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Protein

Nucleolar protein 7

Gene

NOL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 7
Alternative name(s):
Nucleolar protein of 27 kDa
Gene namesi
Name:NOL7
Synonyms:C6orf90, NOP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000225921.6
HGNCiHGNC:21040 NOL7
MIMi611533 gene
neXtProtiNX_Q9UMY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51406
OpenTargetsiENSG00000225921
PharmGKBiPA134881915

Polymorphism and mutation databases

BioMutaiNOL7
DMDMi71152014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969371 – 257Nucleolar protein 7Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei133PhosphoserineCombined sources1
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UMY1
PaxDbiQ9UMY1
PeptideAtlasiQ9UMY1
PRIDEiQ9UMY1
ProteomicsDBi85228
85229 [Q9UMY1-2]
TopDownProteomicsiQ9UMY1-1 [Q9UMY1-1]
Q9UMY1-2 [Q9UMY1-2]

2D gel databases

SWISS-2DPAGEiQ9UMY1

PTM databases

iPTMnetiQ9UMY1
PhosphoSitePlusiQ9UMY1

Expressioni

Tissue specificityi

Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000225921
CleanExiHS_NOL7
ExpressionAtlasiQ9UMY1 baseline and differential
GenevisibleiQ9UMY1 HS

Organism-specific databases

HPAiHPA029185
HPA049693

Interactioni

Protein-protein interaction databases

BioGridi119526, 17 interactors
IntActiQ9UMY1, 6 interactors
MINTiQ9UMY1
STRINGi9606.ENSP00000405674

Structurei

3D structure databases

ProteinModelPortaliQ9UMY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 104Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0GQ Eukaryota
ENOG410YNFM LUCA
GeneTreeiENSGT00390000004118
HOGENOMiHOG000220870
HOVERGENiHBG079866
InParanoidiQ9UMY1
OMAiNNAWGTQ
OrthoDBiEOG091G0WWD
PhylomeDBiQ9UMY1
TreeFamiTF336320

Family and domain databases

InterProiView protein in InterPro
IPR012579 NOL7_C
PfamiView protein in Pfam
PF08157 NUC129, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UMY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLRPRASR APASAEAMVD EGQLASEEEE AEHGLLLGQP SSGAAAEPLE
60 70 80 90 100
EDEEGDDEFD DEAPEELTFA SAQAEAREEE RRVRETVRRD KTLLKEKRKR
110 120 130 140 150
REELFIEQKK RKLLPDTILE KLTTASQTNI KKSPGKVKEV NLQKKNEDCE
160 170 180 190 200
KGNDSKKVKV QKVQSVSQNK SYLAVRLKDQ DLRDSRQQAA QAFIHNSLYG
210 220 230 240 250
PGTNRTTVNK FLSLANKRLP VKRAAVQFLN NAWGIQKKQN AKRFKRRWMV

RKMKTKK
Length:257
Mass (Da):29,426
Last modified:June 1, 2001 - v2
Checksum:i84DB1906362263AF
GO
Isoform 2 (identifier: Q9UMY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-145: VNLQKK → GMTILI
     146-257: Missing.

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:145
Mass (Da):16,329
Checksum:iBD0EA7ECEAC773C6
GO

Sequence cautioni

The sequence CAB43398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAI19840 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200G → A in CAB43398 (PubMed:17974005).Curated1
Sequence conflicti209N → D in CAB43398 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014791140 – 145VNLQKK → GMTILI in isoform 2. Curated6
Alternative sequenceiVSP_014792146 – 257Missing in isoform 2. CuratedAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172066 mRNA Translation: AAD49745.2
AK075301 mRNA Translation: BAC11534.1
AL441883 Genomic DNA Translation: CAI19839.1
AL441883 Genomic DNA Translation: CAI19840.1 Sequence problems.
BC023517 mRNA Translation: AAH23517.1
BC062683 mRNA Translation: AAH62683.1
AL050299 mRNA Translation: CAB43398.1 Sequence problems.
CCDSiCCDS4528.1 [Q9UMY1-1]
PIRiT08718
RefSeqiNP_001304653.1, NM_001317724.1 [Q9UMY1-1]
NP_057251.2, NM_016167.4 [Q9UMY1-1]
UniGeneiHs.306242
Hs.708182

Genome annotation databases

EnsembliENST00000451315; ENSP00000405674; ENSG00000225921 [Q9UMY1-1]
GeneIDi51406
KEGGihsa:51406
UCSCiuc003naz.4 human [Q9UMY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNOL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UMY1
Secondary accession number(s): Q5T297, Q9Y3U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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