Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9UMS5 (PHTF1_HUMAN)

Entry version 157 (02 Jun 2021)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Protein PHTF1

Gene

PHTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The PHTF domain was initially defined as an atypical homeodomain, suggesting that this protein could act as a transcription regulator (PubMed:10395808). However, the protein is not found in the nucleus and mainly localizes in the endoplasmic reticulum membrane, suggesting that it does not act as a transcription factor (By similarity).1 PublicationBy similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UMS5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PHTF1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHTF11 PublicationImported
Synonyms:PHTF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8939, PHTF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604950, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UMS5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116793.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21
Transmembranei737 – 757HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10745

Open Targets

More...OpenTargetsi		ENSG00000116793

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33278

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UMS5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PHTF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		71152973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001274231 – 762Protein PHTF1Add BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei277PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei336PhosphoserineBy similarity1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UMS5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UMS5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UMS5

PeptideAtlas

More...PeptideAtlasi		Q9UMS5

PRoteomics IDEntifications database

More...PRIDEi		Q9UMS5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85208 [Q9UMS5-1]
85209 [Q9UMS5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UMS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UMS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116793, Expressed in cerebellar hemisphere and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UMS5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UMS5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116793, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FEM1B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115968, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q9UMS5, 6 interactors

Molecular INTeraction database

More...MINTi		Q9UMS5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UMS5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UMS5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 150PHTFSequence analysisAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 184DisorderedSequence analysisAdd BLAST33
Regioni344 – 380DisorderedSequence analysisAdd BLAST37
Regioni393 – 415DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi344 – 365Polar residuesSequence analysisAdd BLAST22
Compositional biasi366 – 380Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi393 – 407Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQGQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011648

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UMS5

Identification of Orthologs from Complete Genome Data

More...OMAi		EAQTQMM

Database of Orthologous Groups

More...OrthoDBi		710715at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UMS5

TreeFam database of animal gene trees

More...TreeFami		TF323570

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039775, PHTF1/2
IPR021980, TF_homeodomain_male

The PANTHER Classification System

More...PANTHERi		PTHR12680, PTHR12680, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12129, Phtf-FEM1B_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UMS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNERDAIS WYQKKIGAYD QQIWEKSIEQ TQIKGLKNKP KKMGHIKPDL 
        60         70         80         90        100
IDVDLIRGST FAKAKPEIPW TSLTRKGLVR VVFFPLFSNW WIQVTSLRIF 
       110        120        130        140        150
VWLLLLYFMQ VIAIVLYLMM PIVNISEVLG PLCLMLLMGT VHCQIVSTQI 
       160        170        180        190        200
TRPSGNNGNR RRRKLRKTVN GDGSRENGNN SSDKVRGIET LESVPIIGGF 
       210        220        230        240        250
WETIFGNRIK RVKLISNKGT ETDNDPSCVH PIIKRRQCRP EIRMWQTREK 
       260        270        280        290        300
AKFSDGEKCR REAFRRLGNG VSDDLSSEED GEARTQMILL RRSVEGASSD 
       310        320        330        340        350
NGCEVKNRKS ILSRHLNSQV KKTTTRWCHI VRDSDSLAES EFESAAFSQG 
       360        370        380        390        400
SRSGVSGGSR SLNMSRRDSE STRHDSETED MLWDDLLHGP ECRSSVTSDS 
       410        420        430        440        450
EGAHVNTLHS GTKRDPKEDV FQQNHLFWLQ NSSPSSDRVS AIIWEGNECK 
       460        470        480        490        500
KMDMSVLEIS GIIMSRVNAY QQGVGYQMLG NVVTIGLAFF PFLHRLFREK 
       510        520        530        540        550
SLDQLKSISA EEILTLFCGA PPVTPIIVLS IINFFERLCL TWMFFFMMCV 
       560        570        580        590        600
AERTYKQRFL FAKLFSHITS ARKARKYEIP HFRLKKVENI KIWLSLRSYL 
       610        620        630        640        650
KRRGPQRSVD VVVSSVFLLT LSIAFICCAQ VLQGHKTFLN DAYNWEFLIW 
       660        670        680        690        700
ETALLLFLLR LASLGSETNK KYSNVSILLT EQINLYLKME KKPNKKEQLT 
       710        720        730        740        750
LVNNVLKLST KLLKELDTPF RLYGLTMNPL IYNITRVVIL SAVSGVISDL 
       760 
LGFNIRLWKI KS
Length:762
Mass (Da):87,252
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0813B7A668262DD9
GO
Isoform 2 (identifier: Q9UMS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-637: LQGHKT → KVSHLL
     638-762: Missing.

Show »
Length:637
Mass (Da):72,805
Checksum:i0F1280AC492AAC33
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TCQ5Q5TCQ5_HUMAN
Protein PHTF1
PHTF1
717Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TCQ3Q5TCQ3_HUMAN
Protein PHTF1
PHTF1
709Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y825H0Y825_HUMAN
Protein PHTF1
PHTF1
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T5D1F6T5D1_HUMAN
Protein PHTF1
PHTF1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245W → C in CAB51572 (PubMed:10395808).Curated1
Sequence conflicti251A → P in CAB51572 (PubMed:10395808).Curated1
Sequence conflicti518C → G in CAB51572 (PubMed:10395808).Curated1
Sequence conflicti529L → W in CAB51572 (PubMed:10395808).Curated1
Sequence conflicti638F → S in CAB51572 (PubMed:10395808).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002144632 – 637LQGHKT → KVSHLL in isoform 2. 1 Publication6
Alternative sequenceiVSP_002145638 – 762Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ011863 mRNA Translation: CAB51572.1
AL365321 Genomic DNA No translation available.
AL133517 Genomic DNA No translation available.
BC002447 mRNA Translation: AAH02447.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS81359.1 [Q9UMS5-2]
CCDS861.1 [Q9UMS5-1]

NCBI Reference Sequences

More...RefSeqi		NP_001309970.1, NM_001323041.1 [Q9UMS5-1]
NP_001309971.1, NM_001323042.1 [Q9UMS5-1]
NP_001309972.1, NM_001323043.1 [Q9UMS5-1]
NP_001309976.1, NM_001323047.1 [Q9UMS5-2]
NP_001309977.1, NM_001323048.1 [Q9UMS5-2]
NP_001309978.1, NM_001323049.1 [Q9UMS5-2]
NP_006599.2, NM_006608.2 [Q9UMS5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357783; ENSP00000350428; ENSG00000116793 [Q9UMS5-2]
ENST00000369604; ENSP00000358617; ENSG00000116793 [Q9UMS5-1]
ENST00000393357; ENSP00000377025; ENSG00000116793 [Q9UMS5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10745

UCSC genome browser

More...UCSCi		uc001edn.4, human [Q9UMS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011863 mRNA Translation: CAB51572.1
AL365321 Genomic DNA No translation available.
AL133517 Genomic DNA No translation available.
BC002447 mRNA Translation: AAH02447.1
CCDSiCCDS81359.1 [Q9UMS5-2]
CCDS861.1 [Q9UMS5-1]
RefSeqiNP_001309970.1, NM_001323041.1 [Q9UMS5-1]
NP_001309971.1, NM_001323042.1 [Q9UMS5-1]
NP_001309972.1, NM_001323043.1 [Q9UMS5-1]
NP_001309976.1, NM_001323047.1 [Q9UMS5-2]
NP_001309977.1, NM_001323048.1 [Q9UMS5-2]
NP_001309978.1, NM_001323049.1 [Q9UMS5-2]
NP_006599.2, NM_006608.2 [Q9UMS5-1]

3D structure databases

SMRiQ9UMS5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115968, 7 interactors
IntActiQ9UMS5, 6 interactors
MINTiQ9UMS5
STRINGi9606.ENSP00000358617

PTM databases

iPTMnetiQ9UMS5
PhosphoSitePlusiQ9UMS5

Genetic variation databases

BioMutaiPHTF1
DMDMi71152973

Proteomic databases

EPDiQ9UMS5
MassIVEiQ9UMS5
PaxDbiQ9UMS5
PeptideAtlasiQ9UMS5
PRIDEiQ9UMS5
ProteomicsDBi85208 [Q9UMS5-1]
85209 [Q9UMS5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20143, 28 antibodies

The DNASU plasmid repository

More...DNASUi		10745

Genome annotation databases

EnsembliENST00000357783; ENSP00000350428; ENSG00000116793 [Q9UMS5-2]
ENST00000369604; ENSP00000358617; ENSG00000116793 [Q9UMS5-1]
ENST00000393357; ENSP00000377025; ENSG00000116793 [Q9UMS5-1]
GeneIDi10745
KEGGihsa:10745
UCSCiuc001edn.4, human [Q9UMS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10745
DisGeNETi10745

GeneCards: human genes, protein and diseases

More...GeneCardsi		PHTF1
HGNCiHGNC:8939, PHTF1
HPAiENSG00000116793, Low tissue specificity
MIMi604950, gene
neXtProtiNX_Q9UMS5
OpenTargetsiENSG00000116793
PharmGKBiPA33278
VEuPathDBiHostDB:ENSG00000116793.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQGQ, Eukaryota
GeneTreeiENSGT00390000011648
InParanoidiQ9UMS5
OMAiEAQTQMM
OrthoDBi710715at2759
PhylomeDBiQ9UMS5
TreeFamiTF323570

Enzyme and pathway databases

PathwayCommonsiQ9UMS5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10745, 6 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PHTF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10745
PharosiQ9UMS5, Tdark

Protein Ontology

More...PROi		PR:Q9UMS5
RNActiQ9UMS5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116793, Expressed in cerebellar hemisphere and 183 other tissues
ExpressionAtlasiQ9UMS5, baseline and differential
GenevisibleiQ9UMS5, HS

Family and domain databases

InterProiView protein in InterPro
IPR039775, PHTF1/2
IPR021980, TF_homeodomain_male
PANTHERiPTHR12680, PTHR12680, 1 hit
PfamiView protein in Pfam
PF12129, Phtf-FEM1B_bdg, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHTF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UMS5
Secondary accession number(s): Q5VWP7
, Q5VWP8, Q9BUP2, Q9H1X8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 19, 2005
Last modified: June 2, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again