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UniProtKB - Q9UM54 (MYO6_HUMAN)

Protein

Unconventional myosin-VI

Gene

MYO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).By similarity4 Publications

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).Curated
Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 158ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • ADP binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • minus-end directed microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processEndocytosis, Hearing, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-190873 Gap junction degradation
R-HSA-399719 Trafficking of AMPA receptors
SIGNORiQ9UM54

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VI
Alternative name(s):
Unconventional myosin-6
Gene namesi
Name:MYO6
Synonyms:KIAA0389
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196586.13
HGNCiHGNC:7605 MYO6
MIMi600970 gene
neXtProtiNX_Q9UM54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Coated pit, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 22 (DFNA22)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness.
See also OMIM:606346
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012110442C → Y in DFNA22. 1 Publication1
Deafness, autosomal recessive, 37 (DFNB37)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:607821
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016209216E → V in DFNB37. 1 PublicationCorresponds to variant dbSNP:rs121912559EnsemblClinVar.1
Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy (DFNHCM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant sensorineural deafness associated with hypertrophic cardiomyopathy.
See also OMIM:606346
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029988246H → R in DFNHCM. 1 PublicationCorresponds to variant dbSNP:rs121912560EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi4646
GeneReviewsiMYO6
MalaCardsiMYO6
MIMi606346 phenotype
607821 phenotype
OpenTargetsiENSG00000196586
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
228012 Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome
PharmGKBiPA31410

Polymorphism and mutation databases

BioMutaiMYO6
DMDMi122065628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234641 – 1294Unconventional myosin-VIAdd BLAST1294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineCombined sources1
Modified residuei405PhosphothreonineCombined sources1
Modified residuei604PhosphoserineBy similarity1
Modified residuei1025PhosphoserineBy similarity1
Modified residuei1155PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles and affects F-actin dynamics. Phosphorylated in vitro by p21-activated kinase (PAK) (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UM54
MaxQBiQ9UM54
PaxDbiQ9UM54
PeptideAtlasiQ9UM54
PRIDEiQ9UM54
ProteomicsDBi85177
85178 [Q9UM54-1]
85179 [Q9UM54-2]
85180 [Q9UM54-4]
85181 [Q9UM54-5]
85182 [Q9UM54-6]

PTM databases

iPTMnetiQ9UM54
PhosphoSitePlusiQ9UM54
SwissPalmiQ9UM54

Expressioni

Tissue specificityi

Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000196586 Expressed in 217 organ(s), highest expression level in corpus callosum
CleanExiHS_MYO6
ExpressionAtlasiQ9UM54 baseline and differential
GenevisibleiQ9UM54 HS

Organism-specific databases

HPAiCAB010762
HPA035483

Interactioni

Subunit structurei

Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal. This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium. Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2. In vitro, the C-terminal globular tail binds a C-terminal region of DAB2. Interacts with CFTR. Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells. Interacts with OPTN (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi110730, 109 interactors
DIPiDIP-33123N
IntActiQ9UM54, 60 interactors
MINTiQ9UM54
STRINGi9606.ENSP00000358994

Structurei

Secondary structure

11294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UM54
SMRiQ9UM54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 53Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST52
Domaini57 – 771Myosin motorPROSITE-ProRule annotationAdd BLAST715
Domaini814 – 834IQAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni273 – 317Responsible for slow ATPase activityBy similarityAdd BLAST45
Regioni665 – 672Actin-bindingSequence analysis8
Regioni782 – 810Required for binding calmodulinBy similarityAdd BLAST29
Regioni835 – 916Three-helix bundleAdd BLAST82
Regioni917 – 984SAH1 PublicationAdd BLAST68
Regioni1116 – 1118Interaction with OPTN3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi920 – 1027Glu-richAdd BLAST108

Domaini

Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a three-helix bundle region, a SAH domain and a unique globular domain required for interaction with other proteins such as cargo-binding.Curated
The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. Its contribution to the mechanism confering the myosin movement on actin filaments is debated.1 Publication

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOVERGENiHBG003523
InParanoidiQ9UM54
KOiK10358
PhylomeDBiQ9UM54
TreeFamiTF351449

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9UM54-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDGKPVWAP HPTDGFQMGN IVDIGPDSLT IEPLNQKGKT FLALINQVFP 
        60         70         80         90        100
AEEDSKKDVE DNCSLMYLNE ATLLHNIKVR YSKDRIYTYV ANILIAVNPY 
       110        120        130        140        150
FDIPKIYSSE AIKSYQGKSL GTRPPHVFAI ADKAFRDMKV LKMSQSIIVS 
       160        170        180        190        200
GESGAGKTEN TKFVLRYLTE SYGTGQDIDD RIVEANPLLE AFGNAKTVRN 
       210        220        230        240        250
NNSSRFGKFV EIHFNEKSSV VGGFVSHYLL EKSRICVQGK EERNYHIFYR 
       260        270        280        290        300
LCAGASEDIR EKLHLSSPDN FRYLNRGCTR YFANKETDKQ ILQNRKSPEY 
       310        320        330        340        350
LKAGSMKDPL LDDHGDFIRM CTAMKKIGLD DEEKLDLFRV VAGVLHLGNI 
       360        370        380        390        400
DFEEAGSTSG GCNLKNKSAQ SLEYCAELLG LDQDDLRVSL TTRVMLTTAG 
       410        420        430        440        450
GTKGTVIKVP LKVEQANNAR DALAKTVYSH LFDHVVNRVN QCFPFETSSY 
       460        470        480        490        500
FIGVLDIAGF EYFEHNSFEQ FCINYCNEKL QQFFNERILK EEQELYQKEG 
       510        520        530        540        550
LGVNEVHYVD NQDCIDLIEA KLVGILDILD EENRLPQPSD QHFTSAVHQK 
       560        570        580        590        600
HKDHFRLTIP RKSKLAVHRN IRDDEGFIIR HFAGAVCYET TQFVEKNNDA 
       610        620        630        640        650
LHMSLESLIC ESRDKFIREL FESSTNNNKD TKQKAGKLSF ISVGNKFKTQ 
       660        670        680        690        700
LNLLLDKLRS TGASFIRCIK PNLKMTSHHF EGAQILSQLQ CSGMVSVLDL 
       710        720        730        740        750
MQGGYPSRAS FHELYNMYKK YMPDKLARLD PRLFCKALFK ALGLNENDYK 
       760        770        780        790        800
FGLTKVFFRP GKFAEFDQIM KSDPDHLAEL VKRVNHWLTC SRWKKVQWCS 
       810        820        830        840        850
LSVIKLKNKI KYRAEACIKM QKTIRMWLCK RRHKPRIDGL VKVGTLKKRL 
       860        870        880        890        900
DKFNEVVSVL KDGKPEMNKQ IKNLEISIDT LMAKIKSTMM TQEQIQKEYD 
       910        920        930        940        950
ALVKSSEELL SALQKKKQQE EEAERLRRIQ EEMEKERKRR EEDEKRRRKE 
       960        970        980        990       1000
EEERRMKLEM EAKRKQEEEE RKKREDDEKR IQAEVEAQLA RQKEEESQQQ 
      1010       1020       1030       1040       1050
AVLEQERRDR ELALRIAQSE AELISDEAQA DLALRRSLDS YPVSKNDGTR 
      1060       1070       1080       1090       1100
PKMTPEQMAK EMSEFLSRGP AVLATKAAAG TKKYDLSKWK YAELRDTINT 
      1110       1120       1130       1140       1150
SCDIELLAAC REEFHRRLKV YHAWKSKNKK RNTETEQRAP KSVTDYDFAP 
      1160       1170       1180       1190       1200
FLNNSPQQNP AAQIPARQRE IEMNRQQRFF RIPFIRPADQ YKDPQSKKKG 
      1210       1220       1230       1240       1250
WWYAHFDGPW IARQMELHPD KPPILLVAGK DDMEMCELNL EETGLTRKRG 
      1260       1270       1280       1290 
AEILPRQFEE IWERCGGIQY LQNAIESRQA RPTYATAMLQ SLLK
Length:1,294
Mass (Da):149,691
Last modified:January 9, 2007 - v4
Checksum:i3A8966E6864B8576
GO
Isoform 1 (identifier: Q9UM54-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1045: Missing.

Show »
Length:1,285
Mass (Da):148,714
Checksum:iBCB4FDFE920712CD
GO
Isoform 2 (identifier: Q9UM54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.

Show »
Length:1,262
Mass (Da):146,048
Checksum:iCF1FA35796FC1C60
GO
Isoform 4 (identifier: Q9UM54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1155: Missing.

Show »
Length:1,285
Mass (Da):148,685
Checksum:iF68A79F74AB9170C
GO
Isoform 5 (identifier: Q9UM54-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1037-1068: Missing.
     1147-1155: Missing.

Show »
Length:1,253
Mass (Da):145,042
Checksum:iDD739BA2DD557EEF
GO
Isoform 6 (identifier: Q9UM54-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1156: DFAPFLNNSP → A

Show »
Length:1,285
Mass (Da):148,659
Checksum:iEAE6008E2FAC170C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRM8A0A0A0MRM8_HUMAN
Unconventional myosin-VI
MYO6
1,253Annotation score:
E7EW20E7EW20_HUMAN
Unconventional myosin-VI
MYO6
1,295Annotation score:
A0A0D9SGC1A0A0D9SGC1_HUMAN
Unconventional myosin-VI
MYO6
1,294Annotation score:
Q5JVM0Q5JVM0_HUMAN
Unconventional myosin-VI
MYO6
174Annotation score:

Sequence cautioni

The sequence BAA20843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1156P → A in CAI42826 (PubMed:14574404).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016209216E → V in DFNB37. 1 PublicationCorresponds to variant dbSNP:rs121912559EnsemblClinVar.1
Natural variantiVAR_029988246H → R in DFNHCM. 1 PublicationCorresponds to variant dbSNP:rs121912560EnsemblClinVar.1
Natural variantiVAR_012110442C → Y in DFNA22. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0079851037 – 1068Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0223321037 – 1045Missing in isoform 1. 2 Publications9
Alternative sequenceiVSP_0422081147 – 1156DFAPFLNNSP → A in isoform 6. 1 Publication10
Alternative sequenceiVSP_0223331147 – 1155Missing in isoform 4 and isoform 5. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA Translation: AAC51654.2
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA Translation: AAK00229.1
AL109897, AL136093 Genomic DNA Translation: CAI19520.1
AL109897, AL136093 Genomic DNA Translation: CAI19521.1
AL109897, AL136093 Genomic DNA Translation: CAI19522.1
AL136093, AL109897 Genomic DNA Translation: CAI42824.1
AL136093, AL109897 Genomic DNA Translation: CAI42825.1
AL136093, AL109897 Genomic DNA Translation: CAI42826.1
AB002387 mRNA Translation: BAA20843.2 Different initiation.
CH471051 Genomic DNA Translation: EAW48730.1
CH471051 Genomic DNA Translation: EAW48731.1
BC146764 mRNA Translation: AAI46765.1
BP333853 mRNA No translation available.
CCDSiCCDS34487.1 [Q9UM54-1]
CCDS75481.1 [Q9UM54-2]
RefSeqiNP_001287828.1, NM_001300899.1 [Q9UM54-2]
NP_004990.3, NM_004999.3 [Q9UM54-1]
UniGeneiHs.149387

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586 [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586 [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586 [Q9UM54-2]
GeneIDi4646
KEGGihsa:4646
UCSCiuc003pih.2 human [Q9UM54-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90236 mRNA Translation: AAC51654.2
AF229111
, AF229082, AF229083, AF229084, AF229085, AF229086, AF229087, AF229088, AF229089, AF229090, AF229091, AF229092, AF229093, AF229094, AF229095, AF229096, AF229097, AF229098, AF229099, AF229100, AF229101, AF229102, AF229103, AF229104, AF229105, AF229106, AF229107, AF229108, AF229109, AF229110 Genomic DNA Translation: AAK00229.1
AL109897, AL136093 Genomic DNA Translation: CAI19520.1
AL109897, AL136093 Genomic DNA Translation: CAI19521.1
AL109897, AL136093 Genomic DNA Translation: CAI19522.1
AL136093, AL109897 Genomic DNA Translation: CAI42824.1
AL136093, AL109897 Genomic DNA Translation: CAI42825.1
AL136093, AL109897 Genomic DNA Translation: CAI42826.1
AB002387 mRNA Translation: BAA20843.2 Different initiation.
CH471051 Genomic DNA Translation: EAW48730.1
CH471051 Genomic DNA Translation: EAW48731.1
BC146764 mRNA Translation: AAI46765.1
BP333853 mRNA No translation available.
CCDSiCCDS34487.1 [Q9UM54-1]
CCDS75481.1 [Q9UM54-2]
RefSeqiNP_001287828.1, NM_001300899.1 [Q9UM54-2]
NP_004990.3, NM_004999.3 [Q9UM54-1]
UniGeneiHs.149387

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0ZNMR-A1080-1122[»]
2N10NMR-A1080-1131[»]
2N11NMR-A998-1071[»]
2N12NMR-A1050-1131[»]
2N13NMR-A/D1080-1122[»]
ProteinModelPortaliQ9UM54
SMRiQ9UM54
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110730, 109 interactors
DIPiDIP-33123N
IntActiQ9UM54, 60 interactors
MINTiQ9UM54
STRINGi9606.ENSP00000358994

PTM databases

iPTMnetiQ9UM54
PhosphoSitePlusiQ9UM54
SwissPalmiQ9UM54

Polymorphism and mutation databases

BioMutaiMYO6
DMDMi122065628

Proteomic databases

EPDiQ9UM54
MaxQBiQ9UM54
PaxDbiQ9UM54
PeptideAtlasiQ9UM54
PRIDEiQ9UM54
ProteomicsDBi85177
85178 [Q9UM54-1]
85179 [Q9UM54-2]
85180 [Q9UM54-4]
85181 [Q9UM54-5]
85182 [Q9UM54-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369977; ENSP00000358994; ENSG00000196586 [Q9UM54-1]
ENST00000369985; ENSP00000359002; ENSG00000196586 [Q9UM54-2]
ENST00000615563; ENSP00000478013; ENSG00000196586 [Q9UM54-2]
GeneIDi4646
KEGGihsa:4646
UCSCiuc003pih.2 human [Q9UM54-3]

Organism-specific databases

CTDi4646
DisGeNETi4646
EuPathDBiHostDB:ENSG00000196586.13
GeneCardsiMYO6
GeneReviewsiMYO6
HGNCiHGNC:7605 MYO6
HPAiCAB010762
HPA035483
MalaCardsiMYO6
MIMi600970 gene
606346 phenotype
607821 phenotype
neXtProtiNX_Q9UM54
OpenTargetsiENSG00000196586
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
228012 Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome
PharmGKBiPA31410
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0163 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOVERGENiHBG003523
InParanoidiQ9UM54
KOiK10358
PhylomeDBiQ9UM54
TreeFamiTF351449

Enzyme and pathway databases

ReactomeiR-HSA-190873 Gap junction degradation
R-HSA-399719 Trafficking of AMPA receptors
SIGNORiQ9UM54

Miscellaneous databases

ChiTaRSiMYO6 human
GeneWikiiMYO6
GenomeRNAii4646
PROiPR:Q9UM54
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196586 Expressed in 217 organ(s), highest expression level in corpus callosum
CleanExiHS_MYO6
ExpressionAtlasiQ9UM54 baseline and differential
GenevisibleiQ9UM54 HS

Family and domain databases

CDDicd01382 MYSc_Myo6, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961 Kinesin_motor_dom_sf
IPR032412 Myosin-VI_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036114 MYSc_Myo6
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF16521 Myosin-VI_CBD, 1 hit
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO6_HUMAN
AccessioniPrimary (citable) accession number: Q9UM54
Secondary accession number(s): A6H8V4
, E1P540, Q5TEM5, Q5TEM6, Q5TEM7, Q9BZZ7, Q9UEG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 190 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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