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Protein

Intercellular adhesion molecule 5

Gene

ICAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
Gene namesi
Name:ICAM5
Synonyms:TLCN, TLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105376.4
HGNCiHGNC:5348 ICAM5
MIMi601852 gene
neXtProtiNX_Q9UMF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 835ExtracellularSequence analysisAdd BLAST804
Transmembranei836 – 856HelicalSequence analysisAdd BLAST21
Topological domaini857 – 924CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7087
OpenTargetsiENSG00000105376
PharmGKBiPA29596

Polymorphism and mutation databases

BioMutaiICAM5
DMDMi296439327

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001479932 – 924Intercellular adhesion molecule 5Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation1 Publication
Disulfide bondi59 ↔ 103PROSITE-ProRule annotation1 Publication
Glycosylationi74N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi137N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi142 ↔ 198PROSITE-ProRule annotation1 Publication
Modified residuei182PhosphothreonineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Glycosylationi195N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi214N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 552PROSITE-ProRule annotation
Disulfide bondi580 ↔ 645PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi646N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi673 ↔ 725PROSITE-ProRule annotation
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi769 ↔ 814PROSITE-ProRule annotation
Glycosylationi795N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UMF0
MaxQBiQ9UMF0
PaxDbiQ9UMF0
PeptideAtlasiQ9UMF0
PRIDEiQ9UMF0
ProteomicsDBi85189

PTM databases

iPTMnetiQ9UMF0
PhosphoSitePlusiQ9UMF0

Expressioni

Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Gene expression databases

BgeeiENSG00000105376 Expressed in 93 organ(s), highest expression level in right frontal lobe
CleanExiHS_ICAM5
ExpressionAtlasiQ9UMF0 baseline and differential
GenevisibleiQ9UMF0 HS

Organism-specific databases

HPAiCAB025178
HPA008943
HPA009083

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P050943EBI-6398041,EBI-5847257From Gallus gallus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112942, 20 interactors
IntActiQ9UMF0, 20 interactors
STRINGi9606.ENSP00000221980

Structurei

Secondary structure

1924
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UMF0
SMRiQ9UMF0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UMF0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 130Ig-like C2-type 1Add BLAST83
Domaini135 – 235Ig-like C2-type 2Add BLAST101
Domaini242 – 329Ig-like C2-type 3Add BLAST88
Domaini337 – 402Ig-like C2-type 4Add BLAST66
Domaini408 – 486Ig-like C2-type 5Add BLAST79
Domaini491 – 568Ig-like C2-type 6Add BLAST78
Domaini573 – 662Ig-like C2-type 7Add BLAST90
Domaini666 – 739Ig-like C2-type 8Add BLAST74
Domaini746 – 830Ig-like C2-type 9Add BLAST85

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000168514
HOVERGENiHBG052077
InParanoidiQ9UMF0
KOiK06769
OMAiPSCPSNW
OrthoDBiEOG091G022Y
PhylomeDBiQ9UMF0
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PF13895 Ig_2, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 8 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UMF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELMPLPP WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG AQELIRRSFA GEPPRARGAV LTATVLARRE DHGANFSCRA
210 220 230 240 250
ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE VGSERPVSCT
260 270 280 290 300
LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL
310 320 330 340 350
VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA
360 370 380 390 400
LVTLEGVPAA VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA
410 420 430 440 450
ELRVLYAPRL DDSDCPRSWT WPEGPEQTLR CEARGNPEPS VHCARSDGGA
460 470 480 490 500
VLALGLLGPV TRALSGTYRC KAANDQGEAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL RVAREHAGTY
560 570 580 590 600
RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG
610 620 630 640 650
KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR
660 670 680 690 700
HGSVAKTVVV SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV
710 720 730 740 750
RCSREGIPWP EQQRVSREDA GTYHCVATNA HGTDSRTVTV GVEYRPVVAE
760 770 780 790 800
LAASPPGGVR PGGNFTLTCR AEAWPPAQIS WRAPPGALNI GLSSNNSTLS
810 820 830 840 850
VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV GGAAGGAALL
860 870 880 890 900
AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG
910 920
PEAAGGAAES PAEGEVFAIQ LTSA
Length:924
Mass (Da):97,116
Last modified:May 18, 2010 - v3
Checksum:i97D0A9467BD16D30
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIL3K7EIL3_HUMAN
Intercellular adhesion molecule 5
ICAM5
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614A → T in AAC50959 (PubMed:8995416).Curated1
Sequence conflicti786G → R in AAC97931 (PubMed:9828136).Curated1
Sequence conflicti816A → R in AAC50959 (PubMed:8995416).Curated1
Sequence conflicti816A → R in AAC97931 (PubMed:9828136).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035515140L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035516188R → W in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_056046301V → I1 PublicationCorresponds to variant dbSNP:rs1056538Ensembl.1
Natural variantiVAR_056047348A → T1 PublicationCorresponds to variant dbSNP:rs2228615Ensembl.1
Natural variantiVAR_035517488E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72671 mRNA Translation: AAC50959.1
AF082802 Genomic DNA Translation: AAC97931.1
AC011511 Genomic DNA No translation available.
CCDSiCCDS12233.1
RefSeqiNP_003250.3, NM_003259.3
XP_011526531.1, XM_011528229.1
UniGeneiHs.465862

Genome annotation databases

EnsembliENST00000221980; ENSP00000221980; ENSG00000105376
GeneIDi7087
KEGGihsa:7087
UCSCiuc002mnu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72671 mRNA Translation: AAC50959.1
AF082802 Genomic DNA Translation: AAC97931.1
AC011511 Genomic DNA No translation available.
CCDSiCCDS12233.1
RefSeqiNP_003250.3, NM_003259.3
XP_011526531.1, XM_011528229.1
UniGeneiHs.465862

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BN3X-ray2.10B32-227[»]
4OI9X-ray2.50A32-409[»]
4OIAX-ray3.70A/B32-409[»]
4OIBX-ray3.50A32-409[»]
ProteinModelPortaliQ9UMF0
SMRiQ9UMF0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112942, 20 interactors
IntActiQ9UMF0, 20 interactors
STRINGi9606.ENSP00000221980

PTM databases

iPTMnetiQ9UMF0
PhosphoSitePlusiQ9UMF0

Polymorphism and mutation databases

BioMutaiICAM5
DMDMi296439327

Proteomic databases

EPDiQ9UMF0
MaxQBiQ9UMF0
PaxDbiQ9UMF0
PeptideAtlasiQ9UMF0
PRIDEiQ9UMF0
ProteomicsDBi85189

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221980; ENSP00000221980; ENSG00000105376
GeneIDi7087
KEGGihsa:7087
UCSCiuc002mnu.5 human

Organism-specific databases

CTDi7087
DisGeNETi7087
EuPathDBiHostDB:ENSG00000105376.4
GeneCardsiICAM5
H-InvDBiHIX0014740
HGNCiHGNC:5348 ICAM5
HPAiCAB025178
HPA008943
HPA009083
MIMi601852 gene
neXtProtiNX_Q9UMF0
OpenTargetsiENSG00000105376
PharmGKBiPA29596
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000168514
HOVERGENiHBG052077
InParanoidiQ9UMF0
KOiK06769
OMAiPSCPSNW
OrthoDBiEOG091G022Y
PhylomeDBiQ9UMF0
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions

Miscellaneous databases

EvolutionaryTraceiQ9UMF0
GeneWikiiICAM5
GenomeRNAii7087
PROiPR:Q9UMF0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105376 Expressed in 93 organ(s), highest expression level in right frontal lobe
CleanExiHS_ICAM5
ExpressionAtlasiQ9UMF0 baseline and differential
GenevisibleiQ9UMF0 HS

Family and domain databases

Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PF13895 Ig_2, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 8 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiICAM5_HUMAN
AccessioniPrimary (citable) accession number: Q9UMF0
Secondary accession number(s): Q9Y6F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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