UniProtKB - Q9ULZ3 (ASC_HUMAN)
Apoptosis-associated speck-like protein containing a CARD
PYCARD
Functioni
Miscellaneous
GO - Molecular functioni
- BMP receptor binding Source: AgBase
- cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
- cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- enzyme binding Source: AgBase
- identical protein binding Source: IntAct
- interleukin-6 receptor binding Source: AgBase
- ion channel binding Source: Ensembl
- myosin I binding Source: AgBase
- protease binding Source: AgBase
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: HGNC-UCL
- Pyrin domain binding Source: HGNC-UCL
- tropomyosin binding Source: AgBase
GO - Biological processi
- activation of cysteine-type endopeptidase activity Source: Ensembl
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- activation of innate immune response Source: UniProtKB
- apoptotic process Source: GO_Central
- cellular response to interleukin-1 Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to virus Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- interleukin-1 beta production Source: Ensembl
- intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
- macropinocytosis Source: UniProtKB
- myeloid dendritic cell activation Source: UniProtKB
- myeloid dendritic cell activation involved in immune response Source: UniProtKB
- negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of interferon-beta production Source: UniProtKB
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of protein serine/threonine kinase activity Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of actin filament polymerization Source: UniProtKB
- positive regulation of activated T cell proliferation Source: UniProtKB
- positive regulation of adaptive immune response Source: UniProtKB
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of chemokine secretion Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
- positive regulation of defense response to virus by host Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of interleukin-10 production Source: UniProtKB
- positive regulation of interleukin-1 beta production Source: HGNC-UCL
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
- positive regulation of T cell activation Source: UniProtKB
- positive regulation of T cell migration Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- regulation of autophagy Source: Ensembl
- regulation of GTPase activity Source: Ensembl
- regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- regulation of protein stability Source: UniProtKB
- regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- signal transduction Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: HGNC-UCL
Keywordsi
Biological process | Apoptosis, Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q9ULZ3 |
Reactomei | R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-6798695, Neutrophil degranulation R-HSA-844456, The NLRP3 inflammasome R-HSA-844615, The AIM2 inflammasome R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SIGNORi | Q9ULZ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis-associated speck-like protein containing a CARDShort name: hASC Alternative name(s): Caspase recruitment domain-containing protein 5 PYD and CARD domain-containing protein Target of methylation-induced silencing 1 |
Gene namesi | Name:PYCARD Synonyms:ASC, CARD5, TMS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000103490.13 |
HGNCi | HGNC:16608, PYCARD |
MIMi | 606838, gene |
neXtProti | NX_Q9ULZ3 |
Subcellular locationi
Endoplasmic reticulum
Mitochondrion
Nucleus
Other locations
Note: Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. Upon NLRP3 inflammasome activation redistributes to the perinuclear space localizing to endoplasmic reticulum and mitochondria. Localized primarily to the nucleus in resting monocytes/macrophages and rapidly redistributed to the cytoplasm upon pathogen infection. Localized to large cytoplasmic aggregate appearing as a speck containing AIM2, PYCARD, CASP8 and bacterial DNA after infection with Francisella tularensis (By similarity).By similarity
Golgi apparatus
Note: (Microbial infection) Upon HRSV infection, the protein is mainly located in lipid rafts in the Golgi membrane.1 Publication
Cytosol
- AIM2 inflammasome complex Source: UniProtKB
- cytosol Source: HPA
- IkappaB kinase complex Source: HGNC-UCL
- NLRP1 inflammasome complex Source: UniProtKB
- NLRP3 inflammasome complex Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: Reactome
Golgi apparatus
- Golgi membrane Source: UniProtKB
Lysosome
- azurophil granule lumen Source: Reactome
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- neuronal cell body Source: Ensembl
- protein-containing complex Source: ARUK-UCL
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 8 | I → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 12 | L → A: Abolishes homooligomerization. 2 Publications | 1 | |
Mutagenesisi | 12 | L → Q: Abolishes promotion of apoptosis and NF-kappa-B activation. 2 Publications | 1 | |
Mutagenesisi | 13 | E → A: Abolishes interaction with PYDC1. 3 Publications | 1 | |
Mutagenesisi | 13 | E → W: Abolishes interaction with NLRP2. 3 Publications | 1 | |
Mutagenesisi | 15 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 19 | E → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 20 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 21 | K → A, E or Q: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 23 | F → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 25 | L → A, E, G, K, N or Q: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 26 | K → A or Q: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 27 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 36 | Y → A: Abolishes interaction with PYDC1. 1 Publication | 1 | |
Mutagenesisi | 40 | P → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 41 | R → A, Q or W: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 45 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 47 | M → A, N or Q: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 48 | D → A or K: Abolishes homooligomerization. 2 Publications | 1 | |
Mutagenesisi | 48 | D → A: Abolishes interaction with PYDC1. 2 Publications | 1 | |
Mutagenesisi | 52 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 56 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 62 | E → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 67 | E → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 68 | L → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 72 | V → A: Abolishes homooligomerization. 1 Publication | 1 | |
Mutagenesisi | 76 | M → A: Abolishes homooligomerization. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 29108 |
OpenTargetsi | ENSG00000103490 |
PharmGKBi | PA134950175 |
Miscellaneous databases
Pharosi | Q9ULZ3, Tbio |
Polymorphism and mutation databases
BioMutai | PYCARD |
DMDMi | 18203507 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064692 | 1 – 195 | Apoptosis-associated speck-like protein containing a CARDAdd BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 195 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9ULZ3 |
jPOSTi | Q9ULZ3 |
MassIVEi | Q9ULZ3 |
PaxDbi | Q9ULZ3 |
PeptideAtlasi | Q9ULZ3 |
PRIDEi | Q9ULZ3 |
ProteomicsDBi | 85158 [Q9ULZ3-1] 85159 [Q9ULZ3-2] 85160 [Q9ULZ3-3] |
PTM databases
iPTMneti | Q9ULZ3 |
PhosphoSitePlusi | Q9ULZ3 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000103490, Expressed in monocyte and 204 other tissues |
ExpressionAtlasi | Q9ULZ3, baseline and differential |
Genevisiblei | Q9ULZ3, HS |
Organism-specific databases
HPAi | ENSG00000103490, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Self-associates; enforced oligomerization induces apoptosis, NF-kappa-B regulation and interleukin-1 beta secretion. Homooligomers can form disk-like particles of approximately 12 nm diameter and approximately 1 nm height. Next to isoform 1, also isoform 2 and isoform 3 may be involved in oligomerization leading to functional regulation.
Component of several inflammasomes containing one pattern recognition receptor/sensor, such as NLRP1, NLRP2, NLRP3, AIM2, MEFV or NOD2, and probably NLRC4, NLRP12 or IFI16. Major component of the ASC pyroptosome, a 1-2 um supramolecular assembly (one per macrophage cell) which consists of oligomerized PYCARD dimers and CASP1.
Interacts with CASP1 (precursor form); the interaction induces activation of CASP1 leading to the processing of interleukin-1 beta; PYCARD competes with RIPK2 for binding to CASP1.
Interacts with NLRP3; the interaction requires the homooligomerization of NLRP3.
Interacts with NLRP2, NLRC4, MEFV, CARD16, AIM2, IFI16, NOD2, DDX58, RIPK2, PYDC1, PYDC2, NLRP10, CASP8, CHUK, IKBKB and BAX.
23 PublicationsBinary interactionsi
Hide detailsQ9ULZ3
GO - Molecular functioni
- BMP receptor binding Source: AgBase
- enzyme binding Source: AgBase
- identical protein binding Source: IntAct
- interleukin-6 receptor binding Source: AgBase
- ion channel binding Source: Ensembl
- myosin I binding Source: AgBase
- protease binding Source: AgBase
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: HGNC-UCL
- Pyrin domain binding Source: HGNC-UCL
- tropomyosin binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 118876, 50 interactors |
ComplexPortali | CPX-4082, NLRP1 inflammasome CPX-4141, NLRP3 inflammasome CPX-4142, AIM2 inflammasome CPX-4143, Pyrin inflammasome CPX-4144, NLRC4 inflammasome |
CORUMi | Q9ULZ3 |
DIPi | DIP-27618N |
IntActi | Q9ULZ3, 54 interactors |
MINTi | Q9ULZ3 |
STRINGi | 9606.ENSP00000247470 |
Miscellaneous databases
RNActi | Q9ULZ3, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9ULZ3 |
SMRi | Q9ULZ3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9ULZ3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 91 | PyrinPROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 107 – 195 | CARDPROSITE-ProRule annotationAdd BLAST | 89 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502S3G5, Eukaryota |
GeneTreei | ENSGT00940000161873 |
HOGENOMi | CLU_113553_1_0_1 |
InParanoidi | Q9ULZ3 |
OMAi | AWNLTCK |
OrthoDBi | 1494108at2759 |
PhylomeDBi | Q9ULZ3 |
TreeFami | TF337882 |
Family and domain databases
CDDi | cd08330, CARD_ASC_NALP1, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033516, CARD8/ASC/NALP1_CARD IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50824, DAPIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRARDAILD ALENLTAEEL KKFKLKLLSV PLREGYGRIP RGALLSMDAL
60 70 80 90 100
DLTDKLVSFY LETYGAELTA NVLRDMGLQE MAGQLQAATH QGSGAAPAGI
110 120 130 140 150
QAPPQSAAKP GLHFIDQHRA ALIARVTNVE WLLDALYGKV LTDEQYQAVR
160 170 180 190
AEPTNPSKMR KLFSFTPAWN WTCKDLLLQA LRESQSYLVE DLERS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BP42 | H3BP42_HUMAN | Apoptosis-associated speck-like pro... | PYCARD | 125 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004118 | 26 – 85 | Missing in isoform 3. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_004119 | 93 – 111 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023416 mRNA Translation: BAA87339.2 AF184072 Genomic DNA Translation: AAG01187.1 AF184073 mRNA Translation: AAG01188.1 AF255794 mRNA Translation: AAF99665.1 AF310103 mRNA Translation: AAG30286.1 AF384665 mRNA Translation: AAK63850.1 AK000211 mRNA Translation: BAA91012.1 Frameshift. BC004470 mRNA Translation: AAH04470.1 BC013569 mRNA Translation: AAH13569.2 |
CCDSi | CCDS10708.1 [Q9ULZ3-1] CCDS10709.1 [Q9ULZ3-2] |
RefSeqi | NP_037390.2, NM_013258.4 [Q9ULZ3-1] NP_660183.1, NM_145182.2 [Q9ULZ3-2] |
Genome annotation databases
Ensembli | ENST00000247470; ENSP00000247470; ENSG00000103490 [Q9ULZ3-1] ENST00000350605; ENSP00000340441; ENSG00000103490 [Q9ULZ3-2] |
GeneIDi | 29108 |
KEGGi | hsa:29108 |
UCSCi | uc002ebm.4, human [Q9ULZ3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023416 mRNA Translation: BAA87339.2 AF184072 Genomic DNA Translation: AAG01187.1 AF184073 mRNA Translation: AAG01188.1 AF255794 mRNA Translation: AAF99665.1 AF310103 mRNA Translation: AAG30286.1 AF384665 mRNA Translation: AAK63850.1 AK000211 mRNA Translation: BAA91012.1 Frameshift. BC004470 mRNA Translation: AAH04470.1 BC013569 mRNA Translation: AAH13569.2 |
CCDSi | CCDS10708.1 [Q9ULZ3-1] CCDS10709.1 [Q9ULZ3-2] |
RefSeqi | NP_037390.2, NM_013258.4 [Q9ULZ3-1] NP_660183.1, NM_145182.2 [Q9ULZ3-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UCP | NMR | - | A | 1-91 | [»] | |
2KN6 | NMR | - | A | 1-195 | [»] | |
3J63 | electron microscopy | 3.80 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 1-91 | [»] | |
5H8O | X-ray | 4.21 | B | 115-195 | [»] | |
6KI0 | X-ray | 2.00 | A/B | 112-195 | [»] | |
6N1H | electron microscopy | 3.17 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P | 112-194 | [»] | |
BMRBi | Q9ULZ3 | |||||
SMRi | Q9ULZ3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118876, 50 interactors |
ComplexPortali | CPX-4082, NLRP1 inflammasome CPX-4141, NLRP3 inflammasome CPX-4142, AIM2 inflammasome CPX-4143, Pyrin inflammasome CPX-4144, NLRC4 inflammasome |
CORUMi | Q9ULZ3 |
DIPi | DIP-27618N |
IntActi | Q9ULZ3, 54 interactors |
MINTi | Q9ULZ3 |
STRINGi | 9606.ENSP00000247470 |
PTM databases
iPTMneti | Q9ULZ3 |
PhosphoSitePlusi | Q9ULZ3 |
Polymorphism and mutation databases
BioMutai | PYCARD |
DMDMi | 18203507 |
Proteomic databases
EPDi | Q9ULZ3 |
jPOSTi | Q9ULZ3 |
MassIVEi | Q9ULZ3 |
PaxDbi | Q9ULZ3 |
PeptideAtlasi | Q9ULZ3 |
PRIDEi | Q9ULZ3 |
ProteomicsDBi | 85158 [Q9ULZ3-1] 85159 [Q9ULZ3-2] 85160 [Q9ULZ3-3] |
Protocols and materials databases
ABCDi | Q9ULZ3, 1 sequenced antibody |
Antibodypediai | 3375, 701 antibodies |
DNASUi | 29108 |
Genome annotation databases
Ensembli | ENST00000247470; ENSP00000247470; ENSG00000103490 [Q9ULZ3-1] ENST00000350605; ENSP00000340441; ENSG00000103490 [Q9ULZ3-2] |
GeneIDi | 29108 |
KEGGi | hsa:29108 |
UCSCi | uc002ebm.4, human [Q9ULZ3-1] |
Organism-specific databases
CTDi | 29108 |
DisGeNETi | 29108 |
EuPathDBi | HostDB:ENSG00000103490.13 |
GeneCardsi | PYCARD |
HGNCi | HGNC:16608, PYCARD |
HPAi | ENSG00000103490, Tissue enhanced (blood) |
MIMi | 606838, gene |
neXtProti | NX_Q9ULZ3 |
OpenTargetsi | ENSG00000103490 |
PharmGKBi | PA134950175 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3G5, Eukaryota |
GeneTreei | ENSGT00940000161873 |
HOGENOMi | CLU_113553_1_0_1 |
InParanoidi | Q9ULZ3 |
OMAi | AWNLTCK |
OrthoDBi | 1494108at2759 |
PhylomeDBi | Q9ULZ3 |
TreeFami | TF337882 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULZ3 |
Reactomei | R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-6798695, Neutrophil degranulation R-HSA-844456, The NLRP3 inflammasome R-HSA-844615, The AIM2 inflammasome R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SIGNORi | Q9ULZ3 |
Miscellaneous databases
BioGRID-ORCSi | 29108, 5 hits in 845 CRISPR screens |
ChiTaRSi | PYCARD, human |
EvolutionaryTracei | Q9ULZ3 |
GeneWikii | PYCARD |
GenomeRNAii | 29108 |
Pharosi | Q9ULZ3, Tbio |
PROi | PR:Q9ULZ3 |
RNActi | Q9ULZ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103490, Expressed in monocyte and 204 other tissues |
ExpressionAtlasi | Q9ULZ3, baseline and differential |
Genevisiblei | Q9ULZ3, HS |
Family and domain databases
CDDi | cd08330, CARD_ASC_NALP1, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033516, CARD8/ASC/NALP1_CARD IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR002398, Pept_C14 |
PANTHERi | PTHR10454, PTHR10454, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 2 hits |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit PS50824, DAPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ASC_HUMAN | |
Accessioni | Q9ULZ3Primary (citable) accession number: Q9ULZ3 Secondary accession number(s): Q96D12 Q9NXJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM