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Protein

Homeobox protein BarH-like 2

Gene

BARX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi133 – 192HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 2
Gene namesi
Name:BARX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000043039.6
HGNCiHGNC:956 BARX2
MIMi604823 gene
neXtProtiNX_Q9UMQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8538
OpenTargetsiENSG00000043039
PharmGKBiPA25260

Polymorphism and mutation databases

BioMutaiBARX2
DMDMi254763427

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488381 – 279Homeobox protein BarH-like 2Add BLAST279

Proteomic databases

PaxDbiQ9UMQ3
PeptideAtlasiQ9UMQ3
PRIDEiQ9UMQ3
ProteomicsDBi85192

PTM databases

iPTMnetiQ9UMQ3
PhosphoSitePlusiQ9UMQ3

Expressioni

Tissue specificityi

Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.

Gene expression databases

BgeeiENSG00000043039
CleanExiHS_BARX2
GenevisibleiQ9UMQ3 HS

Organism-specific databases

HPAiCAB033311
HPA068414

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136434EBI-12053927,EBI-741101

Protein-protein interaction databases

BioGridi114108, 1 interactor
IntActiQ9UMQ3, 2 interactors
STRINGi9606.ENSP00000281437

Structurei

3D structure databases

ProteinModelPortaliQ9UMQ3
SMRiQ9UMQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231924
HOVERGENiHBG050665
InParanoidiQ9UMQ3
KOiK09361
OMAiGQPQELP
OrthoDBiEOG091G10IN
PhylomeDBiQ9UMQ3
TreeFamiTF350735

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UMQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS
60 70 80 90 100
LVVRPKPLHS CTGSPSLRAY PLLSVITRQP TVISHLVPAT PGIAQALSCH
110 120 130 140 150
QVTEAVSAEA PGGEALASSE SETEQPTPRQ KKPRRSRTIF TELQLMGLEK
160 170 180 190 200
KFQKQKYLST PDRLDLAQSL GLTQLQVKTW YQNRRMKWKK MVLKGGQEAP
210 220 230 240 250
TKPKGRPKKN SIPTSEEIEA EEKMNSQAQG QEQLEPSQGQ EELCEAQEPK
260 270
ARDVPLEMAE PPDPPQELPI PSSEPPPLS
Length:279
Mass (Da):31,188
Last modified:July 28, 2009 - v3
Checksum:i8C2537E524528467
GO

Sequence cautioni

The sequence AAC04705 differs from that shown. Reason: Frameshift at position 11.Curated
The sequence AAC04705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF09453 differs from that shown. Reason: Frameshift at position 11.Curated
The sequence AAF09453 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031924 mRNA Translation: AAC04705.1 Sequence problems.
AF171222
, AF171219, AF171220, AF171221 Genomic DNA Translation: AAF09453.1 Sequence problems.
AJ243512 mRNA Translation: CAB50736.1
AP003775 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67743.1
BC069378 mRNA Translation: AAH69378.1
BC111432 mRNA Translation: AAI11433.1
BC111572 mRNA Translation: AAI11573.1
CCDSiCCDS8481.1
RefSeqiNP_003649.2, NM_003658.4
UniGeneiHs.591944

Genome annotation databases

EnsembliENST00000281437; ENSP00000281437; ENSG00000043039
GeneIDi8538
KEGGihsa:8538
UCSCiuc001qfc.5 human

Similar proteinsi

Entry informationi

Entry nameiBARX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UMQ3
Secondary accession number(s): O43518, Q6NT51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: June 20, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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