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Entry version 172 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

Anaphase-promoting complex subunit 10

Gene

ANAPC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UM13

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412, Phosphorylation of the APC/C
R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-8853884, Transcriptional Regulation by VENTX
R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UM13

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UM13

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 10
Short name:
APC10
Alternative name(s):
Cyclosome subunit 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC10
Synonyms:APC10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164162.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24077, ANAPC10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613745, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UM13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10393

Open Targets

More...
OpenTargetsi
ENSG00000164162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938672

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UM13, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANAPC10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001740112 – 185Anaphase-promoting complex subunit 10Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei169N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UM13

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UM13

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UM13

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UM13

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UM13

PeptideAtlas

More...
PeptideAtlasi
Q9UM13

PRoteomics IDEntifications database

More...
PRIDEi
Q9UM13

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85170

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UM13

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UM13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164162, Expressed in oocyte and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UM13, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UM13, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164162, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:26083744, PubMed:25043029). The C-terminus of APC10 binds to CDC27/APC3 (PubMed:11524682).

Interacts with PIWIL1; interaction only takes place when PIWIL1 binds piRNA (By similarity).

By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115665, 59 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UM13

Database of interacting proteins

More...
DIPi
DIP-39885N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9UM13

Protein interaction database and analysis system

More...
IntActi
Q9UM13, 35 interactors

Molecular INTeraction database

More...
MINTi
Q9UM13

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478501

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UM13, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UM13

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UM13

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 185DOCPROSITE-ProRule annotationAdd BLAST184

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3437, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013722

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UM13

KEGG Orthology (KO)

More...
KOi
K03357

Identification of Orthologs from Complete Genome Data

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OMAi
FGFGPEC

Database of Orthologous Groups

More...
OrthoDBi
804390at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UM13

TreeFam database of animal gene trees

More...
TreeFami
TF105446

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08366, APC10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016901, APC10/Doc1
IPR004939, APC_su10/DOC_dom
IPR008979, Galactose-bd-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12936, PTHR12936, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256, ANAPC10, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028841, APC10_sub, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284, DOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9UM13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL
60 70 80 90 100
ETYWQSDGSQ PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN
110 120 130 140 150
NFHNLQEIRQ LELVEPSGWI HVPLTDNHKK PTRTFMIQIA VLANHQNGRD
160 170 180
THMRQIKIYT PVEESSIGKF PRCTTIDFMM YRSIR
Length:185
Mass (Da):21,252
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACA7F245B3861FF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD74D6RD74_HUMAN
Anaphase-promoting complex subunit ...
ANAPC10
126Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9Q5D6R9Q5_HUMAN
Anaphase-promoting complex subunit ...
ANAPC10
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA92D6RA92_HUMAN
Anaphase-promoting complex subunit ...
ANAPC10
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB36D6RB36_HUMAN
Anaphase-promoting complex subunit ...
ANAPC10
68Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEY6A0A286YEY6_HUMAN
Anaphase-promoting complex subunit ...
ANAPC10
121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6K → R in AAD30527 (PubMed:10318877).Curated1
Sequence conflicti134T → S in CAB45705 (PubMed:11230166).Curated1
Sequence conflicti146Q → L in CAB45705 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02520046R → Q1 PublicationCorresponds to variant dbSNP:rs35257136Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132794 mRNA Translation: AAD30527.1
AB012109 mRNA Translation: BAA86953.1
AL080090 mRNA Translation: CAB45705.1
DQ304649 Genomic DNA Translation: ABB96248.1
CH471056 Genomic DNA Translation: EAX05050.1
CH471056 Genomic DNA Translation: EAX05051.1
BC005217 mRNA Translation: AAH05217.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43273.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T12476

NCBI Reference Sequences

More...
RefSeqi
NP_001243635.1, NM_001256706.1
NP_001243636.1, NM_001256707.1
NP_001243637.1, NM_001256708.1
NP_001243638.1, NM_001256709.1
NP_001243639.1, NM_001256710.1
NP_001305296.1, NM_001318367.1
NP_055700.2, NM_014885.4
XP_011529826.1, XM_011531524.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309439; ENSP00000310071; ENSG00000164162
ENST00000451299; ENSP00000403891; ENSG00000164162
ENST00000507656; ENSP00000423995; ENSG00000164162
ENST00000613466; ENSP00000478501; ENSG00000164162

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10393

UCSC genome browser

More...
UCSCi
uc003iju.6, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132794 mRNA Translation: AAD30527.1
AB012109 mRNA Translation: BAA86953.1
AL080090 mRNA Translation: CAB45705.1
DQ304649 Genomic DNA Translation: ABB96248.1
CH471056 Genomic DNA Translation: EAX05050.1
CH471056 Genomic DNA Translation: EAX05051.1
BC005217 mRNA Translation: AAH05217.1
CCDSiCCDS43273.1
PIRiT12476
RefSeqiNP_001243635.1, NM_001256706.1
NP_001243636.1, NM_001256707.1
NP_001243637.1, NM_001256708.1
NP_001243638.1, NM_001256709.1
NP_001243639.1, NM_001256710.1
NP_001305296.1, NM_001318367.1
NP_055700.2, NM_014885.4
XP_011529826.1, XM_011531524.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JHJX-ray1.60A2-172[»]
4UI9electron microscopy3.60L2-185[»]
5A31electron microscopy4.30L1-185[»]
5G04electron microscopy4.00L1-185[»]
5G05electron microscopy3.40L1-185[»]
5KHRelectron microscopy6.10L1-185[»]
5KHUelectron microscopy4.80L1-185[»]
5L9Telectron microscopy6.40L1-185[»]
5L9Uelectron microscopy6.40L1-185[»]
5LCWelectron microscopy4.00L1-185[»]
6Q6Gelectron microscopy3.20L1-185[»]
6Q6Helectron microscopy3.20L1-185[»]
6TLJelectron microscopy3.80L1-185[»]
6TM5electron microscopy3.90L1-185[»]
SMRiQ9UM13
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115665, 59 interactors
CORUMiQ9UM13
DIPiDIP-39885N
ELMiQ9UM13
IntActiQ9UM13, 35 interactors
MINTiQ9UM13
STRINGi9606.ENSP00000478501

PTM databases

iPTMnetiQ9UM13
PhosphoSitePlusiQ9UM13

Polymorphism and mutation databases

BioMutaiANAPC10
DMDMi34395509

Proteomic databases

EPDiQ9UM13
jPOSTiQ9UM13
MassIVEiQ9UM13
MaxQBiQ9UM13
PaxDbiQ9UM13
PeptideAtlasiQ9UM13
PRIDEiQ9UM13
ProteomicsDBi85170

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
7474, 221 antibodies

The DNASU plasmid repository

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DNASUi
10393

Genome annotation databases

EnsembliENST00000309439; ENSP00000310071; ENSG00000164162
ENST00000451299; ENSP00000403891; ENSG00000164162
ENST00000507656; ENSP00000423995; ENSG00000164162
ENST00000613466; ENSP00000478501; ENSG00000164162
GeneIDi10393
KEGGihsa:10393
UCSCiuc003iju.6, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10393
DisGeNETi10393
EuPathDBiHostDB:ENSG00000164162.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ANAPC10
HGNCiHGNC:24077, ANAPC10
HPAiENSG00000164162, Low tissue specificity
MIMi613745, gene
neXtProtiNX_Q9UM13
OpenTargetsiENSG00000164162
PharmGKBiPA134938672

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3437, Eukaryota
GeneTreeiENSGT00390000013722
InParanoidiQ9UM13
KOiK03357
OMAiFGFGPEC
OrthoDBi804390at2759
PhylomeDBiQ9UM13
TreeFamiTF105446

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9UM13
ReactomeiR-HSA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412, Phosphorylation of the APC/C
R-HSA-179409, APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-8853884, Transcriptional Regulation by VENTX
R-HSA-9687136, Aberrant regulation of mitotic exit in cancer due to RB1 defects
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9UM13
SIGNORiQ9UM13

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10393, 593 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANAPC10, human
EvolutionaryTraceiQ9UM13

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANAPC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10393
PharosiQ9UM13, Tbio

Protein Ontology

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PROi
PR:Q9UM13
RNActiQ9UM13, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164162, Expressed in oocyte and 235 other tissues
ExpressionAtlasiQ9UM13, baseline and differential
GenevisibleiQ9UM13, HS

Family and domain databases

CDDicd08366, APC10, 1 hit
Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR016901, APC10/Doc1
IPR004939, APC_su10/DOC_dom
IPR008979, Galactose-bd-like_sf
PANTHERiPTHR12936, PTHR12936, 1 hit
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PIRSFiPIRSF028841, APC10_sub, 1 hit
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SUPFAMiSSF49785, SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS51284, DOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UM13
Secondary accession number(s): D3DNZ7
, Q2V500, Q9UG51, Q9Y5R0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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