PLAGL1

Functionⁱ

Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	4 – 26	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	32 – 56	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	62 – 84	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	91 – 113	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 207	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15888726
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9671765
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9671765

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9671765
cell cycle arrest
Source: ProtInc
Traceable author statementⁱ
- 9184226
cell differentiation Source: GO_Central
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 9671765

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SIGNORⁱ	Q9UM63

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein PLAGL1 Alternative name(s): Lost on transformation 1 Short name: LOT-1 Pleiomorphic adenoma-like protein 1 Tumor suppressor ZAC
Gene namesⁱ	Name:PLAGL1 Synonyms:LOT1, ZAC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118495.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9046 PLAGL1
MIMⁱ	603044 gene
neXtProtⁱ	NX_Q9UM63

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Transient neonatal diabetes mellitus 1 (TNDM1)1 Publication

The gene represented in this entry is involved in disease pathogenesis. Imprinted expression of PLAGL1 is relaxed in patients with transient neonatal diabetes (TND) (PubMed:11935319). Aberrant hypomethylation of the TND differentially methylated region within the PLAGL1 promoter as well as other imprinted loci at chromosome 6q24 is caused by ZFP57 mutations (PubMed:18622393).2 Publications

Disease descriptionNeonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5325
GeneReviewsⁱ	PLAGL1
MalaCards human disease database More...MalaCardsⁱ	PLAGL1
MIMⁱ	601410 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000118495
Orphanetⁱ	96191 Paternal uniparental disomy of chromosome 6 99886 Transient neonatal diabetes mellitus
PharmGKBⁱ	PA33379

Polymorphism and mutation databases

BioMutaⁱ	PLAGL1
DMDMⁱ	158523334

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047222	1 – 463	Zinc finger protein PLAGL1Add BLAST		463

Proteomic databases

PaxDbⁱ	Q9UM63
PeptideAtlas More...PeptideAtlasⁱ	Q9UM63
PRIDEⁱ	Q9UM63
ProteomicsDBⁱ	85183 85184 [Q9UM63-2]

PTM databases

iPTMnetⁱ	Q9UM63
PhosphoSitePlusⁱ	Q9UM63

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118495 Expressed in 233 organ(s), highest expression level in metanephros
CleanExⁱ	HS_PLAGL1
ExpressionAtlasⁱ	Q9UM63 baseline and differential
Genevisibleⁱ	Q9UM63 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055706

HPAⁱ

HPA055706

Interactionⁱ

Subunit structureⁱ

Interacts with THRSP.1 Publication

Protein-protein interaction databases

BioGridⁱ	111341, 13 interactors
IntActⁱ	Q9UM63, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9UM63
STRINGⁱ	9606.ENSP00000346810

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UM63
SMRⁱ	Q9UM63
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	4 – 26	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	32 – 56	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	62 – 84	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	91 – 113	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	120 – 142	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 207	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013640
HOVERGENⁱ	HBG053608
InParanoidⁱ	Q9UM63
KEGG Orthology (KO) More...KOⁱ	K19485
OMAⁱ	QCDHCER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G061O
PhylomeDBⁱ	Q9UM63
TreeFamⁱ	TF332024

Family and domain databases

InterProⁱ	View protein in InterPro IPR027770 PLAGL1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR45218 PTHR45218, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9UM63-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM 
        60         70         80         90        100
RHMATHSPQK SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY 
       110        120        130        140        150
NTMLGYKRHL ALHAASSGDL TCGVCALELG STEVLLDHLK AHAEEKPPSG 
       160        170        180        190        200
TKEKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT 
       210        220        230        240        250
RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP PFPLGASAQN 
       260        270        280        290        300
GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN 
       310        320        330        340        350
HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD 
       360        370        380        390        400
LAKGNAGKVN LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN 
       410        420        430        440        450
STLALGPGES LPHRLSCLGQ QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT 
       460 
GSAILPHFHH AFR

Length:463

Mass (Da):50,819

Last modified:September 11, 2007 - v2

Checksum:ⁱB10C74DA409BD4F7

GO

Isoform 2 (identifier: Q9UM63-2) [UniParc]FASTA Add to basket

Also known as: ZACdelta2

The sequence of this isoform differs from the canonical sequence as follows:
1-52: Missing.

« Hide

        10         20         30         40         50
MATHSPQKSH QCAHCEKTFN RKDHLKNHLQ THDPNKMAFG CEECGKKYNT 
        60         70         80         90        100
MLGYKRHLAL HAASSGDLTC GVCALELGST EVLLDHLKAH AEEKPPSGTK 
       110        120        130        140        150
EKKHQCDHCE RCFYTRKDVR RHLVVHTGCK DFLCQFCAQR FGRKDHLTRH 
       160        170        180        190        200
TKKTHSQELM KESLQTGDLL STFHTISPSF QLKAAALPPF PLGASAQNGL 
       210        220        230        240        250
ASSLPAEVHS LTLSPPEQAA QPMQPLPESL ASLHPSVSPG SPPPPLPNHK 
       260        270        280        290        300
YNTTSTSYSP LASLPLKADT KGFCNISLFE DLPLQEPQSP QKLNPGFDLA 
       310        320        330        340        350
KGNAGKVNLP KELPADAVNL TIPASLDLSP LLGFWQLPPP ATQNTFGNST 
       360        370        380        390        400
LALGPGESLP HRLSCLGQQQ QEPPLAMGTV SLGQLPLPPI PHVFSAGTGS 
       410 
AILPHFHHAF R

Show »

Length:411

Mass (Da):44,668

Checksum:ⁱ735121F4BF16F7C8

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
Q68DN7	Q68DN7_HUMAN	Zinc finger protein PLAGL1 Zinc finger protein PLAGL1	PLAGL1 DKFZp781P1017	252	Annotation score:
A1YLA1	A1YLA1_HUMAN	Pleiomorphic adenoma gene-like prot... Pleiomorphic adenoma gene-like protein 1 (Zinc finger protein PLAGL1)	PLAGL1	64	Annotation score:
A0A0D9SFM8	A0A0D9SFM8_HUMAN	Zinc finger protein PLAGL1 Zinc finger protein PLAGL1	PLAGL1	74	Annotation score:
A0A0D9SEQ4	A0A0D9SEQ4_HUMAN	Zinc finger protein PLAGL1 Zinc finger protein PLAGL1	PLAGL1	73	Annotation score:
A0A0D9SFI7	A0A0D9SFI7_HUMAN	Zinc finger protein PLAGL1 Zinc finger protein PLAGL1	PLAGL1	102	Annotation score:
A0A0D9SGF7	A0A0D9SGF7_HUMAN	Zinc finger protein PLAGL1 Zinc finger protein PLAGL1	PLAGL1	80	Annotation score:
A1YLA2	A1YLA2_HUMAN	Pleiomorphic adenoma gene-like prot... Pleiomorphic adenoma gene-like protein 1 (Pleomorphic adenoma gene-like 1) (Zinc finger protein PLAGL1)	PLAGL1	12	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	81	L → F in AAB67041 (PubMed:9150364).Curated		1
Sequence conflictⁱ	197	D → V in AAC34250 (PubMed:9722527).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052729	272	A → V. Corresponds to variant dbSNP:rs35263016Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028123	1 – 52	Missing in isoform 2. 4 PublicationsAdd BLAST		52

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U72621 mRNA Translation: AAB67041.1 U81992 mRNA Translation: AAC34250.1 AJ006354 mRNA Translation: CAA06994.1 AJ303119 mRNA Translation: CAC39614.1 AJ311395 mRNA Translation: CAC39615.1 AK314570 mRNA Translation: BAG37151.1 AK315184 mRNA Translation: BAG37625.1 BX537397 mRNA Translation: CAD97639.1 AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47852.1 CH471051 Genomic DNA Translation: EAW47853.1 CH471051 Genomic DNA Translation: EAW47854.1 CH471051 Genomic DNA Translation: EAW47855.1 CH471051 Genomic DNA Translation: EAW47856.1 BC074814 mRNA Translation: AAH74814.1 BC109085 mRNA Translation: AAI09086.1 BC109086 mRNA Translation: AAI09087.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5202.1 [Q9UM63-1] CCDS5203.1 [Q9UM63-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001074420.1, NM_001080951.2 [Q9UM63-1] NP_001074421.1, NM_001080952.2 [Q9UM63-1] NP_001074422.1, NM_001080953.2 [Q9UM63-1] NP_001074423.1, NM_001080954.2 [Q9UM63-1] NP_001074424.1, NM_001080955.2 [Q9UM63-2] NP_001074425.1, NM_001080956.2 [Q9UM63-2] NP_001275966.1, NM_001289037.1 [Q9UM63-2] NP_001275967.1, NM_001289038.1 [Q9UM63-2] NP_001275968.1, NM_001289039.1 [Q9UM63-2] NP_001275969.1, NM_001289040.1 [Q9UM63-2] NP_001275970.1, NM_001289041.1 [Q9UM63-2] NP_001275971.1, NM_001289042.1 [Q9UM63-1] NP_001275972.1, NM_001289043.1 [Q9UM63-1] NP_001275973.1, NM_001289044.1 [Q9UM63-1] NP_001275974.1, NM_001289045.1 [Q9UM63-1] NP_001275975.1, NM_001289046.1 [Q9UM63-1] NP_001275976.1, NM_001289047.1 [Q9UM63-1] NP_001275977.1, NM_001289048.1 [Q9UM63-1] NP_001275978.1, NM_001289049.1 [Q9UM63-1] NP_001304085.1, NM_001317156.1 [Q9UM63-1] NP_001304086.1, NM_001317157.1 [Q9UM63-1] NP_001304087.1, NM_001317158.1 [Q9UM63-2] NP_001304088.1, NM_001317159.1 [Q9UM63-1] NP_001304089.1, NM_001317160.1 [Q9UM63-2] NP_001304090.1, NM_001317161.1 [Q9UM63-1] NP_001304091.1, NM_001317162.1 [Q9UM63-1] NP_006709.2, NM_006718.4 [Q9UM63-1]
UniGeneⁱ	Hs.743225

Genome annotation databases

Ensemblⁱ	ENST00000354765; ENSP00000346810; ENSG00000118495 [Q9UM63-1] ENST00000360537; ENSP00000353734; ENSG00000118495 [Q9UM63-1] ENST00000367571; ENSP00000356543; ENSG00000118495 [Q9UM63-1] ENST00000367572; ENSP00000356544; ENSG00000118495 [Q9UM63-2] ENST00000416623; ENSP00000400060; ENSG00000118495 [Q9UM63-1] ENST00000417959; ENSP00000395960; ENSG00000118495 [Q9UM63-2] ENST00000437412; ENSP00000392418; ENSG00000118495 [Q9UM63-2] ENST00000444202; ENSP00000400929; ENSG00000118495 [Q9UM63-1] ENST00000625622; ENSP00000486355; ENSG00000118495 [Q9UM63-1]
GeneIDⁱ	5325
KEGGⁱ	hsa:5325
UCSC genome browser More...UCSCⁱ	uc003qjv.4 human [Q9UM63-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UM63	PLAG1 like zinc finger 1		GORGO		463	UniRef100_Q9UM63
Isoform 2 of Zinc finger protein PLAGL1		HUMAN		411
Pleomorphic adenoma gene-like 1 (Fragment)		PANTR		62
PLAGL1 isoform 15 (Fragment)		PONAB		64
Zinc finger protein PLAGL1		HUMAN		252
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9UM63	Zinc finger protein PLAGL1		PIG		463	UniRef90_Q9UM63
PLAG1 like zinc finger 1		GORGO		463
Isoform 2 of Zinc finger protein PLAGL1		HUMAN		411
Pleomorphic adenoma gene-like 1 (Fragment)		PANTR		62
PLAGL1 isoform 15 (Fragment)		PONAB		64
+87

Protein	Similar proteins		Species	Score	Length	Source
Q9UM63	Zinc finger protein PLAGL1		PIG		463	UniRef50_Q9UM63
PLAG1 like zinc finger 1		GORGO		463
Isoform 2 of Zinc finger protein PLAGL1		HUMAN		411
Pleomorphic adenoma gene-like 1 (Fragment)		PANTR		62
PLAGL1 isoform 15 (Fragment)		PONAB		64
+162

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U72621 mRNA Translation: AAB67041.1 U81992 mRNA Translation: AAC34250.1 AJ006354 mRNA Translation: CAA06994.1 AJ303119 mRNA Translation: CAC39614.1 AJ311395 mRNA Translation: CAC39615.1 AK314570 mRNA Translation: BAG37151.1 AK315184 mRNA Translation: BAG37625.1 BX537397 mRNA Translation: CAD97639.1 AL049844 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47852.1 CH471051 Genomic DNA Translation: EAW47853.1 CH471051 Genomic DNA Translation: EAW47854.1 CH471051 Genomic DNA Translation: EAW47855.1 CH471051 Genomic DNA Translation: EAW47856.1 BC074814 mRNA Translation: AAH74814.1 BC109085 mRNA Translation: AAI09086.1 BC109086 mRNA Translation: AAI09087.1
CCDSⁱ	CCDS5202.1 [Q9UM63-1] CCDS5203.1 [Q9UM63-2]
RefSeqⁱ	NP_001074420.1, NM_001080951.2 [Q9UM63-1] NP_001074421.1, NM_001080952.2 [Q9UM63-1] NP_001074422.1, NM_001080953.2 [Q9UM63-1] NP_001074423.1, NM_001080954.2 [Q9UM63-1] NP_001074424.1, NM_001080955.2 [Q9UM63-2] NP_001074425.1, NM_001080956.2 [Q9UM63-2] NP_001275966.1, NM_001289037.1 [Q9UM63-2] NP_001275967.1, NM_001289038.1 [Q9UM63-2] NP_001275968.1, NM_001289039.1 [Q9UM63-2] NP_001275969.1, NM_001289040.1 [Q9UM63-2] NP_001275970.1, NM_001289041.1 [Q9UM63-2] NP_001275971.1, NM_001289042.1 [Q9UM63-1] NP_001275972.1, NM_001289043.1 [Q9UM63-1] NP_001275973.1, NM_001289044.1 [Q9UM63-1] NP_001275974.1, NM_001289045.1 [Q9UM63-1] NP_001275975.1, NM_001289046.1 [Q9UM63-1] NP_001275976.1, NM_001289047.1 [Q9UM63-1] NP_001275977.1, NM_001289048.1 [Q9UM63-1] NP_001275978.1, NM_001289049.1 [Q9UM63-1] NP_001304085.1, NM_001317156.1 [Q9UM63-1] NP_001304086.1, NM_001317157.1 [Q9UM63-1] NP_001304087.1, NM_001317158.1 [Q9UM63-2] NP_001304088.1, NM_001317159.1 [Q9UM63-1] NP_001304089.1, NM_001317160.1 [Q9UM63-2] NP_001304090.1, NM_001317161.1 [Q9UM63-1] NP_001304091.1, NM_001317162.1 [Q9UM63-1] NP_006709.2, NM_006718.4 [Q9UM63-1]
UniGeneⁱ	Hs.743225

3D structure databases

ProteinModelPortalⁱ	Q9UM63
SMRⁱ	Q9UM63
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111341, 13 interactors
IntActⁱ	Q9UM63, 2 interactors
MINTⁱ	Q9UM63
STRINGⁱ	9606.ENSP00000346810

PTM databases

iPTMnetⁱ	Q9UM63
PhosphoSitePlusⁱ	Q9UM63

Polymorphism and mutation databases

BioMutaⁱ	PLAGL1
DMDMⁱ	158523334

Proteomic databases

PaxDbⁱ	Q9UM63
PeptideAtlasⁱ	Q9UM63
PRIDEⁱ	Q9UM63
ProteomicsDBⁱ	85183 85184 [Q9UM63-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5325
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354765; ENSP00000346810; ENSG00000118495 [Q9UM63-1] ENST00000360537; ENSP00000353734; ENSG00000118495 [Q9UM63-1] ENST00000367571; ENSP00000356543; ENSG00000118495 [Q9UM63-1] ENST00000367572; ENSP00000356544; ENSG00000118495 [Q9UM63-2] ENST00000416623; ENSP00000400060; ENSG00000118495 [Q9UM63-1] ENST00000417959; ENSP00000395960; ENSG00000118495 [Q9UM63-2] ENST00000437412; ENSP00000392418; ENSG00000118495 [Q9UM63-2] ENST00000444202; ENSP00000400929; ENSG00000118495 [Q9UM63-1] ENST00000625622; ENSP00000486355; ENSG00000118495 [Q9UM63-1]
GeneIDⁱ	5325
KEGGⁱ	hsa:5325
UCSCⁱ	uc003qjv.4 human [Q9UM63-1]

Organism-specific databases

CTDⁱ	5325
DisGeNETⁱ	5325
EuPathDBⁱ	HostDB:ENSG00000118495.18
GeneCardsⁱ	PLAGL1
GeneReviewsⁱ	PLAGL1
HGNCⁱ	HGNC:9046 PLAGL1
HPAⁱ	HPA055706
MalaCardsⁱ	PLAGL1
MIMⁱ	601410 phenotype 603044 gene
neXtProtⁱ	NX_Q9UM63
OpenTargetsⁱ	ENSG00000118495
Orphanetⁱ	96191 Paternal uniparental disomy of chromosome 6 99886 Transient neonatal diabetes mellitus
PharmGKBⁱ	PA33379
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00390000013640
HOVERGENⁱ	HBG053608
InParanoidⁱ	Q9UM63
KOⁱ	K19485
OMAⁱ	QCDHCER
OrthoDBⁱ	EOG091G061O
PhylomeDBⁱ	Q9UM63
TreeFamⁱ	TF332024

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SIGNORⁱ	Q9UM63

Miscellaneous databases

ChiTaRSⁱ	PLAGL1 human
GeneWikiⁱ	PLAGL1
GenomeRNAiⁱ	5325
Protein Ontology More...PROⁱ	PR:Q9UM63
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118495 Expressed in 233 organ(s), highest expression level in metanephros
CleanExⁱ	HS_PLAGL1
ExpressionAtlasⁱ	Q9UM63 baseline and differential
Genevisibleⁱ	Q9UM63 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027770 PLAGL1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR45218 PTHR45218, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLAL1_HUMAN
Accessionⁱ	Q9UM63Primary (citable) accession number: Q9UM63 Secondary accession number(s): B2RBA4 Q9UIZ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	September 11, 2007
	Last modified:	September 12, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UM63 (PLAL1_HUMAN)

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Zinc finger protein PLAGL1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ