UniProtKB - Q9UM54 (MYO6_HUMAN)
Unconventional myosin-VI
MYO6
Functioni
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 151 – 158 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin-dependent ATPase activity Source: GO_Central
- actin filament binding Source: UniProtKB
- ADP binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB
- identical protein binding Source: IntAct
- microfilament motor activity Source: GO_Central
- minus-end directed microfilament motor activity Source: UniProtKB
- motor activity Source: UniProtKB
GO - Biological processi
- actin filament-based movement Source: UniProtKB
- actin filament organization Source: GO_Central
- DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
- endocytosis Source: UniProtKB
- inner ear auditory receptor cell differentiation Source: GO_Central
- inner ear morphogenesis Source: GO_Central
- intracellular protein transport Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of secretion Source: UniProtKB
- sensory perception of sound Source: UniProtKB-KW
- vesicle transport along actin filament Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Endocytosis, Hearing, Protein transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UM54 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-399719, Trafficking of AMPA receptors |
SIGNORi | Q9UM54 |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-VIAlternative name(s): Unconventional myosin-6 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7605, MYO6 |
MIMi | 600970, gene |
neXtProti | NX_Q9UM54 |
VEuPathDBi | HostDB:ENSG00000196586.13 |
Subcellular locationi
Plasma membrane
- ruffle membrane 1 Publication
Golgi apparatus
- trans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication
- Golgi apparatus 1 Publication
Nucleus
- Nucleus 2 Publications
Cytosol
- cytosol 1 Publication
Other locations
- perinuclear region 1 Publication
- clathrin-coated pit 1 Publication
- clathrin-coated vesicle 1 Publication
- filopodium 1 Publication
- microvillus 1 Publication
Note: Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (By similarity).By similarity3 Publications
Other locations
- clathrin-coated vesicle membrane 1 Publication
Plasma membrane
- ruffle membrane 1 Publication
Other locations
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- actin filament Source: UniProtKB
- filamentous actin Source: UniProtKB
- unconventional myosin complex Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Lysosome
- lysosomal membrane Source: Reactome
Nucleus
- nuclear membrane Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
- RNA polymerase II, holoenzyme Source: UniProtKB
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
- plasma membrane Source: GO_Central
- ruffle membrane Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB
- cell projection Source: GO_Central
- clathrin-coated vesicle membrane Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB
- endocytic vesicle Source: GO_Central
- filopodium Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- microvillus Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- ruffle Source: UniProtKB
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Deafness, autosomal dominant, 22 (DFNA22)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012110 | 442 | C → Y in DFNA22. 1 Publication | 1 |
Deafness, autosomal recessive, 37 (DFNB37)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016209 | 216 | E → V in DFNB37. 1 PublicationCorresponds to variant dbSNP:rs121912559EnsemblClinVar. | 1 |
Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy (DFNHCM)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029988 | 246 | H → R in DFNHCM. 1 PublicationCorresponds to variant dbSNP:rs121912560EnsemblClinVar. | 1 |
Keywords - Diseasei
Cardiomyopathy, Deafness, Disease variant, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 4646 |
GeneReviewsi | MYO6 |
MalaCardsi | MYO6 |
MIMi | 606346, phenotype 607821, phenotype |
OpenTargetsi | ENSG00000196586 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB 228012, Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome |
PharmGKBi | PA31410 |
Miscellaneous databases
Pharosi | Q9UM54, Tbio |
Genetic variation databases
BioMutai | MYO6 |
DMDMi | 122065628 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123464 | 1 – 1294 | Unconventional myosin-VIAdd BLAST | 1294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 405 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 604 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1025 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1155 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UM54 |
jPOSTi | Q9UM54 |
MassIVEi | Q9UM54 |
MaxQBi | Q9UM54 |
PaxDbi | Q9UM54 |
PeptideAtlasi | Q9UM54 |
PRIDEi | Q9UM54 |
ProteomicsDBi | 85177 [Q9UM54-3] 85178 [Q9UM54-1] 85179 [Q9UM54-2] 85180 [Q9UM54-4] 85181 [Q9UM54-5] 85182 [Q9UM54-6] |
PTM databases
iPTMneti | Q9UM54 |
MetOSitei | Q9UM54 |
PhosphoSitePlusi | Q9UM54 |
SwissPalmi | Q9UM54 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196586, Expressed in sural nerve and 229 other tissues |
ExpressionAtlasi | Q9UM54, baseline and differential |
Genevisiblei | Q9UM54, HS |
Organism-specific databases
HPAi | ENSG00000196586, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Able to function as a monomer under specific conditions in vitro (PubMed:15044955).
Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (PubMed:15247260).
Component of the DISP/DOCK7-induced septin displacement complex, at least composed of DOCK7, LRCH3 and MYO6 (PubMed:29467281). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (By similarity). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (By similarity). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity).
Interacts with DAB2 (PubMed:11967127). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity).
Interacts with CFTR (PubMed:15247260).
Interacts with OPTN (By similarity).
Interacts with CABP5 (By similarity).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ9UM54
With | #Exp. | IntAct |
---|---|---|
DAB2 [P98082] | 3 | EBI-350606,EBI-1171238 |
Dab2 [P98078] from Mus musculus. | 4 | EBI-350606,EBI-1391846 |
Gipc1 [Q9Z0G0] from Mus musculus. | 4 | EBI-350606,EBI-300855 |
MYO6 - isoform 1 [Q9UM54-1]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15706115,EBI-15706115 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: UniProtKB
- calmodulin binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110730, 246 interactors |
DIPi | DIP-33123N |
IntActi | Q9UM54, 78 interactors |
MINTi | Q9UM54 |
STRINGi | 9606.ENSP00000358994 |
Miscellaneous databases
RNActi | Q9UM54, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UM54 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 53 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 57 – 771 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 715 | |
Domaini | 814 – 834 | IQBy similarityAdd BLAST | 21 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 273 – 317 | Responsible for slow ATPase activityBy similarityAdd BLAST | 45 | |
Regioni | 665 – 672 | Actin-bindingSequence analysis | 8 | |
Regioni | 782 – 810 | Required for binding calmodulinBy similarityAdd BLAST | 29 | |
Regioni | 835 – 916 | Three-helix bundleBy similarityAdd BLAST | 82 | |
Regioni | 917 – 984 | SAH1 PublicationAdd BLAST | 68 | |
Regioni | 1116 – 1118 | Interaction with OPTNBy similarity | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 920 – 1027 | Glu-richAdd BLAST | 108 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0163, Eukaryota |
GeneTreei | ENSGT00940000156078 |
InParanoidi | Q9UM54 |
PhylomeDBi | Q9UM54 |
TreeFami | TF351449 |
Family and domain databases
CDDi | cd01382, MYSc_Myo6, 1 hit |
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR036961, Kinesin_motor_dom_sf IPR032412, Myosin-VI_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR036114, MYSc_Myo6 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF16521, Myosin-VI_CBD, 1 hit PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP
60 70 80 90 100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY
110 120 130 140 150
FDIPKIYSSE AIKSYQGKSL GTRPPHVFAI ADKAFRDMKV LKMSQSIIVS
160 170 180 190 200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN
210 220 230 240 250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR
260 270 280 290 300
LCAGASEDIR EKLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY
310 320 330 340 350
LKAGSMKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI
360 370 380 390 400
DFEEAGSTSG GCNLKNKSAQ SLEYCAELLG LDQDDLRVSL TTRVMLTTAG
410 420 430 440 450
GTKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY
460 470 480 490 500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG
510 520 530 540 550
LGVNEVHYVD NQDCIDLIEA KLVGILDILD EENRLPQPSD QHFTSAVHQK
560 570 580 590 600
HKDHFRLTIP RKSKLAVHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA
610 620 630 640 650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ
660 670 680 690 700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL
710 720 730 740 750
MQGGYPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNENDYK
760 770 780 790 800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLTC SRWKKVQWCS
810 820 830 840 850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL
860 870 880 890 900
DKFNEVVSVL KDGKPEMNKQ IKNLEISIDT LMAKIKSTMM TQEQIQKEYD
910 920 930 940 950
ALVKSSEELL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEKRRRKE
960 970 980 990 1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQKEEESQQQ
1010 1020 1030 1040 1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DLALRRSLDS YPVSKNDGTR
1060 1070 1080 1090 1100
PKMTPEQMAK EMSEFLSRGP AVLATKAAAG TKKYDLSKWK YAELRDTINT
1110 1120 1130 1140 1150
SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP
1160 1170 1180 1190 1200
FLNNSPQQNP AAQIPARQRE IEMNRQQRFF RIPFIRPADQ YKDPQSKKKG
1210 1220 1230 1240 1250
WWYAHFDGPW IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG
1260 1270 1280 1290
AEILPRQFEE IWERCGGIQY LQNAIESRQA RPTYATAMLQ SLLK
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EW20 | E7EW20_HUMAN | Unconventional myosin-6 | MYO6 | 1,295 | Annotation score: | ||
A0A0A0MRM8 | A0A0A0MRM8_HUMAN | Unconventional myosin-6 | MYO6 | 1,253 | Annotation score: | ||
A0A1Y0BRN3 | A0A1Y0BRN3_HUMAN | Unconventional myosin-6 | MYO6 Myo6-007 | 1,285 | Annotation score: | ||
A0A590UJ40 | A0A590UJ40_HUMAN | Unconventional myosin-6 | MYO6 | 1,294 | Annotation score: | ||
A0A0D9SGC1 | A0A0D9SGC1_HUMAN | Unconventional myosin-VI | MYO6 | 962 | Annotation score: | ||
A0A590UJ75 | A0A590UJ75_HUMAN | Unconventional myosin-VI | MYO6 | 926 | Annotation score: | ||
A0A590UKB0 | A0A590UKB0_HUMAN | Unconventional myosin-VI | MYO6 | 924 | Annotation score: | ||
A0A590UJY4 | A0A590UJY4_HUMAN | Unconventional myosin-VI | MYO6 | 664 | Annotation score: | ||
A0A590UK71 | A0A590UK71_HUMAN | Unconventional myosin-VI | MYO6 | 634 | Annotation score: | ||
A0A590UK86 | A0A590UK86_HUMAN | Unconventional myosin-VI | MYO6 | 690 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016209 | 216 | E → V in DFNB37. 1 PublicationCorresponds to variant dbSNP:rs121912559EnsemblClinVar. | 1 | |
Natural variantiVAR_029988 | 246 | H → R in DFNHCM. 1 PublicationCorresponds to variant dbSNP:rs121912560EnsemblClinVar. | 1 | |
Natural variantiVAR_012110 | 442 | C → Y in DFNA22. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007985 | 1037 – 1068 | Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_022332 | 1037 – 1045 | Missing in isoform 1. 2 Publications | 9 | |
Alternative sequenceiVSP_042208 | 1147 – 1156 | DFAPFLNNSP → A in isoform 6. 1 Publication | 10 | |
Alternative sequenceiVSP_022333 | 1147 – 1155 | Missing in isoform 4 and isoform 5. Curated | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90236 mRNA Translation: AAC51654.2 AF229111 , AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA Translation: AAK00229.1 AL109897 Genomic DNA No translation available. AL136093 Genomic DNA No translation available. AB002387 mRNA Translation: BAA20843.2 Different initiation. CH471051 Genomic DNA Translation: EAW48730.1 CH471051 Genomic DNA Translation: EAW48731.1 BC146764 mRNA Translation: AAI46765.1 BP333853 mRNA No translation available. |
CCDSi | CCDS34487.1 [Q9UM54-1] CCDS75481.1 [Q9UM54-2] |
RefSeqi | NP_001287828.1, NM_001300899.1 [Q9UM54-2] NP_004990.3, NM_004999.3 [Q9UM54-1] |
Genome annotation databases
Ensembli | ENST00000369977; ENSP00000358994; ENSG00000196586 [Q9UM54-1] ENST00000369985; ENSP00000359002; ENSG00000196586 [Q9UM54-2] ENST00000615563; ENSP00000478013; ENSG00000196586 [Q9UM54-2] |
GeneIDi | 4646 |
KEGGi | hsa:4646 |
UCSCi | uc003pih.2, human [Q9UM54-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U90236 mRNA Translation: AAC51654.2 AF229111 , AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA Translation: AAK00229.1 AL109897 Genomic DNA No translation available. AL136093 Genomic DNA No translation available. AB002387 mRNA Translation: BAA20843.2 Different initiation. CH471051 Genomic DNA Translation: EAW48730.1 CH471051 Genomic DNA Translation: EAW48731.1 BC146764 mRNA Translation: AAI46765.1 BP333853 mRNA No translation available. |
CCDSi | CCDS34487.1 [Q9UM54-1] CCDS75481.1 [Q9UM54-2] |
RefSeqi | NP_001287828.1, NM_001300899.1 [Q9UM54-2] NP_004990.3, NM_004999.3 [Q9UM54-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N0Z | NMR | - | A | 1080-1122 | [»] | |
2N10 | NMR | - | A | 1080-1131 | [»] | |
2N11 | NMR | - | A | 998-1071 | [»] | |
2N12 | NMR | - | A | 1050-1131 | [»] | |
2N13 | NMR | - | A/D | 1080-1122 | [»] | |
6E5N | NMR | - | B | 1050-1131 | [»] | |
6J56 | X-ray | 1.80 | A/B | 1166-1294 | [»] | |
SMRi | Q9UM54 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110730, 246 interactors |
DIPi | DIP-33123N |
IntActi | Q9UM54, 78 interactors |
MINTi | Q9UM54 |
STRINGi | 9606.ENSP00000358994 |
PTM databases
iPTMneti | Q9UM54 |
MetOSitei | Q9UM54 |
PhosphoSitePlusi | Q9UM54 |
SwissPalmi | Q9UM54 |
Genetic variation databases
BioMutai | MYO6 |
DMDMi | 122065628 |
Proteomic databases
EPDi | Q9UM54 |
jPOSTi | Q9UM54 |
MassIVEi | Q9UM54 |
MaxQBi | Q9UM54 |
PaxDbi | Q9UM54 |
PeptideAtlasi | Q9UM54 |
PRIDEi | Q9UM54 |
ProteomicsDBi | 85177 [Q9UM54-3] 85178 [Q9UM54-1] 85179 [Q9UM54-2] 85180 [Q9UM54-4] 85181 [Q9UM54-5] 85182 [Q9UM54-6] |
Protocols and materials databases
Antibodypediai | 4385, 139 antibodies |
Genome annotation databases
Ensembli | ENST00000369977; ENSP00000358994; ENSG00000196586 [Q9UM54-1] ENST00000369985; ENSP00000359002; ENSG00000196586 [Q9UM54-2] ENST00000615563; ENSP00000478013; ENSG00000196586 [Q9UM54-2] |
GeneIDi | 4646 |
KEGGi | hsa:4646 |
UCSCi | uc003pih.2, human [Q9UM54-3] |
Organism-specific databases
CTDi | 4646 |
DisGeNETi | 4646 |
GeneCardsi | MYO6 |
GeneReviewsi | MYO6 |
HGNCi | HGNC:7605, MYO6 |
HPAi | ENSG00000196586, Low tissue specificity |
MalaCardsi | MYO6 |
MIMi | 600970, gene 606346, phenotype 607821, phenotype |
neXtProti | NX_Q9UM54 |
OpenTargetsi | ENSG00000196586 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB 228012, Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome |
PharmGKBi | PA31410 |
VEuPathDBi | HostDB:ENSG00000196586.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0163, Eukaryota |
GeneTreei | ENSGT00940000156078 |
InParanoidi | Q9UM54 |
PhylomeDBi | Q9UM54 |
TreeFami | TF351449 |
Enzyme and pathway databases
PathwayCommonsi | Q9UM54 |
Reactomei | R-HSA-190873, Gap junction degradation R-HSA-399719, Trafficking of AMPA receptors |
SIGNORi | Q9UM54 |
Miscellaneous databases
BioGRID-ORCSi | 4646, 5 hits in 879 CRISPR screens |
ChiTaRSi | MYO6, human |
GeneWikii | MYO6 |
GenomeRNAii | 4646 |
Pharosi | Q9UM54, Tbio |
PROi | PR:Q9UM54 |
RNActi | Q9UM54, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196586, Expressed in sural nerve and 229 other tissues |
ExpressionAtlasi | Q9UM54, baseline and differential |
Genevisiblei | Q9UM54, HS |
Family and domain databases
CDDi | cd01382, MYSc_Myo6, 1 hit |
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR036961, Kinesin_motor_dom_sf IPR032412, Myosin-VI_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR036114, MYSc_Myo6 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF16521, Myosin-VI_CBD, 1 hit PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO6_HUMAN | |
Accessioni | Q9UM54Primary (citable) accession number: Q9UM54 Secondary accession number(s): A6H8V4 Q9UEG2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 209 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families