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Entry version 187 (08 May 2019)
Sequence version 2 (01 Mar 2001)
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Protein

Apoptosis-associated speck-like protein containing a CARD

Gene

PYCARD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).18 Publications

Miscellaneous

In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-6798695 Neutrophil degranulation
R-HSA-844456 The NLRP3 inflammasome
R-HSA-844615 The AIM2 inflammasome

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9ULZ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptosis-associated speck-like protein containing a CARD
Short name:
hASC
Alternative name(s):
Caspase recruitment domain-containing protein 5
PYD and CARD domain-containing protein
Target of methylation-induced silencing 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PYCARD
Synonyms:ASC, CARD5, TMS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16608 PYCARD

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606838 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULZ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi8I → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi12L → A: Abolishes homooligomerization. 2 Publications1
Mutagenesisi12L → Q: Abolishes promotion of apoptosis and NF-kappa-B activation. 2 Publications1
Mutagenesisi13E → A: Abolishes interaction with PYDC1. 3 Publications1
Mutagenesisi13E → W: Abolishes interaction with NLRP2. 3 Publications1
Mutagenesisi15L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi19E → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi20L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi21K → A, E or Q: Abolishes homooligomerization. 1 Publication1
Mutagenesisi23F → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi25L → A, E, G, K, N or Q: Abolishes homooligomerization. 1 Publication1
Mutagenesisi26K → A or Q: Abolishes homooligomerization. 1 Publication1
Mutagenesisi27L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi36Y → A: Abolishes interaction with PYDC1. 1 Publication1
Mutagenesisi40P → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi41R → A, Q or W: Abolishes homooligomerization. 1 Publication1
Mutagenesisi45L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi47M → A, N or Q: Abolishes homooligomerization. 1 Publication1
Mutagenesisi48D → A or K: Abolishes homooligomerization. 2 Publications1
Mutagenesisi48D → A: Abolishes interaction with PYDC1. 2 Publications1
Mutagenesisi52L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi56L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi62E → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi67E → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi68L → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi72V → A: Abolishes homooligomerization. 1 Publication1
Mutagenesisi76M → A: Abolishes homooligomerization. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

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DisGeNETi
29108

Open Targets

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OpenTargetsi
ENSG00000103490

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134950175

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PYCARD

Domain mapping of disease mutations (DMDM)

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DMDMi
18203507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646921 – 195Apoptosis-associated speck-like protein containing a CARDAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei195PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9ULZ3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9ULZ3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9ULZ3

PeptideAtlas

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PeptideAtlasi
Q9ULZ3

PRoteomics IDEntifications database

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PRIDEi
Q9ULZ3

ProteomicsDB human proteome resource

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ProteomicsDBi
85158
85159 [Q9ULZ3-2]
85160 [Q9ULZ3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9ULZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9ULZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Expressed in lung epithelial cells (at protein level) (PubMed:23229815). Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In macrophages, up-regulated by endocannabinoid anandamide/AEA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000103490 Expressed in 188 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9ULZ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9ULZ3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006853
CAB015948
HPA049074
HPA054496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates; enforced oligomerization induces apoptosis, NF-kappa-B regulation and interleukin-1 beta secretion. Homooligomers can form disk-like particles of approximately 12 nm diameter and approximately 1 nm height. Next to isoform 1, also isoform 2 and isoform 3 may be involved in oligomerization leading to functional regulation. Component of several inflammasomes containing one pattern recognition receptor/sensor, such as NLRP1, NLRP2, NLRP3, AIM2, MEFV or NOD2, and probably NLRC4, NLRP12 or IFI16. Major component of the ASC pyroptosome, a 1-2 um supramolecular assembly (one per macrophage cell) which consists of oligomerized PYCARD dimers and CASP1. Interacts with CASP1 (precursor form); the interaction induces activation of CASP1 leading to the processing of interleukin-1 beta; PYCARD competes with RIPK2 for binding to CASP1. Interacts with NLRP3; the interaction requires the homooligomerization of NLRP3. Interacts with NLRP2, NLRC4, MEFV, CARD16, AIM2, IFI16, NOD2, DDX58, RIPK2, PYDC1, PYDC2, NLRP10, CASP8, CHUK, IKBKB and BAX.23 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118876, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9ULZ3

Database of interacting proteins

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DIPi
DIP-27618N

Protein interaction database and analysis system

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IntActi
Q9ULZ3, 48 interactors

Molecular INTeraction database

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MINTi
Q9ULZ3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000247470

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UCPNMR-A1-91[»]
2KN6NMR-A1-195[»]
3J63electron microscopy3.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-91[»]
5H8OX-ray4.21B115-195[»]
6N1Helectron microscopy3.17A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P112-194[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9ULZ3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9ULZ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 91PyrinPROSITE-ProRule annotationAdd BLAST91
Domaini107 – 195CARDPROSITE-ProRule annotationAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CARD domain mediates interaction with CASP1 and NLRC4 (PubMed:14634131 and PubMed:11967258).1 Publication
The pyrin domain mediates homotypic interactions with pyrin domains of proteins such as of NLRP3, PYDC1, PYDC2 and AIM2.6 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J02A Eukaryota
ENOG4111XEQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161873

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000034090

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ULZ3

KEGG Orthology (KO)

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KOi
K12799

Identification of Orthologs from Complete Genome Data

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OMAi
FSFAPAW

Database of Orthologous Groups

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OrthoDBi
1494108at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9ULZ3

TreeFam database of animal gene trees

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TreeFami
TF337882

Family and domain databases

Conserved Domains Database

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CDDi
cd08330 CARD_ASC_NALP1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14

The PANTHER Classification System

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PANTHERi
PTHR10454 PTHR10454, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00619 CARD, 1 hit
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01289 PYRIN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS50824 DAPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULZ3-1) [UniParc]FASTAAdd to basket
Also known as: fASC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRARDAILD ALENLTAEEL KKFKLKLLSV PLREGYGRIP RGALLSMDAL
60 70 80 90 100
DLTDKLVSFY LETYGAELTA NVLRDMGLQE MAGQLQAATH QGSGAAPAGI
110 120 130 140 150
QAPPQSAAKP GLHFIDQHRA ALIARVTNVE WLLDALYGKV LTDEQYQAVR
160 170 180 190
AEPTNPSKMR KLFSFTPAWN WTCKDLLLQA LRESQSYLVE DLERS
Length:195
Mass (Da):21,627
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i455987286586F46A
GO
Isoform 2 (identifier: Q9ULZ3-2) [UniParc]FASTAAdd to basket
Also known as: Asc-b, vASC

The sequence of this isoform differs from the canonical sequence as follows:
     93-111: Missing.

Show »
Length:176
Mass (Da):19,969
Checksum:iC4AB645696FA115D
GO
Isoform 3 (identifier: Q9ULZ3-3) [UniParc]FASTAAdd to basket
Also known as: Asc-c

The sequence of this isoform differs from the canonical sequence as follows:
     26-85: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,030
Checksum:iF46DB2DF379E95E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BP42H3BP42_HUMAN
Apoptosis-associated speck-like pro...
PYCARD
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91012 differs from that shown. Reason: Frameshift at position 4.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00411826 – 85Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_00411993 – 111Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB023416 mRNA Translation: BAA87339.2
AF184072 Genomic DNA Translation: AAG01187.1
AF184073 mRNA Translation: AAG01188.1
AF255794 mRNA Translation: AAF99665.1
AF310103 mRNA Translation: AAG30286.1
AF384665 mRNA Translation: AAK63850.1
AK000211 mRNA Translation: BAA91012.1 Frameshift.
BC004470 mRNA Translation: AAH04470.1
BC013569 mRNA Translation: AAH13569.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS10708.1 [Q9ULZ3-1]
CCDS10709.1 [Q9ULZ3-2]

NCBI Reference Sequences

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RefSeqi
NP_037390.2, NM_013258.4 [Q9ULZ3-1]
NP_660183.1, NM_145182.2 [Q9ULZ3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000247470; ENSP00000247470; ENSG00000103490 [Q9ULZ3-1]
ENST00000350605; ENSP00000340441; ENSG00000103490 [Q9ULZ3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29108

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29108

UCSC genome browser

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UCSCi
uc002ebm.4 human [Q9ULZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023416 mRNA Translation: BAA87339.2
AF184072 Genomic DNA Translation: AAG01187.1
AF184073 mRNA Translation: AAG01188.1
AF255794 mRNA Translation: AAF99665.1
AF310103 mRNA Translation: AAG30286.1
AF384665 mRNA Translation: AAK63850.1
AK000211 mRNA Translation: BAA91012.1 Frameshift.
BC004470 mRNA Translation: AAH04470.1
BC013569 mRNA Translation: AAH13569.2
CCDSiCCDS10708.1 [Q9ULZ3-1]
CCDS10709.1 [Q9ULZ3-2]
RefSeqiNP_037390.2, NM_013258.4 [Q9ULZ3-1]
NP_660183.1, NM_145182.2 [Q9ULZ3-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UCPNMR-A1-91[»]
2KN6NMR-A1-195[»]
3J63electron microscopy3.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-91[»]
5H8OX-ray4.21B115-195[»]
6N1Helectron microscopy3.17A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P112-194[»]
SMRiQ9ULZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118876, 45 interactors
CORUMiQ9ULZ3
DIPiDIP-27618N
IntActiQ9ULZ3, 48 interactors
MINTiQ9ULZ3
STRINGi9606.ENSP00000247470

PTM databases

iPTMnetiQ9ULZ3
PhosphoSitePlusiQ9ULZ3

Polymorphism and mutation databases

BioMutaiPYCARD
DMDMi18203507

Proteomic databases

EPDiQ9ULZ3
jPOSTiQ9ULZ3
PaxDbiQ9ULZ3
PeptideAtlasiQ9ULZ3
PRIDEiQ9ULZ3
ProteomicsDBi85158
85159 [Q9ULZ3-2]
85160 [Q9ULZ3-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
29108
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247470; ENSP00000247470; ENSG00000103490 [Q9ULZ3-1]
ENST00000350605; ENSP00000340441; ENSG00000103490 [Q9ULZ3-2]
GeneIDi29108
KEGGihsa:29108
UCSCiuc002ebm.4 human [Q9ULZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29108
DisGeNETi29108

GeneCards: human genes, protein and diseases

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GeneCardsi
PYCARD

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012985
HGNCiHGNC:16608 PYCARD
HPAiCAB006853
CAB015948
HPA049074
HPA054496
MIMi606838 gene
neXtProtiNX_Q9ULZ3
OpenTargetsiENSG00000103490
PharmGKBiPA134950175

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J02A Eukaryota
ENOG4111XEQ LUCA
GeneTreeiENSGT00940000161873
HOGENOMiHOG000034090
InParanoidiQ9ULZ3
KOiK12799
OMAiFSFAPAW
OrthoDBi1494108at2759
PhylomeDBiQ9ULZ3
TreeFamiTF337882

Enzyme and pathway databases

ReactomeiR-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-6798695 Neutrophil degranulation
R-HSA-844456 The NLRP3 inflammasome
R-HSA-844615 The AIM2 inflammasome
SIGNORiQ9ULZ3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PYCARD human
EvolutionaryTraceiQ9ULZ3

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PYCARD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29108

Protein Ontology

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PROi
PR:Q9ULZ3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103490 Expressed in 188 organ(s), highest expression level in blood
ExpressionAtlasiQ9ULZ3 baseline and differential
GenevisibleiQ9ULZ3 HS

Family and domain databases

CDDicd08330 CARD_ASC_NALP1, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR033516 CARD8/ASC/NALP1_CARD
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR002398 Pept_C14
PANTHERiPTHR10454 PTHR10454, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50824 DAPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULZ3
Secondary accession number(s): Q96D12
, Q9BSZ5, Q9HBD0, Q9NXJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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