DDX19B

Functionⁱ

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	119	ATP	1
Binding siteⁱ	429	ATP	1
Binding siteⁱ	432	ATP	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	138 – 145	ATP		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
helicase activity
Source: ProtInc
Traceable author statementⁱ
- 10428971
RNA binding
Source: ProtInc
Traceable author statementⁱ
- 10428971

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA export from nucleus
Source: ProtInc
Traceable author statementⁱ
- 10428971

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	mRNA transport, Protein transport, Translocation, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.4.13 2681

BRENDAⁱ

3.6.4.13 2681

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DDX19B (EC:3.6.4.13) Alternative name(s): DEAD box RNA helicase DEAD5 DEAD box protein 19B
Gene namesⁱ	Name:DDX19B Synonyms:DBP5, DDX19, TDBP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157349.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2742 DDX19B
MIMⁱ	605812 gene
neXtProtⁱ	NX_Q9UMR2

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	223	D → R: Impairs interaction with NUP214 and RNA. 1 Publication	1
Mutagenesisⁱ	243	E → Q: Loss of activity. 1 Publication	1
Mutagenesisⁱ	258	I → A: Impairs interaction with NUP214. 1 Publication	1
Mutagenesisⁱ	259	R → D: Impairs interaction with NUP214. 1 Publication	1
Mutagenesisⁱ	262	R → A: Impairs interaction with NUP214. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11269
Open Targets More...OpenTargetsⁱ	ENSG00000157349
PharmGKBⁱ	PA27208

Polymorphism and mutation databases

BioMutaⁱ	DDX19B
DMDMⁱ	10719979

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000055022	2 – 479	ATP-dependent RNA helicase DDX19BAdd BLAST		478

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9UMR2
PaxDbⁱ	Q9UMR2
PeptideAtlas More...PeptideAtlasⁱ	Q9UMR2
PRIDEⁱ	Q9UMR2
ProteomicsDBⁱ	85194 85195 [Q9UMR2-2] 85196 [Q9UMR2-3]

PTM databases

iPTMnetⁱ	Q9UMR2
PhosphoSitePlusⁱ	Q9UMR2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000157349 Expressed in 131 organ(s), highest expression level in testis
CleanExⁱ	HS_DDX19B
ExpressionAtlasⁱ	Q9UMR2 baseline and differential
Genevisibleⁱ	Q9UMR2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037229 CAB037284 HPA046380 HPA066668

HPAⁱ

CAB037229
CAB037284
HPA046380
HPA066668

Interactionⁱ

Subunit structureⁱ

Interacts with NUP214 or RNA in a mutually exclusive manner.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
MIF4GD	A9UHW6	3	EBI-719232,EBI-373498
NUP214	P35658-1	9	EBI-5773937,EBI-15757000
TERF1	P54274	2	EBI-719232,EBI-710997

Protein-protein interaction databases

BioGridⁱ	116426, 153 interactors
Database of interacting proteins More...DIPⁱ	DIP-48486N
IntActⁱ	Q9UMR2, 20 interactors
Molecular INTeraction database More...MINTⁱ	Q9UMR2
STRINGⁱ	9606.ENSP00000288071

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	56 – 66	Combined sources	11
Helixⁱ	67 – 70	Combined sources	4
Helixⁱ	76 – 80	Combined sources	5
Beta strandⁱ	82 – 86	Combined sources	5
Beta strandⁱ	92 – 94	Combined sources	3
Helixⁱ	95 – 97	Combined sources	3
Helixⁱ	101 – 109	Combined sources	9
Helixⁱ	117 – 127	Combined sources	11
Beta strandⁱ	128 – 130	Combined sources	3
Beta strandⁱ	134 – 137	Combined sources	4
Helixⁱ	144 – 155	Combined sources	12
Beta strandⁱ	165 – 168	Combined sources	4
Helixⁱ	172 – 185	Combined sources	14
Turnⁱ	186 – 188	Combined sources	3
Beta strandⁱ	194 – 197	Combined sources	4
Beta strandⁱ	212 – 216	Combined sources	5
Helixⁱ	218 – 225	Combined sources	8
Turnⁱ	226 – 228	Combined sources	3
Helixⁱ	233 – 235	Combined sources	3
Beta strandⁱ	238 – 242	Combined sources	5
Helixⁱ	244 – 248	Combined sources	5
Turnⁱ	250 – 253	Combined sources	4
Helixⁱ	254 – 262	Combined sources	9
Beta strandⁱ	269 – 275	Combined sources	7
Helixⁱ	279 – 288	Combined sources	10
Beta strandⁱ	289 – 291	Combined sources	3
Beta strandⁱ	293 – 295	Combined sources	3
Helixⁱ	299 – 301	Combined sources	3
Helixⁱ	304 – 306	Combined sources	3
Beta strandⁱ	307 – 313	Combined sources	7
Helixⁱ	317 – 331	Combined sources	15
Beta strandⁱ	332 – 339	Combined sources	8
Helixⁱ	343 – 355	Combined sources	13
Beta strandⁱ	361 – 363	Combined sources	3
Helixⁱ	369 – 380	Combined sources	12
Beta strandⁱ	385 – 389	Combined sources	5
Helixⁱ	391 – 393	Combined sources	3
Beta strandⁱ	394 – 396	Combined sources	3
Beta strandⁱ	402 – 409	Combined sources	8
Beta strandⁱ	414 – 418	Combined sources	5
Helixⁱ	420 – 427	Combined sources	8
Beta strandⁱ	429 – 431	Combined sources	3
Beta strandⁱ	437 – 443	Combined sources	7
Helixⁱ	446 – 459	Combined sources	14
Helixⁱ	471 – 478	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UMR2
SMRⁱ	Q9UMR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UMR2

EvolutionaryTraceⁱ

Q9UMR2

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	125 – 295	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		171
Domainⁱ	306 – 474	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		169

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 300	N-terminal lobeAdd BLAST	299
Regionⁱ	55 – 68	N-terminal helixAdd BLAST	14
Regionⁱ	301 – 479	C-terminal lobeAdd BLAST	179

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	92 – 120	Q motifAdd BLAST		29
Motifⁱ	242 – 245	DEAD box		4

Domainⁱ

The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0332 Eukaryota ENOG410XRGX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063236
HOGENOMⁱ	HOG000268797
HOVERGENⁱ	HBG107989
InParanoidⁱ	Q9UMR2
KEGG Orthology (KO) More...KOⁱ	K18655
PhylomeDBⁱ	Q9UMR2
TreeFamⁱ	TF314957

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UMR2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDSWALAV DEQEAAAESL SNLHLKEEKI KPDTNGAVVK TNANAEKTDE 
        60         70         80         90        100
EEKEDRAAQS LLNKLIRSNL VDNTNQVEVL QRDPNSPLYS VKSFEELRLK 
       110        120        130        140        150
PQLLQGVYAM GFNRPSKIQE NALPLMLAEP PQNLIAQSQS GTGKTAAFVL 
       160        170        180        190        200
AMLSQVEPAN KYPQCLCLSP TYELALQTGK VIEQMGKFYP ELKLAYAVRG 
       210        220        230        240        250
NKLERGQKIS EQIVIGTPGT VLDWCSKLKF IDPKKIKVFV LDEADVMIAT 
       260        270        280        290        300
QGHQDQSIRI QRMLPRNCQM LLFSATFEDS VWKFAQKVVP DPNVIKLKRE 
       310        320        330        340        350
EETLDTIKQY YVLCSSRDEK FQALCNLYGA ITIAQAMIFC HTRKTASWLA 
       360        370        380        390        400
AELSKEGHQV ALLSGEMMVE QRAAVIERFR EGKEKVLVTT NVCARGIDVE 
       410        420        430        440        450
QVSVVINFDL PVDKDGNPDN ETYLHRIGRT GRFGKRGLAV NMVDSKHSMN 
       460        470 
ILNRIQEHFN KKIERLDTDD LDEIEKIAN

Length:479

Mass (Da):53,927

Last modified:May 1, 2000 - v1

Checksum:ⁱ8F6F93B12B7E9871

GO

Isoform 2 (identifier: Q9UMR2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
100-130: Missing.

« Hide

        10         20         30         40         50
MATDSWALAV DEQEAAAESL SNLHLKEEKI KPDTNGAVVK TNANAEKTDE 
        60         70         80         90        100
EEKEDRAAQS LLNKLIRSNL VDNTNQVEVL QRDPNSPLYS VKSFEELRLP 
       110        120        130        140        150
QNLIAQSQSG TGKTAAFVLA MLSQVEPANK YPQCLCLSPT YELALQTGKV 
       160        170        180        190        200
IEQMGKFYPE LKLAYAVRGN KLERGQKISE QIVIGTPGTV LDWCSKLKFI 
       210        220        230        240        250
DPKKIKVFVL DEADVMIATQ GHQDQSIRIQ RMLPRNCQML LFSATFEDSV 
       260        270        280        290        300
WKFAQKVVPD PNVIKLKREE ETLDTIKQYY VLCSSRDEKF QALCNLYGAI 
       310        320        330        340        350
TIAQAMIFCH TRKTASWLAA ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE 
       360        370        380        390        400
GKEKVLVTTN VCARGIDVEQ VSVVINFDLP VDKDGNPDNE TYLHRIGRTG 
       410        420        430        440 
RFGKRGLAVN MVDSKHSMNI LNRIQEHFNK KIERLDTDDL DEIEKIAN

Show »

Length:448

Mass (Da):50,490

Checksum:ⁱ178321CBF4CA276A

GO

Isoform 3 (identifier: Q9UMR2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-109: Missing.

« Hide

        10         20         30         40         50
MGFNRPSKIQ ENALPLMLAE PPQNLIAQSQ SGTGKTAAFV LAMLSQVEPA 
        60         70         80         90        100
NKYPQCLCLS PTYELALQTG KVIEQMGKFY PELKLAYAVR GNKLERGQKI 
       110        120        130        140        150
SEQIVIGTPG TVLDWCSKLK FIDPKKIKVF VLDEADVMIA TQGHQDQSIR 
       160        170        180        190        200
IQRMLPRNCQ MLLFSATFED SVWKFAQKVV PDPNVIKLKR EEETLDTIKQ 
       210        220        230        240        250
YYVLCSSRDE KFQALCNLYG AITIAQAMIF CHTRKTASWL AAELSKEGHQ 
       260        270        280        290        300
VALLSGEMMV EQRAAVIERF REGKEKVLVT TNVCARGIDV EQVSVVINFD 
       310        320        330        340        350
LPVDKDGNPD NETYLHRIGR TGRFGKRGLA VNMVDSKHSM NILNRIQEHF 
       360        370
NKKIERLDTD DLDEIEKIAN

Show »

Length:370

Mass (Da):41,779

Checksum:ⁱA268A0E259FCF3E2

GO

Isoform 4 (identifier: Q9UMR2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-19: MATDSWALAVDEQEAAAES → MAGAAGRVQDRALRRFPITLPVGD
100-130: Missing.

« Hide

        10         20         30         40         50
MAGAAGRVQD RALRRFPITL PVGDLSNLHL KEEKIKPDTN GAVVKTNANA 
        60         70         80         90        100
EKTDEEEKED RAAQSLLNKL IRSNLVDNTN QVEVLQRDPN SPLYSVKSFE 
       110        120        130        140        150
ELRLPQNLIA QSQSGTGKTA AFVLAMLSQV EPANKYPQCL CLSPTYELAL 
       160        170        180        190        200
QTGKVIEQMG KFYPELKLAY AVRGNKLERG QKISEQIVIG TPGTVLDWCS 
       210        220        230        240        250
KLKFIDPKKI KVFVLDEADV MIATQGHQDQ SIRIQRMLPR NCQMLLFSAT 
       260        270        280        290        300
FEDSVWKFAQ KVVPDPNVIK LKREEETLDT IKQYYVLCSS RDEKFQALCN 
       310        320        330        340        350
LYGAITIAQA MIFCHTRKTA SWLAAELSKE GHQVALLSGE MMVEQRAAVI 
       360        370        380        390        400
ERFREGKEKV LVTTNVCARG IDVEQVSVVI NFDLPVDKDG NPDNETYLHR 
       410        420        430        440        450
IGRTGRFGKR GLAVNMVDSK HSMNILNRIQ EHFNKKIERL DTDDLDEIEK 

IAN

Note: No experimental confirmation available.

Show »

Length:453

Mass (Da):51,063

Checksum:ⁱ6D543611ED7E4BFE

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BQK0	H3BQK0_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B (HCG1998531, isoform CRA_g)	DDX19B hCG_1998531	484	Annotation score:
H3BMQ5	H3BMQ5_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B	DDX19B	233	Annotation score:
F6QDS0	F6QDS0_HUMAN	HCG2043426, isoform CRA_b HCG2043426, isoform CRA_b	hCG_2043426	479	Annotation score:
H3BN59	H3BN59_HUMAN	Uncharacterized protein Uncharacterized protein		261	Annotation score:
H3BTX1	H3BTX1_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B	DDX19B	41	Annotation score:
H3BMV7	H3BMV7_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B	DDX19B	32	Annotation score:
H3BPV3	H3BPV3_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B	DDX19B	30	Annotation score:
H3BUH0	H3BUH0_HUMAN	ATP-dependent RNA helicase DDX19B ATP-dependent RNA helicase DDX19B	DDX19B	48	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	128	A → V in CAG33496 (Ref. 4) Curated	1
Sequence conflictⁱ	201	N → Y in BAG63488 (PubMed:14702039).Curated	1
Sequence conflictⁱ	331	I → T in CAG33496 (Ref. 4) Curated	1
Sequence conflictⁱ	367	M → V in CAG38540 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052160	149	V → L. Corresponds to variant dbSNP:rs34607244Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_041347	1 – 109	Missing in isoform 3. 3 PublicationsAdd BLAST	109
Alternative sequenceⁱVSP_044727	1 – 19	MATDS…AAAES → MAGAAGRVQDRALRRFPITL PVGD in isoform 4. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_015239	100 – 130	Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST	31

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ237946 mRNA Translation: CAB52189.1 AF353720 mRNA Translation: AAK40102.1 AL136639 mRNA Translation: CAB66574.1 CR457215 mRNA Translation: CAG33496.1 CR533509 mRNA Translation: CAG38540.1 AK027378 mRNA Translation: BAG51311.1 AK301938 mRNA Translation: BAG63358.1 AK302107 mRNA Translation: BAG63488.1 AK316346 mRNA Translation: BAH14717.1 AC012184 Genomic DNA No translation available. CH471241 Genomic DNA Translation: EAW51827.1 CH471241 Genomic DNA Translation: EAW51831.1 CH471241 Genomic DNA Translation: EAW51832.1 CH471241 Genomic DNA Translation: EAW51834.1 BC003626 mRNA Translation: AAH03626.1 BC010008 mRNA Translation: AAH10008.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10888.1 [Q9UMR2-1] CCDS32475.1 [Q9UMR2-2] CCDS42187.1 [Q9UMR2-3] CCDS58478.1 [Q9UMR2-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001014449.1, NM_001014449.2 [Q9UMR2-3] NP_001014451.1, NM_001014451.2 [Q9UMR2-2] NP_001244101.1, NM_001257172.1 [Q9UMR2-4] NP_001244102.1, NM_001257173.1 [Q9UMR2-3] NP_001244103.1, NM_001257174.1 [Q9UMR2-3] NP_009173.1, NM_007242.5 [Q9UMR2-1] XP_006721190.1, XM_006721127.2 [Q9UMR2-3] XP_016878379.1, XM_017022890.1
UniGeneⁱ	Hs.221761

Genome annotation databases

Ensemblⁱ	ENST00000288071; ENSP00000288071; ENSG00000157349 [Q9UMR2-1] ENST00000355992; ENSP00000348271; ENSG00000157349 [Q9UMR2-2] ENST00000393657; ENSP00000377267; ENSG00000157349 [Q9UMR2-3] ENST00000451014; ENSP00000392639; ENSG00000157349 [Q9UMR2-4] ENST00000563392; ENSP00000456574; ENSG00000157349 [Q9UMR2-3] ENST00000568625; ENSP00000456757; ENSG00000157349 [Q9UMR2-3]
GeneIDⁱ	11269
KEGGⁱ	hsa:11269
UCSC genome browser More...UCSCⁱ	uc002eyo.5 human [Q9UMR2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UMR2	HCG1998531, isoform CRA_c		HUMAN		370	UniRef100_Q9UMR2
DDX19B isoform 3		PONAB		210
ATP-dependent RNA helicase DDX19A-like		LEPWE		113
ATP-dependent RNA helicase DDX19A		CRIGR		113
DEAD (Asp-Glu-Ala-As) box polypeptide 19A		PANTR		479
+13
Q9UMR2-2	Uncharacterized protein		PANPA		448	UniRef100_A0A2R9APT2
UPI0005D02BF3		HUMAN		508

Protein	Similar proteins		Species	Score	Length	Source
Q9UMR2	HCG1998531, isoform CRA_c		HUMAN		370	UniRef90_Q9UMR2
DDX19B isoform 3		PONAB		210
ATP-dependent RNA helicase DDX19A-like		LEPWE		113
ATP-dependent RNA helicase DDX19A		CRIGR		113
DEAD (Asp-Glu-Ala-As) box polypeptide 19A		PANTR		479
+117
Q9UMR2-2	Isoform 4 of ATP-dependent RNA helicase DDX19B		HUMAN		453	UniRef90_Q9UMR2-4
ATP-dependent RNA helicase DDX19B isoform X2		LEPWE		487
ATP-dependent RNA helicase DDX19B isoform X3		ODORO		448
ATP-dependent RNA helicase DDX19B		TUPCH		463
Uncharacterized protein		PROCO		454
+63
Q9UMR2-4	ATP-dependent RNA helicase DDX19B isoform X2		LEPWE		487	UniRef90_Q9UMR2-4
ATP-dependent RNA helicase DDX19B isoform X3		ODORO		448
ATP-dependent RNA helicase DDX19B		TUPCH		463
Uncharacterized protein		PROCO		454
Uncharacterized protein		FELCA		453
+63

Protein	Similar proteins		Species	Score	Length	Source
Q9UMR2	HCG1998531, isoform CRA_c		HUMAN		370	UniRef50_Q9UMR2
DDX19B isoform 3		PONAB		210
ATP-dependent RNA helicase DDX19A-like		LEPWE		113
ATP-dependent RNA helicase DDX19A		CRIGR		113
DEAD (Asp-Glu-Ala-As) box polypeptide 19A		PANTR		479
+135
Q9UMR2-2	Isoform 4 of ATP-dependent RNA helicase DDX19B		HUMAN		453	UniRef50_Q9UMR2-4
ATP-dependent RNA helicase DDX19A		MOUSE		478
ATP-dependent RNA helicase DDX19A		BOVIN		478
ATP-dependent RNA helicase DDX25		XENLA		483
ATP-dependent RNA helicase DDX19B isoform X2		LEPWE		487
+674
Q9UMR2-4	ATP-dependent RNA helicase DDX19A		MOUSE		478	UniRef50_Q9UMR2-4
ATP-dependent RNA helicase DDX19A		BOVIN		478
ATP-dependent RNA helicase DDX19A		HUMAN		478
ATP-dependent RNA helicase DDX25		XENLA		483
ATP-dependent RNA helicase DDX19B isoform X2		LEPWE		487
+674

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ237946 mRNA Translation: CAB52189.1 AF353720 mRNA Translation: AAK40102.1 AL136639 mRNA Translation: CAB66574.1 CR457215 mRNA Translation: CAG33496.1 CR533509 mRNA Translation: CAG38540.1 AK027378 mRNA Translation: BAG51311.1 AK301938 mRNA Translation: BAG63358.1 AK302107 mRNA Translation: BAG63488.1 AK316346 mRNA Translation: BAH14717.1 AC012184 Genomic DNA No translation available. CH471241 Genomic DNA Translation: EAW51827.1 CH471241 Genomic DNA Translation: EAW51831.1 CH471241 Genomic DNA Translation: EAW51832.1 CH471241 Genomic DNA Translation: EAW51834.1 BC003626 mRNA Translation: AAH03626.1 BC010008 mRNA Translation: AAH10008.1
CCDSⁱ	CCDS10888.1 [Q9UMR2-1] CCDS32475.1 [Q9UMR2-2] CCDS42187.1 [Q9UMR2-3] CCDS58478.1 [Q9UMR2-4]
RefSeqⁱ	NP_001014449.1, NM_001014449.2 [Q9UMR2-3] NP_001014451.1, NM_001014451.2 [Q9UMR2-2] NP_001244101.1, NM_001257172.1 [Q9UMR2-4] NP_001244102.1, NM_001257173.1 [Q9UMR2-3] NP_001244103.1, NM_001257174.1 [Q9UMR2-3] NP_009173.1, NM_007242.5 [Q9UMR2-1] XP_006721190.1, XM_006721127.2 [Q9UMR2-3] XP_016878379.1, XM_017022890.1
UniGeneⁱ	Hs.221761

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3EWS	X-ray	2.70	A/B	54-475	[»]
	3FHC	X-ray	2.80	B	68-302	[»]
	3FHT	X-ray	2.20	A/B	68-479	[»]
	3FMO	X-ray	2.51	B	1-300	[»]
	3FMP	X-ray	3.19	B/D	1-479	[»]
	3G0H	X-ray	2.70	A	54-475	[»]
	6B4I	X-ray	3.62	E/F	54-479	[»]
	6B4J	X-ray	3.40	E/F	54-479	[»]
	6B4K	X-ray	2.20	A/B	54-479	[»]
ProteinModelPortalⁱ	Q9UMR2
SMRⁱ	Q9UMR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116426, 153 interactors
DIPⁱ	DIP-48486N
IntActⁱ	Q9UMR2, 20 interactors
MINTⁱ	Q9UMR2
STRINGⁱ	9606.ENSP00000288071

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	Q9UMR2
PhosphoSitePlusⁱ	Q9UMR2

Polymorphism and mutation databases

BioMutaⁱ	DDX19B
DMDMⁱ	10719979

Proteomic databases

EPDⁱ	Q9UMR2
PaxDbⁱ	Q9UMR2
PeptideAtlasⁱ	Q9UMR2
PRIDEⁱ	Q9UMR2
ProteomicsDBⁱ	85194 85195 [Q9UMR2-2] 85196 [Q9UMR2-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11269
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000288071; ENSP00000288071; ENSG00000157349 [Q9UMR2-1] ENST00000355992; ENSP00000348271; ENSG00000157349 [Q9UMR2-2] ENST00000393657; ENSP00000377267; ENSG00000157349 [Q9UMR2-3] ENST00000451014; ENSP00000392639; ENSG00000157349 [Q9UMR2-4] ENST00000563392; ENSP00000456574; ENSG00000157349 [Q9UMR2-3] ENST00000568625; ENSP00000456757; ENSG00000157349 [Q9UMR2-3]
GeneIDⁱ	11269
KEGGⁱ	hsa:11269
UCSCⁱ	uc002eyo.5 human [Q9UMR2-1]

Organism-specific databases

CTDⁱ	11269
DisGeNETⁱ	11269
EuPathDBⁱ	HostDB:ENSG00000157349.16
GeneCardsⁱ	DDX19B
HGNCⁱ	HGNC:2742 DDX19B
HPAⁱ	CAB037229 CAB037284 HPA046380 HPA066668
MIMⁱ	605812 gene
neXtProtⁱ	NX_Q9UMR2
OpenTargetsⁱ	ENSG00000157349
PharmGKBⁱ	PA27208
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0332 Eukaryota ENOG410XRGX LUCA
GeneTreeⁱ	ENSGT00530000063236
HOGENOMⁱ	HOG000268797
HOVERGENⁱ	HBG107989
InParanoidⁱ	Q9UMR2
KOⁱ	K18655
PhylomeDBⁱ	Q9UMR2
TreeFamⁱ	TF314957

Enzyme and pathway databases

BRENDAⁱ	3.6.4.13 2681

BRENDAⁱ

3.6.4.13 2681

Miscellaneous databases

ChiTaRSⁱ	DDX19B human
EvolutionaryTraceⁱ	Q9UMR2
GeneWikiⁱ	DDX19B
GenomeRNAiⁱ	11269
Protein Ontology More...PROⁱ	PR:Q9UMR2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157349 Expressed in 131 organ(s), highest expression level in testis
CleanExⁱ	HS_DDX19B
ExpressionAtlasⁱ	Q9UMR2 baseline and differential
Genevisibleⁱ	Q9UMR2 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DD19B_HUMAN
Accessionⁱ	Q9UMR2Primary (citable) accession number: Q9UMR2 Secondary accession number(s): B3KNE9 Q9H0U0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9UMR2 (DD19B_HUMAN)

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ATP-dependent RNA helicase DDX19B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Extracellular region or secreted

Nucleus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ