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Protein

ATP-dependent RNA helicase DDX19B

Gene

DDX19B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119ATP1
Binding sitei429ATP1
Binding sitei432ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi138 – 145ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: ProtInc
  • RNA binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.4.13 2681

Protein family/group databases

Transport Classification Database

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TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX19B (EC:3.6.4.13)
Alternative name(s):
DEAD box RNA helicase DEAD5
DEAD box protein 19B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX19B
Synonyms:DBP5, DDX19, TDBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157349.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2742 DDX19B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605812 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UMR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi223D → R: Impairs interaction with NUP214 and RNA. 1 Publication1
Mutagenesisi243E → Q: Loss of activity. 1 Publication1
Mutagenesisi258I → A: Impairs interaction with NUP214. 1 Publication1
Mutagenesisi259R → D: Impairs interaction with NUP214. 1 Publication1
Mutagenesisi262R → A: Impairs interaction with NUP214. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
11269

Open Targets

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OpenTargetsi
ENSG00000157349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27208

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX19B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
10719979

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000550222 – 479ATP-dependent RNA helicase DDX19BAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UMR2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UMR2

PeptideAtlas

More...
PeptideAtlasi
Q9UMR2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UMR2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85194
85195 [Q9UMR2-2]
85196 [Q9UMR2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UMR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UMR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000157349 Expressed in 131 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

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CleanExi
HS_DDX19B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UMR2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UMR2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037229
CAB037284
HPA046380
HPA066668

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NUP214 or RNA in a mutually exclusive manner.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116426, 152 interactors

Database of interacting proteins

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DIPi
DIP-48486N

Protein interaction database and analysis system

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IntActi
Q9UMR2, 20 interactors

Molecular INTeraction database

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MINTi
Q9UMR2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000288071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UMR2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UMR2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9UMR2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 295Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini306 – 474Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 300N-terminal lobeAdd BLAST299
Regioni55 – 68N-terminal helixAdd BLAST14
Regioni301 – 479C-terminal lobeAdd BLAST179

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi92 – 120Q motifAdd BLAST29
Motifi242 – 245DEAD box4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0332 Eukaryota
ENOG410XRGX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154417

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000268797

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107989

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UMR2

KEGG Orthology (KO)

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KOi
K18655

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UMR2

TreeFam database of animal gene trees

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TreeFami
TF314957

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UMR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDSWALAV DEQEAAAESL SNLHLKEEKI KPDTNGAVVK TNANAEKTDE
60 70 80 90 100
EEKEDRAAQS LLNKLIRSNL VDNTNQVEVL QRDPNSPLYS VKSFEELRLK
110 120 130 140 150
PQLLQGVYAM GFNRPSKIQE NALPLMLAEP PQNLIAQSQS GTGKTAAFVL
160 170 180 190 200
AMLSQVEPAN KYPQCLCLSP TYELALQTGK VIEQMGKFYP ELKLAYAVRG
210 220 230 240 250
NKLERGQKIS EQIVIGTPGT VLDWCSKLKF IDPKKIKVFV LDEADVMIAT
260 270 280 290 300
QGHQDQSIRI QRMLPRNCQM LLFSATFEDS VWKFAQKVVP DPNVIKLKRE
310 320 330 340 350
EETLDTIKQY YVLCSSRDEK FQALCNLYGA ITIAQAMIFC HTRKTASWLA
360 370 380 390 400
AELSKEGHQV ALLSGEMMVE QRAAVIERFR EGKEKVLVTT NVCARGIDVE
410 420 430 440 450
QVSVVINFDL PVDKDGNPDN ETYLHRIGRT GRFGKRGLAV NMVDSKHSMN
460 470
ILNRIQEHFN KKIERLDTDD LDEIEKIAN
Length:479
Mass (Da):53,927
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F6F93B12B7E9871
GO
Isoform 2 (identifier: Q9UMR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-130: Missing.

Show »
Length:448
Mass (Da):50,490
Checksum:i178321CBF4CA276A
GO
Isoform 3 (identifier: Q9UMR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Show »
Length:370
Mass (Da):41,779
Checksum:iA268A0E259FCF3E2
GO
Isoform 4 (identifier: Q9UMR2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MATDSWALAVDEQEAAAES → MAGAAGRVQDRALRRFPITLPVGD
     100-130: Missing.

Note: No experimental confirmation available.
Show »
Length:453
Mass (Da):51,063
Checksum:i6D543611ED7E4BFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQK0H3BQK0_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B hCG_1998531
484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMQ5H3BMQ5_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QDS0F6QDS0_HUMAN
HCG2043426, isoform CRA_b
hCG_2043426
479Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN59H3BN59_HUMAN
Uncharacterized protein
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTX1H3BTX1_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPV3H3BPV3_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMV7H3BMV7_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUH0H3BUH0_HUMAN
ATP-dependent RNA helicase DDX19B
DDX19B
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128A → V in CAG33496 (Ref. 4) Curated1
Sequence conflicti201N → Y in BAG63488 (PubMed:14702039).Curated1
Sequence conflicti331I → T in CAG33496 (Ref. 4) Curated1
Sequence conflicti367M → V in CAG38540 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052160149V → L. Corresponds to variant dbSNP:rs34607244Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413471 – 109Missing in isoform 3. 3 PublicationsAdd BLAST109
Alternative sequenceiVSP_0447271 – 19MATDS…AAAES → MAGAAGRVQDRALRRFPITL PVGD in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_015239100 – 130Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ237946 mRNA Translation: CAB52189.1
AF353720 mRNA Translation: AAK40102.1
AL136639 mRNA Translation: CAB66574.1
CR457215 mRNA Translation: CAG33496.1
CR533509 mRNA Translation: CAG38540.1
AK027378 mRNA Translation: BAG51311.1
AK301938 mRNA Translation: BAG63358.1
AK302107 mRNA Translation: BAG63488.1
AK316346 mRNA Translation: BAH14717.1
AC012184 Genomic DNA No translation available.
CH471241 Genomic DNA Translation: EAW51827.1
CH471241 Genomic DNA Translation: EAW51831.1
CH471241 Genomic DNA Translation: EAW51832.1
CH471241 Genomic DNA Translation: EAW51834.1
BC003626 mRNA Translation: AAH03626.1
BC010008 mRNA Translation: AAH10008.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10888.1 [Q9UMR2-1]
CCDS32475.1 [Q9UMR2-2]
CCDS42187.1 [Q9UMR2-3]
CCDS58478.1 [Q9UMR2-4]

NCBI Reference Sequences

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RefSeqi
NP_001014449.1, NM_001014449.2 [Q9UMR2-3]
NP_001014451.1, NM_001014451.2 [Q9UMR2-2]
NP_001244101.1, NM_001257172.1 [Q9UMR2-4]
NP_001244102.1, NM_001257173.1 [Q9UMR2-3]
NP_001244103.1, NM_001257174.1 [Q9UMR2-3]
NP_009173.1, NM_007242.5 [Q9UMR2-1]
XP_006721190.1, XM_006721127.2 [Q9UMR2-3]
XP_016878379.1, XM_017022890.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.221761

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000288071; ENSP00000288071; ENSG00000157349 [Q9UMR2-1]
ENST00000355992; ENSP00000348271; ENSG00000157349 [Q9UMR2-2]
ENST00000393657; ENSP00000377267; ENSG00000157349 [Q9UMR2-3]
ENST00000451014; ENSP00000392639; ENSG00000157349 [Q9UMR2-4]
ENST00000563392; ENSP00000456574; ENSG00000157349 [Q9UMR2-3]
ENST00000568625; ENSP00000456757; ENSG00000157349 [Q9UMR2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11269

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11269

UCSC genome browser

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UCSCi
uc002eyo.5 human [Q9UMR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237946 mRNA Translation: CAB52189.1
AF353720 mRNA Translation: AAK40102.1
AL136639 mRNA Translation: CAB66574.1
CR457215 mRNA Translation: CAG33496.1
CR533509 mRNA Translation: CAG38540.1
AK027378 mRNA Translation: BAG51311.1
AK301938 mRNA Translation: BAG63358.1
AK302107 mRNA Translation: BAG63488.1
AK316346 mRNA Translation: BAH14717.1
AC012184 Genomic DNA No translation available.
CH471241 Genomic DNA Translation: EAW51827.1
CH471241 Genomic DNA Translation: EAW51831.1
CH471241 Genomic DNA Translation: EAW51832.1
CH471241 Genomic DNA Translation: EAW51834.1
BC003626 mRNA Translation: AAH03626.1
BC010008 mRNA Translation: AAH10008.1
CCDSiCCDS10888.1 [Q9UMR2-1]
CCDS32475.1 [Q9UMR2-2]
CCDS42187.1 [Q9UMR2-3]
CCDS58478.1 [Q9UMR2-4]
RefSeqiNP_001014449.1, NM_001014449.2 [Q9UMR2-3]
NP_001014451.1, NM_001014451.2 [Q9UMR2-2]
NP_001244101.1, NM_001257172.1 [Q9UMR2-4]
NP_001244102.1, NM_001257173.1 [Q9UMR2-3]
NP_001244103.1, NM_001257174.1 [Q9UMR2-3]
NP_009173.1, NM_007242.5 [Q9UMR2-1]
XP_006721190.1, XM_006721127.2 [Q9UMR2-3]
XP_016878379.1, XM_017022890.1
UniGeneiHs.221761

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EWSX-ray2.70A/B54-475[»]
3FHCX-ray2.80B68-302[»]
3FHTX-ray2.20A/B68-479[»]
3FMOX-ray2.51B1-300[»]
3FMPX-ray3.19B/D1-479[»]
3G0HX-ray2.70A54-475[»]
6B4IX-ray3.62E/F54-479[»]
6B4JX-ray3.40E/F54-479[»]
6B4KX-ray2.20A/B54-479[»]
ProteinModelPortaliQ9UMR2
SMRiQ9UMR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116426, 152 interactors
DIPiDIP-48486N
IntActiQ9UMR2, 20 interactors
MINTiQ9UMR2
STRINGi9606.ENSP00000288071

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9UMR2
PhosphoSitePlusiQ9UMR2

Polymorphism and mutation databases

BioMutaiDDX19B
DMDMi10719979

Proteomic databases

EPDiQ9UMR2
PaxDbiQ9UMR2
PeptideAtlasiQ9UMR2
PRIDEiQ9UMR2
ProteomicsDBi85194
85195 [Q9UMR2-2]
85196 [Q9UMR2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11269
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288071; ENSP00000288071; ENSG00000157349 [Q9UMR2-1]
ENST00000355992; ENSP00000348271; ENSG00000157349 [Q9UMR2-2]
ENST00000393657; ENSP00000377267; ENSG00000157349 [Q9UMR2-3]
ENST00000451014; ENSP00000392639; ENSG00000157349 [Q9UMR2-4]
ENST00000563392; ENSP00000456574; ENSG00000157349 [Q9UMR2-3]
ENST00000568625; ENSP00000456757; ENSG00000157349 [Q9UMR2-3]
GeneIDi11269
KEGGihsa:11269
UCSCiuc002eyo.5 human [Q9UMR2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11269
DisGeNETi11269
EuPathDBiHostDB:ENSG00000157349.16

GeneCards: human genes, protein and diseases

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GeneCardsi
DDX19B
HGNCiHGNC:2742 DDX19B
HPAiCAB037229
CAB037284
HPA046380
HPA066668
MIMi605812 gene
neXtProtiNX_Q9UMR2
OpenTargetsiENSG00000157349
PharmGKBiPA27208

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0332 Eukaryota
ENOG410XRGX LUCA
GeneTreeiENSGT00940000154417
HOGENOMiHOG000268797
HOVERGENiHBG107989
InParanoidiQ9UMR2
KOiK18655
PhylomeDBiQ9UMR2
TreeFamiTF314957

Enzyme and pathway databases

BRENDAi3.6.4.13 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DDX19B human
EvolutionaryTraceiQ9UMR2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DDX19B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11269

Protein Ontology

More...
PROi
PR:Q9UMR2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157349 Expressed in 131 organ(s), highest expression level in testis
CleanExiHS_DDX19B
ExpressionAtlasiQ9UMR2 baseline and differential
GenevisibleiQ9UMR2 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDD19B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UMR2
Secondary accession number(s): B3KNE9
, B4DXS6, E7EMK4, Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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