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Entry version 196 (13 Feb 2019)
Sequence version 3 (18 May 2010)
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Protein

ALK tyrosine kinase receptor

Gene

ALK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.11 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by ligand-binding and subsequent phosphorylation. Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1124ATP; via carbonyl oxygen1
Binding sitei1150ATPPROSITE-ProRule annotation1
Binding sitei1150Inhibitor2 Publications1
Binding sitei1199Inhibitor; via amide nitrogen2 Publications1
Binding sitei1203Inhibitor2 Publications1
Binding sitei1210Inhibitor2 Publications1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1249Proton acceptorPROSITE-ProRule annotation1
Binding sitei1270ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1197 – 1199ATP3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UM73

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UM73

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ALK tyrosine kinase receptor (EC:2.7.10.1)
Alternative name(s):
Anaplastic lymphoma kinase
CD_antigen: CD246
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171094.15

Human Gene Nomenclature Database

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HGNCi
HGNC:427 ALK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
105590 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UM73

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1038ExtracellularSequence analysisAdd BLAST1020
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1039 – 1059HelicalSequence analysisAdd BLAST21
Topological domaini1060 – 1620CytoplasmicSequence analysisAdd BLAST561

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.
A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.
A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.
Neuroblastoma 3 (NBLST3)4 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
See also OMIM:613014
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0638501091D → N in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs864309584EnsemblClinVar.1
Natural variantiVAR_0638511128G → A in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs113994088EnsemblClinVar.1
Natural variantiVAR_0638521151T → M in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs113994091EnsemblClinVar.1
Natural variantiVAR_0638531166M → R in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057520019EnsemblClinVar.1
Natural variantiVAR_0638541171I → N in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057519698EnsemblClinVar.1
Natural variantiVAR_0638551174F → C in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs1057519697EnsemblClinVar.1
Natural variantiVAR_0638561174F → I in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs281864719EnsemblClinVar.1
Natural variantiVAR_0638571174F → L in NBLST3; somatic mutation; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 3 PublicationsCorresponds to variant dbSNP:rs863225281EnsemblClinVar.1
Natural variantiVAR_0638581174F → V in NBLST3; somatic mutation; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 2 PublicationsCorresponds to variant dbSNP:rs281864719EnsemblClinVar.1
Natural variantiVAR_0638591192R → P in NBLST3. 2 PublicationsCorresponds to variant dbSNP:rs113994089EnsemblClinVar.1
Natural variantiVAR_0638601234A → T in NBLST3; somatic mutation. 1 Publication1
Natural variantiVAR_0638611245F → C in NBLST3; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs863225283EnsemblClinVar.1
Natural variantiVAR_0638621245F → V in NBLST3; somatic mutation. Corresponds to variant dbSNP:rs281864720EnsemblClinVar.1
Natural variantiVAR_0638631250I → T in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs113994092EnsemblClinVar.1
Natural variantiVAR_0638651275R → Q in NBLST3; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 4 PublicationsCorresponds to variant dbSNP:rs113994087EnsemblClinVar.1
Natural variantiVAR_0638661278Y → S in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs863225285EnsemblClinVar.1
The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumor of adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth.
A chromosomal aberration involving ALK is found in one subject with colorectal cancer. Translocation t(2;2)(p23.1;p23.3). A 5 million base pair tandem duplication generates an in-frame WDCP-ALK gene fusion.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1507Y → F: Impairs interaction with SHC1. 1 Publication1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
238

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ALK

MalaCards human disease database

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MalaCardsi
ALK
MIMi613014 phenotype

Open Targets

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OpenTargetsi
ENSG00000171094

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
300895 ALK-positive anaplastic large cell lymphoma
364043 ALK-positive large B-cell lymphoma
146 Differentiated thyroid carcinoma
178342 Inflammatory myofibroblastic tumor
635 Neuroblastoma
357191 Selection of therapeutic option in non-small cell lung carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24719

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4247

Drug and drug target database

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DrugBanki
DB00171 Adenosine triphosphate
DB11363 Alectinib
DB09063 Ceritinib
DB08865 Crizotinib

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1839

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ALK

Domain mapping of disease mutations (DMDM)

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DMDMi
296439447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001674019 – 1620ALK tyrosine kinase receptorAdd BLAST1602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi886N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi986N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1078PhosphotyrosineCombined sources1
Modified residuei1092PhosphotyrosineBy similarity1
Modified residuei1096PhosphotyrosineCombined sources1 Publication1
Modified residuei1131PhosphotyrosineCombined sources1
Modified residuei1278Phosphotyrosine1 Publication1
Modified residuei1507Phosphotyrosine1 Publication1
Modified residuei1604PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.5 Publications
N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UM73

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UM73

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UM73

PeptideAtlas

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PeptideAtlasi
Q9UM73

PRoteomics IDEntifications database

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PRIDEi
Q9UM73

ProteomicsDB human proteome resource

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ProteomicsDBi
85185

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UM73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UM73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171094 Expressed in 144 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UM73 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UM73 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA010694

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106739, 65 interactors

Database of interacting proteins

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DIPi
DIP-5954N

Protein interaction database and analysis system

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IntActi
Q9UM73, 12 interactors

Molecular INTeraction database

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MINTi
Q9UM73

STRING: functional protein association networks

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STRINGi
9606.ENSP00000373700

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9UM73

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11620
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUPNMR-B1571-1589[»]
2KUQNMR-A1571-1589[»]
2XB7X-ray2.50A1094-1407[»]
2XBAX-ray1.95A1094-1407[»]
2XP2X-ray1.90A1093-1411[»]
2YFXX-ray1.70A1093-1411[»]
2YHVX-ray1.90A1093-1411[»]
2YJRX-ray1.90A1093-1411[»]
2YJSX-ray1.90A1093-1411[»]
2YS5NMR-B1571-1589[»]
2YT2NMR-A1571-1589[»]
3AOXX-ray1.75A1069-1411[»]
3L9PX-ray1.80A1072-1410[»]
3LCSX-ray1.95A1072-1410[»]
3LCTX-ray2.10A1072-1410[»]
4ANLX-ray1.70A1093-1411[»]
4ANQX-ray1.76A1093-1411[»]
4ANSX-ray1.85A1093-1411[»]
4CCBX-ray2.03A1093-1411[»]
4CCUX-ray2.00A1093-1411[»]
4CD0X-ray2.23A1093-1411[»]
4CLIX-ray2.05A1093-1411[»]
4CLJX-ray1.66A1093-1411[»]
4CMOX-ray2.05A1093-1411[»]
4CMTX-ray1.73A1093-1411[»]
4CMUX-ray1.80A1093-1411[»]
4CNHX-ray1.90A/B1093-1411[»]
4CTBX-ray1.79A1093-1411[»]
4CTCX-ray2.03A1093-1411[»]
4DCEX-ray2.03A/B1078-1410[»]
4FNWX-ray1.75A1084-1410[»]
4FNXX-ray1.70A1084-1410[»]
4FNYX-ray2.45A1084-1410[»]
4FNZX-ray2.60A1084-1410[»]
4FOBX-ray1.90A1058-1410[»]
4FOCX-ray1.70A1058-1410[»]
4FODX-ray2.00A1078-1410[»]
4JOAX-ray2.70A1072-1410[»]
4MKCX-ray2.01A1072-1410[»]
4TT7X-ray2.10A1095-1410[»]
4Z55X-ray1.55A1072-1410[»]
5A9UX-ray1.60A1093-1411[»]
5AA8X-ray1.86A1093-1411[»]
5AA9X-ray1.93A1093-1411[»]
5AAAX-ray1.73A1093-1411[»]
5AABX-ray2.20A1093-1411[»]
5AACX-ray1.70A1093-1411[»]
5FTOX-ray2.22A1094-1407[»]
5FTQX-ray1.70A1094-1407[»]
5IMXX-ray2.12A1093-1411[»]
5IUGX-ray1.93A1084-1410[»]
5IUHX-ray2.10A1084-1410[»]
5IUIX-ray1.88A1084-1410[»]
5KZ0X-ray2.30A1093-1411[»]
5VZ5X-ray2.59C1274-1283[»]
6AT9X-ray2.95C1274-1283[»]
6MX8X-ray1.96A1094-1400[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UM73

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UM73

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UM73

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 427MAM 1PROSITE-ProRule annotationAdd BLAST164
Domaini437 – 473LDL-receptor class AAdd BLAST37
Domaini478 – 636MAM 2PROSITE-ProRule annotationAdd BLAST159
Domaini1116 – 1392Protein kinasePROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1197 – 1199Inhibitor binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi816 – 940Gly-richAdd BLAST125

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1095 Eukaryota
ENOG410XPVX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159280

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231766

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018726

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UM73

KEGG Orthology (KO)

More...
KOi
K05119

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKVQGSR

Database of Orthologous Groups

More...
OrthoDBi
731388at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UM73

TreeFam database of animal gene trees

More...
TreeFami
TF351636

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 1 hit
cd06263 MAM, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026830 ALK
IPR013320 ConA-like_dom_sf
IPR011009 Kinase-like_dom_sf
IPR036055 LDL_receptor-like_sf
IPR002172 LDrepeatLR_classA_rpt
IPR000998 MAM_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS

The PANTHER Classification System

More...
PANTHERi
PTHR24416:SF276 PTHR24416:SF276, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00629 MAM, 2 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192 LDLa, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits
SSF56112 SSF56112, 1 hit
SSF57424 SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50060 MAM_2, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9UM73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ
60 70 80 90 100
RKSLAVDFVV PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR
110 120 130 140 150
LLGPAPGVSW TAGSPAPAEA RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI
160 170 180 190 200
LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ GEGRLRIRLM PEKKASEVGR
210 220 230 240 250
EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY FTWNLTWIMK
260 270 280 290 300
DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ
310 320 330 340 350
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS
360 370 380 390 400
VHRHLQPSGR YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF
410 420 430 440 450
RVALEYISSG NRSLSAVDFF ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ
460 470 480 490 500
LGQACDFHQD CAQGEDESQM CRKLPVGFYC NFEDGFCGWT QGTLSPHTPQ
510 520 530 540 550
WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP APIKSSPCEL
560 570 580 590 600
RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL
610 620 630 640 650
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP
660 670 680 690 700
KSRNLFERNP NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ
710 720 730 740 750
CNNAYQNSNL SVEVGSEGPL KGIQIWKVPA TDTYSISGYG AAGGKGGKNT
760 770 780 790 800
MMRSHGVSVL GIFNLEKDDM LYILVGQQGE DACPSTNQLI QKVCIGENNV
810 820 830 840 850
IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII AAGGGGRAYG
860 870 880 890 900
AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA
910 920 930 940 950
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM
960 970 980 990 1000
DGEDGVSFIS PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE
1010 1020 1030 1040 1050
SHKVICFCDH GTVLAEDGVS CIVSPTPEPH LPLSLILSVV TSALVAALVL
1060 1070 1080 1090 1100
AFSGIMIVYR RKHQELQAMQ MELQSPEYKL SKLRTSTIMT DYNPNYCFAG
1110 1120 1130 1140 1150
KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN DPSPLQVAVK
1160 1170 1180 1190 1200
TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA
1210 1220 1230 1240 1250
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI
1260 1270 1280 1290 1300
AARNCLLTCP GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA
1310 1320 1330 1340 1350
FMEGIFTSKT DTWSFGVLLW EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP
1360 1370 1380 1390 1400
PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL ERIEYCTQDP DVINTALPIE
1410 1420 1430 1440 1450
YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA PPPLPTTSSG
1460 1470 1480 1490 1500
KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT
1510 1520 1530 1540 1550
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL
1560 1570 1580 1590 1600
PGASLLLEPS SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG
1610 1620
AGHYEDTILK SKNSMNQPGP
Length:1,620
Mass (Da):176,442
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0733D6C4FD212F41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZL3A0A087WZL3_HUMAN
Tyrosine-protein kinase receptor
ALK
1,243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K2YUJ3A0A0K2YUJ3_HUMAN
Tyrosine-protein kinase receptor
ALK
552Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPW7E7EPW7_HUMAN
ALK tyrosine kinase receptor
ALK
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ33H7BZ33_HUMAN
ALK tyrosine kinase receptor
ALK
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92714 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36P → S in AAB71619 (PubMed:9174053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04147790S → L1 PublicationCorresponds to variant dbSNP:rs34617074Ensembl.1
Natural variantiVAR_041478163V → L1 PublicationCorresponds to variant dbSNP:rs55697431EnsemblClinVar.1
Natural variantiVAR_041479296E → Q1 PublicationCorresponds to variant dbSNP:rs56077855Ensembl.1
Natural variantiVAR_041480476V → A1 PublicationCorresponds to variant dbSNP:rs35093491EnsemblClinVar.1
Natural variantiVAR_041481560L → F in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041482680T → I1 PublicationCorresponds to variant dbSNP:rs35228363EnsemblClinVar.1
Natural variantiVAR_041483704A → T1 PublicationCorresponds to variant dbSNP:rs34829159Ensembl.1
Natural variantiVAR_061288868L → Q. Corresponds to variant dbSNP:rs55941323EnsemblClinVar.1
Natural variantiVAR_041484877A → S in an ovarian serous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746442213Ensembl.1
Natural variantiVAR_0414851012T → M1 PublicationCorresponds to variant dbSNP:rs35073634EnsemblClinVar.1
Natural variantiVAR_0638501091D → N in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs864309584EnsemblClinVar.1
Natural variantiVAR_0414861121G → D1 PublicationCorresponds to variant dbSNP:rs55760835EnsemblClinVar.1
Natural variantiVAR_0638511128G → A in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs113994088EnsemblClinVar.1
Natural variantiVAR_0638521151T → M in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs113994091EnsemblClinVar.1
Natural variantiVAR_0638531166M → R in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057520019EnsemblClinVar.1
Natural variantiVAR_0638541171I → N in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057519698EnsemblClinVar.1
Natural variantiVAR_0638551174F → C in NBLST3. 1 PublicationCorresponds to variant dbSNP:rs1057519697EnsemblClinVar.1
Natural variantiVAR_0638561174F → I in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs281864719EnsemblClinVar.1
Natural variantiVAR_0638571174F → L in NBLST3; somatic mutation; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 3 PublicationsCorresponds to variant dbSNP:rs863225281EnsemblClinVar.1
Natural variantiVAR_0638581174F → V in NBLST3; somatic mutation; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 2 PublicationsCorresponds to variant dbSNP:rs281864719EnsemblClinVar.1
Natural variantiVAR_0638591192R → P in NBLST3. 2 PublicationsCorresponds to variant dbSNP:rs113994089EnsemblClinVar.1
Natural variantiVAR_0638601234A → T in NBLST3; somatic mutation. 1 Publication1
Natural variantiVAR_0638611245F → C in NBLST3; somatic mutation. 2 PublicationsCorresponds to variant dbSNP:rs863225283EnsemblClinVar.1
Natural variantiVAR_0638621245F → V in NBLST3; somatic mutation. Corresponds to variant dbSNP:rs281864720EnsemblClinVar.1
Natural variantiVAR_0638631250I → T in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs113994092EnsemblClinVar.1
Natural variantiVAR_0414871274A → T1 PublicationCorresponds to variant dbSNP:rs45502292EnsemblClinVar.1
Natural variantiVAR_0638641275R → L Observed in neuroblastoma. 1 PublicationCorresponds to variant dbSNP:rs113994087EnsemblClinVar.1
Natural variantiVAR_0638651275R → Q in NBLST3; constitutively activated; retained in the endoplasmic reticulum and Golgi compartments. 4 PublicationsCorresponds to variant dbSNP:rs113994087EnsemblClinVar.1
Natural variantiVAR_0638661278Y → S in NBLST3; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs863225285EnsemblClinVar.1
Natural variantiVAR_0414881328M → L1 PublicationCorresponds to variant dbSNP:rs56160491Ensembl.1
Natural variantiVAR_0559871376F → S. Corresponds to variant dbSNP:rs17694720Ensembl.1
Natural variantiVAR_0414891416K → N1 PublicationCorresponds to variant dbSNP:rs55782189Ensembl.1
Natural variantiVAR_0414901419E → K1 PublicationCorresponds to variant dbSNP:rs56181542EnsemblClinVar.1
Natural variantiVAR_0414911429Q → R1 PublicationCorresponds to variant dbSNP:rs55906201Ensembl.1
Natural variantiVAR_0310421461I → V4 PublicationsCorresponds to variant dbSNP:rs1670283EnsemblClinVar.1
Natural variantiVAR_0310431491K → R3 PublicationsCorresponds to variant dbSNP:rs1881420EnsemblClinVar.1
Natural variantiVAR_0310441529D → E3 PublicationsCorresponds to variant dbSNP:rs1881421EnsemblClinVar.1
Natural variantiVAR_0559881599P → H. Corresponds to variant dbSNP:rs1881423EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62540 mRNA Translation: AAB71619.1
U66559 mRNA Translation: AAC51104.1
AB209477 mRNA Translation: BAD92714.1 Different initiation.
AC106870 Genomic DNA Translation: AAX93126.1
AC093756 Genomic DNA Translation: AAX88892.1
AC074096 Genomic DNA Translation: AAY15027.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33172.1

NCBI Reference Sequences

More...
RefSeqi
NP_004295.2, NM_004304.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654469

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389048; ENSP00000373700; ENSG00000171094

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:238

UCSC genome browser

More...
UCSCi
uc002rmy.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62540 mRNA Translation: AAB71619.1
U66559 mRNA Translation: AAC51104.1
AB209477 mRNA Translation: BAD92714.1 Different initiation.
AC106870 Genomic DNA Translation: AAX93126.1
AC093756 Genomic DNA Translation: AAX88892.1
AC074096 Genomic DNA Translation: AAY15027.1
CCDSiCCDS33172.1
RefSeqiNP_004295.2, NM_004304.4
UniGeneiHs.654469

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KUPNMR-B1571-1589[»]
2KUQNMR-A1571-1589[»]
2XB7X-ray2.50A1094-1407[»]
2XBAX-ray1.95A1094-1407[»]
2XP2X-ray1.90A1093-1411[»]
2YFXX-ray1.70A1093-1411[»]
2YHVX-ray1.90A1093-1411[»]
2YJRX-ray1.90A1093-1411[»]
2YJSX-ray1.90A1093-1411[»]
2YS5NMR-B1571-1589[»]
2YT2NMR-A1571-1589[»]
3AOXX-ray1.75A1069-1411[»]
3L9PX-ray1.80A1072-1410[»]
3LCSX-ray1.95A1072-1410[»]
3LCTX-ray2.10A1072-1410[»]
4ANLX-ray1.70A1093-1411[»]
4ANQX-ray1.76A1093-1411[»]
4ANSX-ray1.85A1093-1411[»]
4CCBX-ray2.03A1093-1411[»]
4CCUX-ray2.00A1093-1411[»]
4CD0X-ray2.23A1093-1411[»]
4CLIX-ray2.05A1093-1411[»]
4CLJX-ray1.66A1093-1411[»]
4CMOX-ray2.05A1093-1411[»]
4CMTX-ray1.73A1093-1411[»]
4CMUX-ray1.80A1093-1411[»]
4CNHX-ray1.90A/B1093-1411[»]
4CTBX-ray1.79A1093-1411[»]
4CTCX-ray2.03A1093-1411[»]
4DCEX-ray2.03A/B1078-1410[»]
4FNWX-ray1.75A1084-1410[»]
4FNXX-ray1.70A1084-1410[»]
4FNYX-ray2.45A1084-1410[»]
4FNZX-ray2.60A1084-1410[»]
4FOBX-ray1.90A1058-1410[»]
4FOCX-ray1.70A1058-1410[»]
4FODX-ray2.00A1078-1410[»]
4JOAX-ray2.70A1072-1410[»]
4MKCX-ray2.01A1072-1410[»]
4TT7X-ray2.10A1095-1410[»]
4Z55X-ray1.55A1072-1410[»]
5A9UX-ray1.60A1093-1411[»]
5AA8X-ray1.86A1093-1411[»]
5AA9X-ray1.93A1093-1411[»]
5AAAX-ray1.73A1093-1411[»]
5AABX-ray2.20A1093-1411[»]
5AACX-ray1.70A1093-1411[»]
5FTOX-ray2.22A1094-1407[»]
5FTQX-ray1.70A1094-1407[»]
5IMXX-ray2.12A1093-1411[»]
5IUGX-ray1.93A1084-1410[»]
5IUHX-ray2.10A1084-1410[»]
5IUIX-ray1.88A1084-1410[»]
5KZ0X-ray2.30A1093-1411[»]
5VZ5X-ray2.59C1274-1283[»]
6AT9X-ray2.95C1274-1283[»]
6MX8X-ray1.96A1094-1400[»]
ProteinModelPortaliQ9UM73
SMRiQ9UM73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106739, 65 interactors
DIPiDIP-5954N
IntActiQ9UM73, 12 interactors
MINTiQ9UM73
STRINGi9606.ENSP00000373700

Chemistry databases

BindingDBiQ9UM73
ChEMBLiCHEMBL4247
DrugBankiDB00171 Adenosine triphosphate
DB11363 Alectinib
DB09063 Ceritinib
DB08865 Crizotinib
GuidetoPHARMACOLOGYi1839

PTM databases

iPTMnetiQ9UM73
PhosphoSitePlusiQ9UM73

Polymorphism and mutation databases

BioMutaiALK
DMDMi296439447

Proteomic databases

EPDiQ9UM73
jPOSTiQ9UM73
PaxDbiQ9UM73
PeptideAtlasiQ9UM73
PRIDEiQ9UM73
ProteomicsDBi85185

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389048; ENSP00000373700; ENSG00000171094
GeneIDi238
KEGGihsa:238
UCSCiuc002rmy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
238
DisGeNETi238
EuPathDBiHostDB:ENSG00000171094.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ALK
GeneReviewsiALK

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0024259
HIX0030037
HGNCiHGNC:427 ALK
HPAiHPA010694
MalaCardsiALK
MIMi105590 gene
613014 phenotype
neXtProtiNX_Q9UM73
OpenTargetsiENSG00000171094
Orphaneti300895 ALK-positive anaplastic large cell lymphoma
364043 ALK-positive large B-cell lymphoma
146 Differentiated thyroid carcinoma
178342 Inflammatory myofibroblastic tumor
635 Neuroblastoma
357191 Selection of therapeutic option in non-small cell lung carcinoma
PharmGKBiPA24719

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
ENOG410XPVX LUCA
GeneTreeiENSGT00940000159280
HOGENOMiHOG000231766
HOVERGENiHBG018726
InParanoidiQ9UM73
KOiK05119
OMAiHKVQGSR
OrthoDBi731388at2759
PhylomeDBiQ9UM73
TreeFamiTF351636

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
SignaLinkiQ9UM73
SIGNORiQ9UM73

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ALK human
EvolutionaryTraceiQ9UM73

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Anaplastic_lymphoma_kinase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
238

Protein Ontology

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PROi
PR:Q9UM73

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171094 Expressed in 144 organ(s), highest expression level in sperm
ExpressionAtlasiQ9UM73 baseline and differential
GenevisibleiQ9UM73 HS

Family and domain databases

CDDicd00112 LDLa, 1 hit
cd06263 MAM, 2 hits
InterProiView protein in InterPro
IPR026830 ALK
IPR013320 ConA-like_dom_sf
IPR011009 Kinase-like_dom_sf
IPR036055 LDL_receptor-like_sf
IPR002172 LDrepeatLR_classA_rpt
IPR000998 MAM_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PANTHERiPTHR24416:SF276 PTHR24416:SF276, 1 hit
PfamiView protein in Pfam
PF00629 MAM, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF49899 SSF49899, 2 hits
SSF56112 SSF56112, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50060 MAM_2, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UM73
Secondary accession number(s): Q4ZFX9
, Q53QQ6, Q53RZ4, Q59FI3, Q9Y4K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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