q9UMZ2-3]
85234 [Q9UMZ2-4]
85235 [Q9UMZ2-5]
85236 [Q9UMZ2-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
74878, 32 antibodies

The DNASU plasmid repository

More...
DNASUi
11276

Genome annotation databases

EnsembliENST00000610513; ENSP00000478707; ENSG00000274047 [Q9UMZ2-6]
ENST00000612223; ENSP00000483453; ENSG00000275066 [Q9UMZ2-1]
ENST00000613407; ENSP00000483152; ENSG00000274047 [Q9UMZ2-7]
ENST00000614941; ENSP00000481151; ENSG00000275066 [Q9UMZ2-6]
ENST00000616179; ENSP00000482962; ENSG00000275066 [Q9UMZ2-9]
ENST00000618176; ENSP00000482597; ENSG00000274047 [Q9UMZ2-4]
ENST00000618402; ENSP00000480288; ENSG00000274047 [Q9UMZ2-1]
ENST00000619541; ENSP00000477885; ENSG00000275066 [Q9UMZ2-8]
ENST00000621136; ENSP00000484529; ENSG00000275066 [Q9UMZ2-4]
ENST00000622045; ENSP00000483063; ENSG00000275066 [Q9UMZ2-7]
ENST00000632841; ENSP00000487672; ENSG00000274047 [Q9UMZ2-9]
ENST00000633429; ENSP00000488473; ENSG00000274047 [Q9UMZ2-8]
GeneIDi11276
KEGGihsa:11276
UCSCiuc002hoa.4, human [Q9UMZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11276
DisGeNETi11276

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SYNRG
HGNCiHGNC:557, SYNRG
HPAiENSG00000275066, Low tissue specificity
MIMi607291, gene
neXtProtiNX_Q9UMZ2
OpenTargetsiENSG00000275066
PharmGKBiPA24847
VEuPathDBiHostDB:ENSG00000275066.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0998, Eukaryota
GeneTreeiENSGT00390000010789
HOGENOMiCLU_263817_0_0_1
InParanoidiQ9UMZ2
OMAiGPIAMQX
OrthoDBi226328at2759
PhylomeDBiQ9UMZ2
TreeFamiTF316700

Enzyme and pathway databases

PathwayCommonsiQ9UMZ2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11276, 7 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYNRG, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Synergin_gamma

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11276
PharosiQ9UMZ2, Tdark

Protein Ontology

More...
PROi
PR:Q9UMZ2
RNActiQ9UMZ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000275066, Expressed in pituitary gland and 243 other tissues
ExpressionAtlasiQ9UMZ2, baseline and differential
GenevisibleiQ9UMZ2, HS

Family and domain databases

CDDicd00052, EH, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR000261, EH_dom
IPR039656, SYNRG
PANTHERiPTHR15463, PTHR15463, 1 hit
SMARTiView protein in SMART
SM00027, EH, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50031, EH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNRG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UMZ2
Secondary accession number(s): A8MWU4
, B7ZKZ2, B7ZKZ3, Q17RI2, Q5BKU5, Q6ZT17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: April 3, 2007
Last modified: June 2, 2021
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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