Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 192 (17 Jun 2020)
Sequence version 2 (01 Mar 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ubiquilin-1

Gene

UBQLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).1 PublicationBy similarity9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquilin-1
Alternative name(s):
Protein linking IAP with cytoskeleton 1
Short name:
PLIC-1
Short name:
hPLIC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBQLN1
Synonyms:DA41, PLIC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135018.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12508 UBQLN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605046 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UMX0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29979

Open Targets

More...
OpenTargetsi
ENSG00000135018

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37155

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UMX0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBQLN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48475013

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002110082 – 589Ubiquilin-1Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded during both macroautophagy and during chaperone-mediated autophagy (CMA).1 Publication
Phosphorylated.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UMX0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UMX0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UMX0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UMX0

PeptideAtlas

More...
PeptideAtlasi
Q9UMX0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UMX0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85215 [Q9UMX0-1]
85216 [Q9UMX0-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00071180

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UMX0

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9UMX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UMX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain (at protein level) (PubMed:18953672). Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135018 Expressed in placenta and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UMX0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UMX0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135018 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Heterodimer with UBQLN2 (PubMed:16813565). Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3 (By similarity). Binds UBE3A, BTRC, P4HB and MTOR.

Interacts with the proteasome 19S subunit.

Interacts (via ubiquitin-like domain) with TREX1; the interaction is direct and may control TREX1 subcellular location.

Forms a complex with UBXN4 and VCP.

Interacts (via UBA domain) with UBQLN4 (via ubiquitin-like domain).

Found in a complex with UBQLN2 and MAP1LC3A/B/C. The monomeric form interacts with PSEN2 and the monomeric forms of isoform 1 and isoform 3 interact with PSEN1.

Interacts with ORAI1.

Interacts (via UBA domain) with TICAM1.

Interacts with EPS15.

Interacts (via UBA domain) with UBA52 and (via ubiquitin-like domain) with PSMD3 and PSMD4.

Interacts with HERPUD1.

Interacts with MAP1LC3A/B/C in the presence of UBQLN4.

Interacts (via ubiquitin-like domain) with EPS15 (via UIM domains) and both the ubiquitinated and non-ubiquitinated forms can interact with EPS15.

Interacts (via ubiquitin-like domain) with EPS15L1, HGS (via UIM domain) and STAM2 (via UIM domain).

By similarity17 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UMX0
With#Exp.IntAct
ACOT7 [O00154]3EBI-741480,EBI-948905
ACOT7 - isoform 4 [O00154-4]3EBI-741480,EBI-12007918
ADRM1 [Q16186]4EBI-741480,EBI-954387
AGPAT5 [Q9NUQ2]6EBI-741480,EBI-6916385
AGR2 [O95994]9EBI-741480,EBI-712648
AGR3 [Q8TD06]4EBI-741480,EBI-3925742
ANOS1 [P23352]3EBI-741480,EBI-5272188
APOC4 [P55056]3EBI-741480,EBI-18302142
ASCL1 [P50553]3EBI-741480,EBI-957042
BAG6 - isoform 2 [P46379-2]3EBI-741480,EBI-10988864
BPIFA1 [Q9NP55]3EBI-741480,EBI-953896
C1QTNF4 [Q9BXJ3]3EBI-741480,EBI-11955105
C5orf56 [Q8N8D9]3EBI-741480,EBI-18100531
CCL3 [P10147]3EBI-741480,EBI-8459634
CCL7 [P80098]3EBI-741480,EBI-718759
CD99L2 [Q8TCZ2]6EBI-741480,EBI-2824782
CDIP1 [Q9H305]3EBI-741480,EBI-2876678
COL10A1 [Q03692]6EBI-741480,EBI-2528309
COL1A2 [P08123]6EBI-741480,EBI-983038
COL9A2 [Q14055]3EBI-741480,EBI-714971
CSN3 [P07498]3EBI-741480,EBI-2602175
CSTF2 [P33240]7EBI-741480,EBI-711360
CSTF2T [Q9H0L4]7EBI-741480,EBI-747012
CTAG1A [P78358]6EBI-741480,EBI-1188472
CTAG2 - isoform LAGE-1A [O75638-2]3EBI-741480,EBI-12265122
CYB5R1 [Q9UHQ9]3EBI-741480,EBI-953870
DAZAP2 [Q15038]3EBI-741480,EBI-724310
DEFA6 [Q01524]4EBI-741480,EBI-10222451
DEFB115 [Q30KQ5]3EBI-741480,EBI-12253292
DESI1 [Q6ICB0]6EBI-741480,EBI-2806959
DEXI [O95424]3EBI-741480,EBI-724515
DMKN [Q6E0U4]3EBI-741480,EBI-7943171
DOLK [A0A0S2Z5Y1]3EBI-741480,EBI-16431159
ECM1 [Q16610]3EBI-741480,EBI-947964
EFEMP2 [O95967]5EBI-741480,EBI-743414
EPS15 [P42566]5EBI-741480,EBI-396684
ERP27 [Q96DN0]4EBI-741480,EBI-953772
ERP29 [P30040]3EBI-741480,EBI-946830
ETNK1 [Q9HBU6]3EBI-741480,EBI-2834493
FAM163B [P0C2L3]3EBI-741480,EBI-11793223
FCGR2A [P12318]3EBI-741480,EBI-1395970
FKBP2 [P26885]3EBI-741480,EBI-719873
FN1 [P02751]3EBI-741480,EBI-1220319
FOLR3 [P41439]3EBI-741480,EBI-12893875
FZD7 [O75084]5EBI-741480,EBI-746917
GABRD [O14764]4EBI-741480,EBI-744352
GAL [P22466]3EBI-741480,EBI-6624768
GHRL [Q9UBU3]3EBI-741480,EBI-10319458
GPR162 [Q16538]3EBI-741480,EBI-22387200
GUCA2A [Q02747]3EBI-741480,EBI-12244272
GUCA2B [Q16661]3EBI-741480,EBI-12349759
GYPB [P06028]6EBI-741480,EBI-10194756
HK2 [P52789]4EBI-741480,EBI-741469
HSD17B12 [Q53GQ0]3EBI-741480,EBI-2963255
HSPA13 [P48723]8EBI-741480,EBI-750892
IER3IP1 [Q9Y5U9]3EBI-741480,EBI-725665
IGFBP6 [P24592]3EBI-741480,EBI-947015
IGL@ [Q6PIK1]3EBI-741480,EBI-10253735
IGL@ [Q6PIQ7]3EBI-741480,EBI-6677651
IGL@ [Q8N355]4EBI-741480,EBI-748681
IL6ST [Q17RA0]3EBI-741480,EBI-10238517
IST1 [P53990]3EBI-741480,EBI-945994
IST1 - isoform 3 [P53990-3]3EBI-741480,EBI-12188567
ITPRIPL1 [Q6GPH6]3EBI-741480,EBI-953819
JPH4 [Q96JJ6]3EBI-741480,EBI-2847044
JSRP1 [Q96MG2]3EBI-741480,EBI-11305455
KLHL42 [Q9P2K6]4EBI-741480,EBI-739890
LAIR2 [Q6ISS4]3EBI-741480,EBI-10250491
LAMB1 [P07942]3EBI-741480,EBI-949174
LCN2 [P80188]3EBI-741480,EBI-11911016
LHX4 [A0A0S2Z5S9]3EBI-741480,EBI-16429099
LITAF [Q99732]4EBI-741480,EBI-725647
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-741480,EBI-12133176
MDK [P21741]3EBI-741480,EBI-722444
MESD [Q14696]3EBI-741480,EBI-6165891
MIEF2 [Q96C03]4EBI-741480,EBI-750153
MYDGF [Q969H8]3EBI-741480,EBI-718622
NAXD [Q8IW45]3EBI-741480,EBI-8650724
NBL1 [P41271]3EBI-741480,EBI-10208650
NBL1 - isoform 2 [P41271-2]3EBI-741480,EBI-12135485
NDOR1 [Q9UHB4]3EBI-741480,EBI-10249760
NGLY1 [Q96IV0]7EBI-741480,EBI-6165879
NME3 [Q13232]6EBI-741480,EBI-713684
NPPA [P01160]3EBI-741480,EBI-953859
NXF1 [Q9UBU9]3EBI-741480,EBI-398874
OST4 [P0C6T2]3EBI-741480,EBI-18397963
PAUF [C3PTT6]3EBI-741480,EBI-3505892
PCDH18 [Q9HCL0]6EBI-741480,EBI-2949740
PCDHA4 - isoform 2 [Q9UN74-2]3EBI-741480,EBI-12184485
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-741480,EBI-348567
PIK3IP1 [Q96FE7]3EBI-741480,EBI-10285708
PLAAT1 [Q9HDD0]3EBI-741480,EBI-12387058
PLAAT2 [Q9NWW9]3EBI-741480,EBI-12253270
PLAAT3 [P53816]7EBI-741480,EBI-746318
PNMA1 [Q8ND90]4EBI-741480,EBI-302345
PPIB [P23284]3EBI-741480,EBI-359252
PPIC [P45877]3EBI-741480,EBI-953909
PRAP1 [Q96NZ9]6EBI-741480,EBI-2116102
PRB1 [A5D903]3EBI-741480,EBI-10173935
PRR4 [Q16378]3EBI-741480,EBI-738624
PSMD4 [P55036]4EBI-741480,EBI-359318
PSMD6 [Q15008]3EBI-741480,EBI-359701
PSORS1C2 [Q9UIG4]3EBI-741480,EBI-11974061
RAI2 [Q9Y5P3]3EBI-741480,EBI-746228
RIC8A [Q9NPQ8]4EBI-741480,EBI-717509
RIC8A - isoform 4 [Q9NPQ8-4]3EBI-741480,EBI-9091816
RNF208 [Q9H0X6]3EBI-741480,EBI-751555
RNF4 [P78317]3EBI-741480,EBI-2340927
RPN1 [P04843]4EBI-741480,EBI-355963
RPS27A [P62979]3EBI-741480,EBI-357375
RSRC2 - isoform 2 [Q7L4I2-2]3EBI-741480,EBI-10256202
RTL8A [Q9BWD3]4EBI-741480,EBI-741643
RTL8B [Q17RB0]6EBI-741480,EBI-10238588
RTL8C [A6ZKI3]6EBI-741480,EBI-10174072
SCG2 [P13521]4EBI-741480,EBI-947132
SCG5 [P05408]3EBI-741480,EBI-722635
SCMH1 [Q96GD3]3EBI-741480,EBI-713793
SERPINE1 [P05121]3EBI-741480,EBI-953978
SERPINI2 [O75830]10EBI-741480,EBI-750144
SEZ6L - isoform 5 [Q9BYH1-5]3EBI-741480,EBI-12012146
SIL1 [Q9H173]3EBI-741480,EBI-2840325
SLC16A3 [O15427]3EBI-741480,EBI-7600166
SLPI [P03973]5EBI-741480,EBI-355293
SMIM19 [Q96E16]3EBI-741480,EBI-17657124
SMIM2 [Q9BVW6]3EBI-741480,EBI-10300146
SMR3B [P02814]3EBI-741480,EBI-738612
SOD3 [P08294]3EBI-741480,EBI-10195782
SPAG8 - isoform 2 [Q99932-2]3EBI-741480,EBI-11959123
SRGN [P10124]6EBI-741480,EBI-744915
STAM2 [O75886]3EBI-741480,EBI-373258
TFF1 [P04155]6EBI-741480,EBI-743871
TMCO6 [Q96DC7]7EBI-741480,EBI-746174
TMCO6 - isoform 2 [Q96DC7-2]3EBI-741480,EBI-10284552
TMEM258 [P61165]3EBI-741480,EBI-12019210
TMEM31 [Q5JXX7]3EBI-741480,EBI-10244617
TRIM23 [P36406]3EBI-741480,EBI-740098
TRIM32 [Q13049]7EBI-741480,EBI-742790
TXNDC12 [O95881]4EBI-741480,EBI-2564581
UBA52 [P62987]3EBI-741480,EBI-357304
UBB [Q5U5U6]3EBI-741480,EBI-1642104
UBC [Q96C32]3EBI-741480,EBI-745483
UBE2I [Q7KZS0]3EBI-741480,EBI-10180829
UBE2V1 [Q13404]6EBI-741480,EBI-1050671
itself3EBI-741480,EBI-741480
UBQLN2 [Q9UHD9]3EBI-741480,EBI-947187
UBQLN4 [Q9NRR5]8EBI-741480,EBI-711226
UBXN1 [Q04323]3EBI-741480,EBI-1058647
UBXN4 [Q92575]6EBI-741480,EBI-723441
UBXN7 [O94888]3EBI-741480,EBI-1993627
VWC2 [Q2TAL6]3EBI-741480,EBI-11957238
WFDC12 [Q8WWY7]3EBI-741480,EBI-11958577
XPO4 [Q0VG75]3EBI-741480,EBI-10226948
ZBTB8B [Q8NAP8]3EBI-741480,EBI-17494306
ZG16 [O60844]10EBI-741480,EBI-746479
ZMYM4 [Q5VZL5]3EBI-741480,EBI-2514659
ZMYM5 - isoform 2 [Q9UJ78-2]3EBI-741480,EBI-17634549
ZNF343 [Q6P1L6]3EBI-741480,EBI-10252492
A0A1U9X8X83EBI-741480,EBI-17234977
Q8WU023EBI-741480,EBI-747182
Isoform 2 [Q9UMX0-2]
With#Exp.IntAct
ACOT7 [O00154]3EBI-10173939,EBI-948905
AGR2 [O95994]3EBI-10173939,EBI-712648
AGR3 [Q8TD06]3EBI-10173939,EBI-3925742
BPIFA1 [Q9NP55]3EBI-10173939,EBI-953896
C1QTNF2 [Q9BXJ5]3EBI-10173939,EBI-2817707
CALU [O43852]3EBI-10173939,EBI-1171069
CCL7 [P80098]3EBI-10173939,EBI-718759
CD99L2 [Q8TCZ2]6EBI-10173939,EBI-2824782
CLCN2 - isoform 4 [P51788-4]3EBI-10173939,EBI-16431116
COL10A1 [Q03692]3EBI-10173939,EBI-2528309
COL1A2 [A0A0S2Z3K0]3EBI-10173939,EBI-16431143
COL1A2 [P08123]6EBI-10173939,EBI-983038
COLGALT2 [Q8IYK4]3EBI-10173939,EBI-10263496
COMTD1 [Q86VU5]3EBI-10173939,EBI-2836030
CSTF2 [P33240]3EBI-10173939,EBI-711360
CSTF2T [Q9H0L4]3EBI-10173939,EBI-747012
CTAG1A [P78358]3EBI-10173939,EBI-1188472
CTAG2 [O75638]3EBI-10173939,EBI-10188927
CYB5R1 [Q9UHQ9]3EBI-10173939,EBI-953870
DEFA6 [Q01524]3EBI-10173939,EBI-10222451
DOLK [A0A0S2Z5Y1]3EBI-10173939,EBI-16431159
EFEMP2 [O95967]3EBI-10173939,EBI-743414
ERP27 [Q96DN0]3EBI-10173939,EBI-953772
ETNK1 [Q9HBU6]3EBI-10173939,EBI-2834493
FCGR2A [P12318]3EBI-10173939,EBI-1395970
FKBP2 [P26885]3EBI-10173939,EBI-719873
GABRD [O14764]3EBI-10173939,EBI-744352
GHRL [Q9UBU3]3EBI-10173939,EBI-10319458
GPX3 [P22352]3EBI-10173939,EBI-2832946
GRM2 [Q14416]3EBI-10173939,EBI-10232876
GYPB [P06028]3EBI-10173939,EBI-10194756
HK2 [P52789]3EBI-10173939,EBI-741469
HSD17B12 [Q53GQ0]3EBI-10173939,EBI-2963255
HSPA13 [P48723]3EBI-10173939,EBI-750892
IGL@ [Q6PIK1]3EBI-10173939,EBI-10253735
IGL@ [Q6PIQ7]3EBI-10173939,EBI-6677651
IGL@ [Q8N355]3EBI-10173939,EBI-748681
IL6ST [Q17RA0]3EBI-10173939,EBI-10238517
KLHL42 [Q9P2K6]3EBI-10173939,EBI-739890
LITAF [Q99732]7EBI-10173939,EBI-725647
MANBAL [Q9NQG1]3EBI-10173939,EBI-3867271
MCM7 [P33993]3EBI-10173939,EBI-355924
MIEF1 [Q9NQG6]3EBI-10173939,EBI-740987
MIEF2 [Q96C03]3EBI-10173939,EBI-750153
MLLT6 [P55198]3EBI-10173939,EBI-740216
NAXD [Q8IW45]3EBI-10173939,EBI-8650724
NBL1 [P41271]3EBI-10173939,EBI-10208650
NGLY1 [Q96IV0]3EBI-10173939,EBI-6165879
NLGN3 [A0A0S2Z5K2]3EBI-10173939,EBI-16431177
NME3 [Q13232]3EBI-10173939,EBI-713684
NUP58 [Q9BVL2]3EBI-10173939,EBI-2811583
PAUF [C3PTT6]3EBI-10173939,EBI-3505892
PBXIP1 [Q96AQ6]3EBI-10173939,EBI-740845
PIK3IP1 [Q96FE7]3EBI-10173939,EBI-10285708
PLAAT3 [P53816]3EBI-10173939,EBI-746318
PNMA1 [Q8ND90]3EBI-10173939,EBI-302345
PPIB [P23284]3EBI-10173939,EBI-359252
PPIC [P45877]3EBI-10173939,EBI-953909
PRAP1 [Q96NZ9]3EBI-10173939,EBI-2116102
PRB1 [A5D903]3EBI-10173939,EBI-10173935
PSMD6 [Q15008]3EBI-10173939,EBI-359701
RIC8A - isoform 4 [Q9NPQ8-4]3EBI-10173939,EBI-9091816
RPN1 [P04843]3EBI-10173939,EBI-355963
RTL8A [Q9BWD3]3EBI-10173939,EBI-741643
RTL8B [Q17RB0]3EBI-10173939,EBI-10238588
RTL8C [A6ZKI3]3EBI-10173939,EBI-10174072
SCG5 [P05408]3EBI-10173939,EBI-722635
SCMH1 [Q96GD3]3EBI-10173939,EBI-713793
SERPINE1 [P05121]3EBI-10173939,EBI-953978
SERPINI2 [O75830]3EBI-10173939,EBI-750144
SMIM2 [Q9BVW6]3EBI-10173939,EBI-10300146
SMR3B [P02814]3EBI-10173939,EBI-738612
SRGN [P10124]3EBI-10173939,EBI-744915
TMCO6 - isoform 2 [Q96DC7-2]3EBI-10173939,EBI-10284552
TMEM31 [Q5JXX7]3EBI-10173939,EBI-10244617
TMEM67 [A0A0S2Z5T9]3EBI-10173939,EBI-16431189
TMUB2 [Q71RG4]3EBI-10173939,EBI-2820477
TRIM32 [Q13049]3EBI-10173939,EBI-742790
TXNDC12 [O95881]3EBI-10173939,EBI-2564581
UBE2V1 [Q13404]3EBI-10173939,EBI-1050671
UBXN1 [Q04323]3EBI-10173939,EBI-1058647
UBXN4 [Q92575]3EBI-10173939,EBI-723441
XPO4 [Q0VG75]3EBI-10173939,EBI-10226948
ZFAND2B [Q8WV99]3EBI-10173939,EBI-747823
ZG16 [O60844]3EBI-10173939,EBI-746479
ZMYM4 [Q5VZL5]3EBI-10173939,EBI-2514659
Q8WU023EBI-10173939,EBI-747182
Q96FB23EBI-10173939,EBI-2857623

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119007, 270 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UMX0

Database of interacting proteins

More...
DIPi
DIP-41629N

Protein interaction database and analysis system

More...
IntActi
Q9UMX0, 213 interactors

Molecular INTeraction database

More...
MINTi
Q9UMX0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365576

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UMX0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1589
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UMX0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UMX0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 111Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75
Domaini182 – 210STI1 1Sequence analysisAdd BLAST29
Domaini212 – 251STI1 2Sequence analysisAdd BLAST40
Domaini387 – 434STI1 3Sequence analysisAdd BLAST48
Domaini438 – 470STI1 4Sequence analysisAdd BLAST33
Domaini546 – 586UBAPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni178 – 428Interaction with UBXN41 PublicationAdd BLAST251

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBA domain mediates binding to PSEN1 and PSEN2. It also binds ubiquitin with micromolar affinity, independently of polyubiquitin linkage type. Essential for its association with microtubule-associated protein 1 light chain 3 (MAP1LC3).3 Publications
The ubiquitin-like domain mediates its association with the subunits of the proteasome.1 Publication
Dimerization is dependent upon the central region of the protein containing the STI1 domains and is independent of its ubiquitin-like and UBA domains.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0010 Eukaryota
COG5272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156437

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024293_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UMX0

KEGG Orthology (KO)

More...
KOi
K04523

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMDMFGP

Database of Orthologous Groups

More...
OrthoDBi
1553668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UMX0

TreeFam database of animal gene trees

More...
TreeFami
TF314412

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf
IPR028799 UBQLN1

The PANTHER Classification System

More...
PANTHERi
PTHR10677 PTHR10677, 1 hit
PTHR10677:SF16 PTHR10677:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00727 STI1, 4 hits
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UMX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF
60 70 80 90 100
AVPENSSVQQ FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL
110 120 130 140 150
TVHLVIKTQN RPQDHSAQQT NTAGSNVTTS STPNSNSTSG SATSNPFGLG
160 170 180 190 200
GLGGLAGLSS LGLNTTNFSE LQSQMQRQLL SNPEMMVQIM ENPFVQSMLS
210 220 230 240 250
NPDLMRQLIM ANPQMQQLIQ RNPEISHMLN NPDIMRQTLE LARNPAMMQE
260 270 280 290 300
MMRNQDRALS NLESIPGGYN ALRRMYTDIQ EPMLSAAQEQ FGGNPFASLV
310 320 330 340 350
SNTSSGEGSQ PSRTENRDPL PNPWAPQTSQ SSSASSGTAS TVGGTTGSTA
360 370 380 390 400
SGTSGQSTTA PNLVPGVGAS MFNTPGMQSL LQQITENPQL MQNMLSAPYM
410 420 430 440 450
RSMMQSLSQN PDLAAQMMLN NPLFAGNPQL QEQMRQQLPT FLQQMQNPDT
460 470 480 490 500
LSAMSNPRAM QALLQIQQGL QTLATEAPGL IPGFTPGLGA LGSTGGSSGT
510 520 530 540 550
NGSNATPSEN TSPTAGTTEP GHQQFIQQML QALAGVNPQL QNPEVRFQQQ
560 570 580
LEQLSAMGFL NREANLQALI ATGGDINAAI ERLLGSQPS
Length:589
Mass (Da):62,519
Last modified:March 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B4756B6113B7025
GO
Isoform 2 (identifier: Q9UMX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-444: Missing.

Show »
Length:561
Mass (Da):59,220
Checksum:i1E0BC42EC5BA4DA6
GO
Isoform 3 (identifier: Q9UMX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-237: Missing.

Show »
Length:412
Mass (Da):43,038
Checksum:i61264678FFCAA699
GO
Isoform 4 (identifier: Q9UMX0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-181: GGLGGLAGLSSLGLNTTNFSELQSQMQRQLLS → DVGTCQESSNDAGDDEEPGPSFEQPRKHPRGI
     182-589: Missing.

Show »
Length:181
Mass (Da):18,910
Checksum:i92A3D97BF619E306
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEZ9H0YEZ9_HUMAN
Ubiquilin-1
UBQLN1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDS0H0YDS0_HUMAN
Ubiquilin-1
UBQLN1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25A → T in AAH39294 (PubMed:15489334).Curated1
Sequence conflicti41V → A in BAB20436 (PubMed:10807547).Curated1
Sequence conflicti61F → S in BAB20436 (PubMed:10807547).Curated1
Sequence conflicti91L → S in BAB20436 (PubMed:10807547).Curated1
Sequence conflicti125S → G in CAB66578 (PubMed:11230166).Curated1
Sequence conflicti202P → H in AAH39294 (PubMed:15489334).Curated1
Sequence conflicti537 – 538NP → YS in BAB20436 (PubMed:10807547).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05768961 – 237Missing in isoform 3. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_057690150 – 181GGLGG…RQLLS → DVGTCQESSNDAGDDEEPGP SFEQPRKHPRGI in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_057691182 – 589Missing in isoform 4. 1 PublicationAdd BLAST408
Alternative sequenceiVSP_009787417 – 444Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176069 mRNA Translation: AAD49751.3
AF293384 mRNA Translation: AAG02473.1
AB035275 mRNA Translation: BAB20436.1
HM005532 mRNA Translation: AEE61129.1
AL136643 mRNA Translation: CAB66578.1
AL354920 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62659.1
CH471089 Genomic DNA Translation: EAW62661.1
CH471089 Genomic DNA Translation: EAW62664.1
BC010066 mRNA Translation: AAH10066.1
BC039294 mRNA Translation: AAH39294.1
AK074535 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6663.1 [Q9UMX0-1]
CCDS6664.1 [Q9UMX0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_038466.2, NM_013438.4 [Q9UMX0-1]
NP_444295.1, NM_053067.2 [Q9UMX0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257468; ENSP00000257468; ENSG00000135018 [Q9UMX0-2]
ENST00000376395; ENSP00000365576; ENSG00000135018 [Q9UMX0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29979

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29979

UCSC genome browser

More...
UCSCi
uc004amv.4 human [Q9UMX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176069 mRNA Translation: AAD49751.3
AF293384 mRNA Translation: AAG02473.1
AB035275 mRNA Translation: BAB20436.1
HM005532 mRNA Translation: AEE61129.1
AL136643 mRNA Translation: CAB66578.1
AL354920 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62659.1
CH471089 Genomic DNA Translation: EAW62661.1
CH471089 Genomic DNA Translation: EAW62664.1
BC010066 mRNA Translation: AAH10066.1
BC039294 mRNA Translation: AAH39294.1
AK074535 mRNA No translation available.
CCDSiCCDS6663.1 [Q9UMX0-1]
CCDS6664.1 [Q9UMX0-2]
RefSeqiNP_038466.2, NM_013438.4 [Q9UMX0-1]
NP_444295.1, NM_053067.2 [Q9UMX0-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JY5NMR-A541-586[»]
2JY6NMR-B541-586[»]
2KLCNMR-A34-112[»]
SMRiQ9UMX0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119007, 270 interactors
CORUMiQ9UMX0
DIPiDIP-41629N
IntActiQ9UMX0, 213 interactors
MINTiQ9UMX0
STRINGi9606.ENSP00000365576

PTM databases

iPTMnetiQ9UMX0
MetOSiteiQ9UMX0
PhosphoSitePlusiQ9UMX0

Polymorphism and mutation databases

BioMutaiUBQLN1
DMDMi48475013

2D gel databases

REPRODUCTION-2DPAGEiIPI00071180

Proteomic databases

EPDiQ9UMX0
jPOSTiQ9UMX0
MassIVEiQ9UMX0
PaxDbiQ9UMX0
PeptideAtlasiQ9UMX0
PRIDEiQ9UMX0
ProteomicsDBi85215 [Q9UMX0-1]
85216 [Q9UMX0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27540 332 antibodies

Genome annotation databases

EnsembliENST00000257468; ENSP00000257468; ENSG00000135018 [Q9UMX0-2]
ENST00000376395; ENSP00000365576; ENSG00000135018 [Q9UMX0-1]
GeneIDi29979
KEGGihsa:29979
UCSCiuc004amv.4 human [Q9UMX0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29979
DisGeNETi29979
EuPathDBiHostDB:ENSG00000135018.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UBQLN1
HGNCiHGNC:12508 UBQLN1
HPAiENSG00000135018 Low tissue specificity
MIMi605046 gene
neXtProtiNX_Q9UMX0
OpenTargetsiENSG00000135018
PharmGKBiPA37155

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0010 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00940000156437
HOGENOMiCLU_024293_4_0_1
InParanoidiQ9UMX0
KOiK04523
OMAiGMDMFGP
OrthoDBi1553668at2759
PhylomeDBiQ9UMX0
TreeFamiTF314412

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
29979 12 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UBQLN1 human
EvolutionaryTraceiQ9UMX0

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
UBQLN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29979
PharosiQ9UMX0 Tbio

Protein Ontology

More...
PROi
PR:Q9UMX0
RNActiQ9UMX0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135018 Expressed in placenta and 208 other tissues
ExpressionAtlasiQ9UMX0 baseline and differential
GenevisibleiQ9UMX0 HS

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR015496 Ubiquilin
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf
IPR028799 UBQLN1
PANTHERiPTHR10677 PTHR10677, 1 hit
PTHR10677:SF16 PTHR10677:SF16, 1 hit
PfamiView protein in Pfam
PF00627 UBA, 1 hit
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00727 STI1, 4 hits
SM00165 UBA, 1 hit
SM00213 UBQ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBQL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UMX0
Secondary accession number(s): A0A024R284
, Q5T6J5, Q5T6J9, Q8IXS9, Q8N2Q3, Q9H0T8, Q9H3R4, Q9HAZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2002
Last modified: June 17, 2020
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again