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Protein

Signal-transducing adaptor protein 1

Gene

STAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ9ULZ2

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 1
Short name:
STAP-1
Alternative name(s):
BCR downstream-signaling protein 1
Docking protein BRDG1
Stem cell adaptor protein 1
Gene namesi
Name:STAP1
Synonyms:BRDG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000035720.7
HGNCiHGNC:24133 STAP1
MIMi604298 gene
neXtProtiNX_Q9ULZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26228
OpenTargetsiENSG00000035720
Orphaneti406 NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia
PharmGKBiPA162404948

Polymorphism and mutation databases

BioMutaiSTAP1
DMDMi62511239

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722371 – 295Signal-transducing adaptor protein 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine by TEC. Phosphorylated on tyrosine by KIT (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULZ2
MaxQBiQ9ULZ2
PaxDbiQ9ULZ2
PeptideAtlasiQ9ULZ2
PRIDEiQ9ULZ2
ProteomicsDBi85157
TopDownProteomicsiQ9ULZ2

PTM databases

iPTMnetiQ9ULZ2
PhosphoSitePlusiQ9ULZ2

Expressioni

Gene expression databases

BgeeiENSG00000035720 Expressed in 92 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_STAP1
ExpressionAtlasiQ9ULZ2 baseline and differential
GenevisibleiQ9ULZ2 HS

Organism-specific databases

HPAiHPA038529

Interactioni

Subunit structurei

Interacts with KIT and CSF1R (By similarity). Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117619, 7 interactors
CORUMiQ9ULZ2
IntActiQ9ULZ2, 9 interactors
MINTiQ9ULZ2
STRINGi9606.ENSP00000265404

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULZ2
SMRiQ9ULZ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULZ2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 121PHPROSITE-ProRule annotationAdd BLAST97
Domaini177 – 280SH2PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGPX Eukaryota
ENOG4111PK4 LUCA
GeneTreeiENSGT00530000063841
HOGENOMiHOG000234375
HOVERGENiHBG062262
InParanoidiQ9ULZ2
OMAiIDMPRIK
OrthoDBiEOG091G0929
PhylomeDBiQ9ULZ2
TreeFamiTF332087

Family and domain databases

CDDicd10403 SH2_STAP1, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR039111 STAP1/STAP2
IPR035877 STAP1_SH2
PANTHERiPTHR16186 PTHR16186, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR
60 70 80 90 100
GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ
110 120 130 140 150
LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI
160 170 180 190 200
ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM
210 220 230 240 250
ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF
260 270 280 290
SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
Length:295
Mass (Da):34,291
Last modified:May 1, 2000 - v1
Checksum:i8C242AC5C61038E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023483 mRNA Translation: BAA85311.1
AK313676 mRNA Translation: BAG36427.1
CH471057 Genomic DNA Translation: EAX05547.1
BC014958 mRNA Translation: AAH14958.1
CCDSiCCDS3515.1
RefSeqiNP_001304698.1, NM_001317769.1
NP_036240.1, NM_012108.3
UniGeneiHs.435579

Genome annotation databases

EnsembliENST00000265404; ENSP00000265404; ENSG00000035720
ENST00000396225; ENSP00000379527; ENSG00000035720
GeneIDi26228
KEGGihsa:26228
UCSCiuc003hde.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023483 mRNA Translation: BAA85311.1
AK313676 mRNA Translation: BAG36427.1
CH471057 Genomic DNA Translation: EAX05547.1
BC014958 mRNA Translation: AAH14958.1
CCDSiCCDS3515.1
RefSeqiNP_001304698.1, NM_001317769.1
NP_036240.1, NM_012108.3
UniGeneiHs.435579

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1FNMR-A16-151[»]
3MAZX-ray1.90A167-285[»]
ProteinModelPortaliQ9ULZ2
SMRiQ9ULZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117619, 7 interactors
CORUMiQ9ULZ2
IntActiQ9ULZ2, 9 interactors
MINTiQ9ULZ2
STRINGi9606.ENSP00000265404

PTM databases

iPTMnetiQ9ULZ2
PhosphoSitePlusiQ9ULZ2

Polymorphism and mutation databases

BioMutaiSTAP1
DMDMi62511239

Proteomic databases

EPDiQ9ULZ2
MaxQBiQ9ULZ2
PaxDbiQ9ULZ2
PeptideAtlasiQ9ULZ2
PRIDEiQ9ULZ2
ProteomicsDBi85157
TopDownProteomicsiQ9ULZ2

Protocols and materials databases

DNASUi26228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265404; ENSP00000265404; ENSG00000035720
ENST00000396225; ENSP00000379527; ENSG00000035720
GeneIDi26228
KEGGihsa:26228
UCSCiuc003hde.4 human

Organism-specific databases

CTDi26228
DisGeNETi26228
EuPathDBiHostDB:ENSG00000035720.7
GeneCardsiSTAP1
HGNCiHGNC:24133 STAP1
HPAiHPA038529
MIMi604298 gene
neXtProtiNX_Q9ULZ2
OpenTargetsiENSG00000035720
Orphaneti406 NON RARE IN EUROPE: Heterozygous familial hypercholesterolemia
PharmGKBiPA162404948
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPX Eukaryota
ENOG4111PK4 LUCA
GeneTreeiENSGT00530000063841
HOGENOMiHOG000234375
HOVERGENiHBG062262
InParanoidiQ9ULZ2
OMAiIDMPRIK
OrthoDBiEOG091G0929
PhylomeDBiQ9ULZ2
TreeFamiTF332087

Enzyme and pathway databases

SignaLinkiQ9ULZ2

Miscellaneous databases

EvolutionaryTraceiQ9ULZ2
GeneWikiiSTAP1
GenomeRNAii26228
PROiPR:Q9ULZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000035720 Expressed in 92 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_STAP1
ExpressionAtlasiQ9ULZ2 baseline and differential
GenevisibleiQ9ULZ2 HS

Family and domain databases

CDDicd10403 SH2_STAP1, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR039111 STAP1/STAP2
IPR035877 STAP1_SH2
PANTHERiPTHR16186 PTHR16186, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULZ2
Secondary accession number(s): B2R980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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