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Entry version 152 (16 Oct 2019)
Sequence version 2 (21 Feb 2001)
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Protein

Mammalian ependymin-related protein 1

Gene

EPDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds anionic lipids and gangliosides at acidic pH.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mammalian ependymin-related protein 1
Short name:
MERP-11 Publication
Alternative name(s):
Upregulated in colorectal cancer gene 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPDR1
Synonyms:MERP1, UCC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17572 EPDR1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UM22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54749

Open Targets

More...
OpenTargetsi
ENSG00000086289

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UM22

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPDR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124620

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000835138 – 224Mammalian ependymin-related protein 1Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 1721 Publication
Disulfide bondi88 ↔ 2221 Publication
Disulfide bondi113 ↔ 2101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; the glycan contains mannose-6-phosphate moieties.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UM22

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UM22

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UM22

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UM22

PeptideAtlas

More...
PeptideAtlasi
Q9UM22

PRoteomics IDEntifications database

More...
PRIDEi
Q9UM22

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12296
85173 [Q9UM22-1]
85174 [Q9UM22-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UM22

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Detected in brain, heart, skeletal muscle, kidney, testis, ovary and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000086289 Expressed in 187 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UM22 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UM22 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026298

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120127, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UM22, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000199448

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UM22

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ependymin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIY9 Eukaryota
ENOG4112CW8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164413

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172504

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UM22

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAWDPFD

Database of Orthologous Groups

More...
OrthoDBi
827504at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UM22

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001299 Ependymin
IPR018224 Ependymin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR10697 PTHR10697, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00811 Ependymin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00317 EPENDYMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00026 EPEND, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00898 EPENDYMIN_1, 1 hit
PS00899 EPENDYMIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UM22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGRAPLRTV PGALGAWLLG GLWAWTLCGL CSLGAVGAPR PCQAPQQWEG
60 70 80 90 100
RQVMYQQSSG RNSRALLSYD GLNQRVRVLD ERKALIPCKR LFEYILLYKD
110 120 130 140 150
GVMFQIDQAT KQCSKMTLTQ PWDPLDIPQN STFEDQYSIG GPQEQITVQE
160 170 180 190 200
WSDRKSARSY ETWIGIYTVK DCYPVQETFT INYSVILSTR FFDIQLGIKD
210 220
PSVFTPPSTC QMAQLEKMSE DCSW
Length:224
Mass (Da):25,437
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84ADBA3666261611
GO
Isoform 2 (identifier: Q9UM22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-224: Missing.

Show »
Length:90
Mass (Da):9,861
Checksum:i6466489B5052810C
GO
Isoform 3 (identifier: Q9UM22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPGRAPLRTV...DERKALIPCK → MVRDWEGRCAHRGRPAGGGLSNTQRGGG

Show »
Length:163
Mass (Da):18,672
Checksum:i2DD76E6FCFEDECAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIH7D6RIH7_HUMAN
Mammalian ependymin-related protein...
EPDR1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB60269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207P → S in CAB60269 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468291 – 89MPGRA…LIPCK → MVRDWEGRCAHRGRPAGGGL SNTQRGGG in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_03197691 – 224Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF361252 Genomic DNA Translation: AAK26441.1
AY027861 mRNA Translation: AAK15787.1
DQ914439 mRNA Translation: ABI84106.1
AK290885 mRNA Translation: BAF83574.1
AK309180 mRNA No translation available.
AC018634 Genomic DNA No translation available.
AC083860 Genomic DNA No translation available.
AC083865 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94086.1
BC000686 mRNA Translation: AAH00686.2 Different initiation.
BC018299 mRNA Translation: AAH18299.1
AJ250475 mRNA Translation: CAB60269.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5454.2 [Q9UM22-1]
CCDS59051.1 [Q9UM22-2]
CCDS59052.1 [Q9UM22-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001229875.2, NM_001242946.1 [Q9UM22-2]
NP_001229877.1, NM_001242948.1 [Q9UM22-3]
NP_060019.2, NM_017549.4 [Q9UM22-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000199448; ENSP00000199448; ENSG00000086289 [Q9UM22-1]
ENST00000423717; ENSP00000409211; ENSG00000086289 [Q9UM22-2]
ENST00000425345; ENSP00000413359; ENSG00000086289 [Q9UM22-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54749

UCSC genome browser

More...
UCSCi
uc003tfp.5 human [Q9UM22-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361252 Genomic DNA Translation: AAK26441.1
AY027861 mRNA Translation: AAK15787.1
DQ914439 mRNA Translation: ABI84106.1
AK290885 mRNA Translation: BAF83574.1
AK309180 mRNA No translation available.
AC018634 Genomic DNA No translation available.
AC083860 Genomic DNA No translation available.
AC083865 Genomic DNA No translation available.
CH471073 Genomic DNA Translation: EAW94086.1
BC000686 mRNA Translation: AAH00686.2 Different initiation.
BC018299 mRNA Translation: AAH18299.1
AJ250475 mRNA Translation: CAB60269.1 Different initiation.
CCDSiCCDS5454.2 [Q9UM22-1]
CCDS59051.1 [Q9UM22-2]
CCDS59052.1 [Q9UM22-3]
RefSeqiNP_001229875.2, NM_001242946.1 [Q9UM22-2]
NP_001229877.1, NM_001242948.1 [Q9UM22-3]
NP_060019.2, NM_017549.4 [Q9UM22-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6E7OX-ray3.00A/B/C/D38-224[»]
6E8NX-ray3.20A/B38-224[»]
6JLDX-ray2.00A/B/C/D38-224[»]
SMRiQ9UM22
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120127, 20 interactors
IntActiQ9UM22, 26 interactors
STRINGi9606.ENSP00000199448

PTM databases

iPTMnetiQ9UM22

Polymorphism and mutation databases

BioMutaiEPDR1
DMDMi13124620

Proteomic databases

EPDiQ9UM22
jPOSTiQ9UM22
MassIVEiQ9UM22
PaxDbiQ9UM22
PeptideAtlasiQ9UM22
PRIDEiQ9UM22
ProteomicsDBi12296
85173 [Q9UM22-1]
85174 [Q9UM22-2]

Genome annotation databases

EnsembliENST00000199448; ENSP00000199448; ENSG00000086289 [Q9UM22-1]
ENST00000423717; ENSP00000409211; ENSG00000086289 [Q9UM22-2]
ENST00000425345; ENSP00000413359; ENSG00000086289 [Q9UM22-3]
GeneIDi54749
KEGGihsa:54749
UCSCiuc003tfp.5 human [Q9UM22-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54749
DisGeNETi54749

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EPDR1
HGNCiHGNC:17572 EPDR1
HPAiCAB026298
neXtProtiNX_Q9UM22
OpenTargetsiENSG00000086289
PharmGKBiPA142671908

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIY9 Eukaryota
ENOG4112CW8 LUCA
GeneTreeiENSGT00940000164413
HOGENOMiHOG000172504
InParanoidiQ9UM22
OMAiEAWDPFD
OrthoDBi827504at2759
PhylomeDBiQ9UM22

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EPDR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54749
PharosiQ9UM22

Protein Ontology

More...
PROi
PR:Q9UM22

Gene expression databases

BgeeiENSG00000086289 Expressed in 187 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ9UM22 baseline and differential
GenevisibleiQ9UM22 HS

Family and domain databases

InterProiView protein in InterPro
IPR001299 Ependymin
IPR018224 Ependymin_CS
PANTHERiPTHR10697 PTHR10697, 1 hit
PfamiView protein in Pfam
PF00811 Ependymin, 1 hit
PRINTSiPR00317 EPENDYMIN
SMARTiView protein in SMART
SM00026 EPEND, 1 hit
PROSITEiView protein in PROSITE
PS00898 EPENDYMIN_1, 1 hit
PS00899 EPENDYMIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPDR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UM22
Secondary accession number(s): A8K4C0
, C9JYS3, Q06BL0, Q99M77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: October 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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