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Entry version 172 (07 Apr 2021)
Sequence version 4 (18 May 2010)
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Protein

Lysosomal thioesterase PPT2

Gene

PPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.3 Publications

Caution

Was originally referred as a palmitoyl-protein thioesterase (palmitoyl-protein hydrolase).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=67 µM for S-palmitoyl-CoA1 Publication
  2. KM=37 µM for S-palmitoyl-N-acetylcysteamine1 Publication
  3. KM=117 µM for 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside1 Publication
  1. Vmax=1.7 µmol/min/mg enzyme toward S-palmitoyl-CoA1 Publication
  2. Vmax=3.3 µmol/min/mg enzyme toward S-palmitoyl-N-acetylcysteamine1 Publication
  3. Vmax=0.43 µmol/min/mg enzyme toward 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside1 Publication

pH dependencei

Optimum pH is 7.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei111Nucleophile1
Active sitei2281
Active sitei2831

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UMR5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-75105, Fatty acyl-CoA biosynthesis

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-PPT2, Palmitoyl-protein_thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosomal thioesterase PPT2 (EC:3.1.2.-)
Short name:
PPT-2
Alternative name(s):
S-thioesterase G14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9326, PPT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603298, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UMR5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000221988.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111S → A: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi228D → A: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi283H → A: Abolishes enzymatic activity. 1 Publication1
Mutagenesisi287H → A: No effect on enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9374

Open Targets

More...
OpenTargetsi
ENSG00000221988
ENSG00000258388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UMR5, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2189137

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453016

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002555428 – 302Lysosomal thioesterase PPT2Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 1171 Publication
Disulfide bondi165 ↔ 1761 Publication
Glycosylationi190N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 2961 Publication
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UMR5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UMR5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UMR5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UMR5

PeptideAtlas

More...
PeptideAtlasi
Q9UMR5

PRoteomics IDEntifications database

More...
PRIDEi
Q9UMR5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34200
85198 [Q9UMR5-1]
85199 [Q9UMR5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9UMR5, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UMR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed, with highest levels in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000221988, Expressed in secondary oocyte and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UMR5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UMR5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000221988, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114775, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UMR5, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354608

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UMR5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UMR5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UMR5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2541, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155779

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050129_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UMR5

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWHTRRD

Database of Orthologous Groups

More...
OrthoDBi
836806at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UMR5

TreeFam database of animal gene trees

More...
TreeFami
TF323926

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR002472, Palm_thioest
IPR030295, PPT2

The PANTHER Classification System

More...
PANTHERi
PTHR11247:SF27, PTHR11247:SF27, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00414, PPTHIESTRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 23 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UMR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGLCGQRLP AAWVLLLLPF LPLLLLAAPA PHRASYKPVI VVHGLFDSSY
60 70 80 90 100
SFRHLLEYIN ETHPGTVVTV LDLFDGRESL RPLWEQVQGF REAVVPIMAK
110 120 130 140 150
APQGVHLICY SQGGLVCRAL LSVMDDHNVD SFISLSSPQM GQYGDTDYLK
160 170 180 190 200
WLFPTSMRSN LYRICYSPWG QEFSICNYWH DPHHDDLYLN ASSFLALING
210 220 230 240 250
ERDHPNATVW RKNFLRVGHL VLIGGPDDGV ITPWQSSFFG FYDANETVLE
260 270 280 290 300
MEEQLVYLRD SFGLKTLLAR GAIVRCPMAG ISHTAWHSNR TLYETCIEPW

LS
Length:302
Mass (Da):34,225
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE242D677970B4BEA
GO
Isoform 2 (identifier: Q9UMR5-2) [UniParc]FASTAAdd to basket
Also known as: I

The sequence of this isoform differs from the canonical sequence as follows:
     256-300: VYLRDSFGLK...TLYETCIEPW → PARPTHQSEL...ESWGPGLSCA

Note: Catalytically inactive due to lack of His-283. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:301
Mass (Da):34,055
Checksum:i37EC25978B3FE96E
GO
Isoform 3 (identifier: Q9UMR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKSCGSM

Show »
Length:308
Mass (Da):34,819
Checksum:iE83460052465B3A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024RCQ8A0A024RCQ8_HUMAN
HCG1999928, isoform CRA_a
PPT2 hCG_1999928
302Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8X7A0A140T8X7_HUMAN
Lysosomal thioesterase PPT2
PPT2
308Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JH76A0A0G2JH76_HUMAN
Lysosomal thioesterase PPT2
PPT2
302Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLL2G8JLL2_HUMAN
Lysosomal thioesterase PPT2
PPT2
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ABN7A2ABN7_HUMAN
Lysosomal thioesterase PPT2
PPT2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLK9A0A0G2JLK9_HUMAN
Lysosomal thioesterase PPT2
PPT2
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9Y1A0A140T9Y1_HUMAN
Lysosomal thioesterase PPT2
PPT2
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JHB6A0A0G2JHB6_HUMAN
Lysosomal thioesterase PPT2
PPT2
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JKR3A0A0G2JKR3_HUMAN
Lysosomal thioesterase PPT2
PPT2
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JID8A0A0G2JID8_HUMAN
Lysosomal thioesterase PPT2
PPT2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG38577 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189L → P in CAG38577 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0271075C → W10 PublicationsCorresponds to variant dbSNP:rs3134604Ensembl.1
Natural variantiVAR_02710834A → E3 PublicationsCorresponds to variant dbSNP:rs3096696Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0540271M → MKSCGSM in isoform 3. 1 Publication1
Alternative sequenceiVSP_005188256 – 300VYLRD…CIEPW → PARPTHQSELLLLRLVCLKP PRRKKPACRVQRQSESWGPG LSCA in isoform 2. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF020543 mRNA Translation: AAB80730.1
AF020544 mRNA Translation: AAB80731.1
Y17958 mRNA Translation: CAB46981.1
AL110128 mRNA Translation: CAB53659.1
CR533546 mRNA Translation: CAG38577.1 Different initiation.
AK292729 mRNA Translation: BAF85418.1
U89336 Genomic DNA Translation: AAB47495.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03597.1
CH471081 Genomic DNA Translation: EAX03591.1
BC001355 mRNA Translation: AAH01355.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4740.1 [Q9UMR5-3]
CCDS4742.1 [Q9UMR5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191032.1, NM_001204103.1 [Q9UMR5-1]
NP_005146.4, NM_005155.6 [Q9UMR5-1]
NP_619731.2, NM_138717.2 [Q9UMR5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324816; ENSP00000320528; ENSG00000221988 [Q9UMR5-1]
ENST00000361568; ENSP00000354608; ENSG00000221988 [Q9UMR5-3]
ENST00000375137; ENSP00000364279; ENSG00000221988 [Q9UMR5-1]
ENST00000375143; ENSP00000364285; ENSG00000221988 [Q9UMR5-1]
ENST00000383301; ENSP00000372789; ENSG00000206329
ENST00000395523; ENSP00000378894; ENSG00000221988 [Q9UMR5-1]
ENST00000412651; ENSP00000416505; ENSG00000236649
ENST00000414356; ENSP00000398462; ENSG00000168452
ENST00000415972; ENSP00000408333; ENSG00000228116
ENST00000423347; ENSP00000406219; ENSG00000231618
ENST00000433748; ENSP00000410001; ENSG00000206256
ENST00000476214; ENSP00000432308; ENSG00000168452
ENST00000480383; ENSP00000432502; ENSG00000236649
ENST00000483565; ENSP00000431928; ENSG00000231618
ENST00000488579; ENSP00000434992; ENSG00000236649
ENST00000490624; ENSP00000433323; ENSG00000168452
ENST00000493809; ENSP00000436963; ENSG00000227600
ENST00000496937; ENSP00000432964; ENSG00000231618
ENST00000527704; ENSP00000433061; ENSG00000227600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9374

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9374

UCSC genome browser

More...
UCSCi
uc003nzw.4, human [Q9UMR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020543 mRNA Translation: AAB80730.1
AF020544 mRNA Translation: AAB80731.1
Y17958 mRNA Translation: CAB46981.1
AL110128 mRNA Translation: CAB53659.1
CR533546 mRNA Translation: CAG38577.1 Different initiation.
AK292729 mRNA Translation: BAF85418.1
U89336 Genomic DNA Translation: AAB47495.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03597.1
CH471081 Genomic DNA Translation: EAX03591.1
BC001355 mRNA Translation: AAH01355.1
CCDSiCCDS4740.1 [Q9UMR5-3]
CCDS4742.1 [Q9UMR5-1]
RefSeqiNP_001191032.1, NM_001204103.1 [Q9UMR5-1]
NP_005146.4, NM_005155.6 [Q9UMR5-1]
NP_619731.2, NM_138717.2 [Q9UMR5-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PJAX-ray2.70A1-302[»]
SMRiQ9UMR5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114775, 37 interactors
IntActiQ9UMR5, 9 interactors
STRINGi9606.ENSP00000354608

Chemistry databases

ChEMBLiCHEMBL2189137

Protein family/group databases

ESTHERihuman-PPT2, Palmitoyl-protein_thioesterase

PTM databases

GlyGeniQ9UMR5, 5 sites
iPTMnetiQ9UMR5

Genetic variation databases

BioMutaiPPT2
DMDMi296453016

Proteomic databases

EPDiQ9UMR5
jPOSTiQ9UMR5
MassIVEiQ9UMR5
PaxDbiQ9UMR5
PeptideAtlasiQ9UMR5
PRIDEiQ9UMR5
ProteomicsDBi34200
85198 [Q9UMR5-1]
85199 [Q9UMR5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45479, 123 antibodies

The DNASU plasmid repository

More...
DNASUi
9374

Genome annotation databases

EnsembliENST00000324816; ENSP00000320528; ENSG00000221988 [Q9UMR5-1]
ENST00000361568; ENSP00000354608; ENSG00000221988 [Q9UMR5-3]
ENST00000375137; ENSP00000364279; ENSG00000221988 [Q9UMR5-1]
ENST00000375143; ENSP00000364285; ENSG00000221988 [Q9UMR5-1]
ENST00000383301; ENSP00000372789; ENSG00000206329
ENST00000395523; ENSP00000378894; ENSG00000221988 [Q9UMR5-1]
ENST00000412651; ENSP00000416505; ENSG00000236649
ENST00000414356; ENSP00000398462; ENSG00000168452
ENST00000415972; ENSP00000408333; ENSG00000228116
ENST00000423347; ENSP00000406219; ENSG00000231618
ENST00000433748; ENSP00000410001; ENSG00000206256
ENST00000476214; ENSP00000432308; ENSG00000168452
ENST00000480383; ENSP00000432502; ENSG00000236649
ENST00000483565; ENSP00000431928; ENSG00000231618
ENST00000488579; ENSP00000434992; ENSG00000236649
ENST00000490624; ENSP00000433323; ENSG00000168452
ENST00000493809; ENSP00000436963; ENSG00000227600
ENST00000496937; ENSP00000432964; ENSG00000231618
ENST00000527704; ENSP00000433061; ENSG00000227600
GeneIDi9374
KEGGihsa:9374
UCSCiuc003nzw.4, human [Q9UMR5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9374
DisGeNETi9374

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPT2
HGNCiHGNC:9326, PPT2
HPAiENSG00000221988, Low tissue specificity
MIMi603298, gene
neXtProtiNX_Q9UMR5
OpenTargetsiENSG00000221988
ENSG00000258388
PharmGKBiPA33689
VEuPathDBiHostDB:ENSG00000221988.12

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2541, Eukaryota
GeneTreeiENSGT00940000155779
HOGENOMiCLU_050129_1_0_1
InParanoidiQ9UMR5
OMAiAWHTRRD
OrthoDBi836806at2759
PhylomeDBiQ9UMR5
TreeFamiTF323926

Enzyme and pathway databases

PathwayCommonsiQ9UMR5
ReactomeiR-HSA-75105, Fatty acyl-CoA biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9374, 16 hits in 996 CRISPR screens
EvolutionaryTraceiQ9UMR5

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9374
PharosiQ9UMR5, Tbio

Protein Ontology

More...
PROi
PR:Q9UMR5
RNActiQ9UMR5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000221988, Expressed in secondary oocyte and 211 other tissues
ExpressionAtlasiQ9UMR5, baseline and differential
GenevisibleiQ9UMR5, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002472, Palm_thioest
IPR030295, PPT2
PANTHERiPTHR11247:SF27, PTHR11247:SF27, 1 hit
PRINTSiPR00414, PPTHIESTRASE
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UMR5
Secondary accession number(s): A2ABC9
, A2ABD1, A2ARM7, A2BFH7, A2BFH9, A2BFI2, A8K9L4, B0S868, G8JLE1, O14799, Q0P6K0, Q5JP13, Q5JP14, Q5JQF0, Q5SSX4, Q5SSX5, Q5SSX6, Q5STJ4, Q5STJ5, Q5STJ6, Q6FI80, Q99945
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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